AKT phosphorylates FOXO1A
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: AKT-mediated inactivation of FOXO1A
directly activates: Phosphorylated FOXO1A is excluded from the nucleus

Phosphorylated FOXO1A is excluded from the nucleus
type: GO_0003674
BFO_0000050: AKT-mediated inactivation of FOXO1A

Regulation of beta-cell development
type: GO_0008150

Regulation of gene expression in early pancreatic precursor cells
type: GO_0008150
BFO_0000050: Regulation of beta-cell development

Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
type: GO_0008150
BFO_0000050: Regulation of beta-cell development

Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells
type: GO_0008150
BFO_0000050: Regulation of beta-cell development

Regulation of gene expression in beta cells
type: GO_0008150
BFO_0000050: Regulation of beta-cell development

AKT-mediated inactivation of FOXO1A
type: GO_0008150
BFO_0000050: Regulation of gene expression in beta cells

HNF1B-dependent synthesis of HNF6 protein
type: GO_0003674
BFO_0000050: Regulation of gene expression in early pancreatic precursor cells
directly activates: HNF6-dependent synthesis of ONECUT3 protein during early pancreas specification
directly activates: HNF6- and FGF10-dependent synthesis of PDX1 protein
directly activates: HNF6-dependent synthesis of HNF1B protein
directly activates: HNF6-dependent synthesis of ONECUT3 protein during morphogenesis
directly activates: HNF6-dependent synthesis of NEUROG3 protein during morphogenesis
directly activates: TemplateReactionRegulation180
directly activates: TemplateReactionRegulation181
directly activates: TemplateReactionRegulation182
directly activates: TemplateReactionRegulation185
directly activates: TemplateReactionRegulation186
directly activates: TemplateReactionRegulation187
directly activates: TemplateReactionRegulation188

HNF1B- and FGF10-dependent synthesis of PTF1A protein
type: GO_0003674
BFO_0000050: Regulation of gene expression in early pancreatic precursor cells

HNF6-dependent synthesis of ONECUT3 protein during early pancreas specification
type: GO_0003674
BFO_0000050: Regulation of gene expression in early pancreatic precursor cells

HNF6- and FGF10-dependent synthesis of PDX1 protein
type: GO_0003674
BFO_0000050: Regulation of gene expression in early pancreatic precursor cells
directly activates: PDX1-dependent synthesis of NR5A2 protein
directly activates: PDX1-dependent synthesis of NKX6-1 protein
directly activates: TemplateReactionRegulation183
directly activates: TemplateReactionRegulation184

PDX1-dependent synthesis of NR5A2 protein
type: GO_0003674
BFO_0000050: Regulation of gene expression in early pancreatic precursor cells

PDX1-dependent synthesis of NKX6-1 protein
type: GO_0003674
BFO_0000050: Regulation of gene expression in early pancreatic precursor cells

HNF6-dependent synthesis of HNF1B protein
type: GO_0003674
BFO_0000050: Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells

HNF6-dependent synthesis of ONECUT3 protein during morphogenesis
type: GO_0003674
BFO_0000050: Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells

HNF6-dependent synthesis of NEUROG3 protein during morphogenesis
type: GO_0003674
BFO_0000050: Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
directly activates: NEUROG3-dependent synthesis of PAX4 protein
directly activates: NEUROG3-dependent synthesis of NEUROD1
directly activates: NEUROG3-dependent synthesis of NKX2-2
directly activates: NEUROG3-dependent synthesis of INSM1
directly activates: TemplateReactionRegulation191
directly activates: TemplateReactionRegulation192
directly activates: TemplateReactionRegulation193
directly activates: TemplateReactionRegulation194

RBPJ- and NOTCH1-dependent synthesis of HES1 protein during morphogenesis
type: GO_0003674
BFO_0000050: Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells

NEUROG3-dependent synthesis of PAX4 protein
type: GO_0003674
BFO_0000050: Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells

NEUROG3-dependent synthesis of NEUROD1
type: GO_0003674
BFO_0000050: Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells

NEUROG3-dependent synthesis of NKX2-2
type: GO_0003674
BFO_0000050: Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells

NEUROG3-dependent synthesis of INSM1
type: GO_0003674
BFO_0000050: Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells

FOXOA2-, MAFA-, and PAX6-dependent synthesis of PDX1 protein
type: GO_0003674
BFO_0000050: Regulation of gene expression in beta cells
directly activates: MAFA-, NKX2-2-, PAX6-, and PDX1-dependent synthesis of insulin precursor protein
directly activates: PDX1-dependent synthesis of IAPP protein
directly activates: PDX1-dependent synthesis of NKX6-1 protein
directly activates: NEUROD1- and PDX1-dependent synthesis of glucokinase (GCK) protein
directly activates: TemplateReactionRegulation199
directly activates: TemplateReactionRegulation200
directly activates: TemplateReactionRegulation201
directly activates: TemplateReactionRegulation202
directly activates: TemplateReactionRegulation203
directly activates: TemplateReactionRegulation204
directly activates: TemplateReactionRegulation205
directly activates: TemplateReactionRegulation206

MAFA-, NKX2-2-, PAX6-, and PDX1-dependent synthesis of insulin precursor protein
type: GO_0003674
BFO_0000050: Regulation of gene expression in beta cells
directly activates: BiochemicalReaction3599
directly activates: Catalysis1573

PDX1-dependent synthesis of IAPP protein
type: GO_0003674
BFO_0000050: Regulation of gene expression in beta cells

PDX1-dependent synthesis of NKX6-1 protein
type: GO_0003674
BFO_0000050: Regulation of gene expression in beta cells

NEUROD1- and PDX1-dependent synthesis of glucokinase (GCK) protein
type: GO_0003674
BFO_0000050: Regulation of gene expression in beta cells
directly activates: BiochemicalReaction1659
directly activates: Catalysis645

HNF1A-dependent synthesis of GLUT2 protein
type: GO_0003674
BFO_0000050: Regulation of gene expression in beta cells

HNF1A-dependent synthesis of the L isoform of PKLR protein
type: GO_0003674
BFO_0000050: Regulation of gene expression in beta cells

HNF1A-dependent synthesis of HNF4A
type: GO_0003674
BFO_0000050: Regulation of gene expression in beta cells

HNF1A-dependent synthesis of HNF4G protein
type: GO_0003674
BFO_0000050: Regulation of gene expression in beta cells

HNF1A-dependent synthesis of FOXA3
type: GO_0003674
BFO_0000050: Regulation of gene expression in beta cells