EIF4B
label: UniProt:P23588 EIF4B

EEF1A
label: EEF1A1
label: EF1A
label: LENG7
label: UniProt:P68104 EEF1A1

EIF4H
label: KIAA0038
label: UniProt:Q15056 EIF4H
label: WBSCR1
label: WSCR1

Dissociation of L13a from the 60s ribosomal subunit
type: GO_0003674
BFO_0000050: L13a-mediated translational silencing of Ceruloplasmin expression
directly activates: INF-gamma induced phosphorylation of L13a
directly activates: Catalysis95

INF-gamma induced phosphorylation of L13a
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004672
BFO_0000050: L13a-mediated translational silencing of Ceruloplasmin expression
directly activates: Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA

Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA
type: GO_0003674
BFO_0000050: L13a-mediated translational silencing of Ceruloplasmin expression

Release of 40S and 60S subunits from the 80S ribosome
type: GO_0003674
BFO_0000050: Formation of a pool of free 40S subunits
directly activates: eIF3 and eIF1A bind to the 40S subunit
directly activates: The 60S subunit joins the translation initiation complex

eIF3 and eIF1A bind to the 40S subunit
type: GO_0003674
BFO_0000050: Formation of a pool of free 40S subunits
directly activates: Formation of the ternary complex, and subsequently, the 43S complex

De novo formation of eIF2:GTP
type: GO_0003674
BFO_0000050: Formation of the ternary complex, and subsequently, the 43S complex
directly activates: Met-tRNAi binds to eIF2:GTP to form the ternary complex
directly activates: Control44

Met-tRNAi binds to eIF2:GTP to form the ternary complex
type: GO_0003674
BFO_0000050: Formation of the ternary complex, and subsequently, the 43S complex
directly activates: Formation of the 43S pre-initiation complex

Formation of the 43S pre-initiation complex
type: GO_0003674
BFO_0000050: Formation of the ternary complex, and subsequently, the 43S complex

Release of eIF4E from the inactive eIF4E:4E-BP complex
type: GO_0003674
BFO_0000050: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
directly activates: Formation of the cap-binding eIF4F complex

Formation of the cap-binding eIF4F complex
type: GO_0003674
BFO_0000050: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
directly activates: eIF4F binds to mRNP

eIF4F binds to mRNP
type: GO_0003674
BFO_0000050: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
directly activates: Cap-bound mRNA is activated by helicases
directly activates: Catalysis212
directly activates: Catalysis213
directly activates: Catalysis214

Cap-bound mRNA is activated by helicases
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003724
type: GO_0004386
BFO_0000050: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
directly activates: Formation of translation initiation complexes containing mRNA that does not circularize
directly activates: Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation
directly activates: Translation initiation complex formation

Formation of translation initiation complexes containing mRNA that does not circularize
type: GO_0003674
BFO_0000050: Translation initiation complex formation

Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation
type: GO_0003674
BFO_0000050: Translation initiation complex formation
directly activates: L13a-mediated translational silencing of Ceruloplasmin expression

Ribosomal scanning
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003743
BFO_0000050: Ribosomal scanning and start codon recognition
directly activates: Start codon recognition
directly activates: Catalysis216

Start codon recognition
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003743
BFO_0000050: Ribosomal scanning and start codon recognition
directly activates: eIF2:GTP is hydrolyzed, eIFs are released
directly activates: Control46

eIF2:GTP is hydrolyzed, eIFs are released
type: GO_0003674
BFO_0000050: GTP hydrolysis and joining of the 60S ribosomal subunit
directly activates: The 60S subunit joins the translation initiation complex
directly activates: Formation of eIF2:GDP:eIF2B intermediate

eIF5B:GTP is hydrolyzed and released
type: GO_0003674
BFO_0000050: GTP hydrolysis and joining of the 60S ribosomal subunit
directly activates: Aminoacyl-tRNA binds to the ribosome at the A-site

The 60S subunit joins the translation initiation complex
type: GO_0003674
BFO_0000050: GTP hydrolysis and joining of the 60S ribosomal subunit
directly activates: eIF5B:GTP is hydrolyzed and released

Formation of eIF2:GDP:eIF2B intermediate
type: GO_0003674
BFO_0000050: Recycling of eIF2:GDP
directly activates: eIF2 activation
directly activates: Catalysis217

eIF2 activation
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003743
BFO_0000050: Recycling of eIF2:GDP
directly activates: Met-tRNAi binds to eIF2:GTP to form the ternary complex
directly activates: Control44

Synthesis of nascent polypeptide containing signal sequence
type: GO_0003674
BFO_0000050: SRP-dependent cotranslational protein targeting to membrane
directly activates: Association of a nascent polypeptide:mRNA:ribosome complex with a signal recognition particle (SRP)

