CDC2
CDC28A
CDK1
CDKN1
P34CDC2
UniProt:P06493 CDK1
PKCA
PRKACA
PRKCA
UniProt:P17252 PRKCA
p-RAF binds 14-3-3 beta/alpha
Transient dissociation of 14-3-3 upon Ras binding
Stabilisation of RAS:RAF by 14-3-3
Stabilisation of RAF by further phosphorylation
Phosphorylated human RAF1 binds to RAS:GTP complex
Activated RAF1 complex binds MEK
RAF1 phosphorylates MEK1
RAF1 phosphorylates MEK2
Processing of SCF isoform 1
Dimerization of sSCF
Interaction of KIT and sSCF
Dimerization of KIT upon SCF binding
Autophosphorylation of KIT
Direct recruitment of PI3K to p-KIT
Synthesis of PIP3 from PIP2 by PI3K
Phosphorylation and activation of VAV1
Activation of RAC1
Interaction of Src family kinases with p-KIT
Phosphorylation of p-KIT on Y900 by Src kinases
GRB2:SOS interacts with p-KIT
SHP2 interacts with p-KIT
Phosphorylation of SHP2 by SFKs
GRB2 is indirectly recruited to p-KIT through SHP2
Indirect recruitment of GAB2 to p-KIT
Phosphorylation of GAB2 by SFKs
Indirect recruitment of PI3K to KIT via p(Y)-GAB2
Activation of RAS by p-KIT bound SOS1
Interaction of other tyrosine kinases with p-KIT
Interaction of other adapter proteins with p-KIT
JAK2 binds to p-KIT
Phosphorylation of JAK2
Recruitment of STATs
Phosphorylation of STATs
Dimerization of STATs
Disassociation and translocation of STATs to the nucleus
PKC alpha interacts with and phosphorylates KIT
Interaction of SHP1 and KIT
SOCS1 as a regulator of KIT signaling
Interaction of APS and p-KIT
Phosphorylation of APS
Recruitment of CBL to KIT
Downregulation of c-Kit signaling by SOCS6
LNK binds to p-KIT and inhibit downstream signaling
PTP-RO interacts with p-c-Kit complex
PIP3 recruits PDPK1 to the membrane
PIP3 recruits AKT to the membrane
TORC2 (mTOR) phosphorylates AKT at S473
AKT binds PDPK1
PDPK1 phosphorylates AKT at T308
PI3K phosphorylates PIP2 to PIP3
AKT phosphorylates BAD
AKT phosphorylates GSK3
AKT phosphorylates caspase-9
AKT phosphorylates MDM2
AKT phosphorylates IKKalpha
AKT phosphorylates p21Cip1 and p27Kip1
AKT phosphorylates TSC2, inhibiting it
AKT phosphorylates AKT1S1 (PRAS40)
AKT translocates to the nucleus
AKT phosphorylates CREB1
AKT can phosphorylate forkhead box transcription factors
AKT can phosphorylate RSK
AKT can phosphorylate NR4A1 (NUR77)
PTEN dephosphorylates PIP3
THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
PHLPP dephosphorylates S473 in AKT
PDPK1 binds PIP2
MIR26A microRNAs bind PTEN mRNA
PTEN mRNA translation negatively regulated by microRNAs
Inactivation of MEK1 by p34cdc2
MEK1 binds ERK-1
MEK1 phosphorylates ERK-1
Dissociation of phospho-ERK-1:MEK1
Dimerisation of phospho-ERK-1
Nuclear translocation of phospho-ERK-1 dimer
MEK2 binds ERK-2
MEK2 phosphorylates ERK-2
Dissociation of phospho-ERK-2:MEK2
Dimerisation of phospho-ERK-2
Nuclear translocation of phospho-ERK-2 dimer
Signaling by SCF-KIT
Regulation of KIT signaling
PIP3 activates AKT signaling
AKT phosphorylates targets in the cytosol
AKT phosphorylates targets in the nucleus
Negative regulation of the PI3K/AKT network
ERK activation
ERK1 activation
ERK2 activation
RAF/MAP kinase cascade
RAF activation
MEK activation
RAF phosphorylates MEK