PLK
PLK1
UniProt:P53350 PLK1
Inactivation of APC/C via CDC20 sequestration
Formation of the MCC complex
Binding of the MCC complex to the APC/C complex
Association of Securin with Cdc20:APC/C complex
Ubiquitination of Securin by phospho-APC/C:Cdc20 complex
Degradation of multiubiquitinated Securin
Association of Cyclin A:Cdk2 with Cdh1
Phosphorylation of Cdh1 by Cyclin A:Cdk2
Dissociation of phospho-Cdh1 from the APC/C complex
Association of Emi1 with Cdh1
Association of Emi1 with Cdc20
Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2
Phosphorylation of the Emi1 DSGxxS degron by Plk1
Phosphorylated Emi1 binds the beta-TrCP in the SCF complex
Ubiquitination of Emi1 by SCF-beta-TrCP
SCF-mediated degradation of Emi1
Phosphorylation of Cdh1 by Cyclin B1:Cdc2
Free APC/C phosphorylated by Plk1
Free APC/C phosphorylated by Cyclin B:Cdc2
Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1
Association of Cyclin B:Cdc2 with Cdc20:APC/C complex
Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex
Degradation of multiubiquitinated Cyclin B
Dephosphorylation of phospho-Cdh1
Dissociation of Cdc20 from APC/C complex
Association of Cdh1 with the APC/C
Association of cell cycle proteins with the APC/C:Cdh1 complex
Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex
Degradation of multiubiquitinated cell cycle proteins
APC/C:Cdh1-mediated degradation of Skp2
Multiubiquitination of APC/C-associated Cdh1
Degradation of multiubiquitinated Cdh1
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
Inactivation of APC/C via direct inhibition of the APC/C complex
Regulation of mitotic cell cycle
APC/C-mediated degradation of cell cycle proteins
Regulation of APC/C activators between G1/S and early anaphase
Phosphorylation of Emi1
SCF-beta-TrCP mediated degradation of Emi1
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC/C:Cdc20 mediated degradation of mitotic proteins
APC/C:Cdc20 mediated degradation of Cyclin B
APC/C:Cdc20 mediated degradation of Securin
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Autodegradation of Cdh1 by Cdh1:APC/C