Recruitment of TEC kinases to p-SLP-76
Phosphorylation of TEC kinases by p-SYK
Autophosphorylation of BTK/ITK
Phosphorylation of PLC-gamma
Hydrolysis of PIP2 by PLCG
Activation of Calcineurin
Calcineurin binds and dephosphorylates NFAT
Translocation of CaN:CaM:NFAT to nucleus
Calcium binds calmodulin
IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel
Release of calcium from intracellular stores by IP3 receptor activation
FCERI mediated Ca+2 mobilization