CYP17
label: CYP17A1
label: S17AH
label: UniProt:P05093 CYP17A1

CYP11A
label: CYP11A1
label: UniProt:P05108 CYP11A1

CYP21
label: CYP21A2
label: CYP21B
label: UniProt:P08686 CYP21A2

ARO1
label: CYAR
label: CYP19
label: CYP19A1
label: UniProt:P11511 CYP19A1

CYP27
label: CYP27A1
label: UniProt:Q02318 CYP27A1

CYP1B1
label: UniProt:Q16678 CYP1B1

CYP51
label: CYP51A1
label: UniProt:Q16850 CYP51A1

CYP39A1
label: UniProt:Q9NYL5 CYP39A1

CYP46
label: CYP46A1
label: UniProt:Q9Y6A2 CYP46A1

20alpha,22beta-hydroxycholesterol + NADPH + H+ + O2 => pregnenolone + isocaproaldehyde + NADP+ + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: CYP11A
type: GO_0008386
BFO_0000050: Endogenous sterols
directly activates: BiochemicalReaction2555
directly activates: BiochemicalReaction2557
label: 20alpha,22beta-hydroxycholesterol is cleaved by CYP11A1 to yield pregnenolone and isocaproaldehyde

Hydroxylation of pregnenolone to form 17alpha-hydroxypregnenolone
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: CYP17
type: GO_0004508
BFO_0000050: Endogenous sterols
directly activates: BiochemicalReaction2559
directly activates: BiochemicalReaction2573
directly activates: Catalysis1103
directly activates: Catalysis1114
directly activates: Control175
label: pregnenolone + NADPH + H+ => 17alpha-hydroxypregnenolone + NADP+ + H2O

11-deoxycortisol + NADPH + H+ + O2 => cortisol + NADP+ + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: GO_0004507
BFO_0000050: Endogenous sterols
directly activates: BiochemicalReaction2564
label: 11-deoxycortisol is oxidised to cortisol by CYP11B1

21-hydroxylation of progesterone to form 11-deoxycorticosterone
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: CYP21
type: GO_0004509
BFO_0000050: Endogenous sterols
directly activates: BiochemicalReaction2569
label: progesterone + NAPDH + H+ + O2 => 11-deoxycorticosterone + NADP+ + H2O

Androstenedione is converted to estrone by Aromatase (CYP19A1)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: ARO1
type: GO_0008395
BFO_0000050: Endogenous sterols
directly activates: BiochemicalReaction2581
directly activates: Catalysis1122

Lanosterol is oxidatively demethylated to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: CYP51
type: GO_0008398
BFO_0000050: Endogenous sterols
directly activates: BiochemicalReaction4867
directly activates: BiochemicalReaction4868
directly activates: Catalysis2218
directly activates: Catalysis2219
label: lanosterol + 3 NADPH + 3 H+ + 3 O2 => 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol + 3 NADP+ + 4 H2O + formate

Cholesterol + NADPH + H+ + O2 => 7-alpha-hydroxycholesterol + NADP+ + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0008123
BFO_0000050: Endogenous sterols
directly activates: BiochemicalReaction4927
directly activates: Catalysis2233
label: Cholesterol is hydroxylated to 7alpha-hydroxycholesterol by CYP7A1

4-Cholesten-7alpha-ol-3-one is 12alpha-hydroxylated to 7-alpha,12-alpha-dihydroxycholest-4-en-3-one
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0033778
BFO_0000050: Sterols are 12-hydroxylated by CYP8B1
directly activates: BiochemicalReaction4929
directly activates: Catalysis2235
label: 7-alpha-hydroxycholest-4-en-3-one + NADPH + H+ + O2 => 7-alpha,12-alpha-dihydroxycholest-4-en-3-one + NADP+ + H2O

Cholesterol is hydroxylated to 24-hydroxycholesterol by CYP46A1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: CYP46
type: GO_0033781
BFO_0000050: Endogenous sterols
directly activates: BiochemicalReaction4966
label: cholesterol + NADPH + H+ + O2 => 24-hydroxycholesterol + NADP+ + H2O

24-hydroxycholesterol + NADPH + H+ + O2 => cholest-5-ene-3beta,7alpha,24-triol + NADP+ + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: CYP39A1
type: GO_0008396
BFO_0000050: Endogenous sterols
directly activates: BiochemicalReaction4969
directly activates: Catalysis2265
label: 24-hydroxycholesterol is 7alpha-hydroxylated to yield cholest-5-ene-3beta,7alpha,24-triol

4-Cholesten-7alpha,24(S)-diol-3-one + NADPH + H+ + O2 => 4-cholesten-7-alpha,12-alpha,24(S)-triol-3-one + NADP+ + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0033778
BFO_0000050: Sterols are 12-hydroxylated by CYP8B1
directly activates: BiochemicalReaction4971
directly activates: Catalysis2267
label: 4-Cholesten-7alpha,24(S)-diol-3-one is 12alpha-hydroxylated to 4-cholesten-7-alpha,12-alpha,24(S)-triol-3-one

Cholesterol is hydroxylated to 27-hydroxycholesterol by CYP27
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: CYP27
type: GO_0008395
BFO_0000050: Endogenous sterols
directly activates: BiochemicalReaction4994
label: cholesterol + NADPH + H+ + O2 => 27-hydroxycholesterol + H2O + NADP+

4-Cholesten-7alpha,27-diol-3-one + NADPH + H+ + O2 => 4-Cholesten-7alpha,12alpha,27-triol-3-one + NADP+ + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0033778
BFO_0000050: Sterols are 12-hydroxylated by CYP8B1
directly activates: BiochemicalReaction4999
directly activates: Catalysis2287
label: 4-Cholesten-7alpha,27-diol-3-one is 12alpha-hydroxylated to 4-Cholesten-7alpha,12alpha,27-triol-3-one

25-hydroxycholesterol is 7alpha-hydroxylated by CYP7B1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0008396
BFO_0000050: Endogenous sterols

CYP1B1 4-hydroxylates estradiol-17beta
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: CYP1B1
type: GO_0019825
BFO_0000050: Endogenous sterols

11-deoxycorticosterone is oxidised to corticosterone by CYP11B2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: GO_0004507
BFO_0000050: Endogenous sterols

Endogenous sterols
type: GO_0008150

Sterols are 12-hydroxylated by CYP8B1
type: GO_0008150
BFO_0000050: Endogenous sterols