CARDIAK
label: RICK
label: RIP2
label: RIPK2
label: UNQ277/PRO314/PRO34092
label: UniProt:O43353 RIPK2

INPP5D
label: SHIP
label: SHIP1
label: UniProt:Q92835 INPP5D

Recruitment of PI3K to plasmamembrane
type: GO_0003674
BFO_0000050: Downstream TCR signaling
directly activates: PI3K phosphorylates PIP2 to PIP3
directly activates: Catalysis236

PI3K phosphorylates PIP2 to PIP3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0046934
BFO_0000050: Downstream TCR signaling
directly activates: BiochemicalReaction2321
directly activates: Hydrolysis of PIP3 to PI(3,4)P2
directly activates: Hydrolysis of PIP3 to PIP2
directly activates: Translocation of PDK1 to Plasma membrane
directly activates: BiochemicalReaction679
directly activates: BiochemicalReaction680
directly activates: Catalysis237
directly activates: Catalysis238
directly activates: Control158

Hydrolysis of PIP3 to PI(3,4)P2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: INPP5D
type: GO_0016314
BFO_0000050: Downstream TCR signaling
directly activates: Translocation of PDK1 to Plasma membrane

Hydrolysis of PIP3 to PIP2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016314
BFO_0000050: Downstream TCR signaling

Translocation of PDK1 to Plasma membrane
type: GO_0003674
BFO_0000050: Downstream TCR signaling
directly activates: Translocation of PKC theta to plasma membrane

Translocation of PKC theta to plasma membrane
type: GO_0003674
BFO_0000050: Downstream TCR signaling
directly activates: Change of PKC theta conformation
directly activates: Catalysis239

Change of PKC theta conformation
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Downstream TCR signaling
directly activates: Phosphorylation of PKC theta
directly activates: Catalysis240

Phosphorylation of PKC theta
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004674
BFO_0000050: Downstream TCR signaling
directly activates: Translocation of CARMA1 to Plasma membrane

Translocation of CARMA1 to Plasma membrane
type: GO_0003674
BFO_0000050: Downstream TCR signaling
directly activates: Phosphorylation of CARMA1
directly activates: Catalysis241

Phosphorylation of CARMA1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004674
BFO_0000050: Downstream TCR signaling
directly activates: Oligomerization of CARMA1

Oligomerization of CARMA1
type: GO_0003674
BFO_0000050: Downstream TCR signaling
directly activates: Interaction of Bcl10 to CARMA1

Interaction of Bcl10 to CARMA1
type: GO_0003674
BFO_0000050: Downstream TCR signaling
directly activates: Phosphorylation of Bcl10
directly activates: Catalysis242

Phosphorylation of Bcl10
type: Restriction
  on property: enabled by
  some values from: CARDIAK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Downstream TCR signaling
directly activates: Oligomerization of Bcl10

Oligomerization of Bcl10
type: GO_0003674
BFO_0000050: Downstream TCR signaling
directly activates: Interaction and oligomerization of MALT1 to Bcl10

Interaction and oligomerization of MALT1 to Bcl10
type: GO_0003674
BFO_0000050: Downstream TCR signaling
directly activates: Translocation of TRAF6 to CBM complex

Translocation of TRAF6 to CBM complex
type: GO_0003674
BFO_0000050: Downstream TCR signaling
directly activates: Auto-ubiquitination of TRAF6
directly activates: Catalysis243

Auto-ubiquitination of TRAF6
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004842
BFO_0000050: Downstream TCR signaling
directly activates: Activation of TAK1-TAB2 complex
directly activates: Catalysis244

Activation of TAK1-TAB2 complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Downstream TCR signaling
directly activates: Activation of IKK complex
directly activates: Catalysis245

Activation of IKK complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004674
BFO_0000050: Downstream TCR signaling
directly activates: Ubiquitination of NEMO by TRAF6
directly activates: Catalysis246

Ubiquitination of NEMO by TRAF6
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004842
BFO_0000050: Downstream TCR signaling
directly activates: Activation of NF-kB complex
directly activates: Catalysis247

Activation of NF-kB complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Downstream TCR signaling
directly activates: BiochemicalReaction1341
directly activates: BiochemicalReaction3896

Downstream TCR signaling
type: GO_0008150