CDC2
label: CDC28A
label: CDK1
label: CDKN1
label: P34CDC2
label: UniProt:P06493 CDK1

PKCA
label: PRKACA
label: PRKCA
label: UniProt:P17252 PRKCA

p-RAF binds 14-3-3 beta/alpha
type: GO_0003674
BFO_0000050: RAF activation
directly activates: Transient dissociation of 14-3-3 upon Ras binding

Transient dissociation of 14-3-3 upon Ras binding
type: GO_0003674
BFO_0000050: RAF activation
directly activates: Stabilisation of RAS:RAF by 14-3-3

Stabilisation of RAS:RAF by 14-3-3
type: GO_0003674
BFO_0000050: RAF activation
directly activates: Stabilisation of RAF by further phosphorylation
directly activates: Catalysis447

Stabilisation of RAF by further phosphorylation
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: RAF activation
directly activates: Activated RAF1 complex binds MEK

Phosphorylated human RAF1 binds to RAS:GTP complex
type: GO_0003674
BFO_0000050: RAF activation
directly activates: RAF1 phosphorylates MEK1
directly activates: RAF1 phosphorylates MEK2
directly activates: Catalysis448
directly activates: Catalysis449

Activated RAF1 complex binds MEK
type: GO_0003674
BFO_0000050: MEK activation
directly activates: RAF1 phosphorylates MEK1
directly activates: RAF1 phosphorylates MEK2
directly activates: Catalysis448
directly activates: Catalysis449

RAF1 phosphorylates MEK1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0016301
BFO_0000050: RAF phosphorylates MEK
directly activates: MEK1 binds ERK-1

RAF1 phosphorylates MEK2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0016301
BFO_0000050: RAF phosphorylates MEK
directly activates: MEK2 binds ERK-2

Processing of SCF isoform 1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004175
BFO_0000050: Signaling by SCF-KIT
directly activates: Dimerization of sSCF

Dimerization of sSCF
type: GO_0003674
BFO_0000050: Signaling by SCF-KIT
directly activates: Interaction of KIT and sSCF

Interaction of KIT and sSCF
type: GO_0003674
BFO_0000050: Signaling by SCF-KIT
directly activates: Dimerization of KIT upon SCF binding

Dimerization of KIT upon SCF binding
type: GO_0003674
BFO_0000050: Signaling by SCF-KIT
directly activates: Autophosphorylation of KIT
directly activates: Catalysis1811
directly activates: Control312

Autophosphorylation of KIT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Signaling by SCF-KIT
directly activates: Direct recruitment of PI3K to p-KIT
directly activates: Interaction of Src family kinases with p-KIT
directly activates: GRB2:SOS interacts with p-KIT
directly activates: Interaction of other tyrosine kinases with p-KIT
directly activates: Interaction of other adapter proteins with p-KIT
directly activates: JAK2 binds to p-KIT

Direct recruitment of PI3K to p-KIT
type: GO_0003674
BFO_0000050: Signaling by SCF-KIT
directly activates: Synthesis of PIP3 from PIP2 by PI3K
directly activates: Catalysis1812

Synthesis of PIP3 from PIP2 by PI3K
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0035004
BFO_0000050: Signaling by SCF-KIT
directly activates: Phosphorylation and activation of VAV1
directly activates: Catalysis1813

Phosphorylation and activation of VAV1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Signaling by SCF-KIT
directly activates: Activation of RAC1
directly activates: Catalysis1814

Activation of RAC1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005085
BFO_0000050: Signaling by SCF-KIT

Interaction of Src family kinases with p-KIT
type: GO_0003674
BFO_0000050: Signaling by SCF-KIT
directly activates: Phosphorylation and activation of VAV1
directly activates: Phosphorylation of p-KIT on Y900 by Src kinases
directly activates: SHP2 interacts with p-KIT
directly activates: Catalysis1813

Phosphorylation of p-KIT on Y900 by Src kinases
type: GO_0003674
BFO_0000050: Signaling by SCF-KIT

