UniProt:P03468 NA
Binding of the influenza virion to the host cell
Clathrin-Mediated Pit Formation And Endocytosis Of The Influenza Virion
Conformation change in hemagglutinin freeing the fusion peptide of HA2
Fusion of the influenza virion HA2 protein transmembrane domain to the host cell endosome membrane
Concerted hemagglutinin pore formation
Virion-associated M2 protein mediated ion infusion
Ribonucleoprotein release from M1 proteins
Recognition of the Nuclear Localization Signal (NLS) by a Karyopherin Alpha Family Protein
Recruitment of Karyopherin Beta to form a Trimeric Complex
Docking and transport of the RNP:Karyopherin complex through the nuclear pore
Release of the RNP into the host cell nucleus
Viral Polymerase Assembly
NP binds vRNA
Assembly of an Active Transcription Complex
Priming and Initiation of Transcription
Elongation of viral mRNA
Polyadenylation and Termination
Viral mRNA Splicing (M, NS segments)
Export of Spliced Viral mRNA
Viral mRNA Export
Initiation of cRNA Synthesis
cRNA Extension
Initiation of vRNA Synthesis
vRNA Extension
Synthesis of PB1-F2
Viral Protein Synthesis
Newly synthesized vRNP for export
Binding of M1 to vRNP
Binding of NEP/NS2 to vRNP:M1
Binding of vRNP:M1:NEP complex to CRM1 export receptor
vRNP Export through the nuclear pore
Entry of M2 into the endoplasmic reticulum
Assembly of M2 tetramers
Entry of NA into the endoplasmic reticulum
Glycosylation of NA
Assembly of NA tetramers
Entry of HA into the endoplasmic reticulum
Glycosylation and Folding of HA
Trimerization of HA
Budding of vesicle with the HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum into the cytosol
Fusion of vesicle containing the HA trimer, NA tetramer and M2 tetramer to the Golgi apparatus
Palmitoylation of cysteine residues on HA in the cis-Golgi network
Palmitoylation of cysteine residues on M2 in the cis-golgi network
Association of HA into rafts
Association of NP into rafts
Association of NA into rafts
Transport of processed viral proteins to the cell membrane
Accumulation of M1 at the inner leaflet of the lipid bilayer
RNP association
Association with M1 at cell membrane
Membrane fusion
Neuraminidase enzymatic release from sialic acid
Binding of NS1 to cleavage and host polyadenylation specificity factor (CPSF)
Binding of NS1 to poly(A)-binding protein II (PABII)
Binding of NS1 to dsRNA
Binding of NS1 to PKR
NA activation of TGF-beta
PB1-F2 binds to the mitochondrial adenine nucleotide translocator 3 ANT3, inducing apoptosis
Influenza Infection
Influenza Life Cycle
Entry of Influenza Virion into Host Cell via Endocytosis
Fusion and Uncoating of the Influenza Virion
Fusion of the Influenza Virion to the Host Cell Endosome
Uncoating of the Influenza Virion
Transport of Ribonucleoproteins into the Host Nucleus
Influenza Viral RNA Transcription and Replication
vRNP Assembly
Viral Messenger RNA Synthesis
cRNA Synthesis
vRNA Synthesis
Viral mRNA Translation
Export of Viral Ribonucleoproteins from Nucleus
Viral RNP Complexes in the Host Cell Nucleus
NEP/NS2 Interacts with the Cellular Export Machinery
Virus Assembly and Release
Assembly of Viral Components at the Budding Site
Transport of HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatus
Packaging of Eight RNA Segments
Budding
Release
Host Interactions with Influenza Factors
NS1 Mediated Effects on Host Pathways
Inhibition of Host mRNA Processing and RNA Silencing
Inhibition of Interferon Synthesis
Inhibition of IFN-beta
Inhibition of PKR
Influenza Virus Induced Apoptosis