CYP1ALPHA
label: CYP27B
label: CYP27B1
label: UniProt:O15528 CYP27B1

BPNT1
label: UniProt:O95861 BPNT1

CYP1A1
label: UniProt:P04798 CYP1A1

CYP17
label: CYP17A1
label: S17AH
label: UniProt:P05093 CYP17A1

CYP11A
label: CYP11A1
label: UniProt:P05108 CYP11A1

CYP1A2
label: UniProt:P05177 CYP1A2

CYP21
label: CYP21A2
label: CYP21B
label: UniProt:P08686 CYP21A2

AAC2
label: NAT2
label: UniProt:P11245 NAT2

ARO1
label: CYAR
label: CYP19
label: CYP19A1
label: UniProt:P11511 CYP19A1

AAC1
label: NAT1
label: UniProt:P18440 NAT1

COMT
label: UniProt:P21964 COMT

CYP5
label: CYP5A1
label: TBXAS1
label: UniProt:P24557 TBXAS1

NNMT
label: UniProt:P40261 NNMT

TPMT
label: UniProt:P51580 TPMT

CYP27
label: CYP27A1
label: UniProt:Q02318 CYP27A1

CYP24
label: CYP24A1
label: UniProt:Q07973 CYP24A1

CYP1B1
label: UniProt:Q16678 CYP1B1

CYP51
label: CYP51A1
label: UniProt:Q16850 CYP51A1

ACSM2
label: ACSM2B
label: HYST1046
label: UniProt:Q68CK6 ACSM2B

ACGNAT
label: CAT
label: GAT
label: GLYAT
label: UniProt:Q6IB77 GLYAT

CYP2R1
label: UniProt:Q6VVX0 CYP2R1

CYP2U1
label: UniProt:Q7Z449 CYP2U1

CYP2S1
label: UNQ891/PRO1906
label: UniProt:Q96SQ9 CYP2S1

CYP3A43
label: UniProt:Q9HB55 CYP3A43

ACAS2
label: ACSS2
label: UniProt:Q9NR19 ACSS2

CYP26A2
label: CYP26B1
label: P450RAI2
label: UniProt:Q9NR63 CYP26B1

ACAS2L
label: ACSS1
label: KIAA1846
label: UniProt:Q9NUB1 ACSS1

C20orf16
label: SMO
label: SMOX
label: UNQ3039/PRO9854
label: UniProt:Q9NWM0 SMOX

CYP39A1
label: UniProt:Q9NYL5 CYP39A1

CYP46
label: CYP46A1
label: UniProt:Q9Y6A2 CYP46A1

SLC26A1,2 transport extracellular SO4(2-) to cytosol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0015116
BFO_0000050: Transport and synthesis of PAPS
directly activates: ATP + sulfate => adenylyl sulfate (APS) + pyrophosphate
directly activates: Catalysis1300

SLC35B2,3 transport cytosolic PAPS to Golgi lumen
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0046964
BFO_0000050: Transport and synthesis of PAPS
directly activates: BiochemicalReaction3073
directly activates: BiochemicalReaction3074
directly activates: BiochemicalReaction3091
directly activates: BiochemicalReaction3093
directly activates: BiochemicalReaction3094
directly activates: BiochemicalReaction3095
directly activates: BiochemicalReaction3097
directly activates: BiochemicalReaction3116
directly activates: BiochemicalReaction3117
directly activates: BiochemicalReaction3118
directly activates: BiochemicalReaction3121
directly activates: BiochemicalReaction3122
directly activates: Catalysis1307
directly activates: Catalysis1308
directly activates: Catalysis1323
directly activates: Catalysis1325
directly activates: Catalysis1326
directly activates: Catalysis1327
directly activates: Catalysis1329
directly activates: Catalysis1346
directly activates: Catalysis1347
directly activates: Catalysis1348
directly activates: Catalysis1350
directly activates: Catalysis1351

UDP-glucuronate transport from the cytosol to ER lumen
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0005461
BFO_0000050: Formation of the active cofactor, UDP-glucuronate
directly activates: BiochemicalReaction5840
directly activates: BiochemicalReaction5841
directly activates: Formation of O-glucuronides
directly activates: Formation of N-glucuronides
directly activates: Catalysis2981
directly activates: Catalysis2982
directly activates: Catalysis3032
directly activates: Catalysis3033

25-Hydroxylation of vitamin D3 in liver
type: Restriction
  on property: enabled by
  some values from: CYP2R1
type: Restriction
  on property: enabled by
  some values from: CYP2R1
type: Restriction
  on property: enabled by
  some values from: CYP2R1
type: Restriction
  on property: enabled by
  some values from: CYP2R1
type: Restriction
  on property: enabled by
  some values from: CYP2R1
type: Restriction
  on property: enabled by
  some values from: CYP2R1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: CYP2R1
type: Restriction
  on property: enabled by
  some values from: CYP2R1
type: GO_0030343
BFO_0000050: Vitamins
directly activates: BiochemicalReaction2542

Further hydroxylation of calcidiol in kidney to form calcitriol
type: Restriction
  on property: enabled by
  some values from: CYP1ALPHA
type: Restriction
  on property: enabled by
  some values from: CYP1ALPHA
type: Restriction
  on property: enabled by
  some values from: CYP1ALPHA
type: Restriction
  on property: enabled by
  some values from: CYP1ALPHA
type: Restriction
  on property: enabled by
  some values from: CYP1ALPHA
type: Restriction
  on property: enabled by
  some values from: CYP1ALPHA
type: Restriction
  on property: enabled by
  some values from: CYP1ALPHA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: enabled by
  some values from: CYP1ALPHA
type: GO_0004498
BFO_0000050: Vitamins

20alpha,22beta-hydroxycholesterol + NADPH + H+ + O2 => pregnenolone + isocaproaldehyde + NADP+ + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: CYP11A
type: Restriction
  on property: enabled by
  some values from: CYP11A
type: Restriction
  on property: enabled by
  some values from: CYP11A
type: Restriction
  on property: enabled by
  some values from: CYP11A
type: Restriction
  on property: enabled by
  some values from: CYP11A
type: Restriction
  on property: enabled by
  some values from: CYP11A
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: CYP11A
type: Restriction
  on property: enabled by
  some values from: CYP11A
type: GO_0008386
BFO_0000050: Endogenous sterols
directly activates: BiochemicalReaction2555
directly activates: BiochemicalReaction2557
label: 20alpha,22beta-hydroxycholesterol is cleaved by CYP11A1 to yield pregnenolone and isocaproaldehyde

