ELOVL7
label: UniProt:A1L3X0 ELOVL7

LPP1
label: PPAP2A
label: UniProt:O14494 PPAP2A

ACOT8
label: ACTEIII
label: PTE1
label: PTE2
label: UniProt:O14734 ACOT8

ACSVL1
label: FACVL1
label: FATP2
label: SLC27A2
label: UniProt:O14975 SLC27A2
label: VLACS

DEGS1
label: DES1
label: MIG15
label: MLD
label: UniProt:O15121 DEGS1

DAPAT
label: DHAPAT
label: GNPAT
label: UniProt:O15228 GNPAT

ABCC3
label: CMOAT2
label: MLP2
label: MRP3
label: UniProt:O15438 ABCC3

CYP1ALPHA
label: CYP27B
label: CYP27B1
label: UniProt:O15528 CYP27B1

MBTPS2
label: S2P
label: UniProt:O43462 MBTPS2

CAC
label: CACT
label: SLC25A20
label: UniProt:O43772 SLC25A20

PMP34
label: SLC25A17
label: UniProt:O43808 SLC25A17

FADS1
label: FADSD5
label: UniProt:O60427 FADS1

PLA2G6
label: PLPLA9
label: UniProt:O60733 PLA2G6

SC5D
label: SC5DL
label: UniProt:O75845 SC5D

ANG1
label: TM7SF2
label: UniProt:O76062 TM7SF2

ABCB11
label: BSEP
label: UniProt:O95342 ABCB11

KIAA1252
label: SGPL1
label: UniProt:O95470 SGPL1

CDS2
label: UniProt:O95674 CDS2

MLYCD
label: UniProt:O95822 MLYCD

FADS2
label: UniProt:O95864 FADS2

LCAT
label: UniProt:P04180 LCAT

CYP17
label: CYP17A1
label: S17AH
label: UniProt:P05093 CYP17A1

CYP11A
label: CYP11A1
label: UniProt:P05108 CYP11A1

CYP21
label: CYP21A2
label: CYP21B
label: UniProt:P08686 CYP21A2

ACAA
label: ACAA1
label: PTHIO
label: UniProt:P09110 ACAA1

ARO1
label: CYAR
label: CYP19
label: CYP19A1
label: UniProt:P11511 CYP19A1

AKR1B1
label: ALDR1
label: UniProt:P15121 AKR1B1

CBR
label: CBR1
label: CRN
label: UniProt:P16152 CBR1

ASM
label: SMPD1
label: UniProt:P17405 SMPD1

GM2A
label: UniProt:P17900 GM2A

CYP11B2
label: UniProt:P19099 CYP11B2

SCP2
label: UniProt:P22307 SCP2

SCP2
label: UniProt:P22307-1 SCP2

CPT1
label: CPT2
label: UniProt:P23786 CPT2

CYP5
label: CYP5A1
label: TBXAS1
label: UniProt:P24557 TBXAS1

CHAT
label: UniProt:P28329 CHAT

GK
label: UniProt:P32189 GK

ACSL1
label: FACL1
label: FACL2
label: LACS
label: LACS1
label: LACS2
label: UniProt:P33121 ACSL1

ABCC1
label: MRP
label: MRP1
label: UniProt:P33527 ABCC1

ABCD1
label: ALD
label: UniProt:P33897 ABCD1

EDH17B3
label: HSD17B3
label: UniProt:P37058 HSD17B3

PDS
label: PTGDS
label: UniProt:P41222 PTGDS

AKR1C3
label: DDH1
label: HSD17B5
label: KIAA0119
label: PGFS
label: UniProt:P42330 AKR1C3

CAT1
label: CRAT
label: UniProt:P43155 CRAT

GPD2
label: UniProt:P43304 GPD2

OATP
label: OATP1
label: OATP1A2
label: SLC21A3
label: SLCO1A2
label: UniProt:P46721 SLCO1A2

LSS
label: OSC
label: UniProt:P48449 LSS

KIAA0024
label: PSSA
label: PTDSS1
label: UniProt:P48651 PTDSS1

MAPKAPK2
label: UniProt:P49137 MAPKAPK2

AKR1D1
label: SRD5B1
label: UniProt:P51857 AKR1D1

SLC20A3
label: SLC25A1
label: UniProt:P53007 SLC25A1

PLRP2
label: PNLIPRP2
label: UniProt:P54317 PNLIPRP2

GALC
label: UniProt:P54803 GALC

HMGCS2
label: UniProt:P54868 HMGCS2

HSD17B7
label: UNQ2563/PRO6243
label: UniProt:P56937 HSD17B7

CK1G2
label: CSNK1G2
label: UniProt:P78368 CSNK1G2

LRP2
label: UniProt:P98164 LRP2

HMGCS
label: HMGCS1
label: UniProt:Q01581 HMGCS1

CYP27
label: CYP27A1
label: UniProt:Q02318 CYP27A1

FVT1
label: KDSR
label: UniProt:Q06136 KDSR

CYP24
label: CYP24A1
label: UniProt:Q07973 CYP24A1

ASBT
label: ISBT
label: NTCP2
label: SLC10A2
label: UniProt:Q12908 SLC10A2

ACAC
label: ACACA
label: ACC1
label: ACCA
label: UniProt:Q13085 ACACA

BAAT
label: UniProt:Q14032 BAAT

KIAA0091
label: MBTPS1
label: S1P
label: SKI1
label: UniProt:Q14703 MBTPS1

LBR
label: UniProt:Q14739 LBR

LTB4DH
label: PTGR1
label: UniProt:Q14914 PTGR1

GIG29
label: NTCP
label: SLC10A1
label: UniProt:Q14973 SLC10A1

EBP
label: UniProt:Q15125 EBP

PMKI
label: PMVK
label: UniProt:Q15126 PMVK

PKD
label: PKD1
label: PRKCM
label: PRKD1
label: UniProt:Q15139 PRKD1

P23
label: PTGES3
label: TEBP
label: UniProt:Q15185 PTGES3

DHCR24
label: KIAA0018
label: UniProt:Q15392 DHCR24

H105E3
label: NSDHL
label: UniProt:Q15738 NSDHL

DESP4
label: ERG25
label: MSMO1
label: SC4MOL
label: UniProt:Q15800 MSMO1

EFE2
label: G4.5
label: TAZ
label: UniProt:Q16635 TAZ

UGCG
label: UniProt:Q16739 UGCG

CYP51
label: CYP51A1
label: UniProt:Q16850 CYP51A1

PGS1
label: UniProt:Q32NB8 PGS1

HSD17B12
label: UniProt:Q53GQ0 HSD17B12

COQ5
label: UniProt:Q5HYK3 COQ5

ACER2
label: ASAH3L
label: PP11646
label: UniProt:Q5QJU3 ACER2

PLB
label: PLB1
label: UniProt:Q6P1J6 PLB1

C14orf66
label: DEGS2
label: UniProt:Q6QHC5 DEGS2

AGPAT8
label: ALCAT1
label: LCLAT1
label: LYCAT
label: UNQ1849/PRO3579
label: UniProt:Q6UWP7 LCLAT1

ENPP7
label: UNQ3077/PRO9912
label: UniProt:Q6UWV6 ENPP7

CYP2R1
label: UniProt:Q6VVX0 CYP2R1

TPIP
label: TPTE2
label: UniProt:Q6XPS3 TPTE2

AGPAT6
label: GPAT4
label: UNQ551/PRO1108
label: UniProt:Q86UL3 AGPAT6

MOB
label: SGMS1
label: SMS1
label: TMEM23
label: UniProt:Q86VZ5 SGMS1

FGE
label: PSEC0152
label: SUMF1
label: UNQ3037/PRO9852
label: UniProt:Q8NBK3 SUMF1

SGMS2
label: SMS2
label: UniProt:Q8NHU3 SGMS2

C1orf93
label: FAM213B
label: UniProt:Q8TBF2 FAM213B

CERK
label: KIAA1646
label: UniProt:Q8TCT0 CERK

ACER1
label: ASAH3
label: UniProt:Q8TDN7 ACER1

MOSP
label: PLIP
label: PNAS-129
label: PTPMT1
label: UniProt:Q8WUK0 PTPMT1

FAR1
label: MLSTD2
label: UNQ2423/PRO4981
label: UniProt:Q8WVX9 FAR1

CL640
label: COQ2
label: UniProt:Q96H96 COQ2

FAR2
label: MLSTD1
label: UniProt:Q96K12 FAR2

BB1
label: LENG4
label: MBOAT7
label: OACT7
label: UniProt:Q96N66 MBOAT7

DGAT2
label: HMFN1045
label: UNQ738/PRO1433
label: UniProt:Q96PD7 DGAT2

MCEE
label: UniProt:Q96PE7 MCEE

LGMN
label: PRSC1
label: UniProt:Q99538 LGMN

MGLL
label: UniProt:Q99685 MGLL

CST
label: GAL3ST1
label: UniProt:Q99999 GAL3ST1

PSS2
label: PTDSS2
label: UniProt:Q9BVG9 PTDSS2

CGI-88
label: ELOVL1
label: SSC1
label: UniProt:Q9BW60 ELOVL1

ELOVL4
label: UniProt:Q9GZR5 ELOVL4

CBG
label: CBGL1
label: GBA3
label: UniProt:Q9H227 GBA3

HSD3B7
label: UniProt:Q9H2F3 HSD3B7

ELOVL6
label: FACE
label: LCE
label: UniProt:Q9H5J4 ELOVL6

CIG30
label: ELOVL3
label: UniProt:Q9HB03 ELOVL3

AD035
label: GBA2
label: KIAA1605
label: UniProt:Q9HCG7 GBA2

GDE5
label: GPCPD1
label: KIAA1434
label: UniProt:Q9NPB8 GPCPD1

LST2
label: OATP1B3
label: OATP8,SLC21A8
label: SLCO1B3
label: UniProt:Q9NPD5 SLCO1B3

ASAH2
label: HNAC1
label: UniProt:Q9NR71 ASAH2

KIAA0851
label: SACM1L
label: UniProt:Q9NTJ5 SACM1L

ACER3
label: APHC
label: PHCA
label: UniProt:Q9NUN7 ACER3

AGPAT5
label: UniProt:Q9NUQ2 AGPAT5

ELOVL2
label: SSC2
label: UniProt:Q9NXB9 ELOVL2

CYP39A1
label: UniProt:Q9NYL5 CYP39A1

ELOVL2
label: ELOVL5
label: PRO0530
label: UniProt:Q9NYP7 ELOVL5

GPSN2
label: SC2
label: TECR
label: UniProt:Q9NZ01 TECR

COQ3
label: UG0215E05
label: UniProt:Q9NZJ6 COQ3

PEMPT
label: PEMT
label: PNMT
label: UniProt:Q9UBM1 PEMT

D7SR
label: DHCR7
label: UniProt:Q9UBM7 DHCR7

NPC1L1
label: UniProt:Q9UHC9-2 NPC1L1

AMACR
label: UniProt:Q9UHK6 AMACR

C20orf155
label: CLS1
label: CRLS1
label: UniProt:Q9UJA2 CRLS1

COT
label: CROT
label: UniProt:Q9UKG9 CROT

ACS2
label: ACSL6
label: FACL6
label: KIAA0837
label: LACS5
label: UniProt:Q9UKU0 ACSL6

ACS5
label: ACSL5
label: FACL5
label: UNQ633/PRO1250
label: UniProt:Q9ULC5 ACSL5

PLA2G4C
label: UniProt:Q9UP65 PLA2G4C

NEU3
label: UniProt:Q9UQ49 NEU3

ACSB
label: ACSVL6
label: FACVL3
label: FATP5
label: SLC27A5
label: UniProt:Q9Y2P5 SLC27A5

NEU2
label: UniProt:Q9Y3R4 NEU2

CYP46
label: CYP46A1
label: UniProt:Q9Y6A2 CYP46A1

LST1
label: OATP1B1
label: OATP2
label: OATPC
label: SLC21A6
label: SLCO1B1
label: UniProt:Q9Y6L6 SLCO1B1

ABCG5:ABCG8-mediated export of cholesterol and phytosterols
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0015248
BFO_0000050: Pathway1150
label: sterols[cytosol] + ATP => sterols[extracellular] + ADP + Pi

ABCG1-mediated transport of intracellular cholesterol to the cell surface
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0017127
BFO_0000050: Pathway1153
directly activates: Discoidal HDL binds membrane-associated free cholesterol
directly activates: Spherical HDL binds membrane-associated free cholesterol and phospholipids
directly activates: Control384

CTL1-5 can mediate the uptake of choline
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0015220
BFO_0000050: Pathway1200
directly activates: Cho is acetylated to AcCho by CHAT
directly activates: Cho is phosphorylated to PCho by CHK dimer
directly activates: Catalysis1652
directly activates: Catalysis2329
label: Cho transports from the extracellular space to the cytosol

Transport (influx) of bile salts and acids by OATP-A
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: OATP
type: Restriction
  on property: enabled by
  some values from: OATP
type: Restriction
  on property: enabled by
  some values from: OATP
type: Restriction
  on property: enabled by
  some values from: OATP
type: GO_0015125
BFO_0000050: Pathway1191
directly activates: Transport (efflux) of bile salts by ABCB11 (bile salt export pump)
directly activates: Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS)
directly activates: Catalysis2262
directly activates: Catalysis2296

Transport (influx) of glycocholate and taurocholate by OATP-8
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: LST2
type: Restriction
  on property: enabled by
  some values from: LST2
type: Restriction
  on property: enabled by
  some values from: LST2
type: Restriction
  on property: enabled by
  some values from: LST2
type: GO_0015125
BFO_0000050: Pathway1191
directly activates: Transport (efflux) of bile salts by ABCB11 (bile salt export pump)
directly activates: Catalysis2262

Transport (influx) of glycocholate and taurocholate by OATP-C
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: LST1
type: Restriction
  on property: enabled by
  some values from: LST1
type: Restriction
  on property: enabled by
  some values from: LST1
type: Restriction
  on property: enabled by
  some values from: LST1
type: GO_0015125
BFO_0000050: Pathway1191
directly activates: Transport (efflux) of bile salts by ABCB11 (bile salt export pump)
directly activates: Catalysis2262

Photolytic cleavage and thermal isomerization of 7-dehydrocholesterol
type: GO_0003674
BFO_0000050: Pathway580
directly activates: Vitamin D3 translocates to the blood serum and is transported to the liver

Vitamin D3 translocates to the blood serum and is transported to the liver
type: GO_0003674
BFO_0000050: Pathway580
directly activates: Vitamin D3 translocates into the cytosol

Vitamin D3 translocates into the cytosol
type: GO_0003674
BFO_0000050: Pathway580
directly activates: 25-Hydroxylation of vitamin D3 in liver
directly activates: Catalysis1093

25-Hydroxylation of vitamin D3 in liver
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: CYP2R1
type: Restriction
  on property: enabled by
  some values from: CYP2R1
type: Restriction
  on property: enabled by
  some values from: CYP2R1
type: Restriction
  on property: enabled by
  some values from: CYP2R1
type: GO_0030343
BFO_0000050: Pathway580
directly activates: Calcidiol binds to DBP in the bloodstream and is delivered to the kidney

Calcidiol binds to DBP in the bloodstream and is delivered to the kidney
type: GO_0003674
BFO_0000050: Pathway580
directly activates: DBP:Calcidiol is sequestered by cubilin on the cell surface

DBP:Calcidiol is sequestered by cubilin on the cell surface
type: GO_0003674
BFO_0000050: Pathway580
directly activates: Megalin internalizes the cubilin-DBP:Calcidiol complex
directly activates: Catalysis1094

Megalin internalizes the cubilin-DBP:Calcidiol complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: LRP2
type: Restriction
  on property: enabled by
  some values from: LRP2
type: Restriction
  on property: enabled by
  some values from: LRP2
type: Restriction
  on property: enabled by
  some values from: LRP2
type: GO_0042954
BFO_0000050: Pathway580
directly activates: DBP:Calcidiol translocates into lysosomes

DBP:Calcidiol translocates into lysosomes
type: GO_0003674
BFO_0000050: Pathway580
directly activates: Legumain degrades DBP
directly activates: Catalysis1095

Legumain degrades DBP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: enabled by
  some values from: LGMN
type: Restriction
  on property: enabled by
  some values from: LGMN
type: Restriction
  on property: enabled by
  some values from: LGMN
type: Restriction
  on property: enabled by
  some values from: LGMN
type: GO_0004197
BFO_0000050: Pathway580
directly activates: Vitamin D3 translocates to the cytosol and binds to IDBP

Vitamin D3 translocates to the cytosol and binds to IDBP
type: GO_0003674
BFO_0000050: Pathway580
directly activates: Further hydroxylation of calcidiol in kidney to form calcitriol
directly activates: Catalysis1096

Further hydroxylation of calcidiol in kidney to form calcitriol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: enabled by
  some values from: CYP1ALPHA
type: Restriction
  on property: enabled by
  some values from: CYP1ALPHA
type: Restriction
  on property: enabled by
  some values from: CYP1ALPHA
type: Restriction
  on property: enabled by
  some values from: CYP1ALPHA
type: GO_0004498
BFO_0000050: Pathway580

1,25-dihydroxyvitamin D3 is deactivated
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: enabled by
  some values from: CYP24
type: Restriction
  on property: enabled by
  some values from: CYP24
type: Restriction
  on property: enabled by
  some values from: CYP24
type: Restriction
  on property: enabled by
  some values from: CYP24
type: GO_0030342
BFO_0000050: Pathway580

Cholesterol translocates to the inner mitochondrial membrane
type: GO_0003674
BFO_0000050: Pathway581
directly activates: Cholesterol is released into the inner mitochondrial membrane

Cholesterol is released into the inner mitochondrial membrane
type: GO_0003674
BFO_0000050: Pathway581
directly activates: Oxidation of cholesterol
directly activates: Catalysis1098

Oxidation of cholesterol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: CYP11A
type: Restriction
  on property: enabled by
  some values from: CYP11A
type: Restriction
  on property: enabled by
  some values from: CYP11A
type: Restriction
  on property: enabled by
  some values from: CYP11A
type: GO_0008386
BFO_0000050: Pathway581
directly activates: 22beta-hydroxycholesterol + NADPH + H+ + O2 => 20alpha,22beta-hydroxycholesterol + NADP+ + H2O
directly activates: Catalysis1099
label: Oxidation of cholesterol to 22beta-hydroxycholesterol
label: cholesterol + NADPH + H+ => 22beta-hydroxycholesterol + NADP+ + H2O

22beta-hydroxycholesterol + NADPH + H+ + O2 => 20alpha,22beta-hydroxycholesterol + NADP+ + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: CYP11A
type: Restriction
  on property: enabled by
  some values from: CYP11A
type: Restriction
  on property: enabled by
  some values from: CYP11A
type: Restriction
  on property: enabled by
  some values from: CYP11A
type: GO_0008386
BFO_0000050: Pathway581
directly activates: 20alpha,22beta-hydroxycholesterol + NADPH + H+ + O2 => pregnenolone + isocaproaldehyde + NADP+ + H2O
directly activates: Catalysis1100
label: Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol

20alpha,22beta-hydroxycholesterol + NADPH + H+ + O2 => pregnenolone + isocaproaldehyde + NADP+ + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: CYP11A
type: Restriction
  on property: enabled by
  some values from: CYP11A
type: Restriction
  on property: enabled by
  some values from: CYP11A
type: Restriction
  on property: enabled by
  some values from: CYP11A
type: GO_0008386
BFO_0000050: Pathway581
directly activates: Translocation of isocaproaldehyde from the mitochondrial matrix to the cytosol
directly activates: Pregnenolone translocates from the mitochondrial matrix to the cytosol
label: 20alpha,22beta-hydroxycholesterol is cleaved by CYP11A1 to yield pregnenolone and isocaproaldehyde

Translocation of isocaproaldehyde from the mitochondrial matrix to the cytosol
type: GO_0003674
BFO_0000050: Pathway581
directly activates: Reduction of isocaproaldehyde to 4-methylpentan-1-ol
directly activates: Catalysis1101

Reduction of isocaproaldehyde to 4-methylpentan-1-ol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: AKR1B1
type: Restriction
  on property: enabled by
  some values from: AKR1B1
type: Restriction
  on property: enabled by
  some values from: AKR1B1
type: Restriction
  on property: enabled by
  some values from: AKR1B1
type: GO_0004032
BFO_0000050: Pathway581
label: isocaproaldehyde + NADPH + H+ => 4-methylpentan-1-ol + NADP+

Pregnenolone translocates from the mitochondrial matrix to the cytosol
type: GO_0003674
BFO_0000050: Pathway581
directly activates: Hydroxylation of pregnenolone to form 17alpha-hydroxypregnenolone
directly activates: Pregnenolone + NAD+ => pregn-5-ene-3,20-dione + NADH + H+
directly activates: Catalysis1102
directly activates: Catalysis1108

Hydroxylation of pregnenolone to form 17alpha-hydroxypregnenolone
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: CYP17
type: Restriction
  on property: enabled by
  some values from: CYP17
type: Restriction
  on property: enabled by
  some values from: CYP17
type: Restriction
  on property: enabled by
  some values from: CYP17
type: Restriction
  on property: enabled by
  some values from: CYP17
type: Restriction
  on property: enabled by
  some values from: CYP17
type: Restriction
  on property: enabled by
  some values from: CYP17
type: Restriction
  on property: enabled by
  some values from: CYP17
type: GO_0004508
BFO_0000050: Pathway582
BFO_0000050: Pathway584
directly activates: 17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol
directly activates: 17alpha-hydroxyprenenolone + NADPH + H+ + O2 => DHA (dehydroepiandrostenedione) + NADP+ + H2O + acetaldehyde
directly activates: Catalysis1103
directly activates: Catalysis1114
directly activates: Control175
label: pregnenolone + NADPH + H+ => 17alpha-hydroxypregnenolone + NADP+ + H2O

17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0003854
BFO_0000050: Pathway582
directly activates: Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone
directly activates: Catalysis1104
label: 17-hydroxypregnenolone + NAD+ => pregn-5-ene-3,20-dione-17-ol + NADH + H+

Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004769
BFO_0000050: Pathway582
directly activates: 17-hydroxyprogesterone + NADPH + H+ + O2 => 11-deoxycortisol + NADP+ + H2O
directly activates: Catalysis1105

17-hydroxyprogesterone + NADPH + H+ + O2 => 11-deoxycortisol + NADP+ + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: CYP21
type: Restriction
  on property: enabled by
  some values from: CYP21
type: Restriction
  on property: enabled by
  some values from: CYP21
type: Restriction
  on property: enabled by
  some values from: CYP21
type: GO_0004509
BFO_0000050: Pathway582
directly activates: 11-deoxycortisol translocates to the mitochondrion
label: Hydroxylation of 17-hydroxyprogesterone to form 11-deoxycortisol

11-deoxycortisol translocates to the mitochondrion
type: GO_0003674
BFO_0000050: Pathway582
directly activates: 11-deoxycortisol + NADPH + H+ + O2 => cortisol + NADP+ + H2O
directly activates: Catalysis1106
directly activates: Control173

11-deoxycortisol + NADPH + H+ + O2 => cortisol + NADP+ + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: GO_0004507
BFO_0000050: Pathway582
directly activates: Cortisol translocates from the mitochondrial matrix to the cytosol
label: 11-deoxycortisol is oxidised to cortisol by CYP11B1

Cortisol translocates from the mitochondrial matrix to the cytosol
type: GO_0003674
BFO_0000050: Pathway582

Oxidation of cortisol to yield cortisone
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0003845
BFO_0000050: Pathway582
label: cortisol + NADP+ => cortisone + NADPH + H+

Pregnenolone + NAD+ => pregn-5-ene-3,20-dione + NADH + H+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0003854
BFO_0000050: Pathway583
directly activates: Pregn-5-ene-3,20-dione isomerizes to progesterone
directly activates: Catalysis1109
directly activates: Control174
label: Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione

