PCK1
PEPCK1
UniProt:P35558 PCK1
SLC20A3
SLC25A1
UniProt:P53007 SLC25A1
PCK2
PEPCK2
UniProt:Q16822 PCK2
DIC
SLC25A10
UniProt:Q9UBX3 SLC25A10
malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix]
Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate
Pyruvate, CO2, and ATP react to form oxaloacetate, ADP, and orthophosphate
Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+
(S)-malate + NAD+ <=> oxaloacetate + NADH + H+
malate + NAD+ <=> oxaloacetate + NADH + H+
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2]
Exchange of malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane
malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix]
Exchange of cytosolic glutamate and mitochondrial aspartate
aspartate [mitochondrial matrix] + glutamate [cytosol] => aspartate [cytosol] + glutamate [mitochondrial matrix]
aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1]
Oxaloacetate and GTP react to form phosphoenolpyruvate, CO2, and GDP [cytosol]
oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol]
oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix]
Exchange of cytosolic citrate for mitochondrial phosphoenolpyruvate
phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix]
Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate
2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate
ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate
1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+
D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate
dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate
D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate
Phosphorylation of PF2K-Pase by PKA catalytic subunit
Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate
D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate
Gluconeogenesis