Hydroxylation of pregnenolone to form 17alpha-hydroxypregnenolone
type: Restriction
  on property: enabled by
  some values from: CYP17
type: Restriction
  on property: enabled by
  some values from: CYP17
type: Restriction
  on property: enabled by
  some values from: CYP17
type: Restriction
  on property: enabled by
  some values from: CYP17
type: Restriction
  on property: enabled by
  some values from: CYP17
type: Restriction
  on property: enabled by
  some values from: CYP17
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: CYP17
type: Restriction
  on property: enabled by
  some values from: CYP17
type: GO_0004508
BFO_0000050: Endogenous sterols
directly activates: BiochemicalReaction2559
directly activates: BiochemicalReaction2573
directly activates: Catalysis1103
directly activates: Catalysis1114
directly activates: Control175
label: pregnenolone + NADPH + H+ => 17alpha-hydroxypregnenolone + NADP+ + H2O

11-deoxycortisol + NADPH + H+ + O2 => cortisol + NADP+ + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: GO_0004507
BFO_0000050: Endogenous sterols
directly activates: BiochemicalReaction2564
label: 11-deoxycortisol is oxidised to cortisol by CYP11B1

21-hydroxylation of progesterone to form 11-deoxycorticosterone
type: Restriction
  on property: enabled by
  some values from: CYP21
type: Restriction
  on property: enabled by
  some values from: CYP21
type: Restriction
  on property: enabled by
  some values from: CYP21
type: Restriction
  on property: enabled by
  some values from: CYP21
type: Restriction
  on property: enabled by
  some values from: CYP21
type: Restriction
  on property: enabled by
  some values from: CYP21
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: CYP21
type: Restriction
  on property: enabled by
  some values from: CYP21
type: GO_0004509
BFO_0000050: Endogenous sterols
directly activates: BiochemicalReaction2569
label: progesterone + NAPDH + H+ + O2 => 11-deoxycorticosterone + NADP+ + H2O

Androstenedione is converted to estrone by Aromatase (CYP19A1)
type: Restriction
  on property: enabled by
  some values from: ARO1
type: Restriction
  on property: enabled by
  some values from: ARO1
type: Restriction
  on property: enabled by
  some values from: ARO1
type: Restriction
  on property: enabled by
  some values from: ARO1
type: Restriction
  on property: enabled by
  some values from: ARO1
type: Restriction
  on property: enabled by
  some values from: ARO1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: ARO1
type: Restriction
  on property: enabled by
  some values from: ARO1
type: GO_0008395
BFO_0000050: Endogenous sterols
directly activates: BiochemicalReaction2581
directly activates: Catalysis1122

ATP + sulfate => adenylyl sulfate (APS) + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004781
BFO_0000050: Transport and synthesis of PAPS
directly activates: BiochemicalReaction296
directly activates: APS reacts with another ATP molecule to form PAPS
directly activates: Catalysis111
directly activates: Catalysis1301
directly activates: Control14
label: Activation of inorganic sulfate forms APS
label: PAPSS1,2 transfer PO4(2-) group from ATP to form APS

APS reacts with another ATP molecule to form PAPS
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004020
BFO_0000050: Transport and synthesis of PAPS
directly activates: SLC35B2,3 transport cytosolic PAPS to Golgi lumen
directly activates: Acetaminophen can form an O- sulfate conjugate
directly activates: N-hydroxy-4-aminobiphenyl can form a sulfate conjugate
directly activates: Phenol can form a sulfate conjugate
directly activates: Dopamine can form an O-sulfate conjugate
directly activates: 3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP
directly activates: 3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP
directly activates: p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP
directly activates: N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP
directly activates: cholesterol + PAPS => cholesterol sulfate + PAP
directly activates: 27-hydroxycholesterol + PAPS => 27-hydroxycholesterol 3-sulfate + PAP
directly activates: SULTs transfer (SO4)2- group to PREG
directly activates: estrone + PAPS => estrone 3-sulfate + PAP
directly activates: dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP
directly activates: beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP
directly activates: lithocholate + PAPS => lithocholate sulfate + PAP
directly activates: taurolithocholate + PAPS => taurolithocholate sulfate + PAP
directly activates: Catalysis3034
directly activates: Catalysis3035
directly activates: Catalysis3036
directly activates: Catalysis3037
directly activates: Catalysis3038
directly activates: Catalysis3039
directly activates: Catalysis3040
directly activates: Catalysis3041
directly activates: Catalysis3042
directly activates: Catalysis3043
directly activates: Catalysis3044
directly activates: Catalysis3045
directly activates: Catalysis3046
directly activates: Catalysis3047
directly activates: Catalysis3048
directly activates: Catalysis3049
directly activates: Catalysis723
label: PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS
label: adenylyl sulfate (APS) + ATP => PAPS + ADP

Oxidative deamination of 5-Hydroxytryptamine by MAOA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: GO_0008131
BFO_0000050: Monoamines are oxidized to aldehydes by MAOA and MAOB, producing NH3 and H2O2

UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003983
BFO_0000050: Formation of the active cofactor, UDP-glucuronate
directly activates: BiochemicalReaction296
directly activates: BiochemicalReaction4570
directly activates: UDP-glucose is oxidised to UDP-glucuronate
directly activates: Catalysis111
directly activates: Catalysis1987
directly activates: Catalysis3031
directly activates: Control14

Lanosterol is oxidatively demethylated to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol
type: Restriction
  on property: enabled by
  some values from: CYP51
type: Restriction
  on property: enabled by
  some values from: CYP51
type: Restriction
  on property: enabled by
  some values from: CYP51
type: Restriction
  on property: enabled by
  some values from: CYP51
type: Restriction
  on property: enabled by
  some values from: CYP51
type: Restriction
  on property: enabled by
  some values from: CYP51
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: CYP51
type: Restriction
  on property: enabled by
  some values from: CYP51
type: GO_0008398
BFO_0000050: Endogenous sterols
directly activates: BiochemicalReaction4867
directly activates: BiochemicalReaction4868
directly activates: Catalysis2218
directly activates: Catalysis2219
label: lanosterol + 3 NADPH + 3 H+ + 3 O2 => 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol + 3 NADP+ + 4 H2O + formate

Cholesterol + NADPH + H+ + O2 => 7-alpha-hydroxycholesterol + NADP+ + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0008123
BFO_0000050: Endogenous sterols
directly activates: BiochemicalReaction4927
directly activates: Catalysis2233
label: Cholesterol is hydroxylated to 7alpha-hydroxycholesterol by CYP7A1

