CHAT
label: UniProt:P28329 CHAT

PEMPT
label: PEMT
label: PNMT
label: UniProt:Q9UBM1 PEMT

CTL1-5 can mediate the uptake of choline
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0015220
BFO_0000050: Synthesis of PC
directly activates: Cho is acetylated to AcCho by CHAT
directly activates: Cho is phosphorylated to PCho by CHK dimer
directly activates: Catalysis1652
directly activates: Catalysis2329
label: Cho transports from the extracellular space to the cytosol

Cho is acetylated to AcCho by CHAT
type: Restriction
  on property: enabled by
  some values from: CHAT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004102
BFO_0000050: Synthesis of PC
directly activates: BiochemicalReaction3698
directly activates: Catalysis1653
label: Synthesis of o-acetylcholine

AcCho is hydrolyzed to Cho and acetate by ACHE
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0003990
BFO_0000050: Synthesis of PC
directly activates: CTL1-5 can mediate the uptake of choline
directly activates: Catalysis694
label: Acetylcholine clearance from synaptic cleft

PA is dephosphorylated to DAG by LPIN
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0008195
BFO_0000050: Synthesis of PC
directly activates: BiochemicalReaction5030
directly activates: CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane
directly activates: Catalysis2316
directly activates: Catalysis2332

PE is methylated to PC by PEMT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: PEMPT
type: GO_0004608
BFO_0000050: Synthesis of PC

Cho is phosphorylated to PCho by CHK dimer
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004103
BFO_0000050: Synthesis of PC
directly activates: PCho is dephosphorylated to Cho by PHOSPHO1
directly activates: PCho and CTP are condensed to CDP-Cho by PCYT1 dimer
directly activates: Catalysis2330
directly activates: Catalysis2331

PCho is dephosphorylated to Cho by PHOSPHO1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0052731
BFO_0000050: Synthesis of PC
directly activates: Cho is acetylated to AcCho by CHAT
directly activates: Cho is phosphorylated to PCho by CHK dimer
directly activates: Catalysis1652
directly activates: Catalysis2329

PCho and CTP are condensed to CDP-Cho by PCYT1 dimer
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004105
BFO_0000050: Synthesis of PC
directly activates: CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane
directly activates: CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane
directly activates: Catalysis2332
directly activates: Catalysis2333

CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004142
BFO_0000050: Synthesis of PC
directly activates: BiochemicalReaction5018
directly activates: BiochemicalReaction5054
directly activates: BiochemicalReaction5055
directly activates: BiochemicalReaction5057
directly activates: BiochemicalReaction5058
directly activates: BiochemicalReaction5067
directly activates: BiochemicalReaction5083
directly activates: Catalysis2304
directly activates: Catalysis2334
directly activates: Catalysis2335
directly activates: Catalysis2337
directly activates: Catalysis2338
directly activates: Catalysis2347
directly activates: Catalysis2363

CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0004142
BFO_0000050: Synthesis of PC
directly activates: BiochemicalReaction5051

Synthesis of PC
type: GO_0008150