MGLL
label: UniProt:Q99685 MGLL

G alpha (s) activates adenylate cyclase
type: GO_0003674
BFO_0000050: G alpha (s) signalling events
directly activates: BiochemicalReaction1771
directly activates: Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate
directly activates: Catalysis1878
directly activates: Catalysis747
directly activates: Control340
directly activates: Control341
directly activates: Control342

Transport of Ca++ from platelet dense tubular system to cytoplasm
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031095
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031095
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031095
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031095
type: GO_0005262
BFO_0000050: Effects of PIP2 hydrolysis
directly activates: Calcium and Diacylglycerol activate CalDAG-GEFs (RasGRPs)
directly activates: BiochemicalReaction2356
directly activates: BiochemicalReaction242
directly activates: Control159

PIP3 recruits PDK1 and AKT to the membrane
type: GO_0003674
BFO_0000050: G beta:gamma signalling through PI3Kgamma
directly activates: BiochemicalReaction2322

Binding of IP3 to IP3 receptor
type: GO_0003674
BFO_0000050: Effects of PIP2 hydrolysis
directly activates: Transport of Ca++ from platelet dense tubular system to cytoplasm
directly activates: Catalysis1004

Calcium and Diacylglycerol activate CalDAG-GEFs (RasGRPs)
type: GO_0003674
BFO_0000050: Effects of PIP2 hydrolysis
directly activates: BiochemicalReaction850
directly activates: BiochemicalReaction851
directly activates: Catalysis321
directly activates: Catalysis322

Activation of Protein Kinase C novel isoforms
type: GO_0003674
BFO_0000050: Effects of PIP2 hydrolysis

DAG activation of TRPC channels
type: GO_0003674
BFO_0000050: Effects of PIP2 hydrolysis
directly activates: BiochemicalReaction2250
directly activates: Catalysis1006

DAG is metabolized by DAGL to 2-AG
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0047372
BFO_0000050: Arachidonate production from DAG
directly activates: 2-AG hydrolysis to arachidonate by MAGL
directly activates: Catalysis1037

2-AG hydrolysis to arachidonate by MAGL
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: GO_0047372
BFO_0000050: Arachidonate production from DAG

DAG kinase produces phosphatidic acid from DAG
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004143
BFO_0000050: Effects of PIP2 hydrolysis

G alpha (i) inhibits adenylate cyclase
type: GO_0003674
BFO_0000050: G alpha (i) signalling events
directly activates: BiochemicalReaction3761
directly activates: Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate
directly activates: Catalysis1878
directly activates: Control340
directly activates: Control341
directly activates: Control342

PIP3 binds to RhoA and activates it
type: GO_0003674
BFO_0000050: G beta:gamma signalling through PI3Kgamma

Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs
type: GO_0003674
BFO_0000050: G alpha (s) signalling events
directly activates: Liganded Gs-activating GPCR acts as a GEF for Gs
directly activates: Catalysis1877

Liganded Gs-activating GPCR acts as a GEF for Gs
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005085
BFO_0000050: G alpha (s) signalling events
directly activates: The Ligand:GPCR:Gs complex dissociates
directly activates: Gbeta:gamma recruits PI3K gamma
directly activates: Gbeta:gamma activation of PLC beta

The Ligand:GPCR:Gs complex dissociates
type: GO_0003674
BFO_0000050: G alpha (s) signalling events
directly activates: G alpha (s) activates adenylate cyclase
directly activates: G alpha (s) auto-inactivates by hydrolysing GTP to GDP
directly activates: Catalysis1880

Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004016
BFO_0000050: G alpha (s) signalling events
BFO_0000050: G alpha (i) signalling events
BFO_0000050: G alpha (z) signalling events
directly activates: cAMP degradation by Phosphodiesterases
directly activates: Catalysis1879

cAMP degradation by Phosphodiesterases
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004115
BFO_0000050: G alpha (s) signalling events

G alpha (s) auto-inactivates by hydrolysing GTP to GDP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0003924
BFO_0000050: G alpha (s) signalling events
directly activates: Inactive G alpha (s) reassociates with G beta:gamma

Inactive G alpha (s) reassociates with G beta:gamma
type: GO_0003674
BFO_0000050: G alpha (s) signalling events

Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
type: GO_0003674
BFO_0000050: G alpha (i) signalling events
directly activates: Liganded Gi-activating GPCR acts as a GEF for Gi
directly activates: Catalysis1881

Liganded Gi-activating GPCR acts as a GEF for Gi
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005085
BFO_0000050: G alpha (i) signalling events
directly activates: The Ligand:GPCR:Gi complex dissociates
directly activates: G alpha (z) inhibits adenylate cyclase
directly activates: G alpha (z) auto-inactivates by hydrolysing GTP to GDP
directly activates: G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF)
directly activates: LARG activation by G alpha 12/13
directly activates: G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP
directly activates: Gbeta:gamma recruits PI3K gamma
directly activates: Gbeta:gamma activation of PLC beta
directly activates: Catalysis1886
directly activates: Catalysis1893
directly activates: Control344

