CYP17
CYP17A1
S17AH
UniProt:P05093 CYP17A1
CYP11A
CYP11A1
UniProt:P05108 CYP11A1
CYP21
CYP21A2
CYP21B
UniProt:P08686 CYP21A2
ARO1
CYAR
CYP19
CYP19A1
UniProt:P11511 CYP19A1
CYP27
CYP27A1
UniProt:Q02318 CYP27A1
CYP1B1
UniProt:Q16678 CYP1B1
CYP51
CYP51A1
UniProt:Q16850 CYP51A1
CYP39A1
UniProt:Q9NYL5 CYP39A1
CYP46
CYP46A1
UniProt:Q9Y6A2 CYP46A1
20alpha,22beta-hydroxycholesterol + NADPH + H+ + O2 => pregnenolone + isocaproaldehyde + NADP+ + H2O
20alpha,22beta-hydroxycholesterol is cleaved by CYP11A1 to yield pregnenolone and isocaproaldehyde
Hydroxylation of pregnenolone to form 17alpha-hydroxypregnenolone
pregnenolone + NADPH + H+ => 17alpha-hydroxypregnenolone + NADP+ + H2O
11-deoxycortisol + NADPH + H+ + O2 => cortisol + NADP+ + H2O
11-deoxycortisol is oxidised to cortisol by CYP11B1
21-hydroxylation of progesterone to form 11-deoxycorticosterone
progesterone + NAPDH + H+ + O2 => 11-deoxycorticosterone + NADP+ + H2O
Androstenedione is converted to estrone by Aromatase (CYP19A1)
Lanosterol is oxidatively demethylated to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol
lanosterol + 3 NADPH + 3 H+ + 3 O2 => 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol + 3 NADP+ + 4 H2O + formate
Cholesterol + NADPH + H+ + O2 => 7-alpha-hydroxycholesterol + NADP+ + H2O
Cholesterol is hydroxylated to 7alpha-hydroxycholesterol by CYP7A1
4-Cholesten-7alpha-ol-3-one is 12alpha-hydroxylated to 7-alpha,12-alpha-dihydroxycholest-4-en-3-one
7-alpha-hydroxycholest-4-en-3-one + NADPH + H+ + O2 => 7-alpha,12-alpha-dihydroxycholest-4-en-3-one + NADP+ + H2O
Cholesterol is hydroxylated to 24-hydroxycholesterol by CYP46A1
cholesterol + NADPH + H+ + O2 => 24-hydroxycholesterol + NADP+ + H2O
24-hydroxycholesterol + NADPH + H+ + O2 => cholest-5-ene-3beta,7alpha,24-triol + NADP+ + H2O
24-hydroxycholesterol is 7alpha-hydroxylated to yield cholest-5-ene-3beta,7alpha,24-triol
4-Cholesten-7alpha,24(S)-diol-3-one + NADPH + H+ + O2 => 4-cholesten-7-alpha,12-alpha,24(S)-triol-3-one + NADP+ + H2O
4-Cholesten-7alpha,24(S)-diol-3-one is 12alpha-hydroxylated to 4-cholesten-7-alpha,12-alpha,24(S)-triol-3-one
Cholesterol is hydroxylated to 27-hydroxycholesterol by CYP27
cholesterol + NADPH + H+ + O2 => 27-hydroxycholesterol + H2O + NADP+
4-Cholesten-7alpha,27-diol-3-one + NADPH + H+ + O2 => 4-Cholesten-7alpha,12alpha,27-triol-3-one + NADP+ + H2O
4-Cholesten-7alpha,27-diol-3-one is 12alpha-hydroxylated to 4-Cholesten-7alpha,12alpha,27-triol-3-one
25-hydroxycholesterol is 7alpha-hydroxylated by CYP7B1
CYP1B1 4-hydroxylates estradiol-17beta
11-deoxycorticosterone is oxidised to corticosterone by CYP11B2
Endogenous sterols
Sterols are 12-hydroxylated by CYP8B1