Pregn-5-ene-3,20-dione isomerizes to progesterone
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004769
BFO_0000050: Pathway583
directly activates: 21-hydroxylation of progesterone to form 11-deoxycorticosterone
directly activates: Hydroxylation of progesterone to form 17alpha-hydroxyprogesterone
directly activates: Catalysis1110
directly activates: Catalysis1116

21-hydroxylation of progesterone to form 11-deoxycorticosterone
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: CYP21
type: Restriction
  on property: enabled by
  some values from: CYP21
type: Restriction
  on property: enabled by
  some values from: CYP21
type: Restriction
  on property: enabled by
  some values from: CYP21
type: GO_0004509
BFO_0000050: Pathway583
directly activates: 11-deoxycorticosterone translocates from the cytosol to the mitochondrial matrix
label: progesterone + NAPDH + H+ + O2 => 11-deoxycorticosterone + NADP+ + H2O

11-deoxycorticosterone translocates from the cytosol to the mitochondrial matrix
type: GO_0003674
BFO_0000050: Pathway583
directly activates: 11-deoxycorticosterone + NADPH + H+ + O2 => corticosterone + H2O + NADP+
directly activates: BiochemicalReaction5843
directly activates: Catalysis1111
directly activates: Catalysis2984

11-deoxycorticosterone + NADPH + H+ + O2 => corticosterone + H2O + NADP+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: GO_0004507
BFO_0000050: Pathway583
directly activates: Hydroxylation of corticosterone to form 18-hydroxycorticosterone
directly activates: Catalysis1112
label: Hydroxylation of 11-deoxycorticosterone to form corticosterone

Hydroxylation of corticosterone to form 18-hydroxycorticosterone
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: enabled by
  some values from: CYP11B2
type: Restriction
  on property: enabled by
  some values from: CYP11B2
type: Restriction
  on property: enabled by
  some values from: CYP11B2
type: Restriction
  on property: enabled by
  some values from: CYP11B2
type: GO_0008395
BFO_0000050: Pathway583
directly activates: 18-hydroxycorticosterone + NADPH + H+ => aldosterone + NADP+ + 2H2O
directly activates: Catalysis1113
label: corticosterone + NADPH + H+ + O2 => 18-hydroxycorticosterone + NADP+ + H2O

18-hydroxycorticosterone + NADPH + H+ => aldosterone + NADP+ + 2H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: enabled by
  some values from: CYP11B2
type: Restriction
  on property: enabled by
  some values from: CYP11B2
type: Restriction
  on property: enabled by
  some values from: CYP11B2
type: Restriction
  on property: enabled by
  some values from: CYP11B2
type: GO_0008395
BFO_0000050: Pathway583
label: Conversion of 18-hydroxycorticosterone to aldosterone

17alpha-hydroxyprenenolone + NADPH + H+ + O2 => DHA (dehydroepiandrostenedione) + NADP+ + H2O + acetaldehyde
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: CYP17
type: Restriction
  on property: enabled by
  some values from: CYP17
type: Restriction
  on property: enabled by
  some values from: CYP17
type: Restriction
  on property: enabled by
  some values from: CYP17
type: GO_0004508
BFO_0000050: Pathway584
directly activates: DHA isomerizes to 4-Androstene3,17-dione
directly activates: Catalysis1115
directly activates: Control176
label: Side chain cleavage of 17alpha-hydroxypregnenolone to yield DHA

DHA isomerizes to 4-Androstene3,17-dione
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004769
BFO_0000050: Pathway584
directly activates: Reduction of androstenedione to testosterone
directly activates: Catalysis1118
directly activates: Control177
directly activates: Control178

Hydroxylation of progesterone to form 17alpha-hydroxyprogesterone
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: CYP17
type: Restriction
  on property: enabled by
  some values from: CYP17
type: Restriction
  on property: enabled by
  some values from: CYP17
type: Restriction
  on property: enabled by
  some values from: CYP17
type: GO_0004508
BFO_0000050: Pathway584
directly activates: 17alpha-hydroxyprogesterone + NADPH + H+ + O2 => 4-Androstene-3, 17-dione + NADP+ + H2O + acetaldehyde
directly activates: Catalysis1117
label: progesterone + NADPH + H+ + O2 => 17alpha-hydroxyprogesterone + NADP+ + H2O

17alpha-hydroxyprogesterone + NADPH + H+ + O2 => 4-Androstene-3, 17-dione + NADP+ + H2O + acetaldehyde
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: CYP17
type: Restriction
  on property: enabled by
  some values from: CYP17
type: Restriction
  on property: enabled by
  some values from: CYP17
type: Restriction
  on property: enabled by
  some values from: CYP17
type: GO_0004508
BFO_0000050: Pathway584
directly activates: Reduction of androstenedione to testosterone
directly activates: Androstenedione is converted to estrone by Aromatase (CYP19A1)
directly activates: Catalysis1118
directly activates: Catalysis1121
directly activates: Control177
directly activates: Control178
label: Side chain cleavage of 17alpha-hydroxyprogesterone to form 4-Androstene-3, 17-dione

Reduction of androstenedione to testosterone
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: EDH17B3
type: Restriction
  on property: enabled by
  some values from: EDH17B3
type: Restriction
  on property: enabled by
  some values from: EDH17B3
type: Restriction
  on property: enabled by
  some values from: EDH17B3
type: GO_0050327
BFO_0000050: Pathway584
directly activates: Testosterone is converted to 5-alpha-dihydroxytestosterone
directly activates: Testosterone is converted to estradiol
directly activates: Catalysis1119
directly activates: Catalysis1120
directly activates: Control179

Testosterone is converted to 5-alpha-dihydroxytestosterone
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0003865
BFO_0000050: Pathway584

Testosterone is converted to estradiol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: ARO1
type: Restriction
  on property: enabled by
  some values from: ARO1
type: Restriction
  on property: enabled by
  some values from: ARO1
type: Restriction
  on property: enabled by
  some values from: ARO1
type: GO_0008395
BFO_0000050: Pathway585

Androstenedione is converted to estrone by Aromatase (CYP19A1)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: ARO1
type: Restriction
  on property: enabled by
  some values from: ARO1
type: Restriction
  on property: enabled by
  some values from: ARO1
type: Restriction
  on property: enabled by
  some values from: ARO1
type: GO_0008395
BFO_0000050: Pathway585
directly activates: Estrone is hydrogenated to estradiol
directly activates: Catalysis1122

Estrone is hydrogenated to estradiol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004303
type: GO_0006703
BFO_0000050: Pathway585

Digestion of retinyl palmitate by extracellular PTL:colipase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0050253
BFO_0000050: Pathway1149
directly activates: BiochemicalReaction3162
label: PNLIP:CLPS hydrolyses RPALM to atROL and PALM

SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005788
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005788
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005788
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005788
type: Restriction
  on property: enabled by
  some values from: FGE
type: Restriction
  on property: enabled by
  some values from: FGE
type: Restriction
  on property: enabled by
  some values from: FGE
type: Restriction
  on property: enabled by
  some values from: FGE
type: GO_0016491
BFO_0000050: Pathway1239
directly activates: BiochemicalReaction5296

Cho is acetylated to AcCho by CHAT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: CHAT
type: Restriction
  on property: enabled by
  some values from: CHAT
type: Restriction
  on property: enabled by
  some values from: CHAT
type: Restriction
  on property: enabled by
  some values from: CHAT
type: Restriction
  on property: enabled by
  some values from: CHAT
type: Restriction
  on property: enabled by
  some values from: CHAT
type: Restriction
  on property: enabled by
  some values from: CHAT
type: Restriction
  on property: enabled by
  some values from: CHAT
type: GO_0004102
BFO_0000050: Pathway1200
directly activates: BiochemicalReaction3698
directly activates: Catalysis1653
label: Synthesis of o-acetylcholine

AcCho is hydrolyzed to Cho and acetate by ACHE
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0003990
BFO_0000050: Pathway1200
directly activates: CTL1-5 can mediate the uptake of choline
directly activates: Catalysis694
label: Acetylcholine clearance from synaptic cleft

Hydrolysis of phosphatidylcholine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0047498
BFO_0000050: Pathway1227
directly activates: Arachidonate diffuses across the ER membrane
directly activates: Arachidonic acid is oxidised to PGG2 by PTGS1
directly activates: Arachidonic acid is oxidised to PGG2 by PTGS2
directly activates: BiochemicalReaction5258
directly activates: BiochemicalReaction5259
directly activates: BiochemicalReaction5260
directly activates: Catalysis2453
directly activates: Catalysis2454
directly activates: Catalysis2506
directly activates: Catalysis2507
directly activates: Catalysis2508

Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004771
BFO_0000050: Pathway1149
directly activates: NPC1L1-mediated cholesterol uptake
directly activates: Catalysis2078

Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0047372
BFO_0000050: Pathway1149

Digestion of diacylglycerols by extracellular PTL:colipase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0047372
BFO_0000050: Pathway1149
directly activates: Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase)
directly activates: Catalysis2073

Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0047372
BFO_0000050: Pathway1149
directly activates: Digestion of diacylglycerols by extracellular PTL:colipase
directly activates: Catalysis2074

Digestion of triacylglycerols by extracellular PTL:colipase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0047372
BFO_0000050: Pathway1149
directly activates: Digestion of diacylglycerols by extracellular PTL:colipase
directly activates: Catalysis2074

Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: enabled by
  some values from: PLRP2
type: Restriction
  on property: enabled by
  some values from: PLRP2
type: Restriction
  on property: enabled by
  some values from: PLRP2
type: Restriction
  on property: enabled by
  some values from: PLRP2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0047372
BFO_0000050: Pathway1149

NPC1L1-mediated cholesterol uptake
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: NPC1L1
type: Restriction
  on property: enabled by
  some values from: NPC1L1
type: Restriction
  on property: enabled by
  some values from: NPC1L1
type: Restriction
  on property: enabled by
  some values from: NPC1L1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0017127
BFO_0000050: Pathway1150

NPC1L1-mediated phytosterol uptake
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: NPC1L1
type: Restriction
  on property: enabled by
  some values from: NPC1L1
type: Restriction
  on property: enabled by
  some values from: NPC1L1
type: Restriction
  on property: enabled by
  some values from: NPC1L1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0017127
BFO_0000050: Pathway1150

NPC1L1 + ezetimibe => NPC1L1:ezetimibe complex
type: GO_0003674
BFO_0000050: Pathway1150
label: NPC1L1 inactivation by ezetimibe

ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005788
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005788
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005788
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005788
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005788
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005788
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005788
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005788
type: GO_0005319
type: GO_0042158
BFO_0000050: Pathway1152
directly activates: ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron
directly activates: Control376

ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron
type: GO_0042158
BFO_0000050: Pathway1152
directly activates: Exocytosis of nascent chylomicrons
directly activates: Control377

Exocytosis of nascent chylomicrons
type: GO_0042158
BFO_0000050: Pathway1152
directly activates: nascent chylomicron + spherical HDL:apoC-II:apoC-III:apoE =>spherical HDL + chylomicron
label: nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular]

nascent chylomicron + spherical HDL:apoC-II:apoC-III:apoE =>spherical HDL + chylomicron
type: GO_0003674
BFO_0000050: Pathway1152
directly activates: chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols
directly activates: Catalysis2081
directly activates: Control378
directly activates: Control379
directly activates: Control380

chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004465
BFO_0000050: Pathway1152
directly activates: TG-depleted chylomicron + spherical HDL => chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III

TG-depleted chylomicron + spherical HDL => chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III
type: GO_0003674
BFO_0000050: Pathway1152
directly activates: chylomicron remnant + apoE => chylomicron remnant:apoE complex

chylomicron remnant + apoE => chylomicron remnant:apoE complex
type: GO_0042159
BFO_0000050: Pathway1152
directly activates: chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex
directly activates: Control381

chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex
type: GO_0006898
BFO_0000050: Pathway1152
directly activates: chylomicron remnant:apoE:LDLR complex [plasma membrane] => chylomicron remnant:apoE:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent)
directly activates: Control382

chylomicron remnant:apoE:LDLR complex [plasma membrane] => chylomicron remnant:apoE:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent)
type: GO_0003674
BFO_0000050: Pathway1152
directly activates: chylomicron remnant:apoE:LDLR complex [coated vesicle membrane] => chylomicron remnant:apoE:LDLR complex [endosome membrane]

chylomicron remnant:apoE:LDLR complex [coated vesicle membrane] => chylomicron remnant:apoE:LDLR complex [endosome membrane]
type: GO_0006898
BFO_0000050: Pathway1152
directly activates: chylomicron remnant:apoE:LDLR complex => chylomicron remnant:apoE + LDLR

chylomicron remnant:apoE:LDLR complex => chylomicron remnant:apoE + LDLR
type: GO_0006898
BFO_0000050: Pathway1152
directly activates: LDLR [endosome membrane] => LDLR [plasma membrane]

Conversion of pro-apoA-I to apoA-I
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004222
BFO_0000050: Pathway1153
directly activates: ABCA1 tetramer binds apoA-I

ABCA1 tetramer binds apoA-I
type: GO_0003674
BFO_0000050: Pathway1153
directly activates: ABCA1-mediated transport of intracellular cholesterol to the cell surface
directly activates: ABCA1-mediated transport of intracellular phospholipid to the cell surface
directly activates: Catalysis2083
directly activates: Catalysis2084

ABCA1-mediated transport of intracellular cholesterol to the cell surface
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0017127
BFO_0000050: Pathway1153
directly activates: Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle
directly activates: pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle

ABCA1-mediated transport of intracellular phospholipid to the cell surface
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005548
BFO_0000050: Pathway1153
directly activates: Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle
directly activates: pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle

Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle
type: GO_0003674
BFO_0000050: Pathway1153
directly activates: Discoidal HDL binds membrane-associated free cholesterol
directly activates: LCAT + discoidal HDL <=> LCAT:discoidal HDL complex

pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle
type: GO_0003674
BFO_0000050: Pathway1153

Discoidal HDL binds membrane-associated free cholesterol
type: GO_0003674
BFO_0000050: Pathway1153

LCAT + discoidal HDL <=> LCAT:discoidal HDL complex
type: GO_0003674
BFO_0000050: Pathway1153
directly activates: LCAT:discoidal HDL complex <=> LCAT + discoidal HDL

LCAT:discoidal HDL complex <=> LCAT + discoidal HDL
type: GO_0003674
BFO_0000050: Pathway1153

Spherical HDL binds C and E apolipoproteins
type: GO_0003674
BFO_0000050: Pathway1153

Spherical HDL binds membrane-associated free cholesterol and phospholipids
type: GO_0003674
BFO_0000050: Pathway1153

cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: enabled by
  some values from: LCAT
type: Restriction
  on property: enabled by
  some values from: LCAT
type: Restriction
  on property: enabled by
  some values from: LCAT
type: Restriction
  on property: enabled by
  some values from: LCAT
type: Restriction
  on property: enabled by
  some values from: LCAT
type: Restriction
  on property: enabled by
  some values from: LCAT
type: Restriction
  on property: enabled by
  some values from: LCAT
type: Restriction
  on property: enabled by
  some values from: LCAT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004607
BFO_0000050: Pathway1153
directly activates: 2 2-lysophosphatidylcholine + serum albumin => albumin:2-lysophosphatidylcholine complex

2 2-lysophosphatidylcholine + serum albumin => albumin:2-lysophosphatidylcholine complex
type: GO_0003674
BFO_0000050: Pathway1153
label: Serum albumin binds 2-lysophosphatidylcholine

LCAT + spherical HDL <=> LCAT:spherical HDL complex
type: GO_0003674
BFO_0000050: Pathway1153
directly activates: LCAT:spherical HDL complex <=> LCAT + spherical HDL

LCAT:spherical HDL complex <=> LCAT + spherical HDL
type: GO_0003674
BFO_0000050: Pathway1153

CETP-mediated lipid exchange: spherical HDL gains triacylglycerol
type: GO_0003674
BFO_0000050: Pathway1153
directly activates: CETP-mediated lipid exchange: LDL gains cholesterol ester
label: CETP:triacylglycerol complex + spherical HDL <=> CETP:cholesterol ester complex + spherical HDL:triacylglycerol

CETP + spherical HDL + torcetrapib => CETP:spherical HDL:torcetrapib complex
type: GO_0003674
BFO_0000050: Pathway1153

spherical HDL and SR-BI receptor form a complex at the cell surface
type: GO_0003674
BFO_0000050: Pathway1153
directly activates: Disassembly of SR-BI-bound spherical HDL

Disassembly of SR-BI-bound spherical HDL
type: GO_0003674
BFO_0000050: Pathway1153
directly activates: pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle

apoA-I binds to CUBN:AMN
type: GO_0003674
BFO_0000050: Pathway1153
directly activates: Degradation18

CETP-mediated lipid exchange: LDL gains cholesterol ester
type: GO_0003674
BFO_0000050: Pathway1154
directly activates: CETP-mediated lipid exchange: spherical HDL gains triacylglycerol
label: CETP:cholesterol ester complex + LDL <=> LDL:cholesterol ester complex + CETP:triacylglycerol complex

apolipoprotein(a) + LDL => Lp(a)
type: GO_0042157
BFO_0000050: Pathway1154

LDL + LDLR => LDL:LDLR complex
type: GO_0006898
BFO_0000050: Pathway1154
directly activates: Internalization of LDL:LDLR complex (LDLRAP1-dependent)
directly activates: Internalization of LDL:LDLR complex (LDLRAP1-independent)
directly activates: Control386

Internalization of LDL:LDLR complex (LDLRAP1-dependent)
type: GO_0006898
BFO_0000050: Pathway1154
directly activates: LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane]
label: LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent)

Internalization of LDL:LDLR complex (LDLRAP1-independent)
type: GO_0006898
BFO_0000050: Pathway1154
directly activates: LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane]
label: LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent)

LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane]
type: GO_0006898
BFO_0000050: Pathway1154
directly activates: Dissociation of the LDL:LDLR complex in the early endosome
label: Movement of LDL:LDLR complex to early endosome

Dissociation of the LDL:LDLR complex in the early endosome
type: GO_0006898
BFO_0000050: Pathway1154
directly activates: LDLR [endosome membrane] => LDLR [plasma membrane]
label: LDLR:LDL complex => LDLR + LDL

LDLR [endosome membrane] => LDLR [plasma membrane]
type: GO_0006898
BFO_0000050: Pathway1154
directly activates: chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex
directly activates: LDL + LDLR => LDL:LDLR complex
directly activates: Control381
label: Recycling of LDLR to plasma membrane

hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Pathway1155
directly activates: 2 phosphorylated HSL monomers -> phosphorylated HSL dimer
directly activates: phosphorylated HSL + H2O -> HSL + orthophosphate

2 phosphorylated HSL monomers -> phosphorylated HSL dimer
type: GO_0003674
BFO_0000050: Pathway1155
directly activates: Phosphorylated HSL dimer translocates from the cytosol to the lipid particle

perilipin:CGI-58 complex -> perilipin + CGI-58
type: GO_0003674
BFO_0000050: Pathway1155
directly activates: perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP
directly activates: Catalysis2087
directly activates: Control387

perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Pathway1155
directly activates: Phosphorylated HSL dimer translocates from the cytosol to the lipid particle
directly activates: phosphorylated perilipin + H2O -> perilipin + orthophosphate
directly activates: Catalysis2092

Phosphorylated HSL dimer translocates from the cytosol to the lipid particle
type: GO_0003674
BFO_0000050: Pathway1155
directly activates: phosphorylated HSL dimer + FABP4 -> phosphorylated HSL dimer:FABP4 complex

phosphorylated HSL dimer + FABP4 -> phosphorylated HSL dimer:FABP4 complex
type: GO_0003674
BFO_0000050: Pathway1155
directly activates: cholesterol ester + H2O -> cholesterol + fatty acid
directly activates: triacylglycerol + H2O -> diacylglycerol + fatty acid
directly activates: Catalysis2088
directly activates: Catalysis2089

cholesterol ester + H2O -> cholesterol + fatty acid
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005811
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005811
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005811
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005811
type: GO_0016298
BFO_0000050: Pathway1155

triacylglycerol + H2O -> diacylglycerol + fatty acid
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005811
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005811
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005811
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005811
type: GO_0004806
BFO_0000050: Pathway1155
directly activates: diacylglycerol + H2O -> 2-acylglycerol + fatty acid
directly activates: Catalysis2090

diacylglycerol + H2O -> 2-acylglycerol + fatty acid
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005811
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005811
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005811
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005811
type: GO_0016298
BFO_0000050: Pathway1155
directly activates: 2-acylglycerol + H2O -> glycerol + fatty acid
directly activates: Catalysis2091

2-acylglycerol + H2O -> glycerol + fatty acid
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005811
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005811
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005811
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005811
type: GO_0047372
BFO_0000050: Pathway1155

phosphorylated HSL + H2O -> HSL + orthophosphate
type: GO_0003674
BFO_0000050: Pathway1155

phosphorylated perilipin + H2O -> perilipin + orthophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004722
BFO_0000050: Pathway1155

Transport of Citrate from Mitochondrial Matrix to cytosol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: enabled by
  some values from: SLC20A3
type: Restriction
  on property: enabled by
  some values from: SLC20A3
type: Restriction
  on property: enabled by
  some values from: SLC20A3
type: Restriction
  on property: enabled by
  some values from: SLC20A3
type: Restriction
  on property: enabled by
  some values from: SLC20A3
type: Restriction
  on property: enabled by
  some values from: SLC20A3
type: Restriction
  on property: enabled by
  some values from: SLC20A3
type: Restriction
  on property: enabled by
  some values from: SLC20A3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: GO_0015142
BFO_0000050: Pathway1158
directly activates: Generation of Cytoplasmic Acetyl CoA from Citrate
directly activates: Catalysis2094

Generation of Cytoplasmic Acetyl CoA from Citrate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003878
BFO_0000050: Pathway1158
directly activates: Formation of Malonyl-CoA from Acetyl-CoA (liver)
directly activates: Formation of Malonyl-CoA from Acetyl-CoA (muscle)
directly activates: Catalysis2095
directly activates: Catalysis2123
directly activates: Control388

Formation of Malonyl-CoA from Acetyl-CoA (liver)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: ACAC
type: Restriction
  on property: enabled by
  some values from: ACAC
type: Restriction
  on property: enabled by
  some values from: ACAC
type: Restriction
  on property: enabled by
  some values from: ACAC
type: Restriction
  on property: enabled by
  some values from: ACAC
type: Restriction
  on property: enabled by
  some values from: ACAC
type: Restriction
  on property: enabled by
  some values from: ACAC
type: Restriction
  on property: enabled by
  some values from: ACAC
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003989
BFO_0000050: Pathway1158
directly activates: Conversion of malonyl-CoA and acetyl-CoA to palmitate
directly activates: Catalysis2096
label: acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate

Formation of fatty acid synthase (FAS) dimer
type: GO_0003674
BFO_0000050: Pathway1158
directly activates: Conversion of malonyl-CoA and acetyl-CoA to palmitate
directly activates: Catalysis2096

Conversion of malonyl-CoA and acetyl-CoA to palmitate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004312
BFO_0000050: Pathway1158
label: acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O

