PLK
label: PLK1
label: UniProt:P53350 PLK1

Inactivation of APC/C via CDC20 sequestration
type: GO_0003674
BFO_0000050: Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components

Formation of the MCC complex
type: GO_0003674
BFO_0000050: Inactivation of APC/C via direct inhibition of the APC/C complex
directly activates: Binding of the MCC complex to the APC/C complex

Binding of the MCC complex to the APC/C complex
type: GO_0003674
BFO_0000050: Inactivation of APC/C via direct inhibition of the APC/C complex
directly activates: Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1
directly activates: BiochemicalReaction2520
directly activates: BiochemicalReaction3794

Association of Securin with Cdc20:APC/C complex
type: GO_0003674
BFO_0000050: APC/C:Cdc20 mediated degradation of Securin
directly activates: Ubiquitination of Securin by phospho-APC/C:Cdc20 complex
directly activates: Catalysis895

Ubiquitination of Securin by phospho-APC/C:Cdc20 complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004842
type: GO_0042787
BFO_0000050: APC/C:Cdc20 mediated degradation of Securin
directly activates: Degradation of multiubiquitinated Securin
directly activates: Catalysis896

Degradation of multiubiquitinated Securin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004175
BFO_0000050: APC/C:Cdc20 mediated degradation of Securin
directly activates: BiochemicalReaction2003
directly activates: Dissociation of Cdc20 from APC/C complex
directly activates: Catalysis897

Association of Cyclin A:Cdk2 with Cdh1
type: GO_0003674
BFO_0000050: Regulation of APC/C activators between G1/S and early anaphase
directly activates: Phosphorylation of Cdh1 by Cyclin A:Cdk2
directly activates: Catalysis904

Phosphorylation of Cdh1 by Cyclin A:Cdk2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004693
type: GO_0051436
BFO_0000050: Regulation of APC/C activators between G1/S and early anaphase
directly activates: Dissociation of phospho-Cdh1 from the APC/C complex
directly activates: Dephosphorylation of phospho-Cdh1
directly activates: Catalysis913

Dissociation of phospho-Cdh1 from the APC/C complex
type: GO_0051436
BFO_0000050: Regulation of APC/C activators between G1/S and early anaphase

Association of Emi1 with Cdh1
type: GO_0051436
BFO_0000050: Regulation of APC/C activators between G1/S and early anaphase
directly activates: Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2
directly activates: Phosphorylation of the Emi1 DSGxxS degron by Plk1
directly activates: Catalysis905
directly activates: Catalysis906
directly activates: Phosphorylation of Emi1

Association of Emi1 with Cdc20
type: GO_0051436
BFO_0000050: Regulation of APC/C activators between G1/S and early anaphase
directly activates: Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2
directly activates: Phosphorylation of the Emi1 DSGxxS degron by Plk1
directly activates: Catalysis905
directly activates: Catalysis906
directly activates: Phosphorylation of Emi1

Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004693
BFO_0000050: Phosphorylation of Emi1
directly activates: Phosphorylated Emi1 binds the beta-TrCP in the SCF complex

Phosphorylation of the Emi1 DSGxxS degron by Plk1
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: Phosphorylation of Emi1
directly activates: Phosphorylated Emi1 binds the beta-TrCP in the SCF complex

Phosphorylated Emi1 binds the beta-TrCP in the SCF complex
type: GO_0003674
BFO_0000050: SCF-beta-TrCP mediated degradation of Emi1
directly activates: Ubiquitination of Emi1 by SCF-beta-TrCP
directly activates: Catalysis907

Ubiquitination of Emi1 by SCF-beta-TrCP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004842
BFO_0000050: SCF-beta-TrCP mediated degradation of Emi1
directly activates: SCF-mediated degradation of Emi1
directly activates: Catalysis908

SCF-mediated degradation of Emi1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004175
BFO_0000050: SCF-beta-TrCP mediated degradation of Emi1
directly activates: Phosphorylation of Cdh1 by Cyclin B1:Cdc2
directly activates: Catalysis909

Phosphorylation of Cdh1 by Cyclin B1:Cdc2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004693
type: GO_0051436
BFO_0000050: Regulation of APC/C activators between G1/S and early anaphase
directly activates: Dephosphorylation of phospho-Cdh1
directly activates: Catalysis913

Free APC/C phosphorylated by Plk1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: Phosphorylation of the APC/C