GRB2:SOS interacts with p-KIT
type: GO_0003674
BFO_0000050: Signaling by SCF-KIT
directly activates: Activation of RAS by p-KIT bound SOS1
directly activates: Catalysis1817

SHP2 interacts with p-KIT
type: GO_0003674
BFO_0000050: Signaling by SCF-KIT
directly activates: Phosphorylation of SHP2 by SFKs
directly activates: Catalysis1815

Phosphorylation of SHP2 by SFKs
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Signaling by SCF-KIT

GRB2 is indirectly recruited to p-KIT through SHP2
type: GO_0003674
BFO_0000050: Signaling by SCF-KIT
directly activates: Indirect recruitment of GAB2 to p-KIT
directly activates: Activation of RAS by p-KIT bound SOS1
directly activates: Catalysis1817

Indirect recruitment of GAB2 to p-KIT
type: GO_0003674
BFO_0000050: Signaling by SCF-KIT
directly activates: Phosphorylation of GAB2 by SFKs
directly activates: Catalysis1816

Phosphorylation of GAB2 by SFKs
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Signaling by SCF-KIT
directly activates: Indirect recruitment of PI3K to KIT via p(Y)-GAB2

Indirect recruitment of PI3K to KIT via p(Y)-GAB2
type: GO_0003674
BFO_0000050: Signaling by SCF-KIT

Activation of RAS by p-KIT bound SOS1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005088
BFO_0000050: Signaling by SCF-KIT

Interaction of other tyrosine kinases with p-KIT
type: GO_0003674
BFO_0000050: Signaling by SCF-KIT

Interaction of other adapter proteins with p-KIT
type: GO_0003674
BFO_0000050: Signaling by SCF-KIT

JAK2 binds to p-KIT
type: GO_0003674
BFO_0000050: Signaling by SCF-KIT
directly activates: Phosphorylation of JAK2
directly activates: Catalysis1818

Phosphorylation of JAK2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Signaling by SCF-KIT
directly activates: Recruitment of STATs

Recruitment of STATs
type: GO_0003674
BFO_0000050: Signaling by SCF-KIT
directly activates: Phosphorylation of STATs
directly activates: Catalysis1819

Phosphorylation of STATs
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Signaling by SCF-KIT
directly activates: Dimerization of STATs

Dimerization of STATs
type: GO_0003674
BFO_0000050: Signaling by SCF-KIT
directly activates: Disassociation and translocation of STATs to the nucleus

Disassociation and translocation of STATs to the nucleus
type: GO_0003674
BFO_0000050: Signaling by SCF-KIT

PKC alpha interacts with and phosphorylates KIT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: PKCA
type: Restriction
  on property: enabled by
  some values from: PKCA
type: GO_0004674
BFO_0000050: Regulation of KIT signaling

Interaction of SHP1 and KIT
type: GO_0003674
BFO_0000050: Regulation of KIT signaling

SOCS1 as a regulator of KIT signaling
type: GO_0003674
BFO_0000050: Regulation of KIT signaling

Interaction of APS and p-KIT
type: GO_0003674
BFO_0000050: Regulation of KIT signaling
directly activates: Phosphorylation of APS
directly activates: Catalysis1821

Phosphorylation of APS
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Regulation of KIT signaling
directly activates: Recruitment of CBL to KIT

Recruitment of CBL to KIT
type: GO_0003674
BFO_0000050: Regulation of KIT signaling

Downregulation of c-Kit signaling by SOCS6
type: GO_0003674
BFO_0000050: Regulation of KIT signaling

LNK binds to p-KIT and inhibit downstream signaling
type: GO_0003674
BFO_0000050: Regulation of KIT signaling

PTP-RO interacts with p-c-Kit complex
type: GO_0003674
BFO_0000050: Signaling by SCF-KIT

PIP3 recruits PDPK1 to the membrane
type: GO_0003674
BFO_0000050: PIP3 activates AKT signaling