4-Cholesten-7alpha-ol-3-one is 12alpha-hydroxylated to 7-alpha,12-alpha-dihydroxycholest-4-en-3-one
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0033778
BFO_0000050: Sterols are 12-hydroxylated by CYP8B1
directly activates: BiochemicalReaction4929
directly activates: Catalysis2235
label: 7-alpha-hydroxycholest-4-en-3-one + NADPH + H+ + O2 => 7-alpha,12-alpha-dihydroxycholest-4-en-3-one + NADP+ + H2O

Cholesterol is hydroxylated to 24-hydroxycholesterol by CYP46A1
type: Restriction
  on property: enabled by
  some values from: CYP46
type: Restriction
  on property: enabled by
  some values from: CYP46
type: Restriction
  on property: enabled by
  some values from: CYP46
type: Restriction
  on property: enabled by
  some values from: CYP46
type: Restriction
  on property: enabled by
  some values from: CYP46
type: Restriction
  on property: enabled by
  some values from: CYP46
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: CYP46
type: Restriction
  on property: enabled by
  some values from: CYP46
type: GO_0033781
BFO_0000050: Endogenous sterols
directly activates: BiochemicalReaction4966
label: cholesterol + NADPH + H+ + O2 => 24-hydroxycholesterol + NADP+ + H2O

24-hydroxycholesterol + NADPH + H+ + O2 => cholest-5-ene-3beta,7alpha,24-triol + NADP+ + H2O
type: Restriction
  on property: enabled by
  some values from: CYP39A1
type: Restriction
  on property: enabled by
  some values from: CYP39A1
type: Restriction
  on property: enabled by
  some values from: CYP39A1
type: Restriction
  on property: enabled by
  some values from: CYP39A1
type: Restriction
  on property: enabled by
  some values from: CYP39A1
type: Restriction
  on property: enabled by
  some values from: CYP39A1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: CYP39A1
type: Restriction
  on property: enabled by
  some values from: CYP39A1
type: GO_0008396
BFO_0000050: Endogenous sterols
directly activates: BiochemicalReaction4969
directly activates: Catalysis2265
label: 24-hydroxycholesterol is 7alpha-hydroxylated to yield cholest-5-ene-3beta,7alpha,24-triol

4-Cholesten-7alpha,24(S)-diol-3-one + NADPH + H+ + O2 => 4-cholesten-7-alpha,12-alpha,24(S)-triol-3-one + NADP+ + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0033778
BFO_0000050: Sterols are 12-hydroxylated by CYP8B1
directly activates: BiochemicalReaction4971
directly activates: Catalysis2267
label: 4-Cholesten-7alpha,24(S)-diol-3-one is 12alpha-hydroxylated to 4-cholesten-7-alpha,12-alpha,24(S)-triol-3-one

Cholesterol is hydroxylated to 27-hydroxycholesterol by CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: GO_0008395
BFO_0000050: Endogenous sterols
directly activates: BiochemicalReaction4994
label: cholesterol + NADPH + H+ + O2 => 27-hydroxycholesterol + H2O + NADP+

4-Cholesten-7alpha,27-diol-3-one + NADPH + H+ + O2 => 4-Cholesten-7alpha,12alpha,27-triol-3-one + NADP+ + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0033778
BFO_0000050: Sterols are 12-hydroxylated by CYP8B1
directly activates: BiochemicalReaction4999
directly activates: Catalysis2287
label: 4-Cholesten-7alpha,27-diol-3-one is 12alpha-hydroxylated to 4-Cholesten-7alpha,12alpha,27-triol-3-one

25-hydroxycholesterol is 7alpha-hydroxylated by CYP7B1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0008396
BFO_0000050: Endogenous sterols

Arachidonic acid is oxidised to PGG2 by PTGS1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004666
BFO_0000050: COX reactions
directly activates: PGG2 is reduced to PGH2 by PTGS1
directly activates: Catalysis2455
label: Arachidonic acid oxidised to PGG2

PGG2 is reduced to PGH2 by PTGS1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004601
BFO_0000050: COX reactions
directly activates: BiochemicalReaction5196
directly activates: BiochemicalReaction5206
directly activates: PGH2 is isomerised to PGI2 by PTGIS
directly activates: PGH2 is isomerised to TXA2 by TBXAS1
directly activates: BiochemicalReaction5220
directly activates: Catalysis2462
directly activates: Catalysis2467
directly activates: Catalysis2468
directly activates: Catalysis2470
label: Peroxidative reduction of PGG2 to PGH2

PGH2 is isomerised to PGI2 by PTGIS
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0008116
BFO_0000050: Eicosanoids
directly activates: BiochemicalReaction5216
label: Prostacyclin synthase (CYP8A1) mediates the isomerization of prostaglandin H2 to prostaglandin I2

PGH2 is isomerised to TXA2 by TBXAS1
type: Restriction
  on property: enabled by
  some values from: CYP5
type: Restriction
  on property: enabled by
  some values from: CYP5
type: Restriction
  on property: enabled by
  some values from: CYP5
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: CYP5
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: CYP5
type: Restriction
  on property: enabled by
  some values from: CYP5
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: CYP5
type: Restriction
  on property: enabled by
  some values from: CYP5
type: GO_0004796
BFO_0000050: Eicosanoids
directly activates: BiochemicalReaction5218
label: Thromboxane synthase (CYP5A1) mediates the isomerization of prostaglandin H2 to thromboxane A2

CYP4F2 omega-hydroxylates leukotriene B4, thus inactivating it
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0050051
BFO_0000050: Eicosanoids
directly activates: BiochemicalReaction5227
directly activates: Catalysis2477
label: LTB4 is hydroxylated to 20oh-LTB4 by CYP4F2/4F3

MTR transfers CH3 group from MeCbl to HCYS
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008705
BFO_0000050: Methylation
directly activates: BiochemicalReaction5600
directly activates: Catalysis2771
label: Methionine is reformed

N-acetylspermidine is oxidized to putrescine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0052904
BFO_0000050: Polyamines are oxidized to amines, aldehydes and H2O2 by PAOs

N-acetylspermine is oxidised to spermidine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0052904
BFO_0000050: Polyamines are oxidized to amines, aldehydes and H2O2 by PAOs