Free APC/C phosphorylated by Cyclin B:Cdc2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004693
BFO_0000050: Phosphorylation of the APC/C

Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1
type: GO_0051437
BFO_0000050: APC/C:Cdc20 mediated degradation of mitotic proteins
directly activates: Association of Securin with Cdc20:APC/C complex
directly activates: Association of Cyclin B:Cdc2 with Cdc20:APC/C complex

Association of Cyclin B:Cdc2 with Cdc20:APC/C complex
type: GO_0003674
BFO_0000050: APC/C:Cdc20 mediated degradation of Cyclin B
directly activates: Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex
directly activates: Catalysis912

Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004842
type: GO_0042787
BFO_0000050: APC/C:Cdc20 mediated degradation of Cyclin B
directly activates: Degradation of multiubiquitinated Cyclin B

Degradation of multiubiquitinated Cyclin B
type: GO_0003674
BFO_0000050: APC/C:Cdc20 mediated degradation of Cyclin B
directly activates: Dissociation of Cdc20 from APC/C complex

Dephosphorylation of phospho-Cdh1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004721
BFO_0000050: Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
directly activates: Association of Cdh1 with the APC/C

Dissociation of Cdc20 from APC/C complex
type: GO_0003674
BFO_0000050: Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
directly activates: Association of Cdh1 with the APC/C

Association of Cdh1 with the APC/C
type: GO_0003674
BFO_0000050: Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
directly activates: Association of cell cycle proteins with the APC/C:Cdh1 complex

Association of cell cycle proteins with the APC/C:Cdh1 complex
type: GO_0003674
BFO_0000050: APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
directly activates: Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex
directly activates: Catalysis914

Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004842
type: GO_0042787
BFO_0000050: APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
directly activates: Degradation of multiubiquitinated cell cycle proteins
directly activates: Multiubiquitination of APC/C-associated Cdh1
directly activates: Catalysis915
directly activates: Catalysis917

Degradation of multiubiquitinated cell cycle proteins
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004175
BFO_0000050: APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1

APC/C:Cdh1-mediated degradation of Skp2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004175
BFO_0000050: APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1

Multiubiquitination of APC/C-associated Cdh1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004842
type: GO_0042787
BFO_0000050: Autodegradation of Cdh1 by Cdh1:APC/C
directly activates: Degradation of multiubiquitinated Cdh1
directly activates: Catalysis918

Degradation of multiubiquitinated Cdh1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004175
BFO_0000050: Autodegradation of Cdh1 by Cdh1:APC/C

Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
type: GO_0008150
BFO_0000050: Regulation of APC/C activators between G1/S and early anaphase

Inactivation of APC/C via direct inhibition of the APC/C complex
type: GO_0008150
BFO_0000050: Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components

Regulation of mitotic cell cycle
type: GO_0008150

APC/C-mediated degradation of cell cycle proteins
type: GO_0008150
BFO_0000050: Regulation of mitotic cell cycle

Regulation of APC/C activators between G1/S and early anaphase
type: GO_0008150
BFO_0000050: APC/C-mediated degradation of cell cycle proteins

Phosphorylation of Emi1
type: GO_0008150
BFO_0000050: Regulation of APC/C activators between G1/S and early anaphase

SCF-beta-TrCP mediated degradation of Emi1
type: GO_0008150
BFO_0000050: Regulation of APC/C activators between G1/S and early anaphase

Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
type: GO_0008150
BFO_0000050: APC/C-mediated degradation of cell cycle proteins

Phosphorylation of the APC/C
type: GO_0008150
BFO_0000050: Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins

APC/C:Cdc20 mediated degradation of mitotic proteins
type: GO_0008150
BFO_0000050: Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins

APC/C:Cdc20 mediated degradation of Cyclin B
type: GO_0008150
BFO_0000050: APC/C:Cdc20 mediated degradation of mitotic proteins

APC/C:Cdc20 mediated degradation of Securin
type: GO_0008150
BFO_0000050: APC/C:Cdc20 mediated degradation of mitotic proteins

Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
type: GO_0008150
BFO_0000050: APC/C-mediated degradation of cell cycle proteins

APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
type: GO_0008150
BFO_0000050: APC/C-mediated degradation of cell cycle proteins

Autodegradation of Cdh1 by Cdh1:APC/C
type: GO_0008150
BFO_0000050: APC/C-mediated degradation of cell cycle proteins