PIP3 recruits AKT to the membrane
type: GO_0003674
BFO_0000050: PIP3 activates AKT signaling

TORC2 (mTOR) phosphorylates AKT at S473
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: PIP3 activates AKT signaling
directly activates: BiochemicalReaction684
directly activates: AKT phosphorylates BAD
directly activates: AKT phosphorylates GSK3
directly activates: AKT phosphorylates caspase-9
directly activates: AKT phosphorylates MDM2
directly activates: AKT phosphorylates IKKalpha
directly activates: AKT phosphorylates p21Cip1 and p27Kip1
directly activates: AKT phosphorylates TSC2, inhibiting it
directly activates: AKT phosphorylates AKT1S1 (PRAS40)
directly activates: Catalysis252
directly activates: Catalysis282
directly activates: Catalysis283
directly activates: Catalysis284
directly activates: Catalysis285
directly activates: Catalysis286
directly activates: Catalysis287
directly activates: Catalysis288
directly activates: Catalysis289

AKT binds PDPK1
type: GO_0003674
BFO_0000050: PIP3 activates AKT signaling

PDPK1 phosphorylates AKT at T308
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004674
BFO_0000050: PIP3 activates AKT signaling
directly activates: AKT phosphorylates BAD
directly activates: AKT phosphorylates GSK3
directly activates: AKT phosphorylates caspase-9
directly activates: AKT phosphorylates MDM2
directly activates: AKT phosphorylates IKKalpha
directly activates: AKT phosphorylates p21Cip1 and p27Kip1
directly activates: AKT phosphorylates TSC2, inhibiting it
directly activates: AKT phosphorylates AKT1S1 (PRAS40)
directly activates: Catalysis282
directly activates: Catalysis283
directly activates: Catalysis284
directly activates: Catalysis285
directly activates: Catalysis286
directly activates: Catalysis287
directly activates: Catalysis288
directly activates: Catalysis289

PI3K phosphorylates PIP2 to PIP3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0046934
BFO_0000050: PIP3 activates AKT signaling

AKT phosphorylates BAD
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: AKT phosphorylates targets in the cytosol
directly activates: BiochemicalReaction6004

AKT phosphorylates GSK3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: AKT phosphorylates targets in the cytosol

AKT phosphorylates caspase-9
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: AKT phosphorylates targets in the cytosol

AKT phosphorylates MDM2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: AKT phosphorylates targets in the cytosol

AKT phosphorylates IKKalpha
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: AKT phosphorylates targets in the cytosol

AKT phosphorylates p21Cip1 and p27Kip1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: AKT phosphorylates targets in the cytosol

AKT phosphorylates TSC2, inhibiting it
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: AKT phosphorylates targets in the cytosol

AKT phosphorylates AKT1S1 (PRAS40)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: AKT phosphorylates targets in the cytosol

AKT translocates to the nucleus
type: GO_0003674
BFO_0000050: PIP3 activates AKT signaling
directly activates: AKT phosphorylates CREB1
directly activates: AKT can phosphorylate forkhead box transcription factors
directly activates: AKT can phosphorylate RSK
directly activates: AKT can phosphorylate NR4A1 (NUR77)
directly activates: Catalysis290
directly activates: Catalysis291
directly activates: Catalysis292
directly activates: Catalysis293

AKT phosphorylates CREB1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: AKT phosphorylates targets in the nucleus

AKT can phosphorylate forkhead box transcription factors
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: AKT phosphorylates targets in the nucleus

AKT can phosphorylate RSK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: AKT phosphorylates targets in the nucleus

AKT can phosphorylate NR4A1 (NUR77)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: AKT phosphorylates targets in the nucleus

PTEN dephosphorylates PIP3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016314
BFO_0000050: Negative regulation of the PI3K/AKT network
directly activates: BiochemicalReaction3944
directly activates: Catalysis1796

THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
type: GO_0003674
BFO_0000050: Negative regulation of the PI3K/AKT network