Spermine is oxidized to spermidine
type: Restriction
  on property: enabled by
  some values from: C20orf16
type: Restriction
  on property: enabled by
  some values from: C20orf16
type: Restriction
  on property: enabled by
  some values from: C20orf16
type: Restriction
  on property: enabled by
  some values from: C20orf16
type: Restriction
  on property: enabled by
  some values from: C20orf16
type: Restriction
  on property: enabled by
  some values from: C20orf16
type: Restriction
  on property: enabled by
  some values from: C20orf16
type: Restriction
  on property: enabled by
  some values from: C20orf16
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0052901
BFO_0000050: Polyamines are oxidized to amines, aldehydes and H2O2 by PAOs

SAM is sythesized from methionine's reaction with ATP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004478
BFO_0000050: Methylation
directly activates: BiochemicalReaction5755
directly activates: 6-mercaptopurine can be S-methylated
directly activates: 2-mercaptoethanol can be S-methylated
directly activates: Pyridine can be N-methylated
directly activates: 3,4-dihydroxybenzoate can be O-methylated
directly activates: Catalysis2911
directly activates: Catalysis3054
directly activates: Catalysis3055
directly activates: Catalysis3056
directly activates: Catalysis3057

S-adenoylhomocysteine is hydrolyzed
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004013
BFO_0000050: Methylation
directly activates: MTR transfers CH3 group from MeCbl to HCYS
directly activates: BiochemicalReaction5805
directly activates: BiochemicalReaction5806
directly activates: Catalysis2773
directly activates: Catalysis2953
directly activates: Catalysis2954

Glutamate and cysteine combine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004357
BFO_0000050: Glutathione synthesis and recycling
directly activates: Formation of 5-oxoproline from gamma-glutamylcysteine
directly activates: gamma-glutamylcysteine combines with glycine to form glutathione
directly activates: Catalysis3059
directly activates: Catalysis3060
directly activates: Control489

A dipeptidase cleaves cysteinylglycine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004180
BFO_0000050: Glutathione synthesis and recycling
directly activates: Glutamate and cysteine combine
directly activates: gamma-glutamylcysteine combines with glycine to form glutathione
directly activates: Catalysis2956
directly activates: Catalysis3060
directly activates: Control489

CYP1B1 4-hydroxylates estradiol-17beta
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: CYP1B1
type: Restriction
  on property: enabled by
  some values from: CYP1B1
type: Restriction
  on property: enabled by
  some values from: CYP1B1
type: Restriction
  on property: enabled by
  some values from: CYP1B1
type: Restriction
  on property: enabled by
  some values from: CYP1B1
type: Restriction
  on property: enabled by
  some values from: CYP1B1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: CYP1B1
type: Restriction
  on property: enabled by
  some values from: CYP1B1
type: GO_0019825
BFO_0000050: Endogenous sterols

11-deoxycorticosterone is oxidised to corticosterone by CYP11B2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: GO_0004507
BFO_0000050: Endogenous sterols

Ethylene is oxidized to Ethylene oxide by CYP1A1
type: Restriction
  on property: enabled by
  some values from: CYP1A1
type: Restriction
  on property: enabled by
  some values from: CYP1A1
type: Restriction
  on property: enabled by
  some values from: CYP1A1
type: Restriction
  on property: enabled by
  some values from: CYP1A1
type: Restriction
  on property: enabled by
  some values from: CYP1A1
type: Restriction
  on property: enabled by
  some values from: CYP1A1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: CYP1A1
type: Restriction
  on property: enabled by
  some values from: CYP1A1
type: GO_0009692
type: GO_0019825
BFO_0000050: Xenobiotics
directly activates: Glutathione conjugation of luminal substrates
directly activates: Catalysis3063
label: Ethylene oxidized to Ethylene oxide

N-atom dealkylation of caffeine
type: Restriction
  on property: enabled by
  some values from: CYP1A2
type: Restriction
  on property: enabled by
  some values from: CYP1A2
type: Restriction
  on property: enabled by
  some values from: CYP1A2
type: Restriction
  on property: enabled by
  some values from: CYP1A2
type: Restriction
  on property: enabled by
  some values from: CYP1A2
type: Restriction
  on property: enabled by
  some values from: CYP1A2
type: Restriction
  on property: enabled by
  some values from: CYP1A2
type: Restriction
  on property: enabled by
  some values from: CYP1A2
type: Restriction
  on property: enabled by
  some values from: CYP1A2
type: Restriction
  on property: enabled by
  some values from: CYP1A2
type: Restriction
  on property: enabled by
  some values from: CYP1A2
type: Restriction
  on property: enabled by
  some values from: CYP1A2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: CYP1A2
type: Restriction
  on property: enabled by
  some values from: CYP1A2
type: Restriction
  on property: enabled by
  some values from: CYP1A2
type: Restriction
  on property: enabled by
  some values from: CYP1A2
type: GO_0019825
BFO_0000050: Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2

N-hydroxylation of 4-aminobiphenyl
type: Restriction
  on property: enabled by
  some values from: CYP1A2
type: Restriction
  on property: enabled by
  some values from: CYP1A2
type: Restriction
  on property: enabled by
  some values from: CYP1A2
type: Restriction
  on property: enabled by
  some values from: CYP1A2
type: Restriction
  on property: enabled by
  some values from: CYP1A2
type: Restriction
  on property: enabled by
  some values from: CYP1A2
type: Restriction
  on property: enabled by
  some values from: CYP1A2
type: Restriction
  on property: enabled by
  some values from: CYP1A2
type: Restriction
  on property: enabled by
  some values from: CYP1A2
type: Restriction
  on property: enabled by
  some values from: CYP1A2
type: Restriction
  on property: enabled by
  some values from: CYP1A2
type: Restriction
  on property: enabled by
  some values from: CYP1A2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: CYP1A2
type: Restriction
  on property: enabled by
  some values from: CYP1A2
type: Restriction
  on property: enabled by
  some values from: CYP1A2
type: Restriction
  on property: enabled by
  some values from: CYP1A2
type: GO_0019825
BFO_0000050: Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2
directly activates: Formation of O-glucuronides
directly activates: Catalysis3032

Coumarin is 7-hydroxylated by CYP2A6
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0008389
type: GO_0009804
BFO_0000050: Xenobiotics

Coumarin is 7-hydroxylated by CYP2A13
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0008389
type: GO_0009804
BFO_0000050: Xenobiotics

Cyclophosphamide is 4-hydroxylated by CYP2B6
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0019825
BFO_0000050: Xenobiotics

CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0019825
BFO_0000050: Xenobiotics

CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0019825
BFO_0000050: Xenobiotics

CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0019825
BFO_0000050: Xenobiotics

CYP2C19 5-hydroxylates omeprazole
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0019825
BFO_0000050: Xenobiotics

Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0017144
type: GO_0019825
BFO_0000050: CYP2E1 reactions
directly activates: Glutathione conjugation of luminal substrates
directly activates: Catalysis3063

Benzene + O2 + NADPH + H+ -> Phenol + H2O + NADP+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0018910
type: GO_0019825
BFO_0000050: CYP2E1 reactions
label: Benzene is hydroxylated to phenol

Dehalogenation of carbon tetrachloride to form a free radical
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0018885
type: GO_0019825
BFO_0000050: CYP2E1 reactions
label: Dehalogenation of the haloalkane CCl4 to form CCl3. free radical

Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0019825
type: GO_0042197
BFO_0000050: CYP2E1 reactions

MEOS oxidizes ethanol to acetaldehyde
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0019825
BFO_0000050: CYP2E1 reactions

Vinyl chloride is oxidized to 2-Chloroethylene oxide
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0019825
BFO_0000050: CYP2E1 reactions

O-atom dealkylation of dextromethorphan
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0019825
BFO_0000050: Xenobiotics

CYP2D6 4-hydroxylates debrisoquine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0016712
BFO_0000050: Xenobiotics

CYP2F1 dehydrogenates 3-methylindole
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0019825
BFO_0000050: Xenobiotics

CYP3A4 can N-demethylate loperamide
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0019825
BFO_0000050: Xenobiotics

CYP3A5 oxidises aflatoxin B1 to aflatoxin-8,9-oxide
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0019825
BFO_0000050: Xenobiotics

CYP3A7 can 6beta-hydroxylate testosterone
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0019825
BFO_0000050: Xenobiotics

CYP2J2 epoxygenates arachidonic acid
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0008392
BFO_0000050: Fatty acids

CYP4A11 omega-hydroxylates laurate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0006631
type: GO_0019825
BFO_0000050: Fatty acids
label: dodecanoic acid + O2 + NADPH + H+ -> 12-hydroxydodecanoic acid + H2O + NADP+

CYP4B1 can 12-hydroxylate arachidonic acid
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0019825
BFO_0000050: Fatty acids

CYP4F12 hydroxylates arachidonic acid
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0019825
BFO_0000050: Fatty acids

CYP4F8 hydroxylates prostaglandin H2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0019825
BFO_0000050: Eicosanoids

CYP24A1 catalyzes the initial step in the deactivation of the hormonally active form of vitamin D3
type: Restriction
  on property: enabled by
  some values from: CYP24
type: Restriction
  on property: enabled by
  some values from: CYP24
type: Restriction
  on property: enabled by
  some values from: CYP24
type: Restriction
  on property: enabled by
  some values from: CYP24
type: Restriction
  on property: enabled by
  some values from: CYP24
type: Restriction
  on property: enabled by
  some values from: CYP24
type: Restriction
  on property: enabled by
  some values from: CYP24
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: enabled by
  some values from: CYP24
type: GO_0030342
BFO_0000050: Vitamins

CYP26A1 breaks down all-trans-retinoic acid by 4-hydroxylation
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0008401
BFO_0000050: Vitamins

CYP26B1 also deactivates all-trans-retinoic acid by 4-hydroxylation
type: Restriction
  on property: enabled by
  some values from: CYP26A2
type: Restriction
  on property: enabled by
  some values from: CYP26A2
type: Restriction
  on property: enabled by
  some values from: CYP26A2
type: Restriction
  on property: enabled by
  some values from: CYP26A2
type: Restriction
  on property: enabled by
  some values from: CYP26A2
type: Restriction
  on property: enabled by
  some values from: CYP26A2
type: Restriction
  on property: enabled by
  some values from: CYP26A2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: CYP26A2
type: GO_0008401
BFO_0000050: Vitamins

CYP26C1 deactivates 9-cis-retinoic acid by 4-hydroxylation
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0008401
BFO_0000050: Vitamins

CYP2S1 can deactivate all-trans-retinoic acid
type: Restriction
  on property: enabled by
  some values from: CYP2S1
type: Restriction
  on property: enabled by
  some values from: CYP2S1
type: Restriction
  on property: enabled by
  some values from: CYP2S1
type: Restriction
  on property: enabled by
  some values from: CYP2S1
type: Restriction
  on property: enabled by
  some values from: CYP2S1
type: Restriction
  on property: enabled by
  some values from: CYP2S1
type: Restriction
  on property: enabled by
  some values from: CYP2S1
type: Restriction
  on property: enabled by
  some values from: CYP2S1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0008401
BFO_0000050: Miscellaneous substrates

CYP2U1 can omega-hydroxylate arachidonate
type: Restriction
  on property: enabled by
  some values from: CYP2U1
type: Restriction
  on property: enabled by
  some values from: CYP2U1
type: Restriction
  on property: enabled by
  some values from: CYP2U1
type: Restriction
  on property: enabled by
  some values from: CYP2U1
type: Restriction
  on property: enabled by
  some values from: CYP2U1
type: Restriction
  on property: enabled by
  some values from: CYP2U1
type: Restriction
  on property: enabled by
  some values from: CYP2U1
type: Restriction
  on property: enabled by
  some values from: CYP2U1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0019825
BFO_0000050: Miscellaneous substrates

CYP2W1 can oxidize indole
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004497
BFO_0000050: Miscellaneous substrates

CYP3A43 catalyzes the 6beta-hydroxylation of testosterone
type: Restriction
  on property: enabled by
  some values from: CYP3A43
type: Restriction
  on property: enabled by
  some values from: CYP3A43
type: Restriction
  on property: enabled by
  some values from: CYP3A43
type: Restriction
  on property: enabled by
  some values from: CYP3A43
type: Restriction
  on property: enabled by
  some values from: CYP3A43
type: Restriction
  on property: enabled by
  some values from: CYP3A43
type: Restriction
  on property: enabled by
  some values from: CYP3A43
type: Restriction
  on property: enabled by
  some values from: CYP3A43
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004497
BFO_0000050: Miscellaneous substrates

CYP4F11 omega-hydroxylates 3-hydroxypalmitate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004497
BFO_0000050: Miscellaneous substrates

FMO1 N-oxidizes the anti-cancer drug tamoxifen
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004499
BFO_0000050: FMO oxidizes nucleophiles

