KIAA0702
NCKX1
SLC24A1
UniProt:O60721 SLC24A1
Photons induce isomerization of 11cRAL to atRAL
Rhodopsin activation
MII catalyses GDP/GTP exchange on Gt
Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1
GNAT1-GTP binds PDE6 and activates it
PDE hydrolyses cGMP to GMP
cGMP:CNG transports Na+ and Ca2+ into the rod outer segment
NCKX1 exchanges Na+ for Ca2+/K+
NCKX1 removes Ca2+ from the rod outer segment
Decreased cGMP closes cation channels
cGMP dissociates from CNG channels
Activation of the phototransduction cascade