G alpha (s) activates adenylate cyclase
Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs
Liganded Gs-activating GPCR acts as a GEF for Gs
The Ligand:GPCR:Gs complex dissociates
Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate
cAMP degradation by Phosphodiesterases
G alpha (s) auto-inactivates by hydrolysing GTP to GDP
Inactive G alpha (s) reassociates with G beta:gamma
G alpha (s) signalling events