FMO2 S-oxidizes the antithyroid drug methimazole
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004497
BFO_0000050: FMO oxidizes nucleophiles

FMO3 N-oxidizes the tertiary amine trimethylamine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004499
BFO_0000050: FMO oxidizes nucleophiles
label: Trimethylamine N-oxidised to Trimethylamine-N-oxide

Dietary tyramine is oxidatively deaminated to an aldehyde by MAOB
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: GO_0008131
BFO_0000050: Monoamines are oxidized to aldehydes by MAOA and MAOB, producing NH3 and H2O2

Oxidative deamination of Phenyethylamine by MAOB
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: GO_0008131
BFO_0000050: Monoamines are oxidized to aldehydes by MAOA and MAOB, producing NH3 and H2O2

Ethanol is oxidized by NAD+ to form acetaldehyde, NADH, and H+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004024
BFO_0000050: Alcohol catabolism
directly activates: acetaldehyde [cytosolic] => acetaldehyde [mitochondrial]
directly activates: acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic]
directly activates: Catalysis3029
label: ethanol + NAD+ => acetaldehyde + NADH + H+

acetaldehyde [cytosolic] => acetaldehyde [mitochondrial]
type: GO_0003674
BFO_0000050: Alcohol catabolism
directly activates: acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial]
directly activates: Catalysis3027

acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004029
BFO_0000050: Alcohol catabolism
directly activates: acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial]
directly activates: Catalysis3028

acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial]
type: Restriction
  on property: enabled by
  some values from: ACAS2L
type: Restriction
  on property: enabled by
  some values from: ACAS2L
type: Restriction
  on property: enabled by
  some values from: ACAS2L
type: Restriction
  on property: enabled by
  some values from: ACAS2L
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0003987
BFO_0000050: Alcohol catabolism

acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004029
BFO_0000050: Alcohol catabolism
directly activates: acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic]
directly activates: Catalysis3030

acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic]
type: Restriction
  on property: enabled by
  some values from: ACAS2
type: Restriction
  on property: enabled by
  some values from: ACAS2
type: Restriction
  on property: enabled by
  some values from: ACAS2
type: Restriction
  on property: enabled by
  some values from: ACAS2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003987
BFO_0000050: Alcohol catabolism
directly activates: BiochemicalReaction296
directly activates: Catalysis111
directly activates: Control14

UDP-glucose is oxidised to UDP-glucuronate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003979
BFO_0000050: Formation of the active cofactor, UDP-glucuronate
directly activates: UDP-glucuronate transport from the cytosol to ER lumen
directly activates: Catalysis727

Formation of O-glucuronides
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0015020
BFO_0000050: Glucuronidation

Formation of N-glucuronides
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0015020
BFO_0000050: Glucuronidation

Acetaminophen can form an O- sulfate conjugate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004062
BFO_0000050: Cytosolic sulfonation of small molecules
directly activates: Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate
directly activates: Catalysis3050

N-hydroxy-4-aminobiphenyl can form a sulfate conjugate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004062
BFO_0000050: Cytosolic sulfonation of small molecules
directly activates: Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate
directly activates: Catalysis3050

Phenol can form a sulfate conjugate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004062
BFO_0000050: Cytosolic sulfonation of small molecules
directly activates: Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate
directly activates: Catalysis3050

Dopamine can form an O-sulfate conjugate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004062
BFO_0000050: Cytosolic sulfonation of small molecules
directly activates: Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate
directly activates: Catalysis3050

3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004062
BFO_0000050: Cytosolic sulfonation of small molecules
directly activates: Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate
directly activates: Catalysis3050

3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004062
BFO_0000050: Cytosolic sulfonation of small molecules
directly activates: Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate
directly activates: Catalysis3050

p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004062
BFO_0000050: Cytosolic sulfonation of small molecules
directly activates: Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate
directly activates: Catalysis3050

N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008146
BFO_0000050: Cytosolic sulfonation of small molecules
directly activates: Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate
directly activates: Catalysis3050

cholesterol + PAPS => cholesterol sulfate + PAP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004027
BFO_0000050: Cytosolic sulfonation of small molecules
directly activates: Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate
directly activates: Catalysis3050

27-hydroxycholesterol + PAPS => 27-hydroxycholesterol 3-sulfate + PAP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004027
BFO_0000050: Cytosolic sulfonation of small molecules
directly activates: Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate
directly activates: Catalysis3050
label: SULTs transfer (SO4)2- group to 27HCHOL

SULTs transfer (SO4)2- group to PREG
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0050294
BFO_0000050: Cytosolic sulfonation of small molecules
directly activates: Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate
directly activates: Catalysis3050
label: pregnenolone + PAPS => pregnenolone sulfate + PAP

estrone + PAPS => estrone 3-sulfate + PAP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004304
BFO_0000050: Cytosolic sulfonation of small molecules
directly activates: Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate
directly activates: Catalysis3050

dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0050294
BFO_0000050: Cytosolic sulfonation of small molecules
directly activates: Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate
directly activates: Catalysis3050

beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0050294
BFO_0000050: Cytosolic sulfonation of small molecules
directly activates: Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate
directly activates: Catalysis3050

lithocholate + PAPS => lithocholate sulfate + PAP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008146
BFO_0000050: Cytosolic sulfonation of small molecules
directly activates: Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate
directly activates: Catalysis3050

taurolithocholate + PAPS => taurolithocholate sulfate + PAP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008146
BFO_0000050: Cytosolic sulfonation of small molecules
directly activates: Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate
directly activates: Catalysis3050

Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate
type: Restriction
  on property: enabled by
  some values from: BPNT1
type: Restriction
  on property: enabled by
  some values from: BPNT1
type: Restriction
  on property: enabled by
  some values from: BPNT1
type: Restriction
  on property: enabled by
  some values from: BPNT1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008441
type: GO_0050427
BFO_0000050: Cytosolic sulfonation of small molecules

The acetyl group from acetyl-CoA is transferred to the NAT1
type: GO_0003674
BFO_0000050: Acetylation
directly activates: NAT1 acetylation
directly activates: Catalysis3051

The acetyl group from acetyl-CoA is transferred to the NAT2
type: GO_0003674
BFO_0000050: Acetylation
directly activates: NAT2 acetylation
directly activates: Catalysis3052

