NMT2
UniProt:O60551 NMT2
UniProt:P04585 gag-pol
gag-pol
FUR
FURIN
PACE
PCSK3
UniProt:P09958 FURIN
CHC1
RCC1
UniProt:P18754 RCC1
NMT
NMT1
UniProt:P30419 NMT1
CTDP1
FCP1
UniProt:Q9Y5B0 CTDP1
Transesterification to connect viral DNA 3' ends to host DNA 5' ends
Gap repair completes provirus integration
Cleavage of the viral Env gp160 precursor polyprotein
Binding of gp120 of ENV oligomer to the host CD4
Conformational change in gp120 of Env oligomer
CD4:gp120 binds to chemokine co-receptor CCR5/CXCR4
Conformational changes in gp120 exposes gp41
Fusogenic activation of gp41
gp41 N terminal fusion peptide released from viral membrane
Insertion of gp41 fusion peptide into the target membrane
N and C terminal heptad repeat helices of gp41 form six-helix bundle
Fusion of viral membrane with host cell membrane
Disintegration of matrix layer
Disassembly of viral capsid
Formation of RTC (Reverse Transcription Complex)
Annealing of 3'-end of unwound transfer RNA primer with genomic RNA
Synthesis of minus strand strong stop DNA (-sssDNA)
RNase H-mediated cleavage of the RNA strand of the -sssDNA:RNA duplex
RNase H-mediated degradation of the RNA strand of the -sssDNA:RNA duplex
First strand transfer mediated by Repeated (R) sequence
Minus strand DNA synthesis resumes
RNase H-mediated cleavage of the template strand
RNase H-mediated degradation of the template strand
3' PPT-primed initiation of plus-strand DNA synthesis
RNase H-mediated digestion of tRNA, 3'PPT and cPPT RNA primers
Second strand transfer by annealing complementary PBS sequences
Synthesis of full-length duplex viral DNA with a discontinuous plus strand
Removal of plus-strand flap and gap closure complete synthesis of linear duplex viral DNA
Formation of Pre-Integration Complex (PIC)
Integrase binds viral DNA ends
Terminal (3' end) cleavage of viral DNA
Import of PIC to the Host Nucleus
Target DNA binding
1-LTR circle formation
Association of Ku heterodimer with viral DNA ends
Association of XRCC4:DNA ligase IV complex with viral DNA ends
2-LTR formation due to circularization of viral DNA
Suicidal integration leading to inverted circle formation
Suicidal integration leading to smaller circles of viral DNA
HIV Promoter Opening: First Transition
Fall Back to Closed Pre-initiation Complex
NTP binds active site of RNA Polymerase II in HIV-1 open pre-initiation complex
Nucleophillic attack by 3'-hydroxyl oxygen of nascent HIV-1 transcript on the Alpha phosphate of NTP
Newly formed phosphodiester bond stabilized and PPi released
Abortive HIV-1 initiation after formation of the first phosphodiester bond
Addition of the third nucleotide on the nascent HIV-1 transcript
Addition of the fourth nucleotide on the nascent HIV-1 transcript: Second Transition
Abortive HIV-1 Initiation Before Second Transition
Addition of nucleotides 5 through 9 on the growing HIV-1 transcript
Abortive HIV-1 Initiation After Second Transition
Addition of nucleotides 10 and 11 on the growing HIV-1 transcript: Third Transition
Addition of nucleotides between position +11 and +30 on HIV-1 transcript
Extrusion of 5'-end of 30 nt long HIV-1 transcript through the pore in Pol II complex
Phosphorylation (Ser5) of RNA pol II CTD
RNA Polymerase II CTD (phosphorylated) binds to CE
Activation of GT
SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)
Hypophosphorylation of RNA Pol II CTD by FCP1P protein
DSIF complex binds to RNA Pol II (hypophosphorylated)
Formation of DSIF:NELF:HIV-1 early elongation complex
Abortive termination of HIV-1 early transcription elongation by DSIF:NELF
Recognition and binding of the HIV-1 mRNA cap by the cap-binding complex
Association of Tat with P-TEFb(Cyclin T1:Cdk9)
Hyperphosphorylation (Ser2) of RNA Pol II CTD by the P-TEFb(Cyclin T1:Cdk9) complex
Phosphorylation of NEFL by the P-TEFb(Cyclin T1:Cdk9) complex
Phosphorylation of DSIF by the P-TEFb(Cyclin T1:Cdk9) complex
Recruitment of elongation factors to form HIV-1 elongation complex
Addition of nucleotides leads to HIV-1 transcript elongation
Pol II elongation complex moves on the HIV-1 template as transcript elongates
Separation of elongating HIV-1 transcript from template
Limited elongation of the HIV-1 transcript
Separation of abortive HIV-1 transcript from template
7-14 nt. Backtracking of Pol II complex on the HIV-1 template leading to elongation arrest
Abortive termination of HIV-1 elongation after arrest
TFIIS-mediated recovery of HIV-1 elongation from arrest
Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex
2-4 nt.backtracking of Pol II complex on the HIV-1 template leading to elongation pausing
Resumption of elongation of HIV-1 transcript after recovery from pausing
TFIIS-mediated recovery of elongation from arrest
Abortive termination of HIV-1 elongation after arrest (Tat-containing elongation complex)
Rev molecules assemble onto the RRE RNA sequence through their ARM sequence
Multimerization of Rev
Rev multimer-bound HIV mRNA associates with Crm1
Conversion of Ran-GDP to Ran-GTP
Rev multimer-bound HIV mRNA:CRM1 complex associates with Ran:GTP
Rev multimer-bound HIV mRNA:Crm1:Ran:GTP complex associates with the NPC
