G6PT
label: G6PT1
label: PRO0685
label: SLC37A4
label: TRG19
label: UniProt:O43826 SLC37A4

GLUT5
label: SLC2A5
label: UniProt:P22732 SLC2A5

G6PC
label: G6PT
label: UniProt:P35575 G6PC

G6PC3
label: UGRP
label: UniProt:Q9BUM1 G6PC3

G6PC2
label: IGRP
label: UniProt:Q9NQR9 G6PC2

Transport (influx) of fructose by GLUT5
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: GLUT5
type: GO_0005353
BFO_0000050: Hexose transport
directly activates: Transport (efflux) of fructose, galactose, and glucose by GLUT2
directly activates: Catalysis642
label: extracellular fructose => cytosolic fructose

Transport (influx) of glucose, galactose, and sodium ions by SGLT1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005412
BFO_0000050: Hexose transport
directly activates: Transport (efflux) of fructose, galactose, and glucose by GLUT2
directly activates: Catalysis642

Transport (efflux) of fructose, galactose, and glucose by GLUT2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0015149
BFO_0000050: Hexose transport
label: cytosolic fructose, galactose, or glucose => extracellular fructose, galactose, or glucose

Glucose is taken up across the plasma membrane by a glucose transport protein (GLUT)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005355
BFO_0000050: Glucose transport
directly activates: alpha-D-Glucose + ATP => alpha-D-glucose 6-phosphate + ADP
directly activates: Catalysis645
label: alpha-D-glucose (extracellular) <=> alpha-D-glucose (cytosol)

Glucose is secreted across the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005355
BFO_0000050: Glucose transport
label: alpha-D-glucose (cytosol) <=> alpha-D-glucose (extracellular)

GLUT1 + ATP <=> GLUT1:ATP
type: GO_0003674
BFO_0000050: Glucose transport

GLUT1:ATP <=> GLUT1 + ATP
type: GO_0003674
BFO_0000050: Glucose transport

alpha-D-Glucose + ATP => alpha-D-glucose 6-phosphate + ADP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004340
BFO_0000050: Glucose transport
directly activates: BiochemicalReaction4537
directly activates: BiochemicalReaction4568
directly activates: BiochemicalReaction4594
directly activates: Catalysis1954
directly activates: Catalysis1985
directly activates: Catalysis2007

glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex
type: GO_0003674
BFO_0000050: Regulation of Glucokinase by Glucokinase Regulatory Protein
directly activates: cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP)
directly activates: GCK1:GKRP [cytosol] => GCK1:GKRP [nucleoplasm]
directly activates: Catalysis646
directly activates: Control117
directly activates: Control118
directly activates: Control119

cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP)
type: GO_0003674
BFO_0000050: Regulation of Glucokinase by Glucokinase Regulatory Protein

GCK1:GKRP [cytosol] => GCK1:GKRP [nucleoplasm]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005635
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005635
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005635
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005635
type: GO_0005487
BFO_0000050: Regulation of Glucokinase by Glucokinase Regulatory Protein
directly activates: Dissociation of the nucleoplasmic GCK1:GKRP complex
directly activates: Control120
label: Transport of glucokinase (GCK1):GKRP complex to the nucleus

Dissociation of the nucleoplasmic GCK1:GKRP complex
type: GO_0003674
BFO_0000050: Regulation of Glucokinase by Glucokinase Regulatory Protein
directly activates: glucokinase [nucleoplasm] => glucokinase [cytosol]
label: nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP)

glucokinase [nucleoplasm] => glucokinase [cytosol]
type: GO_0003674
BFO_0000050: Regulation of Glucokinase by Glucokinase Regulatory Protein
directly activates: glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex
directly activates: Control114
directly activates: Control115
directly activates: Control116

Cytosolic glucose 6-phosphate is exchanged for orthophosphate from the endoplasmic reticulum lumen by SLC37A4
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: G6PT
type: Restriction
  on property: enabled by
  some values from: G6PT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0061513
BFO_0000050: Glucose transport
directly activates: G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver)
directly activates: Catalysis648
label: alpha-D-glucose 6-phosphate (cytosol) + orthophosphate (ER lumen) => alpha-D-glucose 6-phosphate (ER lumen) + orthophosphate (cytosol) (SLC37A4)

G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: G6PC
type: Restriction
  on property: enabled by
  some values from: G6PC
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004346
BFO_0000050: Glucose transport
directly activates: Efflux of glucose from the endoplasmic reticulum
label: alpha-D-Glucose 6-phosphate + H2O => alpha-D-Glucose + Orthophosphate (G6PC - liver)

G6PC2 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (islet)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: G6PC2
type: Restriction
  on property: enabled by
  some values from: G6PC2
type: GO_0004346
BFO_0000050: Glucose transport
label: alpha-D-Glucose 6-phosphate + H2O => alpha-D-Glucose + Orthophosphate (G6PC2 - islet)

G6PC3 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (ubiquitous)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: G6PC3
type: Restriction
  on property: enabled by
  some values from: G6PC3
type: GO_0004346
BFO_0000050: Glucose transport
label: alpha-D-Glucose 6-phosphate + H2O => alpha-D-Glucose + Orthophosphate (G6PC3 - ubiquitous)

Efflux of glucose from the endoplasmic reticulum
type: GO_0003674
BFO_0000050: Glucose transport

Hexose transport
type: GO_0008150
label: Hexose uptake

Glucose transport
type: GO_0008150
BFO_0000050: Hexose transport

Regulation of Glucokinase by Glucokinase Regulatory Protein
type: GO_0008150
BFO_0000050: Glucose transport