Complex of NOTCH1 with its ligand is cleaved to produce NEXT1
NOTCH1 binds DLL1
NOTCH1 binds DLL4
NOTCH1 binds JAG1
NOTCH1 binds JAG2
Ubiquitination of DLL/JAG ligands upon binding to NOTCH1
NEXT1 is cleaved to produce NICD1
NICD1 traffics to nucleus
DTX binds NOTCH1
Contactin-1 (CNTN1) binds NOTCH1
Cleavage of CNTN1:NOTCH1 complex releases NICD1
NOTCH1 binds DNER
Cleavage of DNER:NOTCH1 complex releases NICD1
DTX recruits beta-arrestin (ARRB) to NOTCH
ARRB mediates NOTCH1 ubiquitination
ITCH binds DTX
ITCH ubiquitinates DTX
NOTCH1 binds DLL/JAG ligand in cis
NOTCH1 binds DLK1
NOTCH1 associates with negative regulators NUMB and ITCH
Ubiquitination of NOTCH1 by ITCH in the absence of ligand
NICD1 displaces co-repressor complex from RBPJ (CSL)
NICD1 in complex with RBPJ (CSL) recruits MAML
HES1 binds TLE
MAML in complex with NICD1 recruits CDK8
NICD1 is phosphorylated by CDK8
Phosphorylated NICD1 binds FBXW7
Ubiquitination of NICD1 by FBWX7
NICD1 binds HIF1A
Signaling by NOTCH1
Activated NOTCH1 Transmits Signal to the Nucleus
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH1 stimulates HES1 transcription
NOTCH1 stimulates MYC transcription
NOTCH1 stimulates HES5 transcription
NOTCH1 stimulates HEY transcription