ELOVL7
UniProt:A1L3X0 ELOVL7
ACSL1
FACL1
FACL2
LACS
LACS1
LACS2
UniProt:P33121 ACSL1
SLC20A3
SLC25A1
UniProt:P53007 SLC25A1
ACAC
ACACA
ACC1
ACCA
UniProt:Q13085 ACACA
HSD17B12
UniProt:Q53GQ0 HSD17B12
CGI-88
ELOVL1
SSC1
UniProt:Q9BW60 ELOVL1
ELOVL4
UniProt:Q9GZR5 ELOVL4
ELOVL6
FACE
LCE
UniProt:Q9H5J4 ELOVL6
CIG30
ELOVL3
UniProt:Q9HB03 ELOVL3
ELOVL2
SSC2
UniProt:Q9NXB9 ELOVL2
ELOVL5
PRO0530
UniProt:Q9NYP7 ELOVL5
GPSN2
SC2
TECR
UniProt:Q9NZ01 TECR
ACS2
ACSL6
FACL6
KIAA0837
LACS5
UniProt:Q9UKU0 ACSL6
ACS5
ACSL5
FACL5
UniProt:Q9ULC5 ACSL5
Transport of Citrate from Mitochondrial Matrix to cytosol
Generation of Cytoplasmic Acetyl CoA from Citrate
Formation of Malonyl-CoA from Acetyl-CoA (liver)
acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate
Formation of fatty acid synthase (FAS) dimer
Conversion of malonyl-CoA and acetyl-CoA to palmitate
acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O
Conversion of palmitic acid to palmitoyl-CoA
palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL1]
palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3]
arachidonate + CoASH + ATP => arachidonoyl-CoA + AMP + pyrophosphate + H2O [ACSL4]
palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL5]
palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL6]
palmitoyl-CoA + malonyl-CoA => 3-oxooctadecanoyl-CoA (3-oxostearoyl-CoA) + CO2 + CoASH [ELOVL1]
palmitoyl-CoA + malonyl-CoA => 3-oxooctadecanoyl-CoA (3-oxostearoyl-CoA) + CO2 + CoASH [ELOVL2]
palmitoyl-CoA + malonyl-CoA => 3-oxooctadecanoyl-CoA (3-oxostearoyl-CoA) + CO2 + CoASH [ELOVL3]
lignoceroyl-CoA + malonyl-CoA => 3-oxocerotoyl-CoA + CO2 + CoASH [ELOVL4]
arachidonoyl-CoA + malonyl-CoA => 3-oxo-(7,10,13,16)-docosatetraenoyl-CoA + CO2 + CoASH [ELOVL5]
palmitoyl-CoA + malonyl-CoA => 3-oxooctadecanoyl-CoA (3-oxostearoyl-CoA) + CO2 + CoASH [ELOVL6]
arachidoyl-CoA + malonyl-CoA => 3-oxobehenoyl-CoA + CO2 + CoASH [ELOVL7]
3-oxooctadecanoyl-CoA (3-oxostearoyl-CoA) + NADPH + H+ => 3-hydroxyoctadecanoyl-CoA + NADP+
3-hydroxyoctadecanoyl-CoA => trans-octadec-2-enoyl-CoA + H2O
trans-octadec-2-enoyl-CoA + NADPH + H+ => stearoyl-CoA + NADP+
Fatty Acyl-CoA Biosynthesis
Conversion of palmitic acid to very long chain fatty acyl-CoAs
Synthesis of very long-chain fatty acyl-CoAs