Gene Ontology Definition Changes
Files used:
- file 1 (old): 06:01:2012 16:33, cvs revision 1.2481
- file 2 (new): 13:01:2012 15:54, cvs revision 1.2512
- Database: unknown DB type, unknown DB release name
Terms with changed definitions
0 annotations
GO:0003376 : sphingosine-1-phosphate signaling pathway
(was sphingolipid signaling pathway)
OLD: A series of molecular signals mediated by a sphingolipid.
NEW: A series of molecular signals initiated by the sphingolipid sphingosine-1-phosphate (S1P) binding to a receptor on the surface of the cell, and which proceeds with the activated receptor transmitting the signal by promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
0 annotations
GO:0003377 : regulation of apoptosis by sphingosine-1-phosphate signaling pathway
(was regulation of apoptosis by sphingolipid signaling pathway)
OLD: A series of molecular signals mediated by a sphingolipid that modulates the rate, frequency, or extent of apoptosis.
NEW: A sphingosine-1-phosphate signaling pathway that modulates the rate, frequency, or extent of apoptosis.
0 annotations
GO:0003378 : regulation of inflammatory response by sphingosine-1-phosphate signaling pathway
(was regulation of inflammatory response by sphingolipid signaling pathway)
OLD: A series of molecular signals mediated by a sphingolipid that modulates the rate, frequency, or extent of the inflammatory response.
NEW: A sphingosine-1-phosphate signaling pathway that modulates the rate, frequency, or extent of the inflammatory response.
GO:0004897 : ciliary neurotrophic factor receptor activity
OLD: Combining with ciliary neurotrophic factor to initiate a change in cell activity.
NEW: Combining with ciliary neurotrophic factor (CNTF) and transmitting the signal to initiate a change in cell activity.
GO:0004923 : leukemia inhibitory factor receptor activity
OLD: Combining with leukemia inhibitory factor to initiate a change in cell activity.
NEW: Combining with leukemia inhibitory factor (LIF) and transmitting the signal to initiate a change in cell activity.
GO:0004968 : gonadotropin-releasing hormone receptor activity
OLD: Combining with gonadotropin-releasing hormone to initiate a change in cell activity.
NEW: Combining with gonadotropin-releasing hormone to initiate a change in cell activity. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus.
GO:0007263 : nitric oxide mediated signal transduction
OLD: A series of molecular signals mediated by nitric oxide (NO).
NEW: Any intracellular signal transduction in which the signal is passed on within the cell via nitric oxide (NO). Includes synthesis of nitric oxide, receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms.
GO:0019221 : cytokine-mediated signaling pathway
OLD: Any series of molecular signals generated as a consequence of a cytokine binding to a cell surface receptor.
NEW: A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
GO:0019722 : calcium-mediated signaling
OLD: A series of molecular signals in which a cell uses calcium ions to convert a signal into a response.
NEW: Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.
GO:0019932 : second-messenger-mediated signaling
OLD: A series of molecular signals in which an ion or small molecule is formed or released into the cytosol, thereby helping relay the signal within the cell.
NEW: Any intracellular signal transduction in which the signal is passed on within the cell via a second messenger; a small molecule or ion that can be quickly generated or released from intracellular stores, and can diffuse within the cell. Second-messenger signaling includes production or release of the second messenger, and effectors downstream of the second messenger that further transmit the signal within the cell.
GO:0019933 : cAMP-mediated signaling
OLD: A series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response.
NEW: Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell.
GO:0019934 : cGMP-mediated signaling
OLD: A series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response.
NEW: Any intracellular signal transduction in which the signal is passed on within the cell via cyclic GMP (cGMP). Includes production of cGMP, and downstream effectors that further transmit the signal within the cell.
GO:0019935 : cyclic-nucleotide-mediated signaling
OLD: A series of molecular signals in which a cell uses a cyclic nucleotide to convert an extracellular signal into a response.
NEW: Any intracellular signal transduction in which the signal is passed on within the cell via a cyclic nucleotide. Includes production or release of the cyclic nucleotide, and downstream effectors that further transmit the signal within the cell.
