Cytosolic Hydroxylation of Asparagine Residue in HIF alpha
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016706
BFO_0000050: Oxygen-dependent Asparagine Hydroxylation of Hypoxia-inducible Factor Alpha

Cytosolic Hydroxylation of Proline Residues on EPAS1 (HIF2A)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0031545
BFO_0000050: Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
directly activates: Cytosolic VHL:EloB/C:CUL2:RBX1 Complex Binds HIF-alpha Hydroxylated at Proline Residues

Cytosolic Hydroxylation of Proline Residues on HIF1A
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0031545
BFO_0000050: Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
directly activates: Cytosolic VHL:EloB/C:CUL2:RBX1 Complex Binds HIF-alpha Hydroxylated at Proline Residues

Cytosolic Hydroxylation of Proline Residues on HIF3A
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0031545
BFO_0000050: Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
directly activates: Cytosolic VHL:EloB/C:CUL2:RBX1 Complex Binds HIF-alpha Hydroxylated at Proline Residues

Nuclear Hydroxylation of Proline Residues on EPAS1 (HIF2A)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0031545
BFO_0000050: Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
directly activates: Nuclear VHL:EloB/C:CUL2:RBX1 Complex Binds HIF-alpha Hydroxylated at Proline Residues

Nuclear Hydroxylation of Proline Residues on HIF1A
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0031545
BFO_0000050: Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
directly activates: Nuclear VHL:EloB/C:CUL2:RBX1 Complex Binds HIF-alpha Hydroxylated at Proline Residues

Nuclear Hydroxylation of Proline Residues on HIF3A
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0031545
BFO_0000050: Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
directly activates: Nuclear VHL:EloB/C:CUL2:RBX1 Complex Binds HIF-alpha Hydroxylated at Proline Residues

Cytosolic VHL:EloB/C:CUL2:RBX1 Complex Binds HIF-alpha Hydroxylated at Proline Residues
type: GO_0003674
BFO_0000050: Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
directly activates: Cytosolic Ubiquitination of HIF-alpha
directly activates: Catalysis28

Nuclear VHL:EloB/C:CUL2:RBX1 Complex Binds HIF-alpha Hydroxylated at Proline Residues
type: GO_0003674
BFO_0000050: Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
directly activates: Nuclear Ubiquitination of HIF-alpha
directly activates: Catalysis29

Cytosolic Ubiquitination of HIF-alpha
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004842
BFO_0000050: Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
directly activates: Destruction of Ubiquitinated HIF-alpha by the Proteasome

Nuclear Ubiquitination of HIF-alpha
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004842
BFO_0000050: Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
directly activates: Nuclear Export of Ubiquitinated HIF-alpha:VHL:EloB/C:CUL2:RBX1 Complex

Nuclear Export of Ubiquitinated HIF-alpha:VHL:EloB/C:CUL2:RBX1 Complex
type: GO_0003674
BFO_0000050: Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
directly activates: Destruction of Ubiquitinated HIF-alpha by the Proteasome

Destruction of Ubiquitinated HIF-alpha by the Proteasome
type: GO_0003674
BFO_0000050: Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha

Translocation of HIF-alpha from Cytosol to Nucleus
type: GO_0003674
BFO_0000050: Regulation of Gene Expression by Hypoxia-inducible Factor
directly activates: Formation of HIF-alpha:ARNT (HIF-1beta) Heterodimer

Formation of HIF-alpha:ARNT (HIF-1beta) Heterodimer
type: GO_0003674
BFO_0000050: Regulation of Gene Expression by Hypoxia-inducible Factor
directly activates: Formation of HIF:CBP:p300 Complex at Promoters

Formation of HIF:CBP:p300 Complex at Promoters
type: GO_0003674
BFO_0000050: Regulation of Gene Expression by Hypoxia-inducible Factor
directly activates: Expression of Carbonic Anhydrase IX (CA9)
directly activates: Expression of VEGFA
directly activates: Expression of Erythropoietin (EPO)
directly activates: TemplateReactionRegulation2
directly activates: TemplateReactionRegulation3
directly activates: TemplateReactionRegulation4

Cellular responses to stress
type: GO_0008150

Cellular response to hypoxia
type: GO_0008150
BFO_0000050: Cellular responses to stress

Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
type: GO_0008150
BFO_0000050: Cellular response to hypoxia

Oxygen-dependent Asparagine Hydroxylation of Hypoxia-inducible Factor Alpha
type: GO_0008150
BFO_0000050: Regulation of Hypoxia-inducible Factor (HIF) by Oxygen

Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
type: GO_0008150
BFO_0000050: Regulation of Hypoxia-inducible Factor (HIF) by Oxygen

Regulation of Gene Expression by Hypoxia-inducible Factor
type: GO_0008150
BFO_0000050: Regulation of Hypoxia-inducible Factor (HIF) by Oxygen

Expression of Carbonic Anhydrase IX (CA9)
type: GO_0003674
BFO_0000050: Regulation of Gene Expression by Hypoxia-inducible Factor

Expression of VEGFA
type: GO_0003674
BFO_0000050: Regulation of Gene Expression by Hypoxia-inducible Factor

Expression of Erythropoietin (EPO)
type: GO_0003674
BFO_0000050: Regulation of Gene Expression by Hypoxia-inducible Factor