ELOVL7
label: UniProt:A1L3X0 ELOVL7

ACSL1
label: FACL1
label: FACL2
label: LACS
label: LACS1
label: LACS2
label: UniProt:P33121 ACSL1

SLC20A3
label: SLC25A1
label: UniProt:P53007 SLC25A1

ACAC
label: ACACA
label: ACC1
label: ACCA
label: UniProt:Q13085 ACACA

HSD17B12
label: UniProt:Q53GQ0 HSD17B12

CGI-88
label: ELOVL1
label: SSC1
label: UniProt:Q9BW60 ELOVL1

ELOVL4
label: UniProt:Q9GZR5 ELOVL4

ELOVL6
label: FACE
label: LCE
label: UniProt:Q9H5J4 ELOVL6

CIG30
label: ELOVL3
label: UniProt:Q9HB03 ELOVL3

ELOVL2
label: SSC2
label: UniProt:Q9NXB9 ELOVL2

ELOVL2
label: ELOVL5
label: PRO0530
label: UniProt:Q9NYP7 ELOVL5

GPSN2
label: SC2
label: TECR
label: UniProt:Q9NZ01 TECR

ACS2
label: ACSL6
label: FACL6
label: KIAA0837
label: LACS5
label: UniProt:Q9UKU0 ACSL6

ACS5
label: ACSL5
label: FACL5
label: UNQ633/PRO1250
label: UniProt:Q9ULC5 ACSL5

Transport of Citrate from Mitochondrial Matrix to cytosol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: enabled by
  some values from: SLC20A3
type: GO_0015142
BFO_0000050: Fatty Acyl-CoA Biosynthesis
directly activates: Generation of Cytoplasmic Acetyl CoA from Citrate
directly activates: Catalysis2094

Generation of Cytoplasmic Acetyl CoA from Citrate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003878
BFO_0000050: Fatty Acyl-CoA Biosynthesis
directly activates: Formation of Malonyl-CoA from Acetyl-CoA (liver)
directly activates: BiochemicalReaction4767
directly activates: Catalysis2095
directly activates: Catalysis2123
directly activates: Control388

Formation of Malonyl-CoA from Acetyl-CoA (liver)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: ACAC
type: GO_0003989
BFO_0000050: Fatty Acyl-CoA Biosynthesis
directly activates: Conversion of malonyl-CoA and acetyl-CoA to palmitate
directly activates: Catalysis2096
label: acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate

Formation of fatty acid synthase (FAS) dimer
type: GO_0003674
BFO_0000050: Fatty Acyl-CoA Biosynthesis
directly activates: Conversion of malonyl-CoA and acetyl-CoA to palmitate
directly activates: Catalysis2096

Conversion of malonyl-CoA and acetyl-CoA to palmitate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004312
BFO_0000050: Fatty Acyl-CoA Biosynthesis
label: acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O

Conversion of palmitic acid to palmitoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: ACSL1
type: Restriction
  on property: enabled by
  some values from: ACSL1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004467
BFO_0000050: Conversion of palmitic acid to very long chain fatty acyl-CoAs
label: palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL1]

palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004467
BFO_0000050: Conversion of palmitic acid to very long chain fatty acyl-CoAs

arachidonate + CoASH + ATP => arachidonoyl-CoA + AMP + pyrophosphate + H2O [ACSL4]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004467
BFO_0000050: Conversion of palmitic acid to very long chain fatty acyl-CoAs

palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL5]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: ACS5
type: Restriction
  on property: enabled by
  some values from: ACS5
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004467
BFO_0000050: Conversion of palmitic acid to very long chain fatty acyl-CoAs

palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL6]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: ACS2
type: Restriction
  on property: enabled by
  some values from: ACS2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004467
BFO_0000050: Conversion of palmitic acid to very long chain fatty acyl-CoAs

palmitoyl-CoA + malonyl-CoA => 3-oxooctadecanoyl-CoA (3-oxostearoyl-CoA) + CO2 + CoASH [ELOVL1]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: CGI-88
type: Restriction
  on property: enabled by
  some values from: CGI-88
type: GO_0009922
BFO_0000050: Conversion of palmitic acid to very long chain fatty acyl-CoAs

palmitoyl-CoA + malonyl-CoA => 3-oxooctadecanoyl-CoA (3-oxostearoyl-CoA) + CO2 + CoASH [ELOVL2]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: GO_0009922
BFO_0000050: Conversion of palmitic acid to very long chain fatty acyl-CoAs

palmitoyl-CoA + malonyl-CoA => 3-oxooctadecanoyl-CoA (3-oxostearoyl-CoA) + CO2 + CoASH [ELOVL3]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: CIG30
type: Restriction
  on property: enabled by
  some values from: CIG30
type: GO_0009922
BFO_0000050: Conversion of palmitic acid to very long chain fatty acyl-CoAs

lignoceroyl-CoA + malonyl-CoA => 3-oxocerotoyl-CoA + CO2 + CoASH [ELOVL4]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: ELOVL4
type: Restriction
  on property: enabled by
  some values from: ELOVL4
type: GO_0009922
BFO_0000050: Conversion of palmitic acid to very long chain fatty acyl-CoAs

arachidonoyl-CoA + malonyl-CoA => 3-oxo-(7,10,13,16)-docosatetraenoyl-CoA + CO2 + CoASH [ELOVL5]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: GO_0009922
BFO_0000050: Conversion of palmitic acid to very long chain fatty acyl-CoAs

palmitoyl-CoA + malonyl-CoA => 3-oxooctadecanoyl-CoA (3-oxostearoyl-CoA) + CO2 + CoASH [ELOVL6]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: ELOVL6
type: Restriction
  on property: enabled by
  some values from: ELOVL6
type: GO_0009922
BFO_0000050: Conversion of palmitic acid to very long chain fatty acyl-CoAs

arachidoyl-CoA + malonyl-CoA => 3-oxobehenoyl-CoA + CO2 + CoASH [ELOVL7]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: ELOVL7
type: Restriction
  on property: enabled by
  some values from: ELOVL7
type: GO_0009922
BFO_0000050: Conversion of palmitic acid to very long chain fatty acyl-CoAs

3-oxooctadecanoyl-CoA (3-oxostearoyl-CoA) + NADPH + H+ => 3-hydroxyoctadecanoyl-CoA + NADP+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: HSD17B12
type: Restriction
  on property: enabled by
  some values from: HSD17B12
type: GO_0016509
BFO_0000050: Conversion of palmitic acid to very long chain fatty acyl-CoAs

3-hydroxyoctadecanoyl-CoA => trans-octadec-2-enoyl-CoA + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0016508
BFO_0000050: Conversion of palmitic acid to very long chain fatty acyl-CoAs

trans-octadec-2-enoyl-CoA + NADPH + H+ => stearoyl-CoA + NADP+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: GPSN2
type: Restriction
  on property: enabled by
  some values from: GPSN2
type: GO_0017099
BFO_0000050: Conversion of palmitic acid to very long chain fatty acyl-CoAs

Fatty Acyl-CoA Biosynthesis
type: GO_0008150

Conversion of palmitic acid to very long chain fatty acyl-CoAs
type: GO_0008150
BFO_0000050: Fatty Acyl-CoA Biosynthesis
label: Synthesis of very long-chain fatty acyl-CoAs