0 annotations
GO:0023014 : signal transduction by phosphorylation
(was signal transduction via phosphorylation event)
OLD: The process in which a signal is conveyed via the transfer of one or more phosphate groups.
NEW: A process in which the transfer of one or more phosphate groups to a substrate transmits a signal to the phosphorylated substrate.
0 annotations
GO:0023015 : signal transduction by cis-phosphorylation
(was signal transduction via a cis-phosphorylation event)
OLD: The process in which a signal is conveyed via the transfer of one or more phosphate groups by a kinase to a residue in the same kinase molecule.
NEW: A process in which the transfer of one or more phosphate groups by a kinase to a residue in the same kinase molecule transmits a signal. For example, ligand-binding can induce autophosphorylation of the activated receptor, creating binding sites for intracellular signaling molecules.
0 annotations
GO:0023016 : signal transduction by trans-phosphorylation
(was signal transduction via a trans-phosphorylation event)
OLD: The process in which a signal is conveyed via the transfer of one or more phosphate groups by a kinase to a residue in a different molecule.
NEW: A process in which the transfer of one or more phosphate groups by a kinase to a residue in a different molecule transmits a signal.
GO:0023035 : CD40 signaling pathway
OLD: Any series of molecular signals generated as a consequence of the receptor CD40 binding to one of its physiological ligands.
NEW: A series of molecular signals initiated by the binding of the cell surface receptor CD40 to one of its physiological ligands, and ending with regulation of a downstream cellular process, e.g. transcription.
0 annotations
GO:0023045 : signal transduction by conformational transition
(was signal transduction via conformational transition)
OLD: The process whereby a signal is passed on within a cell by triggering a conformational change in the molecule that is receiving the signal.
NEW: A process where induction of a conformational change in a molecule transmits a signal to that molecule.
GO:0031530 : gonadotropin-releasing hormone receptor binding
OLD: Interacting selectively and non-covalently with a receptor for gonadotropin-releasing hormone, a peptide hormone that is synthesized and released by the hypothalamus and is responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary.
NEW: Interacting selectively and non-covalently with a receptor for gonadotropin-releasing hormone (GnRH), a peptide hormone that is synthesized and released by the hypothalamus and is responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary.
GO:0033173 : calcineurin-NFAT signaling cascade
(was calcineurin-NFAT signaling pathway)
OLD: A series of molecular signals that results in activation of transcription by a member of the NFAT protein family as a consequence of NFAT dephosphorylation by activated calcineurin. The signaling is generated by a receptor binding a ligand, followed by activation of phospholipase C and the subsequent release of inositol trisphosphate, which in turn leads to an increase in intracellular calcium ion concentration that mediates the activation of calcineurin.
NEW: Any intracellular signal transduction in which the signal is passed on within the by activation of a member of the NFAT protein family as a consequence of NFAT dephosphorylation by Ca(2+)-activated calcineurin. The cascade begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin dephosphorylates multiple phosphoserine residues on NFAT, resulting in the translocation of NFAT to the nucleus. The cascade ends with regulation of transcription by NFAT. The calcineurin-NFAT cascade lies downstream of many cell surface receptors, including G-protein coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs) that signal to mobilize calcium ions (Ca2+).
GO:0033211 : adiponectin-mediated signaling pathway
OLD: A series of molecular signals generated as a consequence of adiponectin binding to a cell surface receptor.
NEW: A series of molecular signals initiated by the binding of adiponectin to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
GO:0035004 : phosphatidylinositol 3-kinase activity
OLD: Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol 3-phosphate. This reaction is the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring to generate the 3-phosphoinositides: phosphatidylinositol-3-phosphate [PI(3)P], phosphatidylinositol-3,4-bisphosphate [PI(3,4)P2] and phosphatidylinositol-3,4,5-trisphosphate [PI(3,4,5)P3].
NEW: Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol 3-phosphate. This reaction is the addition of a phosphate group to phosphatidylinositol or one of its phosphorylated derivatives at the 3' position of the inositol ring.
0 annotations
GO:0035689 : chemokine (C-C motif) ligand 5 signaling pathway
OLD: A series of molecular events generated as a consequence of the chemokine CCL5 binding to a cell surface receptor.