Conversion of palmitic acid to palmitoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: ACSL1
type: Restriction
  on property: enabled by
  some values from: ACSL1
type: Restriction
  on property: enabled by
  some values from: ACSL1
type: Restriction
  on property: enabled by
  some values from: ACSL1
type: Restriction
  on property: enabled by
  some values from: ACSL1
type: Restriction
  on property: enabled by
  some values from: ACSL1
type: Restriction
  on property: enabled by
  some values from: ACSL1
type: Restriction
  on property: enabled by
  some values from: ACSL1
type: Restriction
  on property: enabled by
  some values from: ACSL1
type: Restriction
  on property: enabled by
  some values from: ACSL1
type: Restriction
  on property: enabled by
  some values from: ACSL1
type: Restriction
  on property: enabled by
  some values from: ACSL1
type: Restriction
  on property: enabled by
  some values from: ACSL1
type: Restriction
  on property: enabled by
  some values from: ACSL1
type: Restriction
  on property: enabled by
  some values from: ACSL1
type: Restriction
  on property: enabled by
  some values from: ACSL1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004467
BFO_0000050: Pathway1159
label: palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL1]

palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004467
BFO_0000050: Pathway1159

arachidonate + CoASH + ATP => arachidonoyl-CoA + AMP + pyrophosphate + H2O [ACSL4]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004467
BFO_0000050: Pathway1159

palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL5]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: ACS5
type: Restriction
  on property: enabled by
  some values from: ACS5
type: Restriction
  on property: enabled by
  some values from: ACS5
type: Restriction
  on property: enabled by
  some values from: ACS5
type: Restriction
  on property: enabled by
  some values from: ACS5
type: Restriction
  on property: enabled by
  some values from: ACS5
type: Restriction
  on property: enabled by
  some values from: ACS5
type: Restriction
  on property: enabled by
  some values from: ACS5
type: Restriction
  on property: enabled by
  some values from: ACS5
type: Restriction
  on property: enabled by
  some values from: ACS5
type: Restriction
  on property: enabled by
  some values from: ACS5
type: Restriction
  on property: enabled by
  some values from: ACS5
type: Restriction
  on property: enabled by
  some values from: ACS5
type: Restriction
  on property: enabled by
  some values from: ACS5
type: Restriction
  on property: enabled by
  some values from: ACS5
type: Restriction
  on property: enabled by
  some values from: ACS5
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004467
BFO_0000050: Pathway1159

palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL6]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: ACS2
type: Restriction
  on property: enabled by
  some values from: ACS2
type: Restriction
  on property: enabled by
  some values from: ACS2
type: Restriction
  on property: enabled by
  some values from: ACS2
type: Restriction
  on property: enabled by
  some values from: ACS2
type: Restriction
  on property: enabled by
  some values from: ACS2
type: Restriction
  on property: enabled by
  some values from: ACS2
type: Restriction
  on property: enabled by
  some values from: ACS2
type: Restriction
  on property: enabled by
  some values from: ACS2
type: Restriction
  on property: enabled by
  some values from: ACS2
type: Restriction
  on property: enabled by
  some values from: ACS2
type: Restriction
  on property: enabled by
  some values from: ACS2
type: Restriction
  on property: enabled by
  some values from: ACS2
type: Restriction
  on property: enabled by
  some values from: ACS2
type: Restriction
  on property: enabled by
  some values from: ACS2
type: Restriction
  on property: enabled by
  some values from: ACS2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004467
BFO_0000050: Pathway1159

palmitoyl-CoA + malonyl-CoA => 3-oxooctadecanoyl-CoA (3-oxostearoyl-CoA) + CO2 + CoASH [ELOVL1]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: CGI-88
type: Restriction
  on property: enabled by
  some values from: CGI-88
type: Restriction
  on property: enabled by
  some values from: CGI-88
type: Restriction
  on property: enabled by
  some values from: CGI-88
type: Restriction
  on property: enabled by
  some values from: CGI-88
type: Restriction
  on property: enabled by
  some values from: CGI-88
type: Restriction
  on property: enabled by
  some values from: CGI-88
type: Restriction
  on property: enabled by
  some values from: CGI-88
type: Restriction
  on property: enabled by
  some values from: CGI-88
type: Restriction
  on property: enabled by
  some values from: CGI-88
type: Restriction
  on property: enabled by
  some values from: CGI-88
type: Restriction
  on property: enabled by
  some values from: CGI-88
type: Restriction
  on property: enabled by
  some values from: CGI-88
type: Restriction
  on property: enabled by
  some values from: CGI-88
type: Restriction
  on property: enabled by
  some values from: CGI-88
type: Restriction
  on property: enabled by
  some values from: CGI-88
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0009922
BFO_0000050: Pathway1159

palmitoyl-CoA + malonyl-CoA => 3-oxooctadecanoyl-CoA (3-oxostearoyl-CoA) + CO2 + CoASH [ELOVL2]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0009922
BFO_0000050: Pathway1159

palmitoyl-CoA + malonyl-CoA => 3-oxooctadecanoyl-CoA (3-oxostearoyl-CoA) + CO2 + CoASH [ELOVL3]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: CIG30
type: Restriction
  on property: enabled by
  some values from: CIG30
type: Restriction
  on property: enabled by
  some values from: CIG30
type: Restriction
  on property: enabled by
  some values from: CIG30
type: Restriction
  on property: enabled by
  some values from: CIG30
type: Restriction
  on property: enabled by
  some values from: CIG30
type: Restriction
  on property: enabled by
  some values from: CIG30
type: Restriction
  on property: enabled by
  some values from: CIG30
type: Restriction
  on property: enabled by
  some values from: CIG30
type: Restriction
  on property: enabled by
  some values from: CIG30
type: Restriction
  on property: enabled by
  some values from: CIG30
type: Restriction
  on property: enabled by
  some values from: CIG30
type: Restriction
  on property: enabled by
  some values from: CIG30
type: Restriction
  on property: enabled by
  some values from: CIG30
type: Restriction
  on property: enabled by
  some values from: CIG30
type: Restriction
  on property: enabled by
  some values from: CIG30
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0009922
BFO_0000050: Pathway1159

lignoceroyl-CoA + malonyl-CoA => 3-oxocerotoyl-CoA + CO2 + CoASH [ELOVL4]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: ELOVL4
type: Restriction
  on property: enabled by
  some values from: ELOVL4
type: Restriction
  on property: enabled by
  some values from: ELOVL4
type: Restriction
  on property: enabled by
  some values from: ELOVL4
type: Restriction
  on property: enabled by
  some values from: ELOVL4
type: Restriction
  on property: enabled by
  some values from: ELOVL4
type: Restriction
  on property: enabled by
  some values from: ELOVL4
type: Restriction
  on property: enabled by
  some values from: ELOVL4
type: Restriction
  on property: enabled by
  some values from: ELOVL4
type: Restriction
  on property: enabled by
  some values from: ELOVL4
type: Restriction
  on property: enabled by
  some values from: ELOVL4
type: Restriction
  on property: enabled by
  some values from: ELOVL4
type: Restriction
  on property: enabled by
  some values from: ELOVL4
type: Restriction
  on property: enabled by
  some values from: ELOVL4
type: Restriction
  on property: enabled by
  some values from: ELOVL4
type: Restriction
  on property: enabled by
  some values from: ELOVL4
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0009922
BFO_0000050: Pathway1159

arachidonoyl-CoA + malonyl-CoA => 3-oxo-(7,10,13,16)-docosatetraenoyl-CoA + CO2 + CoASH [ELOVL5]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0009922
BFO_0000050: Pathway1159

palmitoyl-CoA + malonyl-CoA => 3-oxooctadecanoyl-CoA (3-oxostearoyl-CoA) + CO2 + CoASH [ELOVL6]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: ELOVL6
type: Restriction
  on property: enabled by
  some values from: ELOVL6
type: Restriction
  on property: enabled by
  some values from: ELOVL6
type: Restriction
  on property: enabled by
  some values from: ELOVL6
type: Restriction
  on property: enabled by
  some values from: ELOVL6
type: Restriction
  on property: enabled by
  some values from: ELOVL6
type: Restriction
  on property: enabled by
  some values from: ELOVL6
type: Restriction
  on property: enabled by
  some values from: ELOVL6
type: Restriction
  on property: enabled by
  some values from: ELOVL6
type: Restriction
  on property: enabled by
  some values from: ELOVL6
type: Restriction
  on property: enabled by
  some values from: ELOVL6
type: Restriction
  on property: enabled by
  some values from: ELOVL6
type: Restriction
  on property: enabled by
  some values from: ELOVL6
type: Restriction
  on property: enabled by
  some values from: ELOVL6
type: Restriction
  on property: enabled by
  some values from: ELOVL6
type: Restriction
  on property: enabled by
  some values from: ELOVL6
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0009922
BFO_0000050: Pathway1159

arachidoyl-CoA + malonyl-CoA => 3-oxobehenoyl-CoA + CO2 + CoASH [ELOVL7]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: ELOVL7
type: Restriction
  on property: enabled by
  some values from: ELOVL7
type: Restriction
  on property: enabled by
  some values from: ELOVL7
type: Restriction
  on property: enabled by
  some values from: ELOVL7
type: Restriction
  on property: enabled by
  some values from: ELOVL7
type: Restriction
  on property: enabled by
  some values from: ELOVL7
type: Restriction
  on property: enabled by
  some values from: ELOVL7
type: Restriction
  on property: enabled by
  some values from: ELOVL7
type: Restriction
  on property: enabled by
  some values from: ELOVL7
type: Restriction
  on property: enabled by
  some values from: ELOVL7
type: Restriction
  on property: enabled by
  some values from: ELOVL7
type: Restriction
  on property: enabled by
  some values from: ELOVL7
type: Restriction
  on property: enabled by
  some values from: ELOVL7
type: Restriction
  on property: enabled by
  some values from: ELOVL7
type: Restriction
  on property: enabled by
  some values from: ELOVL7
type: Restriction
  on property: enabled by
  some values from: ELOVL7
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0009922
BFO_0000050: Pathway1159

3-oxooctadecanoyl-CoA (3-oxostearoyl-CoA) + NADPH + H+ => 3-hydroxyoctadecanoyl-CoA + NADP+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: HSD17B12
type: Restriction
  on property: enabled by
  some values from: HSD17B12
type: Restriction
  on property: enabled by
  some values from: HSD17B12
type: Restriction
  on property: enabled by
  some values from: HSD17B12
type: Restriction
  on property: enabled by
  some values from: HSD17B12
type: Restriction
  on property: enabled by
  some values from: HSD17B12
type: Restriction
  on property: enabled by
  some values from: HSD17B12
type: Restriction
  on property: enabled by
  some values from: HSD17B12
type: Restriction
  on property: enabled by
  some values from: HSD17B12
type: Restriction
  on property: enabled by
  some values from: HSD17B12
type: Restriction
  on property: enabled by
  some values from: HSD17B12
type: Restriction
  on property: enabled by
  some values from: HSD17B12
type: Restriction
  on property: enabled by
  some values from: HSD17B12
type: Restriction
  on property: enabled by
  some values from: HSD17B12
type: Restriction
  on property: enabled by
  some values from: HSD17B12
type: Restriction
  on property: enabled by
  some values from: HSD17B12
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0016509
BFO_0000050: Pathway1159

3-hydroxyoctadecanoyl-CoA => trans-octadec-2-enoyl-CoA + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0016508
BFO_0000050: Pathway1159

trans-octadec-2-enoyl-CoA + NADPH + H+ => stearoyl-CoA + NADP+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: GPSN2
type: Restriction
  on property: enabled by
  some values from: GPSN2
type: Restriction
  on property: enabled by
  some values from: GPSN2
type: Restriction
  on property: enabled by
  some values from: GPSN2
type: Restriction
  on property: enabled by
  some values from: GPSN2
type: Restriction
  on property: enabled by
  some values from: GPSN2
type: Restriction
  on property: enabled by
  some values from: GPSN2
type: Restriction
  on property: enabled by
  some values from: GPSN2
type: Restriction
  on property: enabled by
  some values from: GPSN2
type: Restriction
  on property: enabled by
  some values from: GPSN2
type: Restriction
  on property: enabled by
  some values from: GPSN2
type: Restriction
  on property: enabled by
  some values from: GPSN2
type: Restriction
  on property: enabled by
  some values from: GPSN2
type: Restriction
  on property: enabled by
  some values from: GPSN2
type: Restriction
  on property: enabled by
  some values from: GPSN2
type: Restriction
  on property: enabled by
  some values from: GPSN2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0017099
BFO_0000050: Pathway1159

Conversion of Dihydroxyacetone Phosphate to Glycerol -3- phosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004367
BFO_0000050: Pathway1157
BFO_0000050: Pathway1195
directly activates: Conversion of glycerol-3-phosphate to lysophosphatidic acid
directly activates: G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM)
directly activates: Catalysis2114
directly activates: Catalysis2115
directly activates: Catalysis2301
label: DHAP is converted to G3P by GPD1/GPD1L

Conversion of Glycerol to Glycerol-3-phosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: GK
type: Restriction
  on property: enabled by
  some values from: GK
type: Restriction
  on property: enabled by
  some values from: GK
type: Restriction
  on property: enabled by
  some values from: GK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004370
BFO_0000050: Pathway1157
directly activates: Conversion of glycerol-3-phosphate to lysophosphatidic acid
directly activates: G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM)
directly activates: Catalysis2114
directly activates: Catalysis2115
directly activates: Catalysis2301

Conversion of glycerol-3-phosphate to lysophosphatidic acid
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: AGPAT6
type: Restriction
  on property: enabled by
  some values from: AGPAT6
type: Restriction
  on property: enabled by
  some values from: AGPAT6
type: Restriction
  on property: enabled by
  some values from: AGPAT6
type: Restriction
  on property: enabled by
  some values from: AGPAT6
type: Restriction
  on property: enabled by
  some values from: AGPAT6
type: Restriction
  on property: enabled by
  some values from: AGPAT6
type: Restriction
  on property: enabled by
  some values from: AGPAT6
type: Restriction
  on property: enabled by
  some values from: AGPAT6
type: Restriction
  on property: enabled by
  some values from: AGPAT6
type: Restriction
  on property: enabled by
  some values from: AGPAT6
type: Restriction
  on property: enabled by
  some values from: AGPAT6
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004366
BFO_0000050: Pathway1157
BFO_0000050: Pathway1195
directly activates: 1-acyl LPA is acylated to PA by AGPAT (LPAAT)
directly activates: Catalysis2116
label: G3P is acylated to 1-acyl LPA by AGPAT6
label: glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [ER membrane-associated]

Conversion of glycerol-3-phosphate to lysophosphatidic acid
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: GO_0004366
BFO_0000050: Pathway1157
directly activates: 1-acyl LPA is acylated to PA by AGPAT (LPAAT)
directly activates: Catalysis2116
label: glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated]

1-acyl LPA is acylated to PA by AGPAT (LPAAT)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0003841
BFO_0000050: Pathway1157
BFO_0000050: Pathway1195
directly activates: 1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate
directly activates: PA is hydrolysed to 1-acyl LPA by PLA2[1]
directly activates: PA is hydrolysed to 1-acyl LPA by PLA2G2A
directly activates: PA is dephosphorylated to DAG by LPIN
directly activates: PA is converted to CDP-DAG by CDS1
directly activates: Catalysis2117
directly activates: Catalysis2299
directly activates: Catalysis2300
directly activates: Catalysis2315
directly activates: Catalysis2355
label: 1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH
label: lysophosphatidic acid + fatty acyl CoA => phosphatidic acid + CoA (1)

1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0008195
BFO_0000050: Pathway1157
directly activates: 1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1]
directly activates: 1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2]
directly activates: Catalysis2118
directly activates: Catalysis2119
label: Conversion of Phosphatidic Acid to Diacylglycerol

1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004144
BFO_0000050: Pathway1157
label: Conversion of Diacylglycerol to Triacylglycerol [DGAT1]

1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: DGAT2
type: Restriction
  on property: enabled by
  some values from: DGAT2
type: Restriction
  on property: enabled by
  some values from: DGAT2
type: Restriction
  on property: enabled by
  some values from: DGAT2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004144
BFO_0000050: Pathway1157
label: Conversion of Diacylglycerol to Triacylglycerol [DGAT2]

CPT1 converts palmitoyl-CoA to palmitoyl carnitine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: GO_0004095
BFO_0000050: Pathway1160
directly activates: Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane
directly activates: Catalysis2121
label: palmitoyl-CoA + carnitine => palmitoylcarnitine + CoASH

Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: enabled by
  some values from: CAC
type: Restriction
  on property: enabled by
  some values from: CAC
type: Restriction
  on property: enabled by
  some values from: CAC
type: Restriction
  on property: enabled by
  some values from: CAC
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: GO_0015227
BFO_0000050: Pathway1160
directly activates: CPT2 converts palmitoyl carnitine to palmitoyl-CoA
directly activates: Catalysis2122

CPT2 converts palmitoyl carnitine to palmitoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: enabled by
  some values from: CPT1
type: Restriction
  on property: enabled by
  some values from: CPT1
type: Restriction
  on property: enabled by
  some values from: CPT1
type: Restriction
  on property: enabled by
  some values from: CPT1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: GO_0004095
BFO_0000050: Pathway1160
directly activates: Pathway1163
label: palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine

Formation of Malonyl-CoA from Acetyl-CoA (muscle)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003989
BFO_0000050: Pathway1160

pAMPK inactivates ACC2 inhibiting malonyl-CoA synthesis
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004679
BFO_0000050: Pathway1160

palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0003995
BFO_0000050: Pathway1163
directly activates: trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA
directly activates: BiochemicalReaction5426
directly activates: Catalysis2126
directly activates: Catalysis2622

trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004300
BFO_0000050: Pathway1163
directly activates: (S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H
directly activates: Catalysis2127

(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0003857
BFO_0000050: Pathway1163
directly activates: 3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA
directly activates: BiochemicalReaction5424
directly activates: Catalysis2128
directly activates: Catalysis2620

3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0050633
BFO_0000050: Pathway1163
directly activates: myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2
directly activates: Catalysis2129

myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0003995
BFO_0000050: Pathway1164
directly activates: trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA
directly activates: BiochemicalReaction5426
directly activates: Catalysis2130
directly activates: Catalysis2622

trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004300
BFO_0000050: Pathway1164
directly activates: (S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H
directly activates: Catalysis2131

(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0003857
BFO_0000050: Pathway1164
directly activates: 3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA
directly activates: BiochemicalReaction5424
directly activates: Catalysis2132
directly activates: Catalysis2620

3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0050633
BFO_0000050: Pathway1164
directly activates: lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2
directly activates: Catalysis2133

lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0003995
BFO_0000050: Pathway1165
directly activates: 2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA
directly activates: BiochemicalReaction5426
directly activates: Catalysis2134
directly activates: Catalysis2622

2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004300
BFO_0000050: Pathway1165
directly activates: (S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H
directly activates: Catalysis2135

(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0003857
BFO_0000050: Pathway1165
directly activates: 3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA
directly activates: BiochemicalReaction5424
directly activates: Catalysis2136
directly activates: Catalysis2620

3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0050633
BFO_0000050: Pathway1165
directly activates: Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2
directly activates: Catalysis2137

Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0003995
BFO_0000050: Pathway1166
directly activates: trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA
directly activates: BiochemicalReaction5426
directly activates: Catalysis2138
directly activates: Catalysis2622

trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004300
BFO_0000050: Pathway1166
directly activates: (S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H
directly activates: Catalysis2139

(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0003857
BFO_0000050: Pathway1166
directly activates: 3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA
directly activates: BiochemicalReaction5424
directly activates: Catalysis2140
directly activates: Catalysis2620

3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0050633
BFO_0000050: Pathway1166
directly activates: Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2
directly activates: Catalysis2141

Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0003995
BFO_0000050: Pathway1167
directly activates: trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA
directly activates: BiochemicalReaction5426
directly activates: Catalysis2142
directly activates: Catalysis2622

trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004300
BFO_0000050: Pathway1167
directly activates: (S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H
directly activates: Catalysis2143

(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0003857
BFO_0000050: Pathway1167
directly activates: 3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA
directly activates: BiochemicalReaction5424
directly activates: Catalysis2144
directly activates: Catalysis2620

3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0050633
BFO_0000050: Pathway1167
directly activates: Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2
directly activates: Catalysis2145

Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0003995
BFO_0000050: Pathway1168
directly activates: trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA
directly activates: BiochemicalReaction5426
directly activates: Catalysis2146
directly activates: Catalysis2622

trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004300
BFO_0000050: Pathway1168
directly activates: (S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H
directly activates: Catalysis2147

(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0003857
BFO_0000050: Pathway1168
directly activates: 3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA
directly activates: BiochemicalReaction5424
directly activates: Catalysis2148
directly activates: Catalysis2620

3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0050633
BFO_0000050: Pathway1168
directly activates: Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2
directly activates: Catalysis2149

Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0003995
BFO_0000050: Pathway1169
directly activates: Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA
directly activates: BiochemicalReaction5426
directly activates: Catalysis2150
directly activates: Catalysis2622

Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004300
BFO_0000050: Pathway1169
directly activates: (S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H
directly activates: Catalysis2151

(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0003857
BFO_0000050: Pathway1169
directly activates: BiochemicalReaction5424
directly activates: Catalysis2620

Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0003857
type: GO_0003995
type: GO_0004300
type: GO_0006635
type: GO_0050633
BFO_0000050: Pathway1170
directly activates: Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA
directly activates: BiochemicalReaction5424
directly activates: BiochemicalReaction5425
directly activates: Catalysis2156
directly activates: Catalysis2620
directly activates: Catalysis2621

Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004165
BFO_0000050: Pathway1170
directly activates: Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA
directly activates: Catalysis2157
directly activates: Catalysis2158
directly activates: Catalysis2159
directly activates: Catalysis2160

Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0003857
type: GO_0003995
type: GO_0004300
type: GO_0006635
type: GO_0050633
BFO_0000050: Pathway1170
directly activates: dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA
directly activates: BiochemicalReaction5424
directly activates: BiochemicalReaction5425
directly activates: Catalysis2161
directly activates: Catalysis2620
directly activates: Catalysis2621

dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0003995
type: GO_0006635
BFO_0000050: Pathway1170
directly activates: Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA
directly activates: BiochemicalReaction5425
directly activates: Catalysis2162
directly activates: Catalysis2621

Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0006635
type: GO_0016651
BFO_0000050: Pathway1170
directly activates: Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA
directly activates: Catalysis2163

Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0006635
type: GO_0016860
BFO_0000050: Pathway1170
directly activates: trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA
directly activates: Catalysis2138

propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004658
BFO_0000050: Pathway1171
directly activates: D-methylmalonyl-CoA <=> L-methylmalonyl-CoA
directly activates: Catalysis2165

D-methylmalonyl-CoA <=> L-methylmalonyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: MCEE
type: Restriction
  on property: enabled by
  some values from: MCEE
type: Restriction
  on property: enabled by
  some values from: MCEE
type: Restriction
  on property: enabled by
  some values from: MCEE
type: Restriction
  on property: enabled by
  some values from: MCEE
type: Restriction
  on property: enabled by
  some values from: MCEE
type: Restriction
  on property: enabled by
  some values from: MCEE
type: Restriction
  on property: enabled by
  some values from: MCEE
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004493
BFO_0000050: Pathway1171
directly activates: L-methylmalonyl-CoA <=> succinyl-CoA
directly activates: Catalysis2166

L-methylmalonyl-CoA <=> succinyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004494
BFO_0000050: Pathway1171
directly activates: BiochemicalReaction5414
directly activates: BiochemicalReaction5415
directly activates: Catalysis2610
directly activates: Catalysis2611
label: MUT transfers adenosyl group from AdoCbl to L-MM-CoA

2 acetyl-CoA <=> acetoacetyl-CoA + CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0003985
BFO_0000050: Pathway1173
directly activates: acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH
directly activates: Catalysis2168

acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: HMGCS2
type: Restriction
  on property: enabled by
  some values from: HMGCS2
type: Restriction
  on property: enabled by
  some values from: HMGCS2
type: Restriction
  on property: enabled by
  some values from: HMGCS2
type: Restriction
  on property: enabled by
  some values from: HMGCS2
type: Restriction
  on property: enabled by
  some values from: HMGCS2
type: Restriction
  on property: enabled by
  some values from: HMGCS2
type: Restriction
  on property: enabled by
  some values from: HMGCS2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004421
BFO_0000050: Pathway1173
directly activates: HMG CoA => acetoacetic acid + acetyl CoA
directly activates: Catalysis2169

HMG CoA => acetoacetic acid + acetyl CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004419
BFO_0000050: Pathway1173
directly activates: Reduction of Acetoacetate to beta-Hydroxybutyrate
directly activates: Catalysis2170

