RPS6KB1
label: STK14A
label: UniProt:P23443 RPS6KB1

PPM1A
label: PPPM1A
label: UniProt:P35813 PPM1A

PDE3B
label: UniProt:Q13370 PDE3B

Phosphorylation of PDE3B
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0016301
BFO_0000050: PDE3B signalling
directly activates: Hydrolysis of cAMP to 5' AMP by Phosphorylated PDE3B
directly activates: Catalysis1087

Hydrolysis of cAMP to 5' AMP by Phosphorylated PDE3B
type: Restriction
  on property: enabled by
  some values from: PDE3B
type: Restriction
  on property: enabled by
  some values from: PDE3B
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004114
BFO_0000050: PDE3B signalling

Phosphorylation of TSC2 by PKB
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0016301
BFO_0000050: Inhibition of TSC complex formation by PKB

Phosphorylation of complexed TSC2 by PKB
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0016301
BFO_0000050: Inhibition of TSC complex formation by PKB

GTP loading by Rheb
type: GO_0003674
BFO_0000050: mTOR signalling
directly activates: Formation of active mTORC1 complex
directly activates: TSC2 activates intrinsic GTPase activity of Rheb
directly activates: Catalysis1753

Formation of active mTORC1 complex
type: GO_0003674
BFO_0000050: mTOR signalling
directly activates: Activation of S6K1
directly activates: Phosphorylation of 4E-BP1 by activated mTORC1
directly activates: Catalysis1743
directly activates: Catalysis1748
directly activates: Control308

Activation of S6K1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016301
BFO_0000050: S6K1-mediated signalling
directly activates: Phosphorylation of Ribosomal protein S6 by activated S6K1
directly activates: Phosphorylation and activation of eIF4G by activated S6K1
directly activates: Phosphorylation and activation of eIF4B by activated S6K1
directly activates: Catalysis1744
directly activates: Catalysis1746
directly activates: Catalysis1747

Phosphorylation of Ribosomal protein S6 by activated S6K1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016301
BFO_0000050: S6K1 signalling

Phosphorylation and inactivation of eEF2K by activated S6K1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016301
BFO_0000050: S6K1 signalling

Phosphorylation and activation of eIF4G by activated S6K1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016301
BFO_0000050: S6K1 signalling

Phosphorylation and activation of eIF4B by activated S6K1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: enabled by
  some values from: RPS6KB1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016301
BFO_0000050: S6K1 signalling

Phosphorylation of 4E-BP1 by activated mTORC1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016301
BFO_0000050: Release of eIF4E
directly activates: mTOR signalling

Dissociation of phosphorylated 4EBP1 from eIF4E
type: GO_0003674
BFO_0000050: Release of eIF4E

LKB1 forms a trimeric complex with STRAD and MO25
type: GO_0003674
BFO_0000050: Regulation of AMPK activity via LKB1
directly activates: Activation of cytosolic AMPK by phosphorylation
directly activates: Catalysis1749
directly activates: Control309
directly activates: Control310

Activation of cytosolic AMPK by phosphorylation
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Regulation of AMPK activity via LKB1
directly activates: AMPK is dephosphorylated
directly activates: Phosphorylated AMPK binds AMP
directly activates: BiochemicalReaction4768
directly activates: Catalysis1750
directly activates: Catalysis2124

AMPK is dephosphorylated
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: PPM1A
type: Restriction
  on property: enabled by
  some values from: PPM1A
type: Restriction
  on property: enabled by
  some values from: PPM1A
type: Restriction
  on property: enabled by
  some values from: PPM1A
type: Restriction
  on property: enabled by
  some values from: PPM1A
type: Restriction
  on property: enabled by
  some values from: PPM1A
type: Restriction
  on property: enabled by
  some values from: PPM1A
type: Restriction
  on property: enabled by
  some values from: PPM1A
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004722
BFO_0000050: Regulation of AMPK activity via LKB1

Phosphorylated AMPK binds AMP
type: GO_0003674
BFO_0000050: Regulation of AMPK activity via LKB1
directly activates: AMPK phosphorylates Raptor
directly activates: p-AMPK phosphorylates TSC2
directly activates: BiochemicalReaction4768
directly activates: BiochemicalReaction5359
directly activates: Catalysis1751
directly activates: Catalysis1752
directly activates: Catalysis2124
directly activates: Catalysis2580
directly activates: Control435
directly activates: Control436

AMPK phosphorylates Raptor
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004679
BFO_0000050: Regulation of AMPK activity via LKB1

p-AMPK phosphorylates TSC2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004679
BFO_0000050: Regulation of Rheb GTPase activity by AMPK
directly activates: TSC2 activates intrinsic GTPase activity of Rheb
directly activates: Catalysis1753

TSC2 activates intrinsic GTPase activity of Rheb
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0005096
BFO_0000050: Regulation of Rheb GTPase activity by AMPK
directly activates: GTP loading by Rheb
directly activates: Control307

PKB-mediated events
type: GO_0008150

PDE3B signalling
type: GO_0008150
BFO_0000050: PKB-mediated events

mTOR signalling
type: GO_0008150
BFO_0000050: PKB-mediated events

Inhibition of TSC complex formation by PKB
type: GO_0008150
BFO_0000050: mTOR signalling

mTORC1-mediated signalling
type: GO_0008150
BFO_0000050: mTOR signalling

S6K1-mediated signalling
type: GO_0008150
BFO_0000050: mTORC1-mediated signalling

S6K1 signalling
type: GO_0008150
BFO_0000050: S6K1-mediated signalling

Release of eIF4E
type: GO_0008150
BFO_0000050: mTORC1-mediated signalling

Energy dependent regulation of mTOR by LKB1-AMPK
type: GO_0008150
BFO_0000050: mTOR signalling

Regulation of AMPK activity via LKB1
type: GO_0008150
BFO_0000050: Energy dependent regulation of mTOR by LKB1-AMPK

Regulation of Rheb GTPase activity by AMPK
type: GO_0008150
BFO_0000050: Energy dependent regulation of mTOR by LKB1-AMPK