CARDIAK
RICK
RIP2
RIPK2
UniProt:O43353 RIPK2
INPP5D
SHIP
SHIP1
UniProt:Q92835 INPP5D
Recruitment of PI3K to plasmamembrane
PI3K phosphorylates PIP2 to PIP3
Hydrolysis of PIP3 to PI(3,4)P2
Hydrolysis of PIP3 to PIP2
Translocation of PDK1 to Plasma membrane
Translocation of PKC theta to plasma membrane
Change of PKC theta conformation
Phosphorylation of PKC theta
Translocation of CARMA1 to Plasma membrane
Phosphorylation of CARMA1
Oligomerization of CARMA1
Interaction of Bcl10 to CARMA1
Phosphorylation of Bcl10
Oligomerization of Bcl10
Interaction and oligomerization of MALT1 to Bcl10
Translocation of TRAF6 to CBM complex
Auto-ubiquitination of TRAF6
Activation of TAK1-TAB2 complex
Activation of IKK complex
Ubiquitination of NEMO by TRAF6
Activation of NF-kB complex
Downstream TCR signaling