CLG
label: MMP1
label: UniProt:P03956 MMP1

CLG4A
label: MMP2
label: UniProt:P08253 MMP2

MMP3
label: STMY1
label: UniProt:P08254 MMP3

MMP7
label: MPSL1
label: PUMP1
label: UniProt:P09237 MMP7

FUR
label: FURIN
label: PACE
label: PCSK3
label: UniProt:P09958 FURIN

Initial activation of proMMP1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Activation of Matrix Metalloproteinases
directly activates: Autocatalytic activation of MMP1
directly activates: Catalysis945

Autocatalytic activation of MMP1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: enabled by
  some values from: CLG
type: GO_0004252
BFO_0000050: Activation of Matrix Metalloproteinases
directly activates: Full activation of MMP1
directly activates: Catalysis946

Full activation of MMP1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Activation of Matrix Metalloproteinases
directly activates: Initial activation of proMMP2 by MMP1, 7
directly activates: Catalysis947

proMMP9 binds TIMP1
type: GO_0003674
BFO_0000050: Activation of Matrix Metalloproteinases

MMP14 (MT1-MMP) binds TIMP2
type: GO_0003674
BFO_0000050: Activation of Matrix Metalloproteinases
directly activates: MMP14:TIMP2 binds proMMP2

MMP14:TIMP2 binds proMMP2
type: GO_0003674
BFO_0000050: Activation of Matrix Metalloproteinases
directly activates: Initial activation of proMMP2 by MMP14
directly activates: Catalysis948

Initial activation of proMMP2 by MMP1, 7
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Activation of Matrix Metalloproteinases
directly activates: Autocatalytic activation of proMMP2
directly activates: Catalysis949
directly activates: Control153

Initial activation of proMMP2 by MMP14
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004252
BFO_0000050: Activation of Matrix Metalloproteinases
directly activates: Autocatalytic activation of bound proMMP2
directly activates: Catalysis950

Autocatalytic activation of proMMP2
type: Restriction
  on property: enabled by
  some values from: CLG4A
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Activation of Matrix Metalloproteinases

Autocatalytic activation of bound proMMP2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004252
BFO_0000050: Activation of Matrix Metalloproteinases

Initial activation of proMMP3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Activation of Matrix Metalloproteinases
directly activates: Autocatalytic activation of MMP3
directly activates: Catalysis952

Autocatalytic activation of MMP3
type: Restriction
  on property: enabled by
  some values from: MMP3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Activation of Matrix Metalloproteinases
directly activates: Activation of proMMP7 by MMP3
directly activates: Catalysis953

Activation of proMMP7 by MMP3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Activation of Matrix Metalloproteinases

Initial activation of proMMP7 by trypsin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Activation of Matrix Metalloproteinases
directly activates: Autocatalytic activation of MMP7
directly activates: Catalysis955
directly activates: Control154

Autocatalytic activation of MMP7
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: enabled by
  some values from: MMP7
type: GO_0004252
BFO_0000050: Activation of Matrix Metalloproteinases

Activation of proMMP8
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Activation of Matrix Metalloproteinases

Initial activation of proMMP9 by MMPs
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Activation of Matrix Metalloproteinases
directly activates: Activation of MMP9 intermediate form by MMPs
directly activates: Catalysis958

Activation of MMP9 intermediate form by MMPs
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Activation of Matrix Metalloproteinases

Activation of proMMP9 by proteases
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Activation of Matrix Metalloproteinases

Activation of proMMP10
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Activation of Matrix Metalloproteinases

Activation of proMMP11 by FURIN
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: FUR
type: GO_0004252
BFO_0000050: Activation of Matrix Metalloproteinases

Initial activation of proMMP13 by plasmin and trypsin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Activation of Matrix Metalloproteinases
directly activates: Autocatalytic activation of proMMP13
directly activates: Catalysis965
directly activates: Control156

Initial activation of proMMP13 by MMP3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Activation of Matrix Metalloproteinases
directly activates: Autocatalytic activation of proMMP13
directly activates: Catalysis965
directly activates: Control156

Initial activation of proMMP13 by MMP14 (MT1-MMP)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004252
BFO_0000050: Activation of Matrix Metalloproteinases
directly activates: Autocatalytic activation of proMMP13
directly activates: Catalysis965
directly activates: Control156

Autocatalytic activation of proMMP13
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Activation of Matrix Metalloproteinases

Activation of MT-MMPs by FURIN
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: FUR
type: GO_0004252
BFO_0000050: Activation of Matrix Metalloproteinases
directly activates: MMP14 (MT1-MMP) binds TIMP2

MT-MMPs are sorted to the plasma membrane
type: GO_0003674
BFO_0000050: Activation of Matrix Metalloproteinases

Activation of Matrix Metalloproteinases
type: GO_0008150