EIF4B
UniProt:P23588 EIF4B
EEF1A
EEF1A1
EF1A
LENG7
UniProt:P68104 EEF1A1
EIF4H
KIAA0038
UniProt:Q15056 EIF4H
WBSCR1
WSCR1
Dissociation of L13a from the 60s ribosomal subunit
INF-gamma induced phosphorylation of L13a
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA
Release of 40S and 60S subunits from the 80S ribosome
eIF3 and eIF1A bind to the 40S subunit
De novo formation of eIF2:GTP
Met-tRNAi binds to eIF2:GTP to form the ternary complex
Formation of the 43S pre-initiation complex
Release of eIF4E from the inactive eIF4E:4E-BP complex
Formation of the cap-binding eIF4F complex
eIF4F binds to mRNP
Cap-bound mRNA is activated by helicases
Formation of translation initiation complexes containing mRNA that does not circularize
Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation
Ribosomal scanning
Start codon recognition
eIF2:GTP is hydrolyzed, eIFs are released
eIF5B:GTP is hydrolyzed and released
The 60S subunit joins the translation initiation complex
Formation of eIF2:GDP:eIF2B intermediate
eIF2 activation
Synthesis of nascent polypeptide containing signal sequence
Association of a nascent polypeptide:mRNA:ribosome complex with a signal recognition particle (SRP)
The SRP receptor binds the SRP:nascent peptide:ribosome complex
Translocation of signal-containing nascent peptide to Endoplasmic Reticulum
Signal peptide cleavage from ribosome-associated nascent protein
eEF1A complexes with GTP
eEF1A:GTP:aminoacyl tRNA ternary complex formation.
Aminoacyl-tRNA binds to the ribosome at the A-site
Hydrolysis of eEF1A:GTP
Peptide transfer from P-site tRNA to the A-site tRNA
Translocation of ribosome by 3 bases in the 3' direction
GTP-binding activates eEF2
Regeneration of eEF1A:GTP by eEF1B activity
Formation of eEF1B complex
GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex
GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex
Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex
Translation
Eukaryotic Translation Initiation
Cap-dependent Translation Initiation
Formation of a pool of free 40S subunits
Formation of the ternary complex, and subsequently, the 43S complex
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Translation initiation complex formation
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit
Recycling of eIF2:GDP
Cap-independent Translation Initiation
SRP-dependent cotranslational protein targeting to membrane
Eukaryotic Translation Elongation
Peptide chain elongation
Eukaryotic Translation Termination
L13a-mediated translational silencing of Ceruloplasmin expression