NEW: A series of molecular signals initiated by the binding of the chemokine CCL5 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
GO:0035722 : interleukin-12-mediated signaling pathway
OLD: A series of molecular signals generated as a consequence of interleukin-12 binding to a cell surface receptor.
NEW: A series of molecular signals initiated by the binding of interleukin-12 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
GO:0038027 : apolipoprotein A-I-mediated signaling pathway
OLD: Any series of molecular signals initiated by the binding of apolipoprotein A-I to a cell surface receptor.
NEW: A series of molecular signals initiated by the binding of apolipoprotein A-I to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
GO:0048016 : inositol phosphate-mediated signaling
OLD: A series of molecular signals in which a cell uses a water-soluble inositol phosphate to convert a signal into a response. Inositol phosphates are a group of mono- to poly-phosphorylated inositols, and include inositol monophosphate (IP), inositol trisphosphate (IP3), inositol pentakisphosphate (IP5) and inositol hexaphosphate (IP6).
NEW: Any intracellular signal transduction in which the signal is passed on within the cell via an inositol phosphate. Includes production of the inositol phosphate, and downstream effectors that further transmit the signal within the cell. Inositol phosphates are a group of mono- to poly-phosphorylated inositols, and include inositol monophosphate (IP), inositol trisphosphate (IP3), inositol pentakisphosphate (IP5) and inositol hexaphosphate (IP6).
0 annotations
GO:0051448 : gonadotropin-releasing hormone binding
OLD: Interacting selectively and non-covalently with gonadotropin-releasing hormone, a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary and it is synthesized and released by the hypothalamus.
NEW: Interacting selectively and non-covalently with gonadotropin-releasing hormone (GnRH), a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus.
GO:0060333 : interferon-gamma-mediated signaling pathway
OLD: A series of molecular events generated as a consequence of interferon-gamma binding to a cell surface receptor.
NEW: A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
GO:0061311 : cell surface receptor signaling pathway involved in heart development
(was cell surface receptor linked signaling pathway involved in heart development)
OLD: Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell contributing to the progression of the heart over time.
NEW: Any series of molecular signals initiated by the binding of a receptor on the surface of a cell to a physiological ligand, which contributes to the progression of the heart over time.
GO:0070098 : chemokine-mediated signaling pathway
OLD: A series of molecular signals generated as a consequence of a chemokine binding to a cell surface receptor.
NEW: A series of molecular signals initiated by the binding of a chemokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
GO:0070120 : ciliary neurotrophic factor-mediated signaling pathway
OLD: A series of molecular signals generated as a consequence of a ciliary neurotrophic factor binding to a cell surface receptor.
NEW: A series of molecular signals initiated by the binding of a ciliary neurotrophic factor (CNTF) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
GO:0070498 : interleukin-1-mediated signaling pathway
OLD: A series of molecular signals generated as a consequence of interleukin-1 binding to a cell surface receptor.
NEW: A series of molecular signals initiated by the binding of interleukin-1 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
GO:0070884 : regulation of calcineurin-NFAT signaling cascade
(was regulation of calcineurin-NFAT signaling pathway)
OLD: Any process that modulates the frequency, rate or extent of signaling via the calcineurin-NFAT signaling pathway.
NEW: Any process that modulates the frequency, rate or extent of the calcineurin-NFAT signaling cascade.
GO:0070885 : negative regulation of calcineurin-NFAT signaling cascade
(was negative regulation of calcineurin-NFAT signaling pathway)
OLD: Any process that stops, prevents, or reduces the frequency, rate or extent of signaling via the calcineurin-NFAT signaling pathway.
NEW: Any process that stops, prevents, or reduces the frequency, rate or extent of the calcineurin-NFAT signaling cascade.
GO:0070886 : positive regulation of calcineurin-NFAT signaling cascade
(was positive regulation of calcineurin-NFAT signaling pathway)
OLD: Any process that activates or increases the frequency, rate or extent of signaling via the calcineurin-NFAT signaling pathway.
NEW: Any process that activates or increases the frequency, rate or extent of signaling via the calcineurin-NFAT signaling cascade.