FUR
label: FURIN
label: PACE
label: PCSK3
label: UniProt:P09958 FURIN

Transport of NOTCH precursor to Golgi
type: GO_0003674
BFO_0000050: Pre-NOTCH Processing in Golgi
directly activates: NOTCH precursor cleaved to form mature NOTCH
directly activates: Glycosylation of Pre-NOTCH by FRINGE
directly activates: Catalysis1871
directly activates: Catalysis1872

NOTCH precursor cleaved to form mature NOTCH
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: FUR
type: GO_0004252
BFO_0000050: Pre-NOTCH Processing in Golgi
directly activates: Mature NOTCH heterodimer traffics to the plasma membrane
directly activates: Control332

Glycosylation of Pre-NOTCH by FRINGE
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0033829
BFO_0000050: Pre-NOTCH Processing in Golgi
directly activates: Galactosylation of Pre-NOTCH
directly activates: Catalysis1873

Galactosylation of Pre-NOTCH
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0003831
BFO_0000050: Pre-NOTCH Processing in Golgi
directly activates: Sialylation of Pre-NOTCH
directly activates: Catalysis1874

Sialylation of Pre-NOTCH
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0003836
BFO_0000050: Pre-NOTCH Processing in Golgi
directly activates: Fringe-modified Pre-NOTCH is cleaved by FURIN
directly activates: Catalysis1875

Fringe-modified Pre-NOTCH is cleaved by FURIN
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: FUR
type: GO_0004252
BFO_0000050: Pre-NOTCH Processing in Golgi
directly activates: Transport of fringe-modified NOTCH to plasma membrane
directly activates: Control333

Mature NOTCH heterodimer traffics to the plasma membrane
type: GO_0003674
BFO_0000050: Pre-NOTCH Processing in Golgi
directly activates: BiochemicalReaction3260
directly activates: BiochemicalReaction3261
directly activates: BiochemicalReaction3262
directly activates: BiochemicalReaction3263
directly activates: BiochemicalReaction3267
directly activates: BiochemicalReaction3276
directly activates: BiochemicalReaction3277
directly activates: BiochemicalReaction3278
directly activates: BiochemicalReaction4171
directly activates: BiochemicalReaction4172
directly activates: BiochemicalReaction4173
directly activates: BiochemicalReaction4174
directly activates: BiochemicalReaction4176
directly activates: BiochemicalReaction4178

Transport of fringe-modified NOTCH to plasma membrane
type: GO_0003674
BFO_0000050: Pre-NOTCH Processing in Golgi
directly activates: BiochemicalReaction3260
directly activates: BiochemicalReaction3261
directly activates: BiochemicalReaction3278
directly activates: BiochemicalReaction4171
directly activates: BiochemicalReaction4172

Pre-NOTCH Processing in Golgi
type: GO_0008150