G6PT
G6PT1
PRO0685
SLC37A4
TRG19
UniProt:O43826 SLC37A4
GLUT5
SLC2A5
UniProt:P22732 SLC2A5
G6PC
UniProt:P35575 G6PC
G6PC3
UGRP
UniProt:Q9BUM1 G6PC3
G6PC2
IGRP
UniProt:Q9NQR9 G6PC2
Transport (influx) of fructose by GLUT5
extracellular fructose => cytosolic fructose
Transport (influx) of glucose, galactose, and sodium ions by SGLT1
Transport (efflux) of fructose, galactose, and glucose by GLUT2
cytosolic fructose, galactose, or glucose => extracellular fructose, galactose, or glucose
Glucose is taken up across the plasma membrane by a glucose transport protein (GLUT)
alpha-D-glucose (extracellular) <=> alpha-D-glucose (cytosol)
Glucose is secreted across the plasma membrane
alpha-D-glucose (cytosol) <=> alpha-D-glucose (extracellular)
GLUT1 + ATP <=> GLUT1:ATP
GLUT1:ATP <=> GLUT1 + ATP
alpha-D-Glucose + ATP => alpha-D-glucose 6-phosphate + ADP
glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex
cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP)
GCK1:GKRP [cytosol] => GCK1:GKRP [nucleoplasm]
Transport of glucokinase (GCK1):GKRP complex to the nucleus
Dissociation of the nucleoplasmic GCK1:GKRP complex
nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP)
glucokinase [nucleoplasm] => glucokinase [cytosol]
Cytosolic glucose 6-phosphate is exchanged for orthophosphate from the endoplasmic reticulum lumen by SLC37A4
alpha-D-glucose 6-phosphate (cytosol) + orthophosphate (ER lumen) => alpha-D-glucose 6-phosphate (ER lumen) + orthophosphate (cytosol) (SLC37A4)
G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver)
alpha-D-Glucose 6-phosphate + H2O => alpha-D-Glucose + Orthophosphate (G6PC - liver)
G6PC2 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (islet)
alpha-D-Glucose 6-phosphate + H2O => alpha-D-Glucose + Orthophosphate (G6PC2 - islet)
G6PC3 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (ubiquitous)
alpha-D-Glucose 6-phosphate + H2O => alpha-D-Glucose + Orthophosphate (G6PC3 - ubiquitous)
Efflux of glucose from the endoplasmic reticulum
Hexose transport
Hexose uptake
Glucose transport
Regulation of Glucokinase by Glucokinase Regulatory Protein