The Ligand:GPCR:Gi complex dissociates
type: GO_0003674
BFO_0000050: G alpha (i) signalling events
directly activates: G alpha (i) inhibits adenylate cyclase
directly activates: G alpha (i) auto-inactivates by hydrolysing GTP to GDP
directly activates: Catalysis1883
directly activates: Control343

Opsins that act as GEFs for G alpha-t
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005085
BFO_0000050: G alpha (i) signalling events

G alpha (i) auto-inactivates by hydrolysing GTP to GDP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0003924
BFO_0000050: G alpha (i) signalling events
directly activates: Inactive G alpha (i) reassociates with G beta:gamma

Inactive G alpha (i) reassociates with G beta:gamma
type: GO_0003674
BFO_0000050: G alpha (i) signalling events

Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz
type: GO_0003674
BFO_0000050: G alpha (z) signalling events
directly activates: Liganded Gz-activating GPCR acts as a GEF for Gz
directly activates: Catalysis1884

Liganded Gz-activating GPCR acts as a GEF for Gz
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005085
BFO_0000050: G alpha (z) signalling events
directly activates: The Ligand:GPCR:Gz complex dissociates

The Ligand:GPCR:Gz complex dissociates
type: GO_0003674
BFO_0000050: G alpha (z) signalling events
directly activates: G alpha (z) inhibits adenylate cyclase
directly activates: G alpha (z) auto-inactivates by hydrolysing GTP to GDP
directly activates: Catalysis1886
directly activates: Control344

G alpha (z) inhibits adenylate cyclase
type: GO_0003674
BFO_0000050: G alpha (z) signalling events
directly activates: Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate
directly activates: Catalysis1878
directly activates: Control340
directly activates: Control341
directly activates: Control342

Gz is a substrate for PKC
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004697
BFO_0000050: G alpha (z) signalling events

G alpha (z) auto-inactivates by hydrolysing GTP to GDP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0003924
BFO_0000050: G alpha (z) signalling events
directly activates: Inactive G alpha (z) reassociates with G beta:gamma

Inactive G alpha (z) reassociates with G beta:gamma
type: GO_0003674
BFO_0000050: G alpha (z) signalling events

Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
type: GO_0003674
BFO_0000050: G alpha (q) signalling events
directly activates: Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
directly activates: Catalysis1887

Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005085
BFO_0000050: G alpha (q) signalling events
directly activates: The Ligand:GPCR:Gq complex dissociates
directly activates: Gbeta:gamma recruits PI3K gamma
directly activates: Gbeta:gamma activation of PLC beta

The Ligand:GPCR:Gq complex dissociates
type: GO_0003674
BFO_0000050: G alpha (q) signalling events
directly activates: GRK2 sequesters activated Gq
directly activates: GRK5 sequesters activated Gq
directly activates: G alpha (q) binds to Trio family RhoGEFs
directly activates: PLC beta is activated by G alpha (q)
directly activates: G alpha (q) inhibits PI3K alpha
directly activates: G alpha (q) auto-inactivates by hydrolysing GTP to GDP
directly activates: Catalysis1889
directly activates: Control345

GRK2 sequesters activated Gq
type: GO_0003674
BFO_0000050: G alpha (q) signalling events

GRK5 sequesters activated Gq
type: GO_0003674
BFO_0000050: G alpha (q) signalling events

G alpha (q) binds to Trio family RhoGEFs
type: GO_0003674
BFO_0000050: G alpha (q) signalling events

PLC beta is activated by G alpha (q)
type: GO_0003674
BFO_0000050: G alpha (q) signalling events
directly activates: PLC beta-mediated PIP2 hydrolysis
directly activates: Catalysis1888

G alpha (q) inhibits PI3K alpha
type: GO_0003674
BFO_0000050: G alpha (q) signalling events

PLC beta-mediated PIP2 hydrolysis
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004629
BFO_0000050: G alpha (q) signalling events
directly activates: Binding of IP3 to IP3 receptor
directly activates: Calcium and Diacylglycerol activate CalDAG-GEFs (RasGRPs)
directly activates: Activation of Protein Kinase C novel isoforms
directly activates: DAG activation of TRPC channels
directly activates: DAG is metabolized by DAGL to 2-AG
directly activates: DAG kinase produces phosphatidic acid from DAG
directly activates: BiochemicalReaction2356
directly activates: BiochemicalReaction4418
directly activates: BiochemicalReaction715
directly activates: Catalysis1036
directly activates: Catalysis1038
directly activates: Control159

G alpha (q) auto-inactivates by hydrolysing GTP to GDP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0003924
BFO_0000050: G alpha (q) signalling events
directly activates: Inactive G alpha (q) reassociates with G beta:gamma

Inactive G alpha (q) reassociates with G beta:gamma
type: GO_0003674
BFO_0000050: G alpha (q) signalling events

Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13
type: GO_0003674
BFO_0000050: G alpha (12/13) signalling events
directly activates: Liganded G12/13-activating GPCR acts as a GEF for G12/13
directly activates: Catalysis1890