NAT1 acetylation
type: Restriction
  on property: enabled by
  some values from: AAC1
type: Restriction
  on property: enabled by
  some values from: AAC1
type: Restriction
  on property: enabled by
  some values from: AAC1
type: Restriction
  on property: enabled by
  some values from: AAC1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004060
BFO_0000050: Acetylation
directly activates: The acetyl group from acetyl-CoA is transferred to the NAT1

NAT2 acetylation
type: Restriction
  on property: enabled by
  some values from: AAC2
type: Restriction
  on property: enabled by
  some values from: AAC2
type: Restriction
  on property: enabled by
  some values from: AAC2
type: Restriction
  on property: enabled by
  some values from: AAC2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004060
BFO_0000050: Acetylation
directly activates: The acetyl group from acetyl-CoA is transferred to the NAT2

S-atom dealkylation of 6-methylmercaptopurine
type: Restriction
  on property: enabled by
  some values from: CYP1A2
type: Restriction
  on property: enabled by
  some values from: CYP1A2
type: Restriction
  on property: enabled by
  some values from: CYP1A2
type: Restriction
  on property: enabled by
  some values from: CYP1A2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0019825
BFO_0000050: Methylation
directly activates: 6-mercaptopurine can be S-methylated
directly activates: Catalysis3054

6-mercaptopurine can be S-methylated
type: Restriction
  on property: enabled by
  some values from: TPMT
type: Restriction
  on property: enabled by
  some values from: TPMT
type: Restriction
  on property: enabled by
  some values from: TPMT
type: Restriction
  on property: enabled by
  some values from: TPMT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008119
BFO_0000050: Methylation
directly activates: S-adenoylhomocysteine is hydrolyzed
directly activates: Catalysis2952

2-mercaptoethanol can be S-methylated
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0018708
BFO_0000050: Methylation
directly activates: S-adenoylhomocysteine is hydrolyzed
directly activates: Catalysis2952

Pyridine can be N-methylated
type: Restriction
  on property: enabled by
  some values from: NNMT
type: Restriction
  on property: enabled by
  some values from: NNMT
type: Restriction
  on property: enabled by
  some values from: NNMT
type: Restriction
  on property: enabled by
  some values from: NNMT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0030760
BFO_0000050: Methylation
directly activates: S-adenoylhomocysteine is hydrolyzed
directly activates: Catalysis2952

3,4-dihydroxybenzoate can be O-methylated
type: Restriction
  on property: enabled by
  some values from: COMT
type: Restriction
  on property: enabled by
  some values from: COMT
type: Restriction
  on property: enabled by
  some values from: COMT
type: Restriction
  on property: enabled by
  some values from: COMT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016206
BFO_0000050: Methylation
directly activates: S-adenoylhomocysteine is hydrolyzed
directly activates: Catalysis2952

Cleavage of 5-oxoproline to form glutamate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0017168
BFO_0000050: Glutathione synthesis and recycling
directly activates: Glutamate and cysteine combine
directly activates: Catalysis2956

Formation of 5-oxoproline from gamma-glutamylcysteine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003839
BFO_0000050: Glutathione synthesis and recycling
directly activates: Cleavage of 5-oxoproline to form glutamate
directly activates: Catalysis3058

gamma-glutamylcysteine combines with glycine to form glutathione
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004363
BFO_0000050: Glutathione synthesis and recycling
directly activates: Export of glutathione to the extracellular space
directly activates: Glutathione conjugation of luminal substrates
directly activates: GST dimers conjugate GSH with cytosolic substrates
directly activates: Catalysis3063
directly activates: Catalysis3064

Export of glutathione to the extracellular space
type: GO_0003674
BFO_0000050: Glutathione synthesis and recycling
directly activates: Glutathione is hydrolyzed
directly activates: Catalysis3061

Glutathione is hydrolyzed
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0003840
BFO_0000050: Glutathione synthesis and recycling
directly activates: Cysteinylglycine and gamma-glutamate:AA are imported into the cell

Cysteinylglycine and gamma-glutamate:AA are imported into the cell
type: GO_0003674
BFO_0000050: Glutathione synthesis and recycling
directly activates: A dipeptidase cleaves cysteinylglycine
directly activates: 5-oxoproline can be formed from gamma-glutamyl-AA products
directly activates: Catalysis2957
directly activates: Catalysis3062

5-oxoproline can be formed from gamma-glutamyl-AA products
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003839
BFO_0000050: Glutathione synthesis and recycling
directly activates: Cleavage of 5-oxoproline to form glutamate
directly activates: Catalysis3058

Glutathione conjugation of luminal substrates
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004364
BFO_0000050: Glutathione conjugation
label: MGST trimers conjugate GSH with luminal substrates

GST dimers conjugate GSH with cytosolic substrates
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004364
BFO_0000050: Glutathione conjugation
label: Glutathione conjugation of cytosolic substrates

Benzoate and Coenzyme A react to form benzoyl-CoA thioester
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0016405
BFO_0000050: Conjugation of benzoate with glycine
directly activates: Benzoyl-CoA forms an amide bond with glycine
directly activates: Catalysis3066
label: benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate

Benzoyl-CoA forms an amide bond with glycine
type: Restriction
  on property: enabled by
  some values from: ACGNAT
type: Restriction
  on property: enabled by
  some values from: ACGNAT
type: Restriction
  on property: enabled by
  some values from: ACGNAT
type: Restriction
  on property: enabled by
  some values from: ACGNAT
type: Restriction
  on property: enabled by
  some values from: ACGNAT
type: Restriction
  on property: enabled by
  some values from: ACGNAT
type: Restriction
  on property: enabled by
  some values from: ACGNAT
type: Restriction
  on property: enabled by
  some values from: ACGNAT
type: Restriction
  on property: enabled by
  some values from: ACGNAT
type: Restriction
  on property: enabled by
  some values from: ACGNAT
type: Restriction
  on property: enabled by
  some values from: ACGNAT
type: Restriction
  on property: enabled by
  some values from: ACGNAT
type: Restriction
  on property: enabled by
  some values from: ACGNAT
type: Restriction
  on property: enabled by
  some values from: ACGNAT
type: Restriction
  on property: enabled by
  some values from: ACGNAT
type: Restriction
  on property: enabled by
  some values from: ACGNAT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0047962
BFO_0000050: Conjugation of benzoate with glycine
label: benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A

Synthesis of phenylacetyl CoA from phenylacetate and Coenzyme A
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0016405
BFO_0000050: Conjugation of phenylacetate with glutamine
directly activates: Synthesis of phenylacetyl glutamine from phenylacetyl-CoA and glutamine
directly activates: Catalysis3068
label: phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate

Synthesis of phenylacetyl glutamine from phenylacetyl-CoA and glutamine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0016410
BFO_0000050: Conjugation of phenylacetate with glutamine
label: phenylacetyl-CoA + glutamine => phenylacetyl glutamine + Coenzyme A

Salicylic acid and Coenzyme A react to form salicylate-CoA thioester
type: Restriction
  on property: enabled by
  some values from: ACSM2
type: Restriction
  on property: enabled by
  some values from: ACSM2
type: Restriction
  on property: enabled by
  some values from: ACSM2
type: Restriction
  on property: enabled by
  some values from: ACSM2
type: Restriction
  on property: enabled by
  some values from: ACSM2
type: Restriction
  on property: enabled by
  some values from: ACSM2
type: Restriction
  on property: enabled by
  some values from: ACSM2
type: Restriction
  on property: enabled by
  some values from: ACSM2
type: Restriction
  on property: enabled by
  some values from: ACSM2
type: Restriction
  on property: enabled by
  some values from: ACSM2
type: Restriction
  on property: enabled by
  some values from: ACSM2
type: Restriction
  on property: enabled by
  some values from: ACSM2
type: Restriction
  on property: enabled by
  some values from: ACSM2
type: Restriction
  on property: enabled by
  some values from: ACSM2
type: Restriction
  on property: enabled by
  some values from: ACSM2
type: Restriction
  on property: enabled by
  some values from: ACSM2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0016405
BFO_0000050: Conjugation of salicylate with glycine
directly activates: Salicylate-CoA forms an amide bond with glycine
directly activates: Catalysis3070
label: salicylic acid + Coenzyme A + ATP => salicylate-CoA + AMP + pyrophosphate

Salicylate-CoA forms an amide bond with glycine
type: Restriction
  on property: enabled by
  some values from: ACGNAT
type: Restriction
  on property: enabled by
  some values from: ACGNAT
type: Restriction
  on property: enabled by
  some values from: ACGNAT
type: Restriction
  on property: enabled by
  some values from: ACGNAT
type: Restriction
  on property: enabled by
  some values from: ACGNAT
type: Restriction
  on property: enabled by
  some values from: ACGNAT
type: Restriction
  on property: enabled by
  some values from: ACGNAT
type: Restriction
  on property: enabled by
  some values from: ACGNAT
type: Restriction
  on property: enabled by
  some values from: ACGNAT
type: Restriction
  on property: enabled by
  some values from: ACGNAT
type: Restriction
  on property: enabled by
  some values from: ACGNAT
type: Restriction
  on property: enabled by
  some values from: ACGNAT
type: Restriction
  on property: enabled by
  some values from: ACGNAT
type: Restriction
  on property: enabled by
  some values from: ACGNAT
type: Restriction
  on property: enabled by
  some values from: ACGNAT
type: Restriction
  on property: enabled by
  some values from: ACGNAT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0047962
BFO_0000050: Conjugation of salicylate with glycine
label: salicylate-CoA + glycine => salicyluric acid + Coenzyme A

Biological oxidations
type: GO_0008150

Phase 1 - Functionalization of compounds
type: GO_0008150
BFO_0000050: Biological oxidations

Cytochrome P450 - arranged by substrate type
type: GO_0008150
BFO_0000050: Phase 1 - Functionalization of compounds

Endogenous sterols
type: GO_0008150
BFO_0000050: Cytochrome P450 - arranged by substrate type

Sterols are 12-hydroxylated by CYP8B1
type: GO_0008150
BFO_0000050: Endogenous sterols

Xenobiotics
type: GO_0008150
BFO_0000050: Cytochrome P450 - arranged by substrate type

Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2
type: GO_0008150
BFO_0000050: Xenobiotics

CYP2E1 reactions
type: GO_0008150
BFO_0000050: Xenobiotics

Fatty acids
type: GO_0008150
BFO_0000050: Cytochrome P450 - arranged by substrate type

Eicosanoids
type: GO_0008150
BFO_0000050: Cytochrome P450 - arranged by substrate type

Vitamins
type: GO_0008150
BFO_0000050: Cytochrome P450 - arranged by substrate type

Miscellaneous substrates
type: GO_0008150
BFO_0000050: Cytochrome P450 - arranged by substrate type

FMO oxidizes nucleophiles
type: GO_0008150
BFO_0000050: Phase 1 - Functionalization of compounds

COX reactions
type: GO_0008150
BFO_0000050: Phase 1 - Functionalization of compounds

Amine Oxidase reactions
type: GO_0008150
BFO_0000050: Phase 1 - Functionalization of compounds

Monoamines are oxidized to aldehydes by MAOA and MAOB, producing NH3 and H2O2
type: GO_0008150
BFO_0000050: Amine Oxidase reactions

Polyamines are oxidized to amines, aldehydes and H2O2 by PAOs
type: GO_0008150
BFO_0000050: Amine Oxidase reactions

Alcohol catabolism
type: GO_0008150
BFO_0000050: Phase 1 - Functionalization of compounds
label: Ethanol oxidation

Phase II conjugation
type: GO_0008150
BFO_0000050: Biological oxidations

Glucuronidation
type: GO_0008150
BFO_0000050: Phase II conjugation

Formation of the active cofactor, UDP-glucuronate
type: GO_0008150
BFO_0000050: Glucuronidation

Cytosolic sulfonation of small molecules
type: GO_0008150
BFO_0000050: Phase II conjugation

Acetylation
type: GO_0008150
BFO_0000050: Phase II conjugation

Methylation
type: GO_0008150
BFO_0000050: Phase II conjugation

Glutathione conjugation
type: GO_0008150
BFO_0000050: Phase II conjugation

Glutathione synthesis and recycling
type: GO_0008150
BFO_0000050: Glutathione conjugation

Amino Acid conjugation
type: GO_0008150
BFO_0000050: Phase II conjugation

Conjugation of carboxylic acids
type: GO_0008150
BFO_0000050: Amino Acid conjugation

Conjugation of benzoate with glycine
type: GO_0008150
BFO_0000050: Conjugation of carboxylic acids

Conjugation of phenylacetate with glutamine
type: GO_0008150
BFO_0000050: Conjugation of carboxylic acids

Conjugation of salicylate with glycine
type: GO_0008150
BFO_0000050: Conjugation of carboxylic acids

Transport and synthesis of PAPS
type: GO_0008150
BFO_0000050: Cytosolic sulfonation of small molecules