Reduction of Acetoacetate to beta-Hydroxybutyrate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0003858
BFO_0000050: Pathway1173
label: acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+

D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0003858
BFO_0000050: Pathway1174
directly activates: acetoacetate + succinyl-CoA <=> acetoacetyl-CoA + succinate
directly activates: Catalysis2172

acetoacetate + succinyl-CoA <=> acetoacetyl-CoA + succinate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0008260
BFO_0000050: Pathway1174
directly activates: acetoacetyl-CoA + CoA <=> 2 acetyl-CoA
directly activates: Catalysis2173

acetoacetyl-CoA + CoA <=> 2 acetyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0003985
BFO_0000050: Pathway1174

Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: enabled by
  some values from: GPD2
type: Restriction
  on property: enabled by
  some values from: GPD2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: GO_0004368
BFO_0000050: Pathway1156

Formation of PPARA:RXRA Heterodimer at Promoters of Target Genes
type: GO_0003674
BFO_0000050: Pathway1175
directly activates: Recruitment of Corepressors by PPARA:RXRA Heterodimer

Recruitment of Corepressors by PPARA:RXRA Heterodimer
type: GO_0003674
BFO_0000050: Pathway1175
directly activates: Activation of PPARA by Fatty Acid Ligands

Activation of PPARA by Fatty Acid Ligands
type: GO_0003674
BFO_0000050: Pathway1175
directly activates: Expression of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase (HMGCR)
directly activates: Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase)
directly activates: Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1)
directly activates: Control390
directly activates: Control391
directly activates: Control395
directly activates: Control396
directly activates: Control397
directly activates: Control398
directly activates: Pathway1176
directly activates: TemplateReaction110
directly activates: TemplateReaction111
directly activates: TemplateReaction112
directly activates: TemplateReaction113
directly activates: TemplateReaction114
directly activates: TemplateReaction115
directly activates: TemplateReaction117
directly activates: TemplateReaction118
directly activates: TemplateReaction119
directly activates: TemplateReaction120
directly activates: TemplateReaction121
directly activates: TemplateReaction122
directly activates: TemplateReaction123
directly activates: TemplateReaction124
directly activates: TemplateReaction125
directly activates: TemplateReaction126
directly activates: TemplateReaction127
directly activates: TemplateReaction128
directly activates: TemplateReaction129
directly activates: TemplateReaction130
directly activates: TemplateReaction131
directly activates: TemplateReaction132
directly activates: TemplateReaction133
directly activates: TemplateReaction134
directly activates: TemplateReaction135
directly activates: TemplateReaction136
directly activates: TemplateReaction137
directly activates: TemplateReaction138
directly activates: TemplateReaction139
directly activates: TemplateReaction140
directly activates: TemplateReaction141
directly activates: TemplateReaction142
directly activates: TemplateReaction143
directly activates: TemplateReaction27
directly activates: TemplateReactionRegulation131
directly activates: TemplateReactionRegulation132
directly activates: TemplateReactionRegulation133
directly activates: TemplateReactionRegulation134
directly activates: TemplateReactionRegulation135
directly activates: TemplateReactionRegulation136
directly activates: TemplateReactionRegulation137
directly activates: TemplateReactionRegulation140
directly activates: TemplateReactionRegulation141
directly activates: TemplateReactionRegulation142
directly activates: TemplateReactionRegulation143
directly activates: TemplateReactionRegulation144
directly activates: TemplateReactionRegulation145
directly activates: TemplateReactionRegulation146
directly activates: TemplateReactionRegulation147
directly activates: TemplateReactionRegulation148
directly activates: TemplateReactionRegulation149
directly activates: TemplateReactionRegulation150
directly activates: TemplateReactionRegulation151
directly activates: TemplateReactionRegulation152
directly activates: TemplateReactionRegulation153
directly activates: TemplateReactionRegulation154
directly activates: TemplateReactionRegulation155
directly activates: TemplateReactionRegulation156
directly activates: TemplateReactionRegulation157
directly activates: TemplateReactionRegulation158
directly activates: TemplateReactionRegulation159
directly activates: TemplateReactionRegulation160
directly activates: TemplateReactionRegulation161
directly activates: TemplateReactionRegulation162
directly activates: TemplateReactionRegulation163
directly activates: TemplateReactionRegulation164
directly activates: TemplateReactionRegulation165
directly activates: TemplateReactionRegulation166

Expression of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase (HMGCR)
type: GO_0003674
BFO_0000050: Pathway1176
BFO_0000050: Pathway1185

Expression of 5-aminolevulinate synthase 1
type: GO_0003674
BFO_0000050: Pathway1176
label: Expression of ALAS1

Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase)
type: GO_0003674
BFO_0000050: Pathway1176
BFO_0000050: Pathway1185

Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1)
type: GO_0003674
BFO_0000050: Pathway1176
BFO_0000050: Pathway1185

PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: Restriction
  on property: enabled by
  some values from: PMP34
type: Restriction
  on property: enabled by
  some values from: PMP34
type: Restriction
  on property: enabled by
  some values from: PMP34
type: Restriction
  on property: enabled by
  some values from: PMP34
type: GO_0000295
BFO_0000050: Pathway1178
directly activates: phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate
directly activates: pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate
directly activates: Catalysis2176
directly activates: Catalysis2180

phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: GO_0050197
BFO_0000050: Pathway1178
directly activates: PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP
directly activates: phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2
directly activates: Catalysis2175
directly activates: Catalysis2177

phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0048244
BFO_0000050: Pathway1178
directly activates: 2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA
directly activates: Catalysis2178

2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0016830
BFO_0000050: Pathway1178
directly activates: formyl-CoA + H2O => formate + CoASH
directly activates: pristanal + NAD+ => pristanate + NADH + H+
directly activates: Catalysis2179

formyl-CoA + H2O => formate + CoASH
type: GO_0003674
BFO_0000050: Pathway1178

pristanal + NAD+ => pristanate + NADH + H+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0004029
BFO_0000050: Pathway1178
directly activates: pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate
directly activates: Catalysis2180

pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: GO_0070251
BFO_0000050: Pathway1178
directly activates: Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA
directly activates: Catalysis2181

Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: enabled by
  some values from: AMACR
type: Restriction
  on property: enabled by
  some values from: AMACR
type: Restriction
  on property: enabled by
  some values from: AMACR
type: Restriction
  on property: enabled by
  some values from: AMACR
type: GO_0008111
BFO_0000050: Pathway1179
directly activates: (2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX2)
directly activates: (2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3)
directly activates: Catalysis2182
directly activates: Catalysis2183

(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX2)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0016402
BFO_0000050: Pathway1179
directly activates: trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA
directly activates: Catalysis2184

(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0016402
BFO_0000050: Pathway1179
directly activates: trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA
directly activates: Catalysis2184

trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0016508
BFO_0000050: Pathway1179
directly activates: 3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+
directly activates: Catalysis2185

3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0003857
BFO_0000050: Pathway1179
directly activates: 3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA
directly activates: Catalysis2186

3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: enabled by
  some values from: SCP2
type: Restriction
  on property: enabled by
  some values from: SCP2
type: Restriction
  on property: enabled by
  some values from: SCP2
type: Restriction
  on property: enabled by
  some values from: SCP2
type: GO_0050632
BFO_0000050: Pathway1179
directly activates: 4,8,12-trimethyltridecanoyl-CoA + 2 O2 + 2 H2O + 2 NAD+ + 2 CoASH => 4,8-dimethylnonanoyl-CoA + 2 H2O2 + 2 NADH + 2 H+ + acetyl-CoA + propionyl-CoA
directly activates: propionyl-CoA + carnitine => propionylcarnitine + CoASH
directly activates: Catalysis2190

4,8,12-trimethyltridecanoyl-CoA + 2 O2 + 2 H2O + 2 NAD+ + 2 CoASH => 4,8-dimethylnonanoyl-CoA + 2 H2O2 + 2 NADH + 2 H+ + acetyl-CoA + propionyl-CoA
type: GO_0003674
BFO_0000050: Pathway1179
directly activates: 4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH
directly activates: acetyl-CoA + carnitine => acetylcarnitine + CoASH
directly activates: acetyl-CoA + H2O => acetate + CoASH
directly activates: propionyl-CoA + carnitine => propionylcarnitine + CoASH
directly activates: Catalysis2187
directly activates: Catalysis2188
directly activates: Catalysis2189
directly activates: Catalysis2190

4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: enabled by
  some values from: COT
type: Restriction
  on property: enabled by
  some values from: COT
type: Restriction
  on property: enabled by
  some values from: COT
type: Restriction
  on property: enabled by
  some values from: COT
type: GO_0008458
BFO_0000050: Pathway1179

acetyl-CoA + carnitine => acetylcarnitine + CoASH
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: enabled by
  some values from: CAT1
type: Restriction
  on property: enabled by
  some values from: CAT1
type: Restriction
  on property: enabled by
  some values from: CAT1
type: Restriction
  on property: enabled by
  some values from: CAT1
type: Restriction
  on property: enabled by
  some values from: CAT1
type: Restriction
  on property: enabled by
  some values from: CAT1
type: Restriction
  on property: enabled by
  some values from: CAT1
type: Restriction
  on property: enabled by
  some values from: CAT1
type: GO_0004092
BFO_0000050: Pathway1179
BFO_0000050: Pathway1180

acetyl-CoA + H2O => acetate + CoASH
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: enabled by
  some values from: ACOT8
type: Restriction
  on property: enabled by
  some values from: ACOT8
type: Restriction
  on property: enabled by
  some values from: ACOT8
type: Restriction
  on property: enabled by
  some values from: ACOT8
type: Restriction
  on property: enabled by
  some values from: ACOT8
type: Restriction
  on property: enabled by
  some values from: ACOT8
type: Restriction
  on property: enabled by
  some values from: ACOT8
type: Restriction
  on property: enabled by
  some values from: ACOT8
type: GO_0003986
BFO_0000050: Pathway1179
BFO_0000050: Pathway1180

propionyl-CoA + carnitine => propionylcarnitine + CoASH
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: enabled by
  some values from: CAT1
type: Restriction
  on property: enabled by
  some values from: CAT1
type: Restriction
  on property: enabled by
  some values from: CAT1
type: Restriction
  on property: enabled by
  some values from: CAT1
type: GO_0004092
BFO_0000050: Pathway1179

Peroxisomal uptake of very long-chain fatty acyl CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: GO_0005325
BFO_0000050: Pathway1180
directly activates: hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2
directly activates: Catalysis2192

hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0003997
BFO_0000050: Pathway1180
directly activates: trans-2,3-dehydrohexacosanoyl-CoA + H2O => 3-hydroxyhexacosanoyl-CoA
directly activates: Catalysis2193

trans-2,3-dehydrohexacosanoyl-CoA + H2O => 3-hydroxyhexacosanoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0016508
BFO_0000050: Pathway1180
directly activates: 3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+
directly activates: Catalysis2194

3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0003857
BFO_0000050: Pathway1180
directly activates: 3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA
directly activates: Catalysis2195

3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: enabled by
  some values from: ACAA
type: Restriction
  on property: enabled by
  some values from: ACAA
type: Restriction
  on property: enabled by
  some values from: ACAA
type: Restriction
  on property: enabled by
  some values from: ACAA
type: GO_0003988
BFO_0000050: Pathway1180
directly activates: acetyl-CoA + carnitine => acetylcarnitine + CoASH
directly activates: acetyl-CoA + H2O => acetate + CoASH
directly activates: tetracosenoyl-CoA + 8 O2 + 8 H2O + 8 NAD+ + 8 CoASH => octanoyl-CoA + 8 H2O2 + 8 NADH + 8 H+ + 8 acetyl-CoA
directly activates: Catalysis2188
directly activates: Catalysis2189

tetracosenoyl-CoA + 8 O2 + 8 H2O + 8 NAD+ + 8 CoASH => octanoyl-CoA + 8 H2O2 + 8 NADH + 8 H+ + 8 acetyl-CoA
type: GO_0003674
BFO_0000050: Pathway1180
directly activates: acetyl-CoA + carnitine => acetylcarnitine + CoASH
directly activates: acetyl-CoA + H2O => acetate + CoASH
directly activates: Catalysis2188
directly activates: Catalysis2189

palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: enabled by
  some values from: FAR1
type: Restriction
  on property: enabled by
  some values from: FAR1
type: Restriction
  on property: enabled by
  some values from: FAR1
type: Restriction
  on property: enabled by
  some values from: FAR1
type: GO_0016491
BFO_0000050: Pathway1181
directly activates: 1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate
directly activates: Catalysis2199

palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: enabled by
  some values from: FAR2
type: Restriction
  on property: enabled by
  some values from: FAR2
type: Restriction
  on property: enabled by
  some values from: FAR2
type: Restriction
  on property: enabled by
  some values from: FAR2
type: GO_0016491
BFO_0000050: Pathway1181
directly activates: 1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate
directly activates: Catalysis2199

palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0016287
BFO_0000050: Pathway1181
directly activates: 1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate
directly activates: Catalysis2199

1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0008609
BFO_0000050: Pathway1181
directly activates: Movement of O-hexadecylglycerone phosphate from the peroxisomal matrix to the cytosol

Movement of O-hexadecylglycerone phosphate from the peroxisomal matrix to the cytosol
type: GO_0003674
BFO_0000050: Pathway1181
directly activates: Conversion of acylated DHAP to lysophosphatidic acid acid
directly activates: Catalysis2200

Conversion of acylated DHAP to lysophosphatidic acid acid
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: GO_0000140
BFO_0000050: Pathway1181
directly activates: 1-acyl LPA is acylated to PA by AGPAT (LPAAT)
directly activates: Catalysis2116
label: O-hexadecylglycerone phosphate + NADPH + H+ => 1-hexadecyl glycerol-3-phosphate + NADP+

isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0004450
BFO_0000050: Pathway1182
directly activates: phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2
directly activates: Exchange of isocitrate and 2-oxoglutarate across the peroxisomal membrane
directly activates: Catalysis2177
directly activates: Catalysis2203

isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004450
BFO_0000050: Pathway1182

Exchange of isocitrate and 2-oxoglutarate across the peroxisomal membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: GO_0046943
BFO_0000050: Pathway1182
directly activates: isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+
directly activates: Catalysis2201

malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: enabled by
  some values from: MLYCD
type: Restriction
  on property: enabled by
  some values from: MLYCD
type: GO_0006637
type: GO_0050080
BFO_0000050: Pathway1177

Condensation of acetyl CoA with acetoacetyl CoA to form HMG-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: HMGCS
type: Restriction
  on property: enabled by
  some values from: HMGCS
type: GO_0004421
BFO_0000050: Pathway1183
directly activates: Reduction of HMG-CoA produces mevalonate
directly activates: Catalysis2206

Reduction of HMG-CoA produces mevalonate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004420
BFO_0000050: Pathway1183
directly activates: Mevalonate is phosphorylated to mevalonate-5-phosphate
directly activates: Catalysis2207

Mevalonate is phosphorylated to mevalonate-5-phosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004496
BFO_0000050: Pathway1183
directly activates: Mevalonate-5-phosphate is further phosphorylated.
directly activates: Catalysis2208

Mevalonate-5-phosphate is further phosphorylated.
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: PMKI
type: Restriction
  on property: enabled by
  some values from: PMKI
type: GO_0004631
BFO_0000050: Pathway1183
directly activates: Mevalonate-5-pyrophosphate is decarboxylated
directly activates: Catalysis2209

Mevalonate-5-pyrophosphate is decarboxylated
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004163
BFO_0000050: Pathway1183
directly activates: Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate
directly activates: Catalysis2210

Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004452
BFO_0000050: Pathway1183
directly activates: Addition of isopentenyl pyrophosphate to DMAPP
directly activates: Catalysis2211

Addition of isopentenyl pyrophosphate to DMAPP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004161
BFO_0000050: Pathway1183
directly activates: Another isopentenyl pyrophosphate is added to geranyl pyrophosphate
directly activates: Catalysis2212

Another isopentenyl pyrophosphate is added to geranyl pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004337
BFO_0000050: Pathway1183
directly activates: Two FPP molecules dimerize to form presqualene diphosphate
directly activates: Catalysis2213

Two FPP molecules dimerize to form presqualene diphosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004310
BFO_0000050: Pathway1183
directly activates: Reduction of presqualene diphosphate to form squalene
directly activates: Catalysis2214

Reduction of presqualene diphosphate to form squalene
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004310
BFO_0000050: Pathway1183
directly activates: Squalene is oxidized to its epoxide
directly activates: Catalysis2215

Squalene is oxidized to its epoxide
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004506
BFO_0000050: Pathway1183
directly activates: Squalene 2,3-epoxide cyclizes, forming lanosterol
directly activates: Catalysis2216

Squalene 2,3-epoxide cyclizes, forming lanosterol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: LSS
type: Restriction
  on property: enabled by
  some values from: LSS
type: GO_0000250
BFO_0000050: Pathway1183
directly activates: Lanosterol is oxidatively demethylated to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol
directly activates: Catalysis2217

Lanosterol is oxidatively demethylated to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: CYP51
type: Restriction
  on property: enabled by
  some values from: CYP51
type: GO_0008398
BFO_0000050: Pathway1183
directly activates: 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol + NADPH + H+ => 4,4-dimethylcholesta-8(9),24-dien-3beta-ol + NADP+ [LBR]
directly activates: 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol + NADPH + H+ => 4,4-dimethylcholesta-8(9),24-dien-3beta-ol + NADP+ [TM7SF2]
directly activates: Catalysis2218
directly activates: Catalysis2219
label: lanosterol + 3 NADPH + 3 H+ + 3 O2 => 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol + 3 NADP+ + 4 H2O + formate

4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol + NADPH + H+ => 4,4-dimethylcholesta-8(9),24-dien-3beta-ol + NADP+ [LBR]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005635
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005635
type: Restriction
  on property: enabled by
  some values from: LBR
type: Restriction
  on property: enabled by
  some values from: LBR
type: GO_0050613
BFO_0000050: Pathway1183
directly activates: 4,4-dimethylcholesta-8(9),24-dien-3beta-ol + 3 NADPH + 3 H+ + 3 O2 => 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol + 3 NADP+ + 4 H2O
directly activates: Catalysis2220
label: 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR]

4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol + NADPH + H+ => 4,4-dimethylcholesta-8(9),24-dien-3beta-ol + NADP+ [TM7SF2]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: ANG1
type: Restriction
  on property: enabled by
  some values from: ANG1
type: GO_0050613
BFO_0000050: Pathway1183
directly activates: 4,4-dimethylcholesta-8(9),24-dien-3beta-ol + 3 NADPH + 3 H+ + 3 O2 => 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol + 3 NADP+ + 4 H2O
directly activates: Catalysis2220
label: 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2]

4,4-dimethylcholesta-8(9),24-dien-3beta-ol + 3 NADPH + 3 H+ + 3 O2 => 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol + 3 NADP+ + 4 H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: DESP4
type: Restriction
  on property: enabled by
  some values from: DESP4
type: GO_0000254
BFO_0000050: Pathway1183
directly activates: 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol + NAD+ => 4-methylcholesta-8(9),24-dien-3-one + CO2 + NADH + H+
directly activates: Catalysis2221
label: 4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol

4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol + NAD+ => 4-methylcholesta-8(9),24-dien-3-one + CO2 + NADH + H+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: H105E3
type: Restriction
  on property: enabled by
  some values from: H105E3
type: GO_0000252
BFO_0000050: Pathway1183
directly activates: 4-methylcholesta-8(9),24-dien-3-one + NADPH + H+ => 4-methylcholesta-8(9),24-dien-3beta-ol + NADP+
directly activates: Catalysis2222
label: 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one

4-methylcholesta-8(9),24-dien-3-one + NADPH + H+ => 4-methylcholesta-8(9),24-dien-3beta-ol + NADP+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: HSD17B7
type: Restriction
  on property: enabled by
  some values from: HSD17B7
type: GO_0000253
BFO_0000050: Pathway1183
directly activates: 4-methylcholesta-8(9),24-dien-3beta-ol + 3 NADPH + 3 H+ + 3 O2 => 4-carboxycholesta-8(9),24-dien-3beta-ol + 3 NADP+ + 4 H2O
directly activates: Catalysis2223
label: 4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol

4-methylcholesta-8(9),24-dien-3beta-ol + 3 NADPH + 3 H+ + 3 O2 => 4-carboxycholesta-8(9),24-dien-3beta-ol + 3 NADP+ + 4 H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: DESP4
type: Restriction
  on property: enabled by
  some values from: DESP4
type: GO_0000254
BFO_0000050: Pathway1183
directly activates: 4-carboxycholesta-8(9),24-dien-3beta-ol + NAD+ => cholesta-8(9),24-dien-3-one (zymosterone) + CO2 + NADH + H+
directly activates: Catalysis2224
label: 4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol

4-carboxycholesta-8(9),24-dien-3beta-ol + NAD+ => cholesta-8(9),24-dien-3-one (zymosterone) + CO2 + NADH + H+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: H105E3
type: Restriction
  on property: enabled by
  some values from: H105E3
type: GO_0000252
BFO_0000050: Pathway1183
directly activates: Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol)
directly activates: Catalysis2225
label: 4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone)

Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: HSD17B7
type: Restriction
  on property: enabled by
  some values from: HSD17B7
type: GO_0000253
BFO_0000050: Pathway1183
directly activates: Zymosterol => cholesta-7,24-dien-3beta-ol
directly activates: Catalysis2226
label: zymosterone (cholesta-8(9),24-dien-3-one) + NADPH + H+ => zymosterol (cholesta-8(9),24-dien-3beta-ol) + NADP+

Zymosterol => cholesta-7,24-dien-3beta-ol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: EBP
type: Restriction
  on property: enabled by
  some values from: EBP
type: GO_0004769
BFO_0000050: Pathway1183
directly activates: Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol
directly activates: Catalysis2227
label: Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol

Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: SC5D
type: Restriction
  on property: enabled by
  some values from: SC5D
type: GO_0000248
BFO_0000050: Pathway1183
directly activates: Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol
directly activates: Catalysis2228
label: cholesta-7,24-dien-3beta-ol + NADPH + H+ + O2 => cholesta-5,7,24-trien-3beta-ol + NADP+ + 2 H2O

Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: D7SR
type: Restriction
  on property: enabled by
  some values from: D7SR
type: GO_0047598
BFO_0000050: Pathway1183
directly activates: Reduction of desmosterol to cholesterol
directly activates: Catalysis2229
label: cholesta-5,7,24-trien-3beta-ol + NADPH + H+ => desmosterol + NADP+

Reduction of desmosterol to cholesterol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: DHCR24
type: Restriction
  on property: enabled by
  some values from: DHCR24
type: GO_0050614
BFO_0000050: Pathway1183
label: desmosterol + NADPH + H+ => cholesterol + NADP+

SREBF1A/1C/2 is retained in the endoplasmic reticulum by SCAP:cholesterol:INSIG
type: GO_0003674
BFO_0000050: Pathway1184
label: SREBP1A/1C/2 is retained in the endoplasmic reticulum by SCAP:cholesterol:INSIG

SREBF1A/1C/2 is retained in the endoplasmic reticulum by SCAP:INSIG:oxysterol
type: GO_0003674
BFO_0000050: Pathway1184
label: SREBP1A/1C/2 is retained in the endoplasmic reticulum by SCAP:INSIG:oxysterol

SREBF1A/1C/2:SCAP Binds CopII Coat Complex
type: GO_0003674
BFO_0000050: Pathway1184
directly activates: SREBF1A/1C/2:SCAP Transits to the Golgi
label: SREBP1A/1C/2:SCAP Binds CopII Coat Complex

SREBF1A/1C/2:SCAP Transits to the Golgi
type: GO_0003674
BFO_0000050: Pathway1184
directly activates: S1P Cleaves SREBF1A/1C/2
directly activates: Catalysis2230
label: SREBP1A/1C/2:SCAP Transits to the Golgi

