PCK1
label: PEPCK1
label: UniProt:P35558 PCK1

SLC20A3
label: SLC25A1
label: UniProt:P53007 SLC25A1

PCK2
label: PEPCK2
label: UniProt:Q16822 PCK2

DIC
label: SLC25A10
label: UniProt:Q9UBX3 SLC25A10

malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix]
type: Restriction
  on property: enabled by
  some values from: DIC
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: GO_0005310
BFO_0000050: Gluconeogenesis
directly activates: (S)-malate + NAD+ <=> oxaloacetate + NADH + H+
directly activates: Catalysis1967

Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004736
BFO_0000050: Gluconeogenesis
directly activates: Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+
directly activates: oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2]
directly activates: oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix]
directly activates: Catalysis1966
directly activates: Catalysis1968
directly activates: Catalysis1973
label: Pyruvate, CO2, and ATP react to form oxaloacetate, ADP, and orthophosphate

Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0030060
BFO_0000050: Gluconeogenesis
directly activates: malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix]
directly activates: Exchange of malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane
directly activates: Catalysis1969
directly activates: Catalysis636

(S)-malate + NAD+ <=> oxaloacetate + NADH + H+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0030060
BFO_0000050: Gluconeogenesis
directly activates: Oxaloacetate and GTP react to form phosphoenolpyruvate, CO2, and GDP [cytosol]
directly activates: Catalysis1972
label: malate + NAD+ <=> oxaloacetate + NADH + H+

oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004069
BFO_0000050: Gluconeogenesis
directly activates: Exchange of cytosolic glutamate and mitochondrial aspartate
directly activates: BiochemicalReaction5706
directly activates: Catalysis1970
directly activates: Catalysis2866

Exchange of malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: GO_0015367
BFO_0000050: Gluconeogenesis
directly activates: (S)-malate + NAD+ <=> oxaloacetate + NADH + H+
directly activates: Catalysis1967
label: malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix]

Exchange of cytosolic glutamate and mitochondrial aspartate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: GO_0015172
BFO_0000050: Gluconeogenesis
directly activates: aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1]
directly activates: Catalysis1971
label: aspartate [mitochondrial matrix] + glutamate [cytosol] => aspartate [cytosol] + glutamate [mitochondrial matrix]

aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004069
BFO_0000050: Gluconeogenesis
directly activates: Oxaloacetate and GTP react to form phosphoenolpyruvate, CO2, and GDP [cytosol]
directly activates: Catalysis1972

Oxaloacetate and GTP react to form phosphoenolpyruvate, CO2, and GDP [cytosol]
type: Restriction
  on property: enabled by
  some values from: PCK1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004613
BFO_0000050: Gluconeogenesis
directly activates: Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate
directly activates: Catalysis1975
label: oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol]

oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix]
type: Restriction
  on property: enabled by
  some values from: PCK2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004613
BFO_0000050: Gluconeogenesis
directly activates: Exchange of cytosolic citrate for mitochondrial phosphoenolpyruvate
directly activates: Catalysis1974

Exchange of cytosolic citrate for mitochondrial phosphoenolpyruvate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: enabled by
  some values from: SLC20A3
type: GO_0015142
BFO_0000050: Gluconeogenesis
directly activates: Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate
directly activates: Catalysis1975
label: phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix]

Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004634
BFO_0000050: Gluconeogenesis
directly activates: 2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate
directly activates: Catalysis1976

2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004619
BFO_0000050: Gluconeogenesis
directly activates: ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate
directly activates: Catalysis1977

ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004618
BFO_0000050: Gluconeogenesis
directly activates: 1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+
directly activates: Catalysis1978

1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004365
BFO_0000050: Gluconeogenesis
directly activates: D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate
directly activates: dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate
directly activates: Catalysis1979
directly activates: Catalysis1980

D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004807
BFO_0000050: Gluconeogenesis
directly activates: dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate
directly activates: Catalysis1980

dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004332
BFO_0000050: Gluconeogenesis
directly activates: D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate
directly activates: Catalysis1981
directly activates: Control368

D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0042132
BFO_0000050: Gluconeogenesis
directly activates: D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate
directly activates: Catalysis1984

Phosphorylation of PF2K-Pase by PKA catalytic subunit
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004691
BFO_0000050: Gluconeogenesis
directly activates: BiochemicalReaction4539
directly activates: Catalysis1956
directly activates: Control357

Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004331
BFO_0000050: Gluconeogenesis

D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004347
BFO_0000050: Gluconeogenesis
directly activates: BiochemicalReaction1665
directly activates: BiochemicalReaction4594
directly activates: Catalysis2007
directly activates: Catalysis647

Gluconeogenesis
type: GO_0008150