Liganded G12/13-activating GPCR acts as a GEF for G12/13
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005085
BFO_0000050: G alpha (12/13) signalling events
directly activates: The Ligand:GPCR:G12/13 complex dissociates

The Ligand:GPCR:G12/13 complex dissociates
type: GO_0003674
BFO_0000050: G alpha (12/13) signalling events
directly activates: G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF)
directly activates: LARG activation by G alpha 12/13
directly activates: G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP
directly activates: Catalysis1893

G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF)
type: GO_0003674
BFO_0000050: G alpha (12/13) signalling events
directly activates: p115-RhoGEF activation of Rac1
directly activates: GEFs activate RhoA,B,C
directly activates: Catalysis1891
directly activates: Catalysis1892

p115-RhoGEF activation of Rac1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005085
BFO_0000050: G alpha (12/13) signalling events
directly activates: Rac1 activation of PI3K

Rac1 activation of PI3K
type: GO_0003674
BFO_0000050: G alpha (12/13) signalling events
directly activates: BiochemicalReaction2320
directly activates: Catalysis1027

GEFs activate RhoA,B,C
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0005089
BFO_0000050: G alpha (12/13) signalling events
directly activates: ROCK activation by Rho

ROCK activation by Rho
type: GO_0003674
BFO_0000050: G alpha (12/13) signalling events
directly activates: BiochemicalReaction6113
directly activates: BiochemicalReaction6114
directly activates: Catalysis3170
directly activates: Catalysis3171

LARG activation by G alpha 12/13
type: GO_0003674
BFO_0000050: G alpha (12/13) signalling events
directly activates: GEFs activate RhoA,B,C
directly activates: LARG binds plexin B1
directly activates: Catalysis1892

LARG binds plexin B1
type: GO_0003674
BFO_0000050: G alpha (12/13) signalling events

G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0003924
BFO_0000050: G alpha (12/13) signalling events
directly activates: Inactive G alpha (12/13) reassociates with G beta:gamma

Inactive G alpha (12/13) reassociates with G beta:gamma
type: GO_0003674
BFO_0000050: G alpha (12/13) signalling events

Gbeta:gamma recruits PI3K gamma
type: GO_0003674
BFO_0000050: G beta:gamma signalling through PI3Kgamma
directly activates: G beta:gamma activated PI3Kgamma converts PIP2 to PIP3
directly activates: Catalysis1894

G beta:gamma activated PI3Kgamma converts PIP2 to PIP3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0046934
BFO_0000050: G beta:gamma signalling through PI3Kgamma
directly activates: PIP3 recruits PDK1 and AKT to the membrane
directly activates: PIP3 binds to RhoA and activates it
directly activates: BiochemicalReaction679
directly activates: BiochemicalReaction680
directly activates: Control158

Gbeta:gamma activation of PLC beta
type: GO_0003674
BFO_0000050: G beta:gamma signalling through PLC beta
directly activates: PLC beta-mediated PIP2 hydrolysis
directly activates: Catalysis1895

PLC beta-mediated PIP2 hydrolysis
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004629
BFO_0000050: G beta:gamma signalling through PLC beta
directly activates: Binding of IP3 to IP3 receptor
directly activates: Calcium and Diacylglycerol activate CalDAG-GEFs (RasGRPs)
directly activates: Activation of Protein Kinase C novel isoforms
directly activates: DAG activation of TRPC channels
directly activates: DAG is metabolized by DAGL to 2-AG
directly activates: DAG kinase produces phosphatidic acid from DAG
directly activates: BiochemicalReaction2356
directly activates: BiochemicalReaction715
directly activates: Catalysis1036
directly activates: Catalysis1038
directly activates: Control159

G Protein trimer formation (olfactory)
type: GO_0003674
BFO_0000050: Olfactory Signaling Pathway

Olfactory Receptor - G Protein olfactory trimer complex formation
type: GO_0003674
BFO_0000050: Olfactory Signaling Pathway

GPCR downstream signaling
type: GO_0008150

G alpha (s) signalling events
type: GO_0008150
BFO_0000050: GPCR downstream signaling

G alpha (i) signalling events
type: GO_0008150
BFO_0000050: GPCR downstream signaling

G alpha (z) signalling events
type: GO_0008150
BFO_0000050: GPCR downstream signaling

G alpha (q) signalling events
type: GO_0008150
BFO_0000050: GPCR downstream signaling

G alpha (12/13) signalling events
type: GO_0008150
BFO_0000050: GPCR downstream signaling

G-protein beta:gamma signalling
type: GO_0008150
BFO_0000050: GPCR downstream signaling

G beta:gamma signalling through PI3Kgamma
type: GO_0008150
BFO_0000050: G-protein beta:gamma signalling

G beta:gamma signalling through PLC beta
type: GO_0008150
BFO_0000050: G-protein beta:gamma signalling

Olfactory Signaling Pathway
type: GO_0008150
BFO_0000050: GPCR downstream signaling

Effects of PIP2 hydrolysis
type: GO_0008150
BFO_0000050: G alpha (q) signalling events

Arachidonate production from DAG
type: GO_0008150
BFO_0000050: Effects of PIP2 hydrolysis