S1P Cleaves SREBF1A/1C/2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: KIAA0091
type: Restriction
  on property: enabled by
  some values from: KIAA0091
type: GO_0004252
BFO_0000050: Pathway1184
directly activates: S2P Cleaves SREBF1A/1C/2
directly activates: Catalysis2231
label: S1P Cleaves SREBP1A/1C/2
label: SKI-1 Cleaves SREBP1A/1C/2

S2P Cleaves SREBF1A/1C/2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: MBTPS2
type: Restriction
  on property: enabled by
  some values from: MBTPS2
type: GO_0008237
BFO_0000050: Pathway1184
directly activates: SREBF1A/1C/2 Dimerizes
label: S2P Cleaves SREBP1A/1C/2

SREBF1A/1C/2 Dimerizes
type: GO_0003674
BFO_0000050: Pathway1184
directly activates: SREBF1A/1C/2 Binds Importin beta-1
label: SREBP1A/1C/2 Dimerizes

SREBF1A/1C/2 Binds Importin beta-1
type: GO_0003674
BFO_0000050: Pathway1184
directly activates: SREBF1A/1C/2 Transits to the Nucleus
directly activates: SREBF1A/2 Binds the PMVK Promoter
label: SREBP1A/1C/2 Binds Importin beta-1

SREBF1A/1C/2 Transits to the Nucleus
type: GO_0003674
BFO_0000050: Pathway1184
directly activates: SREBF1A/1C/2 Dissociates from Importin beta-1
label: SREBP1A/1C/2 Transits to the Nucleus

SREBF1A/1C/2 Dissociates from Importin beta-1
type: GO_0003674
BFO_0000050: Pathway1184
directly activates: SREBF1A/1C Binds the ACACA Promoter
directly activates: SREBF1A/1C Binds the ACACB Promoter
directly activates: Formation of SREBF:NF-Y:TM7SF2 gene complex
directly activates: SREBF1A/1C Binds the GPAM Promoter
directly activates: SREBF1A/1C Binds the FASN Promoter
directly activates: SREBF1A/2 Binds the LSS Promoter
directly activates: SREBF1A/2 Binds the MVD Promoter
directly activates: SREBF1A/2 Binds the HMGCR Promoter
directly activates: SREBF1A/2 Binds the SC5DL Promoter
directly activates: SREBF1A/2 Binds the CYP51A1 Promoter
directly activates: SREBF1A/2 Binds the DHCR7 Promoter
directly activates: SREBF1A/2 Binds the GGPS1 Promoter
directly activates: SREBF1A/2 Binds the IDI1 Promoter
directly activates: SREBF1A/2 Binds the MVK Promoter
directly activates: SREBF1A/2 Binds the SQLE Promoter
directly activates: SREBF1A/1C/2 Binds the ELOVL6 Promoter
directly activates: SREBF1A/1C/2 Binds the FDPS Promoter
directly activates: SREBF1A/1C/2 Binds the HMGCS1 Promoter
directly activates: SREBF1A/1C/2 Binds the FDFT1 Promoter
label: SREBP1A/1C/2 Dissociates from Importin beta-1

SREBF1A/1C Binds the ACACA Promoter
type: GO_0003674
BFO_0000050: Pathway1185
directly activates: Expression of Acetyl CoA Carboxylase 1 (ACACA, ACC1)
directly activates: Control400
label: SREBP1A/1C/2 Binds the ACACA Promoter

SREBF1A/1C Binds the ACACB Promoter
type: GO_0003674
BFO_0000050: Pathway1185
directly activates: Expression of Acetyl CoA Carboxylase 2 (ACACB, ACC2)
directly activates: Control401
label: SREBP1A/1C Binds the ACACB Promoter

Formation of SREBF:NF-Y:TM7SF2 gene complex
type: GO_0003674
BFO_0000050: Pathway1185
directly activates: Expression of TM7SF2
directly activates: Control415
label: Formation of SREBP:NF-Y:TM7SF2 gene complex
label: SREBP1A/1C/2 Binds the TM7SF2 Promoter

SREBF1A/1C Binds the GPAM Promoter
type: GO_0003674
BFO_0000050: Pathway1185
directly activates: Expression of Glycerol-3-phosphate Acyltransferase (GPAM, GPAT)
directly activates: Control407
label: SREBP1A/1C Binds the GPAM Promoter

SREBF1A/1C Binds the FASN Promoter
type: GO_0003674
BFO_0000050: Pathway1185
directly activates: Expression of Fatty Acid Synthase (FASN)
directly activates: Control405
label: SREBP1A/1C Binds the FASN Promoter

SREBF1A/2 Binds the LSS Promoter
type: GO_0003674
BFO_0000050: Pathway1185
directly activates: Expression of Lanosterol Synthase (LSS)
directly activates: Control410
label: SREBP1A/2 Binds the LSS Promoter

SREBF1A/2 Binds the MVD Promoter
type: GO_0003674
BFO_0000050: Pathway1185
directly activates: Expression of Diphosphomevalonate Decarboxylase (MVD)
directly activates: Control402
label: SREBP1A/2 Binds the MVD Promoter

SREBF1A/2 Binds the HMGCR Promoter
type: GO_0003674
BFO_0000050: Pathway1185
directly activates: Expression of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase (HMGCR)
directly activates: Control390
directly activates: Control391
label: SREBP1A/2 Binds the HMGCR Promoter

SREBF1A/2 Binds the SC5DL Promoter
type: GO_0003674
BFO_0000050: Pathway1185
directly activates: Expression of Lathosterol Oxidase (SC5D, SC5DL)
directly activates: Control411
label: SREBP1A/2 Binds the SC5DL Promoter

SREBF1A/2 Binds the CYP51A1 Promoter
type: GO_0003674
BFO_0000050: Pathway1185
directly activates: Expression of Lanosterol Demethylase (CYP51A1)
directly activates: Control409
label: SREBP1A/2 Binds the CYP51A1 Promoter

SREBF1A/2 Binds the DHCR7 Promoter
type: GO_0003674
BFO_0000050: Pathway1185
directly activates: Expression of 7-Dehydrocholesterol Reductase (DHCR7)
directly activates: Control399
label: SREBP1A/2 Binds the DHCR7 Promoter

SREBF1A/2 Binds the GGPS1 Promoter
type: GO_0003674
BFO_0000050: Pathway1185
directly activates: Expression of Geranylgeranyl Pyrophosphate Synthase (GGPS1)
directly activates: Control406
label: SREBP1A/2 Binds the GGPS1 Promoter

SREBF1A/2 Binds the IDI1 Promoter
type: GO_0003674
BFO_0000050: Pathway1185
directly activates: Expression of Isopentenyl-diphosphate Delta-isomerase 1 (IDI1)
directly activates: Control408
label: SREBP1A/2 Binds the IDI1 Promoter

SREBF1A/2 Binds the MVK Promoter
type: GO_0003674
BFO_0000050: Pathway1185
directly activates: Expression of Mevalonate Kinase (MVK)
directly activates: Control412
label: SREBP1A/2 Binds the MVK Promoter

SREBF1A/2 Binds the PMVK Promoter
type: GO_0003674
BFO_0000050: Pathway1185
directly activates: Expression of Phosphomevalonate Kinase (PMVK)
directly activates: Control413
label: SREBP1A/2 Binds the PMVK Promoter

SREBF1A/2 Binds the SQLE Promoter
type: GO_0003674
BFO_0000050: Pathway1185
directly activates: Expression of Squalene Monooxygenase (SQLE)
directly activates: Control414
label: SREBP1A/2 Binds the SQLE Promoter

SREBF1A/1C/2 Binds the ELOVL6 Promoter
type: GO_0003674
BFO_0000050: Pathway1185
directly activates: Expression of ELOVL6
directly activates: Control403
label: SREBP1A/1C/2 Binds the ELOVL6 Promoter

SREBF1A/1C/2 Binds the FDPS Promoter
type: GO_0003674
BFO_0000050: Pathway1185
directly activates: Expression of Farnesyl Diphosphate Synthase (FDPS)
directly activates: Control404
label: SREBP1A/1C/2 Binds the FDPS Promoter

SREBF1A/1C/2 Binds the HMGCS1 Promoter
type: GO_0003674
BFO_0000050: Pathway1185
directly activates: Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1)
directly activates: Control397
directly activates: Control398
label: SREBP1A/1C/2 Binds the HMGCS1 Promoter

SREBF1A/1C/2 Binds the FDFT1 Promoter
type: GO_0003674
BFO_0000050: Pathway1185
directly activates: Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase)
directly activates: Control395
directly activates: Control396
label: SREBP1A/1C/2 Binds the FDFT1 Promoter

Expression of 7-Dehydrocholesterol Reductase (DHCR7)
type: GO_0003674
BFO_0000050: Pathway1185

Expression of Acetyl CoA Carboxylase 1 (ACACA, ACC1)
type: GO_0003674
BFO_0000050: Pathway1185

Expression of Acetyl CoA Carboxylase 2 (ACACB, ACC2)
type: GO_0003674
BFO_0000050: Pathway1185

Expression of Diphosphomevalonate Decarboxylase (MVD)
type: GO_0003674
BFO_0000050: Pathway1185

Expression of ELOVL6
type: GO_0003674
BFO_0000050: Pathway1185

Expression of Farnesyl Diphosphate Synthase (FDPS)
type: GO_0003674
BFO_0000050: Pathway1185

Expression of Fatty Acid Synthase (FASN)
type: GO_0003674
BFO_0000050: Pathway1185

Expression of Geranylgeranyl Pyrophosphate Synthase (GGPS1)
type: GO_0003674
BFO_0000050: Pathway1185

Expression of Glycerol-3-phosphate Acyltransferase (GPAM, GPAT)
type: GO_0003674
BFO_0000050: Pathway1185

Expression of Isopentenyl-diphosphate Delta-isomerase 1 (IDI1)
type: GO_0003674
BFO_0000050: Pathway1185

Expression of Lanosterol Demethylase (CYP51A1)
type: GO_0003674
BFO_0000050: Pathway1185

Expression of Lanosterol Synthase (LSS)
type: GO_0003674
BFO_0000050: Pathway1185

Expression of Lathosterol Oxidase (SC5D, SC5DL)
type: GO_0003674
BFO_0000050: Pathway1185

Expression of Mevalonate Kinase (MVK)
type: GO_0003674
BFO_0000050: Pathway1185

Expression of Phosphomevalonate Kinase (PMVK)
type: GO_0003674
BFO_0000050: Pathway1185

Expression of Squalene Monooxygenase (SQLE)
type: GO_0003674
BFO_0000050: Pathway1185

Expression of TM7SF2
type: GO_0003674
BFO_0000050: Pathway1185

Cholesterol + NADPH + H+ + O2 => 7-alpha-hydroxycholesterol + NADP+ + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0008123
BFO_0000050: Pathway1188
directly activates: 7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one
directly activates: Catalysis2233
label: Cholesterol is hydroxylated to 7alpha-hydroxycholesterol by CYP7A1

7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: HSD3B7
type: Restriction
  on property: enabled by
  some values from: HSD3B7
type: Restriction
  on property: enabled by
  some values from: HSD3B7
type: Restriction
  on property: enabled by
  some values from: HSD3B7
type: Restriction
  on property: enabled by
  some values from: HSD3B7
type: Restriction
  on property: enabled by
  some values from: HSD3B7
type: Restriction
  on property: enabled by
  some values from: HSD3B7
type: Restriction
  on property: enabled by
  some values from: HSD3B7
type: GO_0003854
BFO_0000050: Pathway1188
directly activates: 4-Cholesten-7alpha-ol-3-one is 12alpha-hydroxylated to 7-alpha,12-alpha-dihydroxycholest-4-en-3-one
directly activates: 4-cholesten-7alpha-ol-3-one + NADPH + H+ => 5beta-cholestan-7alpha-ol-3-one + NADP+
directly activates: Catalysis2234
directly activates: Catalysis2236

4-Cholesten-7alpha-ol-3-one is 12alpha-hydroxylated to 7-alpha,12-alpha-dihydroxycholest-4-en-3-one
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0033778
BFO_0000050: Pathway1188
directly activates: 4-cholesten-7alpha, 12alpha-diol-3-one + NADPH + H+ => 5beta-cholesten-7alpha,12alpha-diol-3-one + NADP+
directly activates: Catalysis2235
label: 7-alpha-hydroxycholest-4-en-3-one + NADPH + H+ + O2 => 7-alpha,12-alpha-dihydroxycholest-4-en-3-one + NADP+ + H2O

4-cholesten-7alpha, 12alpha-diol-3-one + NADPH + H+ => 5beta-cholesten-7alpha,12alpha-diol-3-one + NADP+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: GO_0004033
BFO_0000050: Pathway1188
directly activates: 5Beta-cholesten-7alpha, 12alpha-diol-3-one + NADPH + H+ => 5beta-cholestan-3alpha, 7alpha, 12alpha-triol + NAPDP+
directly activates: Catalysis2237
label: 4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one

4-cholesten-7alpha-ol-3-one + NADPH + H+ => 5beta-cholestan-7alpha-ol-3-one + NADP+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: GO_0004033
BFO_0000050: Pathway1188
directly activates: 5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol
directly activates: Catalysis2238
label: 4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one

5Beta-cholesten-7alpha, 12alpha-diol-3-one + NADPH + H+ => 5beta-cholestan-3alpha, 7alpha, 12alpha-triol + NAPDP+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004033
BFO_0000050: Pathway1188
directly activates: 5beta-cholestan-3alpha, 7alpha, 12alpha-triol is translocated from the cytosol to the mitochondrial matrix
label: 5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol

5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004033
BFO_0000050: Pathway1188
directly activates: 5beta-cholestan-3alpha, 7alpha-diol is translocated from the cytosol to the mitochondrial matrix
label: 5beta-cholestan-7alpha-ol-3-one+ NADPH + H+ => 5beta-cholestan-3alpha, 7alpha-diol + NADP+

5beta-cholestan-3alpha, 7alpha, 12alpha-triol is translocated from the cytosol to the mitochondrial matrix
type: GO_0003674
BFO_0000050: Pathway1188
directly activates: 5beta-cholestan-3alpha, 7alpha, 12alpha-triol + NADPH + H+ + O2 => 5beta-cholestan-3alpha, 7alpha, 12alpha, 27-tetrol + NADP+ + H2O
directly activates: Catalysis2239

5beta-cholestan-3alpha, 7alpha-diol is translocated from the cytosol to the mitochondrial matrix
type: GO_0003674
BFO_0000050: Pathway1188
directly activates: 5beta-cholestan-3alpha, 7alpha-diol + NADPH + H+ + O2 => 5beta-cholestan-3alpha, 7alpha, 26-triol + NADP+ + H2O
directly activates: Catalysis2240

5beta-cholestan-3alpha, 7alpha, 12alpha-triol + NADPH + H+ + O2 => 5beta-cholestan-3alpha, 7alpha, 12alpha, 27-tetrol + NADP+ + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: GO_0008395
BFO_0000050: Pathway1188
directly activates: 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol + NADP+ => 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al + NADPH + H+
directly activates: Catalysis2241
label: 5beta-cholestan-3alpha, 7alpha, 12alpha-triol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 12alpha, 27-tetrol

5beta-cholestan-3alpha, 7alpha-diol + NADPH + H+ + O2 => 5beta-cholestan-3alpha, 7alpha, 26-triol + NADP+ + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: GO_0008395
BFO_0000050: Pathway1188
directly activates: 5beta-cholestan-3alpha, 7alpha, 26-triol + NADP+ => 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al + NADPH + H+
directly activates: Catalysis2242
label: 5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol

5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol + NADP+ => 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al + NADPH + H+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: GO_0008395
BFO_0000050: Pathway1188
directly activates: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al + NADPH + H+ + O2 => 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) + NADP+ + H2O
directly activates: Catalysis2243
label: 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al

5beta-cholestan-3alpha, 7alpha, 26-triol + NADP+ => 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al + NADPH + H+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: GO_0008395
BFO_0000050: Pathway1188
directly activates: 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al + NADPH + H+ + O2 => 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) + NADP+ + H2O
directly activates: Catalysis2244
label: 5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al

3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al + NADPH + H+ + O2 => 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) + NADP+ + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: GO_0008395
BFO_0000050: Pathway1188
directly activates: THCA [mitochondrial matrix] => THCA [cytosol]
label: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA)

3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al + NADPH + H+ + O2 => 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) + NADP+ + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: GO_0008395
BFO_0000050: Pathway1188
directly activates: DHCA [mitochondrial matrix] => DHCA [cytosol]
label: 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA)

THCA [mitochondrial matrix] => THCA [cytosol]
type: GO_0003674
BFO_0000050: Pathway1188
directly activates: THCA + ATP + CoASH => 25(R) THCA-CoA + AMP + pyrophosphate (SLC27A2 "VLCS")
directly activates: THCA + ATP + CoASH => 25(R) THCA-CoA + AMP + pyrophosphate (SCLS25A5 "BACS")
directly activates: Catalysis2245
directly activates: Catalysis2247
label: THCA is translocated from the mitochondrial matrix to the cytosol

DHCA [mitochondrial matrix] => DHCA [cytosol]
type: GO_0003674
BFO_0000050: Pathway1188
directly activates: DHCA + ATP + CoASH => 25(R) DHCA-CoA + AMP + pyrophosphate (SLC27A2 "VLCS")
directly activates: DHCA + ATP + CoASH => 25(R) DHCA-CoA + AMP + pyrophosphate (SCLS25A5 "BACS")
directly activates: Catalysis2246
directly activates: Catalysis2248
label: DHCA is translocated from the mitochondrial matrix to the cytosol

THCA + ATP + CoASH => 25(R) THCA-CoA + AMP + pyrophosphate (SLC27A2 "VLCS")
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: GO_0004467
BFO_0000050: Pathway1188
directly activates: 25(R) THCA-CoA [ cytosol] => 25(R) THCA-CoA [peroxisome]
label: THCA is conjugated with Coenzyme A (SLC27A2 VLCS)

DHCA + ATP + CoASH => 25(R) DHCA-CoA + AMP + pyrophosphate (SLC27A2 "VLCS")
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: GO_0004467
BFO_0000050: Pathway1188
directly activates: 25(R) DHCA-CoA [ cytosol] => 25(R) DHCA-CoA [peroxisome]
label: DHCA is conjugated with Coenzyme A (SLC27A2 VLCS)

THCA + ATP + CoASH => 25(R) THCA-CoA + AMP + pyrophosphate (SCLS25A5 "BACS")
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: ACSB
type: Restriction
  on property: enabled by
  some values from: ACSB
type: Restriction
  on property: enabled by
  some values from: ACSB
type: Restriction
  on property: enabled by
  some values from: ACSB
type: Restriction
  on property: enabled by
  some values from: ACSB
type: Restriction
  on property: enabled by
  some values from: ACSB
type: Restriction
  on property: enabled by
  some values from: ACSB
type: Restriction
  on property: enabled by
  some values from: ACSB
type: GO_0004467
BFO_0000050: Pathway1188
directly activates: 25(R) THCA-CoA [ cytosol] => 25(R) THCA-CoA [peroxisome]
label: THCA is conjugated with Coenzyme A (SLC27A5 BACS)

DHCA + ATP + CoASH => 25(R) DHCA-CoA + AMP + pyrophosphate (SCLS25A5 "BACS")
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: ACSB
type: Restriction
  on property: enabled by
  some values from: ACSB
type: Restriction
  on property: enabled by
  some values from: ACSB
type: Restriction
  on property: enabled by
  some values from: ACSB
type: Restriction
  on property: enabled by
  some values from: ACSB
type: Restriction
  on property: enabled by
  some values from: ACSB
type: Restriction
  on property: enabled by
  some values from: ACSB
type: Restriction
  on property: enabled by
  some values from: ACSB
type: GO_0004467
BFO_0000050: Pathway1188
directly activates: 25(R) DHCA-CoA [ cytosol] => 25(R) DHCA-CoA [peroxisome]
label: DHCA is conjugated with Coenzyme A (SLC27A5 BACS)

25(R) THCA-CoA [ cytosol] => 25(R) THCA-CoA [peroxisome]
type: GO_0003674
BFO_0000050: Pathway1188
directly activates: 25(R) THCA-CoA => 25(S) THCA-CoA
directly activates: Catalysis2249
label: 25(R) THCA-CoA is translocated from the cytosol to the peroxisome

25(R) DHCA-CoA [ cytosol] => 25(R) DHCA-CoA [peroxisome]
type: GO_0003674
BFO_0000050: Pathway1188
directly activates: 25(R) DHCA-CoA => 25(S) DHCA-CoA
directly activates: Catalysis2250
label: 25(R) DHCA-CoA is translocated from the cytosol to the peroxisome

25(R) THCA-CoA => 25(S) THCA-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: enabled by
  some values from: AMACR
type: Restriction
  on property: enabled by
  some values from: AMACR
type: Restriction
  on property: enabled by
  some values from: AMACR
type: Restriction
  on property: enabled by
  some values from: AMACR
type: Restriction
  on property: enabled by
  some values from: AMACR
type: Restriction
  on property: enabled by
  some values from: AMACR
type: Restriction
  on property: enabled by
  some values from: AMACR
type: Restriction
  on property: enabled by
  some values from: AMACR
type: GO_0008111
BFO_0000050: Pathway1188
directly activates: 25(S) THCA-CoA + O2 => THCA-CoA + H2O2
directly activates: Catalysis2251
label: Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA

25(R) DHCA-CoA => 25(S) DHCA-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: enabled by
  some values from: AMACR
type: Restriction
  on property: enabled by
  some values from: AMACR
type: Restriction
  on property: enabled by
  some values from: AMACR
type: Restriction
  on property: enabled by
  some values from: AMACR
type: Restriction
  on property: enabled by
  some values from: AMACR
type: Restriction
  on property: enabled by
  some values from: AMACR
type: Restriction
  on property: enabled by
  some values from: AMACR
type: Restriction
  on property: enabled by
  some values from: AMACR
type: GO_0008111
BFO_0000050: Pathway1188
directly activates: 25(S) DHCA-CoA + O2 => 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA + H2O2
directly activates: Catalysis2252
label: Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA

25(S) THCA-CoA + O2 => THCA-CoA + H2O2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0003997
BFO_0000050: Pathway1188
directly activates: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA
directly activates: Catalysis2253
label: 25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA)

25(S) DHCA-CoA + O2 => 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA + H2O2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0003997
BFO_0000050: Pathway1188
directly activates: 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA + H2O => (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA
directly activates: Catalysis2254
label: 25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA

3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0033989
BFO_0000050: Pathway1188
directly activates: (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA + NAD+ => 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + NADH + H+
directly activates: Catalysis2255
label: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA + H2O => (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA

25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA + H2O => (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0033989
BFO_0000050: Pathway1188
directly activates: (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA + NAD+ => 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA + NADH + H+
directly activates: Catalysis2256
label: 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA

(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA + NAD+ => 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + NADH + H+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0003857
BFO_0000050: Pathway1188
directly activates: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA + CoASH => choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) + propionyl CoA
directly activates: Catalysis2257
label: (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA

(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA + NAD+ => 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA + NADH + H+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0003857
BFO_0000050: Pathway1188
directly activates: 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA + CoASH => chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) + propionyl CoA
directly activates: Catalysis2258
label: (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA

3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA + CoASH => choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) + propionyl CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: enabled by
  some values from: SCP2
type: Restriction
  on property: enabled by
  some values from: SCP2
type: Restriction
  on property: enabled by
  some values from: SCP2
type: Restriction
  on property: enabled by
  some values from: SCP2
type: Restriction
  on property: enabled by
  some values from: SCP2
type: Restriction
  on property: enabled by
  some values from: SCP2
type: Restriction
  on property: enabled by
  some values from: SCP2
type: Restriction
  on property: enabled by
  some values from: SCP2
type: GO_0050632
BFO_0000050: Pathway1188
directly activates: Hydrolysis of choloyl-CoA to cholate and CoASH
directly activates: Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate
directly activates: Catalysis2259
directly activates: Catalysis2260
label: Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA

3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA + CoASH => chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) + propionyl CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: enabled by
  some values from: SCP2
type: Restriction
  on property: enabled by
  some values from: SCP2
type: Restriction
  on property: enabled by
  some values from: SCP2
type: Restriction
  on property: enabled by
  some values from: SCP2
type: Restriction
  on property: enabled by
  some values from: SCP2
type: Restriction
  on property: enabled by
  some values from: SCP2
type: Restriction
  on property: enabled by
  some values from: SCP2
type: Restriction
  on property: enabled by
  some values from: SCP2
type: GO_0050632
BFO_0000050: Pathway1188
directly activates: Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate
directly activates: Catalysis2261
label: Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA

Hydrolysis of choloyl-CoA to cholate and CoASH
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: enabled by
  some values from: ACOT8
type: Restriction
  on property: enabled by
  some values from: ACOT8
type: Restriction
  on property: enabled by
  some values from: ACOT8
type: Restriction
  on property: enabled by
  some values from: ACOT8
type: Restriction
  on property: enabled by
  some values from: ACOT8
type: Restriction
  on property: enabled by
  some values from: ACOT8
type: Restriction
  on property: enabled by
  some values from: ACOT8
type: Restriction
  on property: enabled by
  some values from: ACOT8
type: GO_0016289
BFO_0000050: Pathway1188
directly activates: Cholate is translocated from the peroxisomal matrix to the cytosol

Cholate is translocated from the peroxisomal matrix to the cytosol
type: GO_0003674
BFO_0000050: Pathway1188
label: cholate [peroxisomal matrix] => cholate [cytosol]

Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: enabled by
  some values from: BAAT
type: Restriction
  on property: enabled by
  some values from: BAAT
type: Restriction
  on property: enabled by
  some values from: BAAT
type: Restriction
  on property: enabled by
  some values from: BAAT
type: Restriction
  on property: enabled by
  some values from: BAAT
type: Restriction
  on property: enabled by
  some values from: BAAT
type: Restriction
  on property: enabled by
  some values from: BAAT
type: Restriction
  on property: enabled by
  some values from: BAAT
type: GO_0016746
BFO_0000050: Pathway1188
directly activates: Bile salts are translocated from the peroxisomal matrix to the cytosol

Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: enabled by
  some values from: BAAT
type: Restriction
  on property: enabled by
  some values from: BAAT
type: Restriction
  on property: enabled by
  some values from: BAAT
type: Restriction
  on property: enabled by
  some values from: BAAT
type: Restriction
  on property: enabled by
  some values from: BAAT
type: Restriction
  on property: enabled by
  some values from: BAAT
type: Restriction
  on property: enabled by
  some values from: BAAT
type: Restriction
  on property: enabled by
  some values from: BAAT
type: GO_0016746
BFO_0000050: Pathway1188
directly activates: Bile salts are translocated from the peroxisomal matrix to the cytosol

Bile salts are translocated from the peroxisomal matrix to the cytosol
type: GO_0003674
BFO_0000050: Pathway1188
directly activates: Transport (efflux) of bile salts by ABCB11 (bile salt export pump)
directly activates: Catalysis2262
label: bile salts [peroxisomal matrix] => cholate bile salts [cytosol]

Transport (efflux) of bile salts by ABCB11 (bile salt export pump)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: ABCB11
type: Restriction
  on property: enabled by
  some values from: ABCB11
type: Restriction
  on property: enabled by
  some values from: ABCB11
type: Restriction
  on property: enabled by
  some values from: ABCB11
type: Restriction
  on property: enabled by
  some values from: ABCB11
type: Restriction
  on property: enabled by
  some values from: ABCB11
type: Restriction
  on property: enabled by
  some values from: ABCB11
type: Restriction
  on property: enabled by
  some values from: ABCB11
type: Restriction
  on property: enabled by
  some values from: ABCB11
type: Restriction
  on property: enabled by
  some values from: ABCB11
type: Restriction
  on property: enabled by
  some values from: ABCB11
type: Restriction
  on property: enabled by
  some values from: ABCB11
type: GO_0015432
BFO_0000050: Pathway1188
BFO_0000050: Pathway1191

Cholesterol is hydroxylated to 24-hydroxycholesterol by CYP46A1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: CYP46
type: Restriction
  on property: enabled by
  some values from: CYP46
type: Restriction
  on property: enabled by
  some values from: CYP46
type: Restriction
  on property: enabled by
  some values from: CYP46
type: Restriction
  on property: enabled by
  some values from: CYP46
type: Restriction
  on property: enabled by
  some values from: CYP46
type: Restriction
  on property: enabled by
  some values from: CYP46
type: Restriction
  on property: enabled by
  some values from: CYP46
type: GO_0033781
BFO_0000050: Pathway1189
directly activates: Efflux of 24-hydroxycholesterol
label: cholesterol + NADPH + H+ + O2 => 24-hydroxycholesterol + NADP+ + H2O

Efflux of 24-hydroxycholesterol
type: GO_0003674
BFO_0000050: Pathway1189
directly activates: Influx of 24-hydroxycholesterol

Influx of 24-hydroxycholesterol
type: GO_0003674
BFO_0000050: Pathway1189
directly activates: 24-hydroxycholesterol + NADPH + H+ + O2 => cholest-5-ene-3beta,7alpha,24-triol + NADP+ + H2O
directly activates: Catalysis2264

24-hydroxycholesterol + NADPH + H+ + O2 => cholest-5-ene-3beta,7alpha,24-triol + NADP+ + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: CYP39A1
type: Restriction
  on property: enabled by
  some values from: CYP39A1
type: Restriction
  on property: enabled by
  some values from: CYP39A1
type: Restriction
  on property: enabled by
  some values from: CYP39A1
type: Restriction
  on property: enabled by
  some values from: CYP39A1
type: Restriction
  on property: enabled by
  some values from: CYP39A1
type: Restriction
  on property: enabled by
  some values from: CYP39A1
type: Restriction
  on property: enabled by
  some values from: CYP39A1
type: GO_0008396
BFO_0000050: Pathway1189
directly activates: Cholest-5-ene-3beta,7alpha,24(S)-triol + NAD+ => 4-cholesten-7alpha,24(S)-diol-3-one + NADH + H+
directly activates: Catalysis2265
label: 24-hydroxycholesterol is 7alpha-hydroxylated to yield cholest-5-ene-3beta,7alpha,24-triol

Cholest-5-ene-3beta,7alpha,24(S)-triol + NAD+ => 4-cholesten-7alpha,24(S)-diol-3-one + NADH + H+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: HSD3B7
type: Restriction
  on property: enabled by
  some values from: HSD3B7
type: Restriction
  on property: enabled by
  some values from: HSD3B7
type: Restriction
  on property: enabled by
  some values from: HSD3B7
type: Restriction
  on property: enabled by
  some values from: HSD3B7
type: Restriction
  on property: enabled by
  some values from: HSD3B7
type: Restriction
  on property: enabled by
  some values from: HSD3B7
type: Restriction
  on property: enabled by
  some values from: HSD3B7
type: GO_0003854
BFO_0000050: Pathway1189
directly activates: 4-Cholesten-7alpha,24(S)-diol-3-one + NADPH + H+ + O2 => 4-cholesten-7-alpha,12-alpha,24(S)-triol-3-one + NADP+ + H2O
directly activates: 4-cholesten-7alpha,24(S)-diol-3-one + NADPH + H+ => 5beta-cholestan-7alpha,24(S)-diol-3-one + NADP+
directly activates: Catalysis2266
directly activates: Catalysis2268
label: Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one

4-Cholesten-7alpha,24(S)-diol-3-one + NADPH + H+ + O2 => 4-cholesten-7-alpha,12-alpha,24(S)-triol-3-one + NADP+ + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0033778
BFO_0000050: Pathway1189
directly activates: 4-cholesten-7alpha,12alpha,24(S)-triol-3-one + NADPH + H+ => 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one + NADP+
directly activates: Catalysis2267
label: 4-Cholesten-7alpha,24(S)-diol-3-one is 12alpha-hydroxylated to 4-cholesten-7-alpha,12-alpha,24(S)-triol-3-one

4-cholesten-7alpha,12alpha,24(S)-triol-3-one + NADPH + H+ => 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one + NADP+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: GO_0004033
BFO_0000050: Pathway1189
directly activates: 5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one + NADPH + H+ => 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol + NAPDP+
directly activates: Catalysis2269
label: 4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one

4-cholesten-7alpha,24(S)-diol-3-one + NADPH + H+ => 5beta-cholestan-7alpha,24(S)-diol-3-one + NADP+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: GO_0004033
BFO_0000050: Pathway1189
directly activates: 5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol
directly activates: Catalysis2270
label: 4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one

5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one + NADPH + H+ => 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol + NAPDP+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004033
BFO_0000050: Pathway1189
directly activates: 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is translocated from the cytosol to the mitochondrial matrix
label: 5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol

5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004033
BFO_0000050: Pathway1189
directly activates: 5beta-cholestan-3alpha,7alpha,24(S)-triol is translocated from the cytosol to the mitochondrial matrix
label: 5beta-cholestan-7alpha,24(S)-diol-3-one+ NADPH + H+ => 5beta-cholestan-3alpha,7alpha,24(S)-triol + NADP+

5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is translocated from the cytosol to the mitochondrial matrix
type: GO_0003674
BFO_0000050: Pathway1189
directly activates: 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol + NADPH + H+ + O2 => 5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol + NADP+ + H2O
directly activates: Catalysis2271

5beta-cholestan-3alpha,7alpha,24(S)-triol is translocated from the cytosol to the mitochondrial matrix
type: GO_0003674
BFO_0000050: Pathway1189
directly activates: 5beta-cholestan-3alpha,7alpha,24(S)-triol + NADPH + H+ + O2 => 5beta-cholestan-3alpha,7alpha,24(S),27-tetrol + NADP+ + H2O
directly activates: Catalysis2272

5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol + NADPH + H+ + O2 => 5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol + NADP+ + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: GO_0008395
BFO_0000050: Pathway1189
directly activates: 5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol + NADPH + H+ + O2 => 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al + NADP+ + H2O
directly activates: Catalysis2273
label: 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol

5beta-cholestan-3alpha,7alpha,24(S)-triol + NADPH + H+ + O2 => 5beta-cholestan-3alpha,7alpha,24(S),27-tetrol + NADP+ + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: GO_0008395
BFO_0000050: Pathway1189
directly activates: 5beta-cholestan-3alpha,7alpha,24(S),27-tetrol + NADPH + H+ + O2 => 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al + NADP+ + H2O
directly activates: Catalysis2274
label: 5beta-cholestan-3alpha,7alpha,24(S)-triol is hydroxylated to 5beta-cholestan-3alpha,7alpha,24(S), 27-tetrol

5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol + NADPH + H+ + O2 => 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al + NADP+ + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: GO_0008395
BFO_0000050: Pathway1189
directly activates: 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al + NADPH + H+ + O2 => 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) + NADP+ + H2O
directly activates: Catalysis2275
label: 5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al

5beta-cholestan-3alpha,7alpha,24(S),27-tetrol + NADPH + H+ + O2 => 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al + NADP+ + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: GO_0008395
BFO_0000050: Pathway1189
directly activates: 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al + NADPH + H+ + O2 => 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) + NADP+ + H2O
directly activates: Catalysis2276
label: 5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al

3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al + NADPH + H+ + O2 => 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) + NADP+ + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: GO_0008395
BFO_0000050: Pathway1189
directly activates: TetraHCA [mitochondrial matrix] => TetraHCA [cytosol]
label: 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA)

3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al + NADPH + H+ + O2 => 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) + NADP+ + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: GO_0008395
BFO_0000050: Pathway1189
directly activates: 3,7,24THCA [mitochondrial matrix] => 3,7,24THCA [cytosol]
label: 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA)

TetraHCA [mitochondrial matrix] => TetraHCA [cytosol]
type: GO_0003674
BFO_0000050: Pathway1189
directly activates: TetraHCA + ATP + CoASH => 25(R) TetraHCA-CoA + AMP + pyrophosphate + H2O (SCLS25A5 "BACS")
directly activates: TetraHCA + ATP + CoASH => 25(R) THCA-CoA + AMP + pyrophosphate + H2O (SLC27A2 "VLCS")
directly activates: Catalysis2277
directly activates: Catalysis2279
label: TetraHCA is translocated from the mitochondrial matrix to the cytosol

3,7,24THCA [mitochondrial matrix] => 3,7,24THCA [cytosol]
type: GO_0003674
BFO_0000050: Pathway1189
directly activates: 3,7,24THCA + ATP + CoASH => 3,7,24THCA-CoA + AMP + pyrophosphate + H2O (SCLS25A5 "BACS")
directly activates: 3,7,24THCA + ATP + CoASH => 3,7,24THCA-CoA + AMP + pyrophosphate + H2O (SLC27A2 "VLCS")
directly activates: Catalysis2278
directly activates: Catalysis2280
label: 3,7,24THCA is translocated from the mitochondrial matrix to the cytosol

TetraHCA + ATP + CoASH => 25(R) TetraHCA-CoA + AMP + pyrophosphate + H2O (SCLS25A5 "BACS")
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: ACSB
type: Restriction
  on property: enabled by
  some values from: ACSB
type: Restriction
  on property: enabled by
  some values from: ACSB
type: Restriction
  on property: enabled by
  some values from: ACSB
type: Restriction
  on property: enabled by
  some values from: ACSB
type: Restriction
  on property: enabled by
  some values from: ACSB
type: Restriction
  on property: enabled by
  some values from: ACSB
type: Restriction
  on property: enabled by
  some values from: ACSB
type: GO_0004467
BFO_0000050: Pathway1189
directly activates: 25(R) TetraHCA-CoA [ cytosol] => 25(R) TetraHCA-CoA [peroxisome]
label: TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS)

3,7,24THCA + ATP + CoASH => 3,7,24THCA-CoA + AMP + pyrophosphate + H2O (SCLS25A5 "BACS")
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: ACSB
type: Restriction
  on property: enabled by
  some values from: ACSB
type: Restriction
  on property: enabled by
  some values from: ACSB
type: Restriction
  on property: enabled by
  some values from: ACSB
type: Restriction
  on property: enabled by
  some values from: ACSB
type: Restriction
  on property: enabled by
  some values from: ACSB
type: Restriction
  on property: enabled by
  some values from: ACSB
type: Restriction
  on property: enabled by
  some values from: ACSB
type: GO_0004467
BFO_0000050: Pathway1189
directly activates: 3,7,24THCA-CoA [ cytosol] => 3,7,24THCA-CoA [peroxisome]
label: 3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS)

TetraHCA + ATP + CoASH => 25(R) THCA-CoA + AMP + pyrophosphate + H2O (SLC27A2 "VLCS")
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: GO_0004467
BFO_0000050: Pathway1189
directly activates: 25(R) TetraHCA-CoA [ cytosol] => 25(R) TetraHCA-CoA [peroxisome]
label: TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS)

3,7,24THCA + ATP + CoASH => 3,7,24THCA-CoA + AMP + pyrophosphate + H2O (SLC27A2 "VLCS")
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: GO_0004467
BFO_0000050: Pathway1189
directly activates: 3,7,24THCA-CoA [ cytosol] => 3,7,24THCA-CoA [peroxisome]
label: 3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS)

25(R) TetraHCA-CoA [ cytosol] => 25(R) TetraHCA-CoA [peroxisome]
type: GO_0003674
BFO_0000050: Pathway1189
directly activates: 25(R) TetraHCA-CoA => (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA
directly activates: Catalysis2281
label: 25(R) TetraHCA-CoA is translocated from the cytosol to the peroxisome

3,7,24THCA-CoA [ cytosol] => 3,7,24THCA-CoA [peroxisome]
type: GO_0003674
BFO_0000050: Pathway1189
directly activates: 3,7,24THCA-CoA => (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA
directly activates: Catalysis2282
label: 3,7,24THCA-CoA is translocated from the cytosol to the peroxisome

25(R) TetraHCA-CoA => (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: enabled by
  some values from: AMACR
type: Restriction
  on property: enabled by
  some values from: AMACR
type: Restriction
  on property: enabled by
  some values from: AMACR
type: Restriction
  on property: enabled by
  some values from: AMACR
type: Restriction
  on property: enabled by
  some values from: AMACR
type: Restriction
  on property: enabled by
  some values from: AMACR
type: Restriction
  on property: enabled by
  some values from: AMACR
type: Restriction
  on property: enabled by
  some values from: AMACR
type: GO_0008111
BFO_0000050: Pathway1189
directly activates: (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA + NAD+ => 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + NADH + H+
directly activates: Catalysis2255
label: Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA

3,7,24THCA-CoA => (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: enabled by
  some values from: AMACR
type: Restriction
  on property: enabled by
  some values from: AMACR
type: Restriction
  on property: enabled by
  some values from: AMACR
type: Restriction
  on property: enabled by
  some values from: AMACR
type: Restriction
  on property: enabled by
  some values from: AMACR
type: Restriction
  on property: enabled by
  some values from: AMACR
type: Restriction
  on property: enabled by
  some values from: AMACR
type: Restriction
  on property: enabled by
  some values from: AMACR
type: GO_0008111
BFO_0000050: Pathway1189
directly activates: (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA + NAD+ => 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA + NADH + H+
directly activates: Catalysis2256
label: Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA

Cholesterol is hydroxylated to 27-hydroxycholesterol by CYP27
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: GO_0008395
BFO_0000050: Pathway1190
directly activates: Efflux of 27-hydroxycholesterol
label: cholesterol + NADPH + H+ + O2 => 27-hydroxycholesterol + H2O + NADP+

Efflux of 27-hydroxycholesterol
type: GO_0003674
BFO_0000050: Pathway1190
directly activates: Influx of 27-hydroxycholesterol

Influx of 27-hydroxycholesterol
type: GO_0003674
BFO_0000050: Pathway1190
directly activates: 27-hydroxycholesterol + NADPH + H+ + O2 => cholest-5-ene-3beta,7alpha,27-triol + H2O + NADP+
directly activates: Catalysis2284

27-hydroxycholesterol + NADPH + H+ + O2 => cholest-5-ene-3beta,7alpha,27-triol + H2O + NADP+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0008396
BFO_0000050: Pathway1190
directly activates: Cholest-5-ene-3beta,7alpha,27-triol + NAD+ => 4-cholesten-7alpha,27-diol-3-one +NADH + H+
directly activates: Catalysis2285
label: 27-hydroxycholesterol is 7alpha-hydroxylated

Cholest-5-ene-3beta,7alpha,27-triol + NAD+ => 4-cholesten-7alpha,27-diol-3-one +NADH + H+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: HSD3B7
type: Restriction
  on property: enabled by
  some values from: HSD3B7
type: Restriction
  on property: enabled by
  some values from: HSD3B7
type: Restriction
  on property: enabled by
  some values from: HSD3B7
type: Restriction
  on property: enabled by
  some values from: HSD3B7
type: Restriction
  on property: enabled by
  some values from: HSD3B7
type: Restriction
  on property: enabled by
  some values from: HSD3B7
type: Restriction
  on property: enabled by
  some values from: HSD3B7
type: GO_0003854
BFO_0000050: Pathway1190
directly activates: 4-Cholesten-7alpha,27-diol-3-one + NADPH + H+ + O2 => 4-Cholesten-7alpha,12alpha,27-triol-3-one + NADP+ + H2O
directly activates: 4-cholesten-7alpha,27-diol-3-one + NADPH + H+ => 5beta-cholestan-7alpha,27-diol-3-one + NADP+
directly activates: Catalysis2286
directly activates: Catalysis2288
label: Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one

4-Cholesten-7alpha,27-diol-3-one + NADPH + H+ + O2 => 4-Cholesten-7alpha,12alpha,27-triol-3-one + NADP+ + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0033778
BFO_0000050: Pathway1190
directly activates: 4-cholesten-7alpha,12alpha,27-triol-3-one + NADPH + H+ => 5beta-cholestan-7alpha,12alpha,27-triol-3-one + NADP+
directly activates: Catalysis2287
label: 4-Cholesten-7alpha,27-diol-3-one is 12alpha-hydroxylated to 4-Cholesten-7alpha,12alpha,27-triol-3-one

4-cholesten-7alpha,12alpha,27-triol-3-one + NADPH + H+ => 5beta-cholestan-7alpha,12alpha,27-triol-3-one + NADP+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: GO_0004033
BFO_0000050: Pathway1190
directly activates: 5Beta-cholestan-7alpha,12alpha,27-triol-3-one + NADPH + H+ => 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol + NAPDP+
directly activates: Catalysis2289
label: 4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one

4-cholesten-7alpha,27-diol-3-one + NADPH + H+ => 5beta-cholestan-7alpha,27-diol-3-one + NADP+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: GO_0004033
BFO_0000050: Pathway1190
directly activates: 5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol
directly activates: Catalysis2290
label: 4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one

5Beta-cholestan-7alpha,12alpha,27-triol-3-one + NADPH + H+ => 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol + NAPDP+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004033
BFO_0000050: Pathway1190
directly activates: 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is translocated from the cytosol to the mitochondrial matrix
label: 5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol

5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004033
BFO_0000050: Pathway1190
directly activates: 5beta-cholestan-3alpha,7alpha,27-triol is translocated from the cytosol to the mitochondrial matrix
label: 5beta-cholestan-7alpha,27-diol-3-one+ NADPH + H+ => 5beta-cholestan-3alpha,7alpha,27-triol + NADP+

5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is translocated from the cytosol to the mitochondrial matrix
type: GO_0003674
BFO_0000050: Pathway1190
directly activates: 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol + NADP+ => 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al + NADPH + H+
directly activates: Catalysis2241

5beta-cholestan-3alpha,7alpha,27-triol is translocated from the cytosol to the mitochondrial matrix
type: GO_0003674
BFO_0000050: Pathway1190
directly activates: 5beta-cholestan-3alpha, 7alpha, 26-triol + NADP+ => 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al + NADPH + H+
directly activates: Catalysis2242

Cholesterol is hydroxylated to 25-hydroxycholesterol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0008395
BFO_0000050: Pathway1187
directly activates: 25-hydroxycholesterol is 7alpha-hydroxylated by CYP7B1
directly activates: Catalysis2292

25-hydroxycholesterol is 7alpha-hydroxylated by CYP7B1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0008396
BFO_0000050: Pathway1187

Co-transport (influx) of bile salts and acids and sodium ions by ASBT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: ASBT
type: Restriction
  on property: enabled by
  some values from: ASBT
type: Restriction
  on property: enabled by
  some values from: ASBT
type: Restriction
  on property: enabled by
  some values from: ASBT
type: GO_0008508
BFO_0000050: Pathway1191
directly activates: Transport (efflux) of bile salts by ABCC3 (MRP3)
directly activates: Catalysis2294

Transport (efflux) of bile salts by ABCC3 (MRP3)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: ABCC3
type: Restriction
  on property: enabled by
  some values from: ABCC3
type: Restriction
  on property: enabled by
  some values from: ABCC3
type: Restriction
  on property: enabled by
  some values from: ABCC3
type: GO_0015432
BFO_0000050: Pathway1191
directly activates: Transport (influx) of bile salts and acids by OATP-A
directly activates: Transport (influx) of glycocholate and taurocholate by OATP-8
directly activates: Transport (influx) of glycocholate and taurocholate by OATP-C
directly activates: Co-transport (influx) of bile salts and sodium ions by NTCP
directly activates: Catalysis2295
directly activates: Catalysis731
directly activates: Catalysis732
directly activates: Catalysis733

Co-transport (influx) of bile salts and sodium ions by NTCP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: GIG29
type: Restriction
  on property: enabled by
  some values from: GIG29
type: Restriction
  on property: enabled by
  some values from: GIG29
type: Restriction
  on property: enabled by
  some values from: GIG29
type: GO_0008508
BFO_0000050: Pathway1191
directly activates: Transport (efflux) of bile salts by ABCB11 (bile salt export pump)
directly activates: Catalysis2262

Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: ACSB
type: Restriction
  on property: enabled by
  some values from: ACSB
type: Restriction
  on property: enabled by
  some values from: ACSB
type: Restriction
  on property: enabled by
  some values from: ACSB
type: GO_0004467
BFO_0000050: Pathway1191
directly activates: Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine
directly activates: Catalysis2297

Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: BAAT
type: Restriction
  on property: enabled by
  some values from: BAAT
type: Restriction
  on property: enabled by
  some values from: BAAT
type: Restriction
  on property: enabled by
  some values from: BAAT
type: GO_0008206
type: GO_0016746
BFO_0000050: Pathway1191
directly activates: Transport (efflux) of bile salts by ABCB11 (bile salt export pump)
directly activates: Catalysis2262

DHAP is converted to 1-acyl GO3P by GNPAT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: Restriction
  on property: enabled by
  some values from: DAPAT
type: Restriction
  on property: enabled by
  some values from: DAPAT
type: Restriction
  on property: enabled by
  some values from: DAPAT
type: Restriction
  on property: enabled by
  some values from: DAPAT
type: Restriction
  on property: enabled by
  some values from: DAPAT
type: Restriction
  on property: enabled by
  some values from: DAPAT
type: Restriction
  on property: enabled by
  some values from: DAPAT
type: Restriction
  on property: enabled by
  some values from: DAPAT
type: GO_0016287
BFO_0000050: Pathway1195

PA is hydrolysed to 1-acyl LPA by PLA2[1]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004623
BFO_0000050: Pathway1195
directly activates: 1-acyl LPA is acylated to PA by AGPAT (LPAAT)
directly activates: Catalysis2116

PA is hydrolysed to 1-acyl LPA by PLA2G2A
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004623
BFO_0000050: Pathway1195
directly activates: 1-acyl LPA is acylated to PA by AGPAT (LPAAT)
directly activates: Catalysis2116

G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: GO_0004366
BFO_0000050: Pathway1195
directly activates: 1-acyl LPA is acylated to PA by AGPAT5 (OM)
directly activates: Catalysis2302

1-acyl LPA is acylated to PA by AGPAT5 (OM)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: enabled by
  some values from: AGPAT5
type: Restriction
  on property: enabled by
  some values from: AGPAT5
type: Restriction
  on property: enabled by
  some values from: AGPAT5
type: Restriction
  on property: enabled by
  some values from: AGPAT5
type: Restriction
  on property: enabled by
  some values from: AGPAT5
type: Restriction
  on property: enabled by
  some values from: AGPAT5
type: Restriction
  on property: enabled by
  some values from: AGPAT5
type: Restriction
  on property: enabled by
  some values from: AGPAT5
type: GO_0003841
BFO_0000050: Pathway1195
directly activates: PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)
directly activates: PA transports from the outer to the inner mitochondrial membrane
directly activates: Catalysis2303

PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004623
BFO_0000050: Pathway1195
directly activates: 1-acyl LPA is acylated to PA by AGPAT5 (OM)
directly activates: Catalysis2302

PC is hydrolyzed to PA and choline by PLD1/2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004630
BFO_0000050: Pathway1195
directly activates: Cho is acetylated to AcCho by CHAT
directly activates: PA is hydrolysed to 1-acyl LPA by PLA2[1]
directly activates: PA is hydrolysed to 1-acyl LPA by PLA2G2A
directly activates: PA is dephosphorylated to DAG by LPIN
directly activates: Cho is phosphorylated to PCho by CHK dimer
directly activates: PA is converted to CDP-DAG by CDS1
directly activates: Catalysis1652
directly activates: Catalysis2299
directly activates: Catalysis2300
directly activates: Catalysis2315
directly activates: Catalysis2329
directly activates: Catalysis2355

PA is hydrolyzed to 1-acyl LPA by PLA2[15]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004623
BFO_0000050: Pathway1195

TAG is hydrolyzed to DAG by PNPLA2/3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004806
BFO_0000050: Pathway1196
directly activates: DAG is acylated to TAG by DGAT1/2
directly activates: DAG is hydrolyzed to 2-MAG by PNPLA2/3
directly activates: 2-MAG and DAG are transacylated to TAG by PNPLA2/3
directly activates: CDP-ETA and DAG are converted to PE by CEPT1/EPT1
directly activates: CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane
directly activates: Catalysis2307
directly activates: Catalysis2308
directly activates: Catalysis2310
directly activates: Catalysis2316
directly activates: Catalysis2332

DAG is acylated to TAG by DGAT1/2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004144
BFO_0000050: Pathway1196
directly activates: TAG is hydrolyzed to DAG by PNPLA2/3
directly activates: Catalysis2306

DAG is hydrolyzed to 2-MAG by PNPLA2/3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004465
BFO_0000050: Pathway1196
directly activates: 2-MAG is transacylated to DAG by PNPLA2/3
directly activates: 2-MAG and DAG are transacylated to TAG by PNPLA2/3
directly activates: 2-MAG is hydrolyzed to fatty acid and glycerol by MGLL
directly activates: Catalysis2309
directly activates: Catalysis2310
directly activates: Catalysis2311

2-MAG is transacylated to DAG by PNPLA2/3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0016411
BFO_0000050: Pathway1196
directly activates: DAG is acylated to TAG by DGAT1/2
directly activates: DAG is hydrolyzed to 2-MAG by PNPLA2/3
directly activates: 2-MAG and DAG are transacylated to TAG by PNPLA2/3
directly activates: CDP-ETA and DAG are converted to PE by CEPT1/EPT1
directly activates: CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane
directly activates: Catalysis2307
directly activates: Catalysis2308
directly activates: Catalysis2310
directly activates: Catalysis2316
directly activates: Catalysis2332

2-MAG and DAG are transacylated to TAG by PNPLA2/3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0016411
BFO_0000050: Pathway1196
directly activates: TAG is hydrolyzed to DAG by PNPLA2/3
directly activates: Catalysis2306

2-MAG is hydrolyzed to fatty acid and glycerol by MGLL
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0047372
BFO_0000050: Pathway1196

ETA is phosphorylated to PETA by CHK/ETNK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004305
BFO_0000050: Pathway1197
directly activates: PETA is dephosphorylated to ETA by PHOSPHO1
directly activates: PETA and CTP are condensed to CDP-ETA by PCY2
directly activates: Catalysis2313
directly activates: Catalysis2314

PETA is dephosphorylated to ETA by PHOSPHO1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0052732
BFO_0000050: Pathway1197
directly activates: ETA is phosphorylated to PETA by CHK/ETNK
directly activates: Catalysis2312

PETA and CTP are condensed to CDP-ETA by PCY2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004306
BFO_0000050: Pathway1197
directly activates: CDP-ETA and DAG are converted to PE by CEPT1/EPT1
directly activates: Catalysis2316

PA is dephosphorylated to DAG by LPIN
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0008195
BFO_0000050: Pathway1197
BFO_0000050: Pathway1200
directly activates: CDP-ETA and DAG are converted to PE by CEPT1/EPT1
directly activates: CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane
directly activates: Catalysis2316
directly activates: Catalysis2332

CDP-ETA and DAG are converted to PE by CEPT1/EPT1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004307
BFO_0000050: Pathway1197
directly activates: PE is hydrolyzed to 1-acyl LPE by PLA2[2]
directly activates: PE is hydrolyzed to 1-acyl LPE by PLA2[3]
directly activates: PE is hydrolyzed to 2-acyl LPE by PLA2[4]
directly activates: PE is hydrolyzed to 2-acyl LPE by PLA2G4C
directly activates: PE is methylated to PC by PEMT
directly activates: PE is converted to PS by PTDSS2
directly activates: Catalysis2318
directly activates: Catalysis2319
directly activates: Catalysis2321
directly activates: Catalysis2322
directly activates: Catalysis2328
directly activates: Catalysis2348

PS transports from the ER membrane to the IM membrane
type: GO_0003674
BFO_0000050: Pathway1197
directly activates: PS is decarboxylated to PE by PISD
directly activates: Catalysis2317

PS is decarboxylated to PE by PISD
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: GO_0004609
BFO_0000050: Pathway1197
directly activates: PE transports from the mitochondrial membrane to the ER
directly activates: MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible)
directly activates: Catalysis2381

PE transports from the mitochondrial membrane to the ER
type: GO_0003674
BFO_0000050: Pathway1197
directly activates: PE is hydrolyzed to 1-acyl LPE by PLA2[2]
directly activates: PE is hydrolyzed to 1-acyl LPE by PLA2[3]
directly activates: PE is hydrolyzed to 2-acyl LPE by PLA2[4]
directly activates: PE is hydrolyzed to 2-acyl LPE by PLA2G4C
directly activates: PE is methylated to PC by PEMT
directly activates: PE is converted to PS by PTDSS2
directly activates: Catalysis2318
directly activates: Catalysis2319
directly activates: Catalysis2321
directly activates: Catalysis2322
directly activates: Catalysis2328
directly activates: Catalysis2348

PE is hydrolyzed to 1-acyl LPE by PLA2[2]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004623
BFO_0000050: Pathway1198
directly activates: 1-acyl LPE is acylated to PE by LPEAT
directly activates: 1-acyl LPE is hydrolyzed to GPETA by PLA2G4C
directly activates: Catalysis2320
directly activates: Catalysis2325

PE is hydrolyzed to 1-acyl LPE by PLA2[3]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004623
BFO_0000050: Pathway1198
directly activates: 1-acyl LPE is acylated to PE by LPEAT
directly activates: 1-acyl LPE is hydrolyzed to GPETA by PLA2G4C
directly activates: Catalysis2320
directly activates: Catalysis2325

1-acyl LPE is acylated to PE by LPEAT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0003841
BFO_0000050: Pathway1198
directly activates: PE is hydrolyzed to 1-acyl LPE by PLA2[2]
directly activates: PE is hydrolyzed to 1-acyl LPE by PLA2[3]
directly activates: PE is hydrolyzed to 2-acyl LPE by PLA2[4]
directly activates: PE is hydrolyzed to 2-acyl LPE by PLA2G4C
directly activates: PE is methylated to PC by PEMT
directly activates: PE is converted to PS by PTDSS2
directly activates: Catalysis2318
directly activates: Catalysis2319
directly activates: Catalysis2321
directly activates: Catalysis2322
directly activates: Catalysis2328
directly activates: Catalysis2348

PE is hydrolyzed to 2-acyl LPE by PLA2[4]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008970
BFO_0000050: Pathway1198
directly activates: 2-acyl LPE is acylated to PE by LPEAT
directly activates: 2-acyl LPE is hydrolyzed to GPETA by PLA2G4C
directly activates: Catalysis2323
directly activates: Catalysis2326

PE is hydrolyzed to 2-acyl LPE by PLA2G4C
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: GO_0008970
BFO_0000050: Pathway1198
directly activates: 2-acyl LPE is acylated to PE by LPEAT
directly activates: 2-acyl LPE is hydrolyzed to GPETA by PLA2G4C
directly activates: Catalysis2323
directly activates: Catalysis2326

2-acyl LPE is acylated to PE by LPEAT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0047144
BFO_0000050: Pathway1198
directly activates: PE is hydrolyzed to 1-acyl LPE by PLA2[2]
directly activates: PE is hydrolyzed to 1-acyl LPE by PLA2[3]
directly activates: PE is hydrolyzed to 2-acyl LPE by PLA2[4]
directly activates: PE is hydrolyzed to 2-acyl LPE by PLA2G4C
directly activates: PE is methylated to PC by PEMT
directly activates: PE is converted to PS by PTDSS2
directly activates: Catalysis2318
directly activates: Catalysis2319
directly activates: Catalysis2321
directly activates: Catalysis2322
directly activates: Catalysis2328
directly activates: Catalysis2348

PE is hydrolyzed to 1-acyl LPE by PLA2[16]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004623
BFO_0000050: Pathway1198

1-acyl LPE is hydrolyzed to GPETA by PLA2G4C
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: GO_0004622
BFO_0000050: Pathway1199
directly activates: GPETA is hydrolyzed to ETA and G3P by GPCPD1
directly activates: Catalysis2327

2-acyl LPE is hydrolyzed to GPETA by PLA2G4C
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: GO_0004622
BFO_0000050: Pathway1199
directly activates: GPETA is hydrolyzed to ETA and G3P by GPCPD1
directly activates: Catalysis2327

GPETA is hydrolyzed to ETA and G3P by GPCPD1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: GDE5
type: Restriction
  on property: enabled by
  some values from: GDE5
type: Restriction
  on property: enabled by
  some values from: GDE5
type: Restriction
  on property: enabled by
  some values from: GDE5
type: Restriction
  on property: enabled by
  some values from: GDE5
type: Restriction
  on property: enabled by
  some values from: GDE5
type: Restriction
  on property: enabled by
  some values from: GDE5
type: Restriction
  on property: enabled by
  some values from: GDE5
type: GO_0008889
BFO_0000050: Pathway1199
directly activates: Conversion of glycerol-3-phosphate to lysophosphatidic acid
directly activates: G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM)
directly activates: ETA is phosphorylated to PETA by CHK/ETNK
directly activates: Catalysis2114
directly activates: Catalysis2301
directly activates: Catalysis2312

PE is methylated to PC by PEMT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: PEMPT
type: Restriction
  on property: enabled by
  some values from: PEMPT
type: Restriction
  on property: enabled by
  some values from: PEMPT
type: Restriction
  on property: enabled by
  some values from: PEMPT
type: Restriction
  on property: enabled by
  some values from: PEMPT
type: Restriction
  on property: enabled by
  some values from: PEMPT
type: Restriction
  on property: enabled by
  some values from: PEMPT
type: Restriction
  on property: enabled by
  some values from: PEMPT
type: GO_0004608
BFO_0000050: Pathway1200

Cho is phosphorylated to PCho by CHK dimer
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004103
BFO_0000050: Pathway1200
directly activates: PCho is dephosphorylated to Cho by PHOSPHO1
directly activates: PCho and CTP are condensed to CDP-Cho by PCYT1 dimer
directly activates: Catalysis2330
directly activates: Catalysis2331

PCho is dephosphorylated to Cho by PHOSPHO1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0052731
BFO_0000050: Pathway1200
directly activates: Cho is acetylated to AcCho by CHAT
directly activates: Cho is phosphorylated to PCho by CHK dimer
directly activates: Catalysis1652
directly activates: Catalysis2329

PCho and CTP are condensed to CDP-Cho by PCYT1 dimer
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004105
BFO_0000050: Pathway1200
directly activates: CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane
directly activates: CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane
directly activates: Catalysis2332
directly activates: Catalysis2333

CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004142
BFO_0000050: Pathway1200
directly activates: PC is hydrolyzed to PA and choline by PLD1/2
directly activates: PC is hydrolyzed to 1-acyl LPC by PLA2[5]
directly activates: PC is hydrolyzed to 1-acyl LPC by PLA2[6]
directly activates: PC is hydrolysed to 2-acyl LPC by PLA2[7]
directly activates: PC is hydrolyzed to 2-acyl LPC by PLA2G4C
directly activates: PC is converted to PS by PTDSS1
directly activates: PC is transphosphatidylated to PG by PLD1-4/6
directly activates: Catalysis2304
directly activates: Catalysis2334
directly activates: Catalysis2335
directly activates: Catalysis2337
directly activates: Catalysis2338
directly activates: Catalysis2347
directly activates: Catalysis2363

CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0004142
BFO_0000050: Pathway1200
directly activates: PI is exchanged with PC by PITPNB

PI:PITPNB is transported from the ER membrane to the Golgi membrane
type: GO_0003674
BFO_0000050: Pathway1201
directly activates: PI is exchanged with PC by PITPNB

PI is exchanged with PC by PITPNB
type: GO_0003674
BFO_0000050: Pathway1201
directly activates: PC:PITPNB is transported from the Golgi membrane to the ER membrane
directly activates: PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane
directly activates: PI is phosphorylated to PI4P by PI4KB at the Golgi membrane
directly activates: PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane
directly activates: Catalysis2389
directly activates: Catalysis2390
directly activates: Catalysis2392

PC:PITPNB is transported from the Golgi membrane to the ER membrane
type: GO_0003674
BFO_0000050: Pathway1201
directly activates: PC is exchanged with PI by PITPNB

PC is exchanged with PI by PITPNB
type: GO_0003674
BFO_0000050: Pathway1201
directly activates: PC is hydrolyzed to PA and choline by PLD1/2
directly activates: PI:PITPNB is transported from the ER membrane to the Golgi membrane
directly activates: PC is hydrolyzed to 1-acyl LPC by PLA2[5]
directly activates: PC is hydrolyzed to 1-acyl LPC by PLA2[6]
directly activates: PC is hydrolysed to 2-acyl LPC by PLA2[7]
directly activates: PC is hydrolyzed to 2-acyl LPC by PLA2G4C
directly activates: PC is converted to PS by PTDSS1
directly activates: PC is transphosphatidylated to PG by PLD1-4/6
directly activates: Catalysis2304
directly activates: Catalysis2334
directly activates: Catalysis2335
directly activates: Catalysis2337
directly activates: Catalysis2338
directly activates: Catalysis2347
directly activates: Catalysis2363

PC is hydrolyzed to 1-acyl LPC by PLA2[5]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004623
BFO_0000050: Pathway1202
directly activates: 1-acyl LPC is acylated to PC by LPCAT
directly activates: 1-acyl LPC is hydrolyzed to GPCho by PLA2[8]
directly activates: 1-acyl LPC is hydrolyzed to GPCho by PLA2G4C
directly activates: Catalysis2336
directly activates: Catalysis2342
directly activates: Catalysis2343

PC is hydrolyzed to 1-acyl LPC by PLA2[6]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004623
BFO_0000050: Pathway1202
directly activates: 1-acyl LPC is acylated to PC by LPCAT
directly activates: 1-acyl LPC is hydrolyzed to GPCho by PLA2[8]
directly activates: 1-acyl LPC is hydrolyzed to GPCho by PLA2G4C
directly activates: Catalysis2336
directly activates: Catalysis2342
directly activates: Catalysis2343

1-acyl LPC is acylated to PC by LPCAT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0003841
BFO_0000050: Pathway1202
directly activates: PC is hydrolyzed to PA and choline by PLD1/2
directly activates: PC is hydrolyzed to 1-acyl LPC by PLA2[5]
directly activates: PC is hydrolyzed to 1-acyl LPC by PLA2[6]
directly activates: PC is hydrolysed to 2-acyl LPC by PLA2[7]
directly activates: PC is hydrolyzed to 2-acyl LPC by PLA2G4C
directly activates: PC is converted to PS by PTDSS1
directly activates: PC is transphosphatidylated to PG by PLD1-4/6
directly activates: Catalysis2304
directly activates: Catalysis2334
directly activates: Catalysis2335
directly activates: Catalysis2337
directly activates: Catalysis2338
directly activates: Catalysis2347
directly activates: Catalysis2363

PC is hydrolysed to 2-acyl LPC by PLA2[7]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008970
BFO_0000050: Pathway1202
directly activates: 2-acyl LPC is acylated to PC by LPCAT
directly activates: 2-acyl LPC is hydrolyzed to GPCho by PLA2[8]
directly activates: 2-acyl LPC is hydrolyzed to GPCho by PLA2G4C
directly activates: Catalysis2339
directly activates: Catalysis2344
directly activates: Catalysis2345

PC is hydrolyzed to 2-acyl LPC by PLA2G4C
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: GO_0008970
BFO_0000050: Pathway1202
directly activates: 2-acyl LPC is acylated to PC by LPCAT
directly activates: 2-acyl LPC is hydrolyzed to GPCho by PLA2[8]
directly activates: 2-acyl LPC is hydrolyzed to GPCho by PLA2G4C
directly activates: Catalysis2339
directly activates: Catalysis2344
directly activates: Catalysis2345

2-acyl LPC is acylated to PC by LPCAT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0047144
BFO_0000050: Pathway1202
directly activates: PC is hydrolyzed to PA and choline by PLD1/2
directly activates: PC is hydrolyzed to 1-acyl LPC by PLA2[5]
directly activates: PC is hydrolyzed to 1-acyl LPC by PLA2[6]
directly activates: PC is hydrolysed to 2-acyl LPC by PLA2[7]
directly activates: PC is hydrolyzed to 2-acyl LPC by PLA2G4C
directly activates: PC is converted to PS by PTDSS1
directly activates: PC is transphosphatidylated to PG by PLD1-4/6
directly activates: Catalysis2304
directly activates: Catalysis2334
directly activates: Catalysis2335
directly activates: Catalysis2337
directly activates: Catalysis2338
directly activates: Catalysis2347
directly activates: Catalysis2363

PC is hydrolyzed to 1-acyl LPC by PLA2[16]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004623
BFO_0000050: Pathway1202

PC is hydrolyzed to 1-acyl LPC by PLB1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: PLB
type: Restriction
  on property: enabled by
  some values from: PLB
type: Restriction
  on property: enabled by
  some values from: PLB
type: Restriction
  on property: enabled by
  some values from: PLB
type: Restriction
  on property: enabled by
  some values from: PLB
type: Restriction
  on property: enabled by
  some values from: PLB
type: Restriction
  on property: enabled by
  some values from: PLB
type: Restriction
  on property: enabled by
  some values from: PLB
type: GO_0004623
BFO_0000050: Pathway1202

1-acyl LPC is hydrolyzed to GPCho by PLA2[8]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004622
BFO_0000050: Pathway1203
directly activates: GPCho is hydrolyzed to Cho and G3P by GPCPD1
directly activates: Catalysis2346

1-acyl LPC is hydrolyzed to GPCho by PLA2G4C
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: GO_0004622
BFO_0000050: Pathway1203
directly activates: GPCho is hydrolyzed to Cho and G3P by GPCPD1
directly activates: Catalysis2346

2-acyl LPC is hydrolyzed to GPCho by PLA2[8]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004622
BFO_0000050: Pathway1203
directly activates: GPCho is hydrolyzed to Cho and G3P by GPCPD1
directly activates: Catalysis2346

2-acyl LPC is hydrolyzed to GPCho by PLA2G4C
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: GO_0004622
BFO_0000050: Pathway1203
directly activates: GPCho is hydrolyzed to Cho and G3P by GPCPD1
directly activates: Catalysis2346

GPCho is hydrolyzed to Cho and G3P by GPCPD1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: GDE5
type: Restriction
  on property: enabled by
  some values from: GDE5
type: Restriction
  on property: enabled by
  some values from: GDE5
type: Restriction
  on property: enabled by
  some values from: GDE5
type: Restriction
  on property: enabled by
  some values from: GDE5
type: Restriction
  on property: enabled by
  some values from: GDE5
type: Restriction
  on property: enabled by
  some values from: GDE5
type: Restriction
  on property: enabled by
  some values from: GDE5
type: GO_0008889
BFO_0000050: Pathway1203
directly activates: Cho is acetylated to AcCho by CHAT
directly activates: Conversion of glycerol-3-phosphate to lysophosphatidic acid
directly activates: G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM)
directly activates: Cho is phosphorylated to PCho by CHK dimer
directly activates: Catalysis1652
directly activates: Catalysis2114
directly activates: Catalysis2301
directly activates: Catalysis2329

PC is converted to PS by PTDSS1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: KIAA0024
type: Restriction
  on property: enabled by
  some values from: KIAA0024
type: Restriction
  on property: enabled by
  some values from: KIAA0024
type: Restriction
  on property: enabled by
  some values from: KIAA0024
type: Restriction
  on property: enabled by
  some values from: KIAA0024
type: Restriction
  on property: enabled by
  some values from: KIAA0024
type: Restriction
  on property: enabled by
  some values from: KIAA0024
type: Restriction
  on property: enabled by
  some values from: KIAA0024
type: GO_0016740
BFO_0000050: Pathway1204
directly activates: PS transports from the ER membrane to the IM membrane
directly activates: PS is hydrolyzed to 1-acyl LPS by PLA2[9]
directly activates: PS is hydrolyzed to 1-acyl LPS by PLA2G2A
directly activates: PS is hydrolyzed to 2-acyl LPS by PLA2[10]
directly activates: Catalysis2349
directly activates: Catalysis2350
directly activates: Catalysis2352