Association of a nascent polypeptide:mRNA:ribosome complex with a signal recognition particle (SRP)
type: GO_0003674
BFO_0000050: SRP-dependent cotranslational protein targeting to membrane
directly activates: The SRP receptor binds the SRP:nascent peptide:ribosome complex

The SRP receptor binds the SRP:nascent peptide:ribosome complex
type: GO_0003674
BFO_0000050: SRP-dependent cotranslational protein targeting to membrane
directly activates: Translocation of signal-containing nascent peptide to Endoplasmic Reticulum

Translocation of signal-containing nascent peptide to Endoplasmic Reticulum
type: GO_0003674
BFO_0000050: SRP-dependent cotranslational protein targeting to membrane
directly activates: Signal peptide cleavage from ribosome-associated nascent protein
directly activates: Catalysis218

Signal peptide cleavage from ribosome-associated nascent protein
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004252
BFO_0000050: SRP-dependent cotranslational protein targeting to membrane
directly activates: BiochemicalReaction3599
directly activates: Catalysis1573

eEF1A complexes with GTP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: EEF1A
type: Restriction
  on property: enabled by
  some values from: EEF1A
type: GO_0019001
BFO_0000050: Eukaryotic Translation Elongation
directly activates: eEF1A:GTP:aminoacyl tRNA ternary complex formation.

eEF1A:GTP:aminoacyl tRNA ternary complex formation.
type: GO_0003674
BFO_0000050: Eukaryotic Translation Elongation
directly activates: Aminoacyl-tRNA binds to the ribosome at the A-site

Aminoacyl-tRNA binds to the ribosome at the A-site
type: GO_0003674
BFO_0000050: Peptide chain elongation
directly activates: Hydrolysis of eEF1A:GTP
directly activates: Catalysis220

Hydrolysis of eEF1A:GTP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003924
BFO_0000050: Peptide chain elongation
directly activates: Peptide transfer from P-site tRNA to the A-site tRNA
directly activates: Regeneration of eEF1A:GTP by eEF1B activity
directly activates: Catalysis221
directly activates: Catalysis222

Peptide transfer from P-site tRNA to the A-site tRNA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0000048
BFO_0000050: Peptide chain elongation
directly activates: Translocation of ribosome by 3 bases in the 3' direction

Translocation of ribosome by 3 bases in the 3' direction
type: GO_0003674
BFO_0000050: Peptide chain elongation
directly activates: GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex

GTP-binding activates eEF2
type: GO_0003674
BFO_0000050: Peptide chain elongation
directly activates: Translocation of ribosome by 3 bases in the 3' direction

Regeneration of eEF1A:GTP by eEF1B activity
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0005085
BFO_0000050: Eukaryotic Translation Elongation
directly activates: eEF1A:GTP:aminoacyl tRNA ternary complex formation.

Formation of eEF1B complex
type: GO_0003674
BFO_0000050: Eukaryotic Translation Elongation
directly activates: Regeneration of eEF1A:GTP by eEF1B activity
directly activates: Catalysis222

GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex
type: GO_0006415
BFO_0000050: Eukaryotic Translation Termination
directly activates: GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex

GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex
type: GO_0006415
BFO_0000050: Eukaryotic Translation Termination
directly activates: Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex

Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex
type: GO_0006415
BFO_0000050: Eukaryotic Translation Termination

Translation
type: GO_0008150

Eukaryotic Translation Initiation
type: GO_0008150
BFO_0000050: Translation

Cap-dependent Translation Initiation
type: GO_0008150
BFO_0000050: Eukaryotic Translation Initiation

Formation of a pool of free 40S subunits
type: GO_0008150
BFO_0000050: Cap-dependent Translation Initiation

Formation of the ternary complex, and subsequently, the 43S complex
type: GO_0008150
BFO_0000050: Cap-dependent Translation Initiation

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
type: GO_0008150
BFO_0000050: Cap-dependent Translation Initiation

Translation initiation complex formation
type: GO_0008150
BFO_0000050: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

Ribosomal scanning and start codon recognition
type: GO_0008150
BFO_0000050: Cap-dependent Translation Initiation

GTP hydrolysis and joining of the 60S ribosomal subunit
type: GO_0008150
BFO_0000050: Cap-dependent Translation Initiation

Recycling of eIF2:GDP
type: GO_0008150
BFO_0000050: Cap-dependent Translation Initiation

Cap-independent Translation Initiation
type: GO_0003674
BFO_0000050: Eukaryotic Translation Initiation

SRP-dependent cotranslational protein targeting to membrane
type: GO_0008150
BFO_0000050: Translation

Eukaryotic Translation Elongation
type: GO_0008150
BFO_0000050: Translation

Peptide chain elongation
type: GO_0008150
BFO_0000050: Eukaryotic Translation Elongation

Eukaryotic Translation Termination
type: GO_0008150
BFO_0000050: Translation

L13a-mediated translational silencing of Ceruloplasmin expression
type: GO_0008150
BFO_0000050: Eukaryotic Translation Initiation