MGLL
UniProt:Q99685 MGLL
G alpha (s) activates adenylate cyclase
Transport of Ca++ from platelet dense tubular system to cytoplasm
PIP3 recruits PDK1 and AKT to the membrane
Binding of IP3 to IP3 receptor
Calcium and Diacylglycerol activate CalDAG-GEFs (RasGRPs)
Activation of Protein Kinase C novel isoforms
DAG activation of TRPC channels
DAG is metabolized by DAGL to 2-AG
2-AG hydrolysis to arachidonate by MAGL
DAG kinase produces phosphatidic acid from DAG
G alpha (i) inhibits adenylate cyclase
PIP3 binds to RhoA and activates it
Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs
Liganded Gs-activating GPCR acts as a GEF for Gs
The Ligand:GPCR:Gs complex dissociates
Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate
cAMP degradation by Phosphodiesterases
G alpha (s) auto-inactivates by hydrolysing GTP to GDP
Inactive G alpha (s) reassociates with G beta:gamma
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
Liganded Gi-activating GPCR acts as a GEF for Gi
The Ligand:GPCR:Gi complex dissociates
Opsins that act as GEFs for G alpha-t
G alpha (i) auto-inactivates by hydrolysing GTP to GDP
Inactive G alpha (i) reassociates with G beta:gamma
Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz
Liganded Gz-activating GPCR acts as a GEF for Gz
The Ligand:GPCR:Gz complex dissociates
G alpha (z) inhibits adenylate cyclase
Gz is a substrate for PKC
G alpha (z) auto-inactivates by hydrolysing GTP to GDP
Inactive G alpha (z) reassociates with G beta:gamma
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
The Ligand:GPCR:Gq complex dissociates
GRK2 sequesters activated Gq
GRK5 sequesters activated Gq
G alpha (q) binds to Trio family RhoGEFs
PLC beta is activated by G alpha (q)
G alpha (q) inhibits PI3K alpha
PLC beta-mediated PIP2 hydrolysis
G alpha (q) auto-inactivates by hydrolysing GTP to GDP
Inactive G alpha (q) reassociates with G beta:gamma
Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13
Liganded G12/13-activating GPCR acts as a GEF for G12/13
The Ligand:GPCR:G12/13 complex dissociates
G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF)
p115-RhoGEF activation of Rac1
Rac1 activation of PI3K
GEFs activate RhoA,B,C
ROCK activation by Rho
LARG activation by G alpha 12/13
LARG binds plexin B1
G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP
Inactive G alpha (12/13) reassociates with G beta:gamma
Gbeta:gamma recruits PI3K gamma
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3
Gbeta:gamma activation of PLC beta
G Protein trimer formation (olfactory)
Olfactory Receptor - G Protein olfactory trimer complex formation
GPCR downstream signaling
G alpha (s) signalling events
G alpha (i) signalling events
G alpha (z) signalling events
G alpha (q) signalling events
G alpha (12/13) signalling events
G-protein beta:gamma signalling
G beta:gamma signalling through PI3Kgamma
G beta:gamma signalling through PLC beta
Olfactory Signaling Pathway
Effects of PIP2 hydrolysis
Arachidonate production from DAG