PE is converted to PS by PTDSS2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: PSS2
type: Restriction
  on property: enabled by
  some values from: PSS2
type: Restriction
  on property: enabled by
  some values from: PSS2
type: Restriction
  on property: enabled by
  some values from: PSS2
type: Restriction
  on property: enabled by
  some values from: PSS2
type: Restriction
  on property: enabled by
  some values from: PSS2
type: Restriction
  on property: enabled by
  some values from: PSS2
type: Restriction
  on property: enabled by
  some values from: PSS2
type: GO_0016740
BFO_0000050: Pathway1204
directly activates: PS transports from the ER membrane to the IM membrane
directly activates: PS is hydrolyzed to 1-acyl LPS by PLA2[9]
directly activates: PS is hydrolyzed to 1-acyl LPS by PLA2G2A
directly activates: PS is hydrolyzed to 2-acyl LPS by PLA2[10]
directly activates: Catalysis2349
directly activates: Catalysis2350
directly activates: Catalysis2352

PS is hydrolyzed to 1-acyl LPS by PLA2[9]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004623
BFO_0000050: Pathway1205
directly activates: 1-acyl LPS is acylated to PS by LPSAT
directly activates: Catalysis2351

PS is hydrolyzed to 1-acyl LPS by PLA2G2A
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004623
BFO_0000050: Pathway1205
directly activates: 1-acyl LPS is acylated to PS by LPSAT
directly activates: Catalysis2351

1-acyl LPS is acylated to PS by LPSAT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0003841
BFO_0000050: Pathway1205
directly activates: PS transports from the ER membrane to the IM membrane
directly activates: PS is hydrolyzed to 1-acyl LPS by PLA2[9]
directly activates: PS is hydrolyzed to 1-acyl LPS by PLA2G2A
directly activates: PS is hydrolyzed to 2-acyl LPS by PLA2[10]
directly activates: Catalysis2349
directly activates: Catalysis2350
directly activates: Catalysis2352

PS is hydrolyzed to 2-acyl LPS by PLA2[10]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004623
BFO_0000050: Pathway1205
directly activates: 2-acyl LPS is acylated to PS by LPSAT
directly activates: Catalysis2353

2-acyl LPS is acylated to PS by LPSAT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0047144
BFO_0000050: Pathway1205
directly activates: PS transports from the ER membrane to the IM membrane
directly activates: PS is hydrolyzed to 1-acyl LPS by PLA2[9]
directly activates: PS is hydrolyzed to 1-acyl LPS by PLA2G2A
directly activates: PS is hydrolyzed to 2-acyl LPS by PLA2[10]
directly activates: Catalysis2349
directly activates: Catalysis2350
directly activates: Catalysis2352

PS is hydrolyzed to 1-acyl LPS by PLA2[15]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004623
BFO_0000050: Pathway1205

PA is converted to CDP-DAG by CDS1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004605
BFO_0000050: Pathway1206
directly activates: CDP-DAG is converted to PI by CDIPT
directly activates: Catalysis2356

CDP-DAG is converted to PI by CDIPT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0003881
BFO_0000050: Pathway1206
directly activates: PC is exchanged with PI by PITPNB
directly activates: PI is hydrolyzed to 1-acyl LPI by PLA2[11]
directly activates: PI is hydrolyzed to 1-acyl LPI by PLA2[12]
directly activates: PI is hydrolyzed to 2-acyl LPI by PLA2[13]
directly activates: PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane
directly activates: Catalysis2357
directly activates: Catalysis2358
directly activates: Catalysis2360
directly activates: Catalysis2387

PI is hydrolyzed to 1-acyl LPI by PLA2[11]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004623
BFO_0000050: Pathway1207
directly activates: 1-acyl LPI is acylated to PI by MBOAT7
directly activates: Catalysis2359

PI is hydrolyzed to 1-acyl LPI by PLA2[12]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004623
BFO_0000050: Pathway1207
directly activates: 1-acyl LPI is acylated to PI by MBOAT7
directly activates: Catalysis2359

1-acyl LPI is acylated to PI by MBOAT7
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: BB1
type: Restriction
  on property: enabled by
  some values from: BB1
type: Restriction
  on property: enabled by
  some values from: BB1
type: Restriction
  on property: enabled by
  some values from: BB1
type: Restriction
  on property: enabled by
  some values from: BB1
type: Restriction
  on property: enabled by
  some values from: BB1
type: Restriction
  on property: enabled by
  some values from: BB1
type: Restriction
  on property: enabled by
  some values from: BB1
type: GO_0003841
BFO_0000050: Pathway1207
directly activates: PC is exchanged with PI by PITPNB
directly activates: PI is hydrolyzed to 1-acyl LPI by PLA2[11]
directly activates: PI is hydrolyzed to 1-acyl LPI by PLA2[12]
directly activates: PI is hydrolyzed to 2-acyl LPI by PLA2[13]
directly activates: PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane
directly activates: Catalysis2357
directly activates: Catalysis2358
directly activates: Catalysis2360
directly activates: Catalysis2387

PI is hydrolyzed to 2-acyl LPI by PLA2[13]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008970
BFO_0000050: Pathway1207
directly activates: 2-acyl LPI is acylated to PI by MBOAT7
directly activates: Catalysis2361

2-acyl LPI is acylated to PI by MBOAT7
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: BB1
type: Restriction
  on property: enabled by
  some values from: BB1
type: Restriction
  on property: enabled by
  some values from: BB1
type: Restriction
  on property: enabled by
  some values from: BB1
type: Restriction
  on property: enabled by
  some values from: BB1
type: Restriction
  on property: enabled by
  some values from: BB1
type: Restriction
  on property: enabled by
  some values from: BB1
type: Restriction
  on property: enabled by
  some values from: BB1
type: GO_0047144
BFO_0000050: Pathway1207
directly activates: PC is exchanged with PI by PITPNB
directly activates: PI is hydrolyzed to 1-acyl LPI by PLA2[11]
directly activates: PI is hydrolyzed to 1-acyl LPI by PLA2[12]
directly activates: PI is hydrolyzed to 2-acyl LPI by PLA2[13]
directly activates: PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane
directly activates: Catalysis2357
directly activates: Catalysis2358
directly activates: Catalysis2360
directly activates: Catalysis2387

PI is hydrolyzed to 1-acyl LPI by PLA2[15]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004623
BFO_0000050: Pathway1207

PC is transphosphatidylated to PG by PLD1-4/6
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004630
BFO_0000050: Pathway1208
directly activates: PG is hydrolyzed to 1-acyl LPG by PLA2[1]
directly activates: PG is hydrolyzed to 1-acyl LPG by PLA2G2A
directly activates: PG is hydrolyzed to 2-acyl LPG by PLA2[14]
directly activates: PG transports from the ER membrane to the late endosome membrane
directly activates: Catalysis2367
directly activates: Catalysis2368
directly activates: Catalysis2370

PA transports from the outer to the inner mitochondrial membrane
type: GO_0003674
BFO_0000050: Pathway1208
directly activates: PA is converted to CDP-DAG by CDS2
directly activates: Catalysis2364

PA is converted to CDP-DAG by CDS2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: enabled by
  some values from: CDS2
type: Restriction
  on property: enabled by
  some values from: CDS2
type: Restriction
  on property: enabled by
  some values from: CDS2
type: Restriction
  on property: enabled by
  some values from: CDS2
type: Restriction
  on property: enabled by
  some values from: CDS2
type: Restriction
  on property: enabled by
  some values from: CDS2
type: Restriction
  on property: enabled by
  some values from: CDS2
type: Restriction
  on property: enabled by
  some values from: CDS2
type: GO_0004605
BFO_0000050: Pathway1208
directly activates: CDP-DAG is converted to PGP by PGS1
directly activates: PG and CDP-DAG are converted to CL by CRLS1
directly activates: Catalysis2365
directly activates: Catalysis2377

CDP-DAG is converted to PGP by PGS1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: enabled by
  some values from: PGS1
type: Restriction
  on property: enabled by
  some values from: PGS1
type: Restriction
  on property: enabled by
  some values from: PGS1
type: Restriction
  on property: enabled by
  some values from: PGS1
type: Restriction
  on property: enabled by
  some values from: PGS1
type: Restriction
  on property: enabled by
  some values from: PGS1
type: Restriction
  on property: enabled by
  some values from: PGS1
type: Restriction
  on property: enabled by
  some values from: PGS1
type: GO_0008444
BFO_0000050: Pathway1208
directly activates: PTPMT1 dephosphorylates PGP to PG
directly activates: Catalysis2366

PTPMT1 dephosphorylates PGP to PG
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: enabled by
  some values from: MOSP
type: Restriction
  on property: enabled by
  some values from: MOSP
type: Restriction
  on property: enabled by
  some values from: MOSP
type: Restriction
  on property: enabled by
  some values from: MOSP
type: Restriction
  on property: enabled by
  some values from: MOSP
type: Restriction
  on property: enabled by
  some values from: MOSP
type: Restriction
  on property: enabled by
  some values from: MOSP
type: Restriction
  on property: enabled by
  some values from: MOSP
type: GO_0008962
BFO_0000050: Pathway1208
directly activates: PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM)
directly activates: PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM)
directly activates: PG and CDP-DAG are converted to CL by CRLS1
directly activates: Catalysis2372
directly activates: Catalysis2374
directly activates: Catalysis2377

PG is hydrolyzed to 1-acyl LPG by PLA2[1]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004623
BFO_0000050: Pathway1209
directly activates: 1-acyl LPG is acylated to PG by LPGAT
directly activates: Catalysis2369

PG is hydrolyzed to 1-acyl LPG by PLA2G2A
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004623
BFO_0000050: Pathway1209
directly activates: 1-acyl LPG is acylated to PG by LPGAT
directly activates: Catalysis2369

1-acyl LPG is acylated to PG by LPGAT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0003841
BFO_0000050: Pathway1209
directly activates: PG is hydrolyzed to 1-acyl LPG by PLA2[1]
directly activates: PG is hydrolyzed to 1-acyl LPG by PLA2G2A
directly activates: PG is hydrolyzed to 2-acyl LPG by PLA2[14]
directly activates: PG transports from the ER membrane to the late endosome membrane
directly activates: Catalysis2367
directly activates: Catalysis2368
directly activates: Catalysis2370

PG is hydrolyzed to 2-acyl LPG by PLA2[14]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008970
BFO_0000050: Pathway1209
directly activates: 2-acyl LPG is acylated to PG by LPGAT
directly activates: Catalysis2371

2-acyl LPG is acylated to PG by LPGAT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0047144
BFO_0000050: Pathway1209
directly activates: PG is hydrolyzed to 1-acyl LPG by PLA2[1]
directly activates: PG is hydrolyzed to 1-acyl LPG by PLA2G2A
directly activates: PG is hydrolyzed to 2-acyl LPG by PLA2[14]
directly activates: PG transports from the ER membrane to the late endosome membrane
directly activates: Catalysis2367
directly activates: Catalysis2368
directly activates: Catalysis2370

PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: GO_0004623
BFO_0000050: Pathway1209
directly activates: 1-acyl LPG is acylated to PG by CRLS1 (IM)
directly activates: Catalysis2373

1-acyl LPG is acylated to PG by CRLS1 (IM)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: enabled by
  some values from: C20orf155
type: Restriction
  on property: enabled by
  some values from: C20orf155
type: Restriction
  on property: enabled by
  some values from: C20orf155
type: Restriction
  on property: enabled by
  some values from: C20orf155
type: Restriction
  on property: enabled by
  some values from: C20orf155
type: Restriction
  on property: enabled by
  some values from: C20orf155
type: Restriction
  on property: enabled by
  some values from: C20orf155
type: Restriction
  on property: enabled by
  some values from: C20orf155
type: GO_0003841
BFO_0000050: Pathway1209
directly activates: PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM)
directly activates: PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM)
directly activates: Catalysis2372
directly activates: Catalysis2374

PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: GO_0008970
BFO_0000050: Pathway1209
directly activates: 2-acyl LPG is acylated to PG by CRLS1 (IM)
directly activates: Catalysis2375

2-acyl LPG is acylated to PG by CRLS1 (IM)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: enabled by
  some values from: C20orf155
type: Restriction
  on property: enabled by
  some values from: C20orf155
type: Restriction
  on property: enabled by
  some values from: C20orf155
type: Restriction
  on property: enabled by
  some values from: C20orf155
type: Restriction
  on property: enabled by
  some values from: C20orf155
type: Restriction
  on property: enabled by
  some values from: C20orf155
type: Restriction
  on property: enabled by
  some values from: C20orf155
type: Restriction
  on property: enabled by
  some values from: C20orf155
type: GO_0047144
BFO_0000050: Pathway1209
directly activates: PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM)
directly activates: PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM)
directly activates: Catalysis2372
directly activates: Catalysis2374

PG is hydrolyzed to 1-acyl LPG by PLA2[16]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004623
BFO_0000050: Pathway1209

PG and CDP-DAG are converted to CL by CRLS1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: enabled by
  some values from: C20orf155
type: Restriction
  on property: enabled by
  some values from: C20orf155
type: Restriction
  on property: enabled by
  some values from: C20orf155
type: Restriction
  on property: enabled by
  some values from: C20orf155
type: Restriction
  on property: enabled by
  some values from: C20orf155
type: Restriction
  on property: enabled by
  some values from: C20orf155
type: Restriction
  on property: enabled by
  some values from: C20orf155
type: Restriction
  on property: enabled by
  some values from: C20orf155
type: GO_0043337
BFO_0000050: Pathway1210
directly activates: CL is hydrolyzed to MLCL by PLA2G6 (IM)
directly activates: CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible)
directly activates: CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible)
directly activates: Catalysis2378
directly activates: Catalysis2380
directly activates: Catalysis2382

CL is hydrolyzed to MLCL by PLA2G6 (IM)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: enabled by
  some values from: PLA2G6
type: Restriction
  on property: enabled by
  some values from: PLA2G6
type: Restriction
  on property: enabled by
  some values from: PLA2G6
type: Restriction
  on property: enabled by
  some values from: PLA2G6
type: Restriction
  on property: enabled by
  some values from: PLA2G6
type: Restriction
  on property: enabled by
  some values from: PLA2G6
type: Restriction
  on property: enabled by
  some values from: PLA2G6
type: Restriction
  on property: enabled by
  some values from: PLA2G6
type: GO_0004623
BFO_0000050: Pathway1211
directly activates: MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible)
directly activates: MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible)
directly activates: MLCL is acylated to CL by HADH (IM)
directly activates: MLCL transports from the IM to the ER
directly activates: MLCL is hydrolyzed to DLCL by PLA2G4A (IM)
directly activates: Catalysis2379
directly activates: Catalysis2381
directly activates: Catalysis2383
directly activates: Catalysis2385

MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: enabled by
  some values from: EFE2
type: Restriction
  on property: enabled by
  some values from: EFE2
type: Restriction
  on property: enabled by
  some values from: EFE2
type: Restriction
  on property: enabled by
  some values from: EFE2
type: Restriction
  on property: enabled by
  some values from: EFE2
type: Restriction
  on property: enabled by
  some values from: EFE2
type: Restriction
  on property: enabled by
  some values from: EFE2
type: Restriction
  on property: enabled by
  some values from: EFE2
type: GO_0008374
BFO_0000050: Pathway1211
directly activates: CL is hydrolyzed to MLCL by PLA2G6 (IM)
directly activates: CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible)
directly activates: CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible)
directly activates: Catalysis2378
directly activates: Catalysis2380
directly activates: Catalysis2382

CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: enabled by
  some values from: EFE2
type: Restriction
  on property: enabled by
  some values from: EFE2
type: Restriction
  on property: enabled by
  some values from: EFE2
type: Restriction
  on property: enabled by
  some values from: EFE2
type: Restriction
  on property: enabled by
  some values from: EFE2
type: Restriction
  on property: enabled by
  some values from: EFE2
type: Restriction
  on property: enabled by
  some values from: EFE2
type: Restriction
  on property: enabled by
  some values from: EFE2
type: GO_0047184
BFO_0000050: Pathway1211
directly activates: MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible)
directly activates: MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible)
directly activates: MLCL is acylated to CL by HADH (IM)
directly activates: MLCL transports from the IM to the ER
directly activates: MLCL is hydrolyzed to DLCL by PLA2G4A (IM)
directly activates: Catalysis2379
directly activates: Catalysis2381
directly activates: Catalysis2383
directly activates: Catalysis2385

MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: enabled by
  some values from: EFE2
type: Restriction
  on property: enabled by
  some values from: EFE2
type: Restriction
  on property: enabled by
  some values from: EFE2
type: Restriction
  on property: enabled by
  some values from: EFE2
type: Restriction
  on property: enabled by
  some values from: EFE2
type: Restriction
  on property: enabled by
  some values from: EFE2
type: Restriction
  on property: enabled by
  some values from: EFE2
type: Restriction
  on property: enabled by
  some values from: EFE2
type: GO_0008374
BFO_0000050: Pathway1211
directly activates: CL is hydrolyzed to MLCL by PLA2G6 (IM)
directly activates: CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible)
directly activates: CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible)
directly activates: Catalysis2378
directly activates: Catalysis2380
directly activates: Catalysis2382

CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: enabled by
  some values from: EFE2
type: Restriction
  on property: enabled by
  some values from: EFE2
type: Restriction
  on property: enabled by
  some values from: EFE2
type: Restriction
  on property: enabled by
  some values from: EFE2
type: Restriction
  on property: enabled by
  some values from: EFE2
type: Restriction
  on property: enabled by
  some values from: EFE2
type: Restriction
  on property: enabled by
  some values from: EFE2
type: Restriction
  on property: enabled by
  some values from: EFE2
type: GO_0003841
BFO_0000050: Pathway1211
directly activates: PE transports from the mitochondrial membrane to the ER
directly activates: MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible)
directly activates: MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible)
directly activates: MLCL is acylated to CL by HADH (IM)
directly activates: MLCL transports from the IM to the ER
directly activates: MLCL is hydrolyzed to DLCL by PLA2G4A (IM)
directly activates: Catalysis2379
directly activates: Catalysis2381
directly activates: Catalysis2383
directly activates: Catalysis2385

MLCL is acylated to CL by HADH (IM)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: GO_0008374
BFO_0000050: Pathway1211
directly activates: CL is hydrolyzed to MLCL by PLA2G6 (IM)
directly activates: CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible)
directly activates: CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible)
directly activates: Catalysis2378
directly activates: Catalysis2380
directly activates: Catalysis2382

MLCL transports from the IM to the ER
type: GO_0003674
BFO_0000050: Pathway1211
directly activates: MLCL is acylated to CL by LCLAT1 (ER)
directly activates: Catalysis2384

MLCL is acylated to CL by LCLAT1 (ER)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: AGPAT8
type: Restriction
  on property: enabled by
  some values from: AGPAT8
type: Restriction
  on property: enabled by
  some values from: AGPAT8
type: Restriction
  on property: enabled by
  some values from: AGPAT8
type: Restriction
  on property: enabled by
  some values from: AGPAT8
type: Restriction
  on property: enabled by
  some values from: AGPAT8
type: Restriction
  on property: enabled by
  some values from: AGPAT8
type: Restriction
  on property: enabled by
  some values from: AGPAT8
type: GO_0008374
BFO_0000050: Pathway1211
directly activates: CL transports from the ER to the IM

CL transports from the ER to the IM
type: GO_0003674
BFO_0000050: Pathway1211
directly activates: CL is hydrolyzed to MLCL by PLA2G6 (IM)
directly activates: CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible)
directly activates: CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible)
directly activates: Catalysis2378
directly activates: Catalysis2380
directly activates: Catalysis2382

MLCL is hydrolyzed to DLCL by PLA2G4A (IM)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: GO_0004623
BFO_0000050: Pathway1211
directly activates: DLCL transports from the IM to the ER

DLCL transports from the IM to the ER
type: GO_0003674
BFO_0000050: Pathway1211
directly activates: DLCL is acylated to MLCL by LCLAT1 (ER)
directly activates: Catalysis2386

DLCL is acylated to MLCL by LCLAT1 (ER)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: AGPAT8
type: Restriction
  on property: enabled by
  some values from: AGPAT8
type: Restriction
  on property: enabled by
  some values from: AGPAT8
type: Restriction
  on property: enabled by
  some values from: AGPAT8
type: Restriction
  on property: enabled by
  some values from: AGPAT8
type: Restriction
  on property: enabled by
  some values from: AGPAT8
type: Restriction
  on property: enabled by
  some values from: AGPAT8
type: Restriction
  on property: enabled by
  some values from: AGPAT8
type: GO_0008374
BFO_0000050: Pathway1211
directly activates: MLCL is acylated to CL by LCLAT1 (ER)
directly activates: Catalysis2384

PG transports from the ER membrane to the late endosome membrane
type: GO_0003674
BFO_0000050: Pathway1212
directly activates: PG is converted to BMP

PG is converted to BMP
type: GO_0003674
BFO_0000050: Pathway1212

PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004430
BFO_0000050: Pathway1214
directly activates: PI4P is dephosphorylated to PI by SACM1L at the ER membrane
directly activates: Catalysis2388

PI4P is dephosphorylated to PI by SACM1L at the ER membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: KIAA0851
type: Restriction
  on property: enabled by
  some values from: KIAA0851
type: Restriction
  on property: enabled by
  some values from: KIAA0851
type: Restriction
  on property: enabled by
  some values from: KIAA0851
type: Restriction
  on property: enabled by
  some values from: KIAA0851
type: Restriction
  on property: enabled by
  some values from: KIAA0851
type: Restriction
  on property: enabled by
  some values from: KIAA0851
type: Restriction
  on property: enabled by
  some values from: KIAA0851
type: GO_0034596
BFO_0000050: Pathway1214
directly activates: PC is exchanged with PI by PITPNB
directly activates: PI is hydrolyzed to 1-acyl LPI by PLA2[11]
directly activates: PI is hydrolyzed to 1-acyl LPI by PLA2[12]
directly activates: PI is hydrolyzed to 2-acyl LPI by PLA2[13]
directly activates: PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane
directly activates: Catalysis2357
directly activates: Catalysis2358
directly activates: Catalysis2360
directly activates: Catalysis2387

PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004430
BFO_0000050: Pathway1215
directly activates: PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane
directly activates: PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane
directly activates: PI4P transports from the Golgi membrane to the plasma membrane
directly activates: Catalysis2391
directly activates: Catalysis2396

PI4KB binds to ARF1/3:GTP at the Golgi membrane
type: GO_0003674
BFO_0000050: Pathway1215
directly activates: PI is phosphorylated to PI4P by PI4KB at the Golgi membrane
directly activates: Catalysis2390

PI is phosphorylated to PI4P by PI4KB at the Golgi membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0004430
BFO_0000050: Pathway1215
directly activates: PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane
directly activates: PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane
directly activates: PI4P transports from the Golgi membrane to the plasma membrane
directly activates: Catalysis2391
directly activates: Catalysis2396

PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: KIAA0851
type: Restriction
  on property: enabled by
  some values from: KIAA0851
type: Restriction
  on property: enabled by
  some values from: KIAA0851
type: Restriction
  on property: enabled by
  some values from: KIAA0851
type: Restriction
  on property: enabled by
  some values from: KIAA0851
type: Restriction
  on property: enabled by
  some values from: KIAA0851
type: Restriction
  on property: enabled by
  some values from: KIAA0851
type: Restriction
  on property: enabled by
  some values from: KIAA0851
type: GO_0034596
BFO_0000050: Pathway1215
directly activates: PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane
directly activates: PI is phosphorylated to PI4P by PI4