DICER
label: DICER1
label: HERNA
label: KIAA0928
label: UniProt:Q9UPY3 DICER1

Microprocessor complex cleaves pri-miRNA to pre-miRNA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004525
BFO_0000050: MicroRNA (miRNA) Biogenesis
directly activates: Exportin-5 recognizes 3' overhang of pre-miRNA
directly activates: Catalysis198

Exportin-5 recognizes 3' overhang of pre-miRNA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003723
BFO_0000050: MicroRNA (miRNA) Biogenesis
directly activates: Exportin complex translocates pre-miRNA to cytosol
directly activates: Catalysis199

Exportin complex translocates pre-miRNA to cytosol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0051033
BFO_0000050: MicroRNA (miRNA) Biogenesis
directly activates: Dicer cleaves pre-miRNA to yield duplex miRNA
directly activates: Catalysis200

Dicer cleaves pre-miRNA to yield duplex miRNA
type: Restriction
  on property: enabled by
  some values from: DICER
type: Restriction
  on property: enabled by
  some values from: DICER
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004525
BFO_0000050: MicroRNA (miRNA) Biogenesis
directly activates: Duplex miRNA is loaded into Argonaute
directly activates: Binding of Exactly Matching Target RNAs by Nonendonucleolytic RISC

Duplex miRNA is loaded into Argonaute
type: GO_0003674
BFO_0000050: MicroRNA (miRNA) Biogenesis
directly activates: Removal of miRNA passenger strand

Removal of miRNA passenger strand
type: GO_0003674
BFO_0000050: MicroRNA (miRNA) Biogenesis
directly activates: Binding of Inexactly Matching Target RNAs by RISC.

Dicer cleaves double-stranded RNA to yield double-stranded siRNA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: DICER
type: Restriction
  on property: enabled by
  some values from: DICER
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004525
BFO_0000050: Small Interfering RNA (siRNA) Biogenesis
directly activates: Duplex siRNA is loaded into Argonaute
directly activates: Binding of Exactly Matching Target RNAs by Nonendonucleolytic RISC

Duplex siRNA is loaded into Argonaute
type: GO_0003674
BFO_0000050: Small Interfering RNA (siRNA) Biogenesis
directly activates: Cleavage-based removal of the siRNA passenger strand by AGO2
directly activates: Removal of siRNA passenger strand
directly activates: Catalysis202

Cleavage-based removal of the siRNA passenger strand by AGO2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004521
BFO_0000050: Small Interfering RNA (siRNA) Biogenesis
directly activates: Cleavage of Target RNAs by Endonucleolytic RISC
directly activates: Binding of Inexactly Matching Target RNAs by RISC.
directly activates: Catalysis203

Removal of siRNA passenger strand
type: GO_0003674
BFO_0000050: Small Interfering RNA (siRNA) Biogenesis

Cleavage of Target RNAs by Endonucleolytic RISC
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004521
BFO_0000050: Post-transcriptional Silencing By Small RNAs

Binding of Inexactly Matching Target RNAs by RISC.
type: GO_0003674
BFO_0000050: Post-transcriptional Silencing By Small RNAs

Binding of Exactly Matching Target RNAs by Nonendonucleolytic RISC
type: GO_0003674
BFO_0000050: Post-transcriptional Silencing By Small RNAs

Regulatory RNA pathways
type: GO_0008150

MicroRNA (miRNA) Biogenesis
type: GO_0008150
BFO_0000050: Regulatory RNA pathways

Small Interfering RNA (siRNA) Biogenesis
type: GO_0008150
BFO_0000050: Regulatory RNA pathways

Post-transcriptional Silencing By Small RNAs
type: GO_0008150
BFO_0000050: Regulatory RNA pathways

Pol II mediated transcription of microRNA genes
type: GO_0003674
BFO_0000050: MicroRNA (miRNA) Biogenesis
directly activates: Microprocessor complex cleaves pri-miRNA to pre-miRNA
directly activates: Catalysis197