PHLPP dephosphorylates S473 in AKT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004722
BFO_0000050: Negative regulation of the PI3K/AKT network

PDPK1 binds PIP2
type: GO_0003674
BFO_0000050: PIP3 activates AKT signaling
directly activates: BiochemicalReaction3238

MIR26A microRNAs bind PTEN mRNA
type: GO_0003674
BFO_0000050: PIP3 activates AKT signaling

PTEN mRNA translation negatively regulated by microRNAs
type: GO_0003674
BFO_0000050: PIP3 activates AKT signaling

Inactivation of MEK1 by p34cdc2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: ERK1 activation

MEK1 binds ERK-1
type: GO_0003674
BFO_0000050: ERK1 activation
directly activates: MEK1 phosphorylates ERK-1
directly activates: Catalysis344
directly activates: Control57

MEK1 phosphorylates ERK-1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: ERK1 activation
directly activates: Dissociation of phospho-ERK-1:MEK1

Dissociation of phospho-ERK-1:MEK1
type: GO_0003674
BFO_0000050: ERK1 activation
directly activates: Dimerisation of phospho-ERK-1

Dimerisation of phospho-ERK-1
type: GO_0003674
BFO_0000050: ERK1 activation
directly activates: Nuclear translocation of phospho-ERK-1 dimer

Nuclear translocation of phospho-ERK-1 dimer
type: GO_0000189
BFO_0000050: ERK1 activation
directly activates: BiochemicalReaction905
directly activates: BiochemicalReaction906
directly activates: BiochemicalReaction908
directly activates: Catalysis346
directly activates: Catalysis347
directly activates: Catalysis349

MEK2 binds ERK-2
type: GO_0003674
BFO_0000050: ERK2 activation
directly activates: MEK2 phosphorylates ERK-2
directly activates: Catalysis345

MEK2 phosphorylates ERK-2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: ERK2 activation
directly activates: Dissociation of phospho-ERK-2:MEK2

Dissociation of phospho-ERK-2:MEK2
type: GO_0003674
BFO_0000050: ERK2 activation
directly activates: Dimerisation of phospho-ERK-2

Dimerisation of phospho-ERK-2
type: GO_0003674
BFO_0000050: ERK2 activation
directly activates: Nuclear translocation of phospho-ERK-2 dimer

Nuclear translocation of phospho-ERK-2 dimer
type: GO_0000189
BFO_0000050: ERK2 activation
directly activates: BiochemicalReaction905
directly activates: BiochemicalReaction906
directly activates: BiochemicalReaction908
directly activates: Catalysis346
directly activates: Catalysis347
directly activates: Catalysis349

Signaling by SCF-KIT
type: GO_0008150

Regulation of KIT signaling
type: GO_0008150
BFO_0000050: Signaling by SCF-KIT

PIP3 activates AKT signaling
type: GO_0008150
BFO_0000050: Signaling by SCF-KIT

AKT phosphorylates targets in the cytosol
type: GO_0008150
BFO_0000050: PIP3 activates AKT signaling

AKT phosphorylates targets in the nucleus
type: GO_0008150
BFO_0000050: PIP3 activates AKT signaling

Negative regulation of the PI3K/AKT network
type: GO_0008150
BFO_0000050: PIP3 activates AKT signaling

ERK activation
type: GO_0008150
BFO_0000050: RAF/MAP kinase cascade

ERK1 activation
type: GO_0008150
BFO_0000050: ERK activation

ERK2 activation
type: GO_0008150
BFO_0000050: ERK activation

RAF/MAP kinase cascade
type: GO_0008150
BFO_0000050: Signaling by SCF-KIT

RAF activation
type: GO_0008150
BFO_0000050: RAF/MAP kinase cascade

MEK activation
type: GO_0008150
BFO_0000050: RAF/MAP kinase cascade

RAF phosphorylates MEK
type: GO_0008150
BFO_0000050: MEK activation