KIAA0702
label: NCKX1
label: SLC24A1
label: UniProt:O60721 SLC24A1

Photons induce isomerization of 11cRAL to atRAL
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0009881
BFO_0000050: Activation of the phototransduction cascade
directly activates: MII catalyses GDP/GTP exchange on Gt
directly activates: BiochemicalReaction3221
directly activates: Catalysis1391
directly activates: Catalysis1399
directly activates: Control225
directly activates: Control226
directly activates: Control234
directly activates: Control235
directly activates: Control236
directly activates: Control237
directly activates: Control238
label: Rhodopsin activation

MII catalyses GDP/GTP exchange on Gt
type: Restriction
  on property: BFO_0000066
  some values from: GO_0097381
type: GO_0005085
BFO_0000050: Activation of the phototransduction cascade
directly activates: Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1

Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1
type: GO_0003674
BFO_0000050: Activation of the phototransduction cascade
directly activates: GNAT1-GTP binds PDE6 and activates it
directly activates: Control227

GNAT1-GTP binds PDE6 and activates it
type: GO_0003674
BFO_0000050: Activation of the phototransduction cascade
directly activates: PDE hydrolyses cGMP to GMP
directly activates: Catalysis1392
directly activates: Control228

PDE hydrolyses cGMP to GMP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0097381
type: GO_0047555
BFO_0000050: Activation of the phototransduction cascade
directly activates: Decreased cGMP closes cation channels
directly activates: Control231
directly activates: Control232
directly activates: Control233

cGMP:CNG transports Na+ and Ca2+ into the rod outer segment
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005221
BFO_0000050: Activation of the phototransduction cascade
directly activates: NCKX1 exchanges Na+ for Ca2+/K+
directly activates: Catalysis1394
directly activates: Control230

NCKX1 exchanges Na+ for Ca2+/K+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: KIAA0702
type: GO_0008273
BFO_0000050: Activation of the phototransduction cascade
label: NCKX1 removes Ca2+ from the rod outer segment

Decreased cGMP closes cation channels
type: GO_0003674
BFO_0000050: Activation of the phototransduction cascade
label: cGMP dissociates from CNG channels

Activation of the phototransduction cascade
type: GO_0008150