Translocation of nuclear RNA transport complex to cytoplasm
Association of RanBP1 with Ran-GTP:CRM1:Rev:mRNA complex
Release of the HIV mRNA and Crm1 from Rev in the cytoplasm
Hydrolysis of Ran:GTP to Ran:GDP
Myristoylation of Nef
Synthesis of GAG polyprotein
Splicing of HIV RNA transcript
Synthesis of ENV polyprotein
Glycosylation of ENV polyprotein
Folding and Oligomerization of ENV glycoprotein
Transport of trimeric ENV precursor to Golgi apparatus
Transport of trimeric gp41:gp120 to plasma membrane
Synthesis of VPU protein
Transport of VPU to Golgi apparatus
Transport of VPU to Plasma Membrane
Packaging of HIV virion on the host cell plasma membrane
Recruitment Of HIV Virion Budding Machinery
HIV Virion Budding
Maturation of HIV Virion
Translocation of Vpr to the mitochondria
Association of Vpr with ANT1
Vpr binds nucleoporins
Interaction of Vpr with importin alpha
Association of multimerized Rev with beta-importin
Rev associates with B23
Rev:importin beta:B23 recruited to the nuclear pore
Translocation of Rev:importin-beta:B23 to the nucleus
Association of Ran-GTP with importin-beta
Disassembly of the Rev-importin beta-B23:Ran-GTP complex
Association of APOBEC3G with Gag
Association of APOBEC3G with single-stranded region of forming HIV-1 minus strand
Deamination of C residues during synthesis of HIV-1 reverse transcript minus-strand
Association of Vif with APOBEC3G
Association of APOBEC3G:Vif with the Cul5-SCF complex
Multi-ubiquitination of APOBEC3G
Proteosome-mediated degradation of APOBEC3G
Nef mediated activation of the T-cell receptor
Nef Binds and activates the Src-family tyrosine kinase Hck
Nef Binds and activates the Src-family tyrosine kinase Fyn
Nef Binds and activates the Src-family tyrosine kinase Lck
Nef binds a ternary complex comprising DOCK2 guanine nucleotide exchange factor for small Rho-family GTPase Rac, its cofactor ELMO1, and Rac, and activates Rac through this interaction
Formation of Nef CD28 cytoplasmic tail complex
Formation of Nef:Cd28:Clathrin-coated Pit Adapter Protein complex
Internalization of Nef:CD28:Clathrin-Coated Pit Adapter Protein Complex
Formation of MHC I:Nef Complex
Formation of MHC I:Nef:AP-1:PACS-1 Complex
Transport of MHC I:Nef:AP-1:PACS-1 Complex
Degradation of MHC I Complex
Nef mediated disruption of CD4:Lck Complex
Formation of CD4:Nef:AP-2 Complex:v-ATPase Complex
Internalization of the CD4:Nef:AP-2 Complex:v-ATPase Complex
Formation of a Nef:ARF1:CD4 complex
Degradation of CD4
Formation of CD8:Nef:AP-2 Complex:v-ATPase Complex
Internalization of the CD8:Nef:AP-2 Complex:v-ATPase Complex
Degradation of CD8
Association of Vpu with CD4
Vpu:CD4 associates with beta-TrCP
The Vpu:CD4:beta-TrCP complex recruits SKP1
Ubiquitination of CD4 by Vpu:CD4:beta-TrCP:SKP1 complex
Degradation of ubiquitinated CD4
N-myristoylation of GAG polyprotein by NMT2
Monoubiquitination of N-myristoyl GAG polyprotein
Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex
Transport of GAG to the Plasma Membrane
Membrane binding and targetting of GAG proteins
HIV Infection
HIV Life Cycle
Early Phase of HIV Life Cycle
Binding and entry of HIV virion
Uncoating of the HIV Virion
Reverse Transcription of HIV RNA
Minus-strand DNA synthesis
minus-strand DNA synthesis
Plus-strand DNA synthesis
Integration of provirus
Integration of viral DNA into host genomic DNA
2-LTR circle formation
Autointegration results in viral DNA circles
Late Phase of HIV Life Cycle
Transcription of the HIV genome
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
RNA Pol II CTD phosphorylation and interaction with CE
HIV Transcription Elongation
Formation of the HIV-1 Early Elongation Complex
Tat-mediated elongation of the HIV-1 transcript
Formation of HIV-1 elongation complex containing HIV-1 Tat
Abortive elongation of HIV-1 transcript in the absence of Tat
HIV elongation arrest and recovery
Formation of HIV elongation complex in the absence of HIV Tat
Pausing and recovery of HIV elongation
Tat-mediated HIV elongation arrest and recovery
Pausing and recovery of Tat-mediated HIV elongation
HIV Transcription Termination
Rev-mediated nuclear export of HIV RNA
Assembly Of The HIV Virion
Synthesis And Processing Of GAG, GAGPOL Polyproteins
Synthesis and organization of GAG, GAGPOL polyproteins
Synthesis and processing of ENV and VPU
Budding and maturation of HIV virion
Host Interactions of HIV factors
Interactions of Vpr with host cellular proteins
Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization
Vpr-mediated nuclear import of PICs
Interactions of Rev with host cellular proteins
Nuclear import of Rev protein
APOBEC3G mediated resistance to HIV-1 infection
Vif-mediated degradation of APOBEC3G
Interactions of Tat with host cellular proteins
The role of Nef in HIV-1 replication and disease pathogenesis
Nef and signal transduction
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
Nef mediated downregulation of CD28 cell surface expression
Nef mediated downregulation of MHC class I complex cell surface expression
Nef Mediated CD4 Down-regulation
Nef Mediated CD8 Down-regulation
Vpu mediated degradation of CD4