CLG
MMP1
UniProt:P03956 MMP1
CLG4A
MMP2
UniProt:P08253 MMP2
MMP3
STMY1
UniProt:P08254 MMP3
MMP7
MPSL1
PUMP1
UniProt:P09237 MMP7
FUR
FURIN
PACE
PCSK3
UniProt:P09958 FURIN
Initial activation of proMMP1
Autocatalytic activation of MMP1
Full activation of MMP1
proMMP9 binds TIMP1
MMP14 (MT1-MMP) binds TIMP2
MMP14:TIMP2 binds proMMP2
Initial activation of proMMP2 by MMP1, 7
Initial activation of proMMP2 by MMP14
Autocatalytic activation of proMMP2
Autocatalytic activation of bound proMMP2
Initial activation of proMMP3
Autocatalytic activation of MMP3
Activation of proMMP7 by MMP3
Initial activation of proMMP7 by trypsin
Autocatalytic activation of MMP7
Activation of proMMP8
Initial activation of proMMP9 by MMPs
Activation of MMP9 intermediate form by MMPs
Activation of proMMP9 by proteases
Activation of proMMP10
Activation of proMMP11 by FURIN
Initial activation of proMMP13 by plasmin and trypsin
Initial activation of proMMP13 by MMP3
Initial activation of proMMP13 by MMP14 (MT1-MMP)
Autocatalytic activation of proMMP13
Activation of MT-MMPs by FURIN
MT-MMPs are sorted to the plasma membrane
Activation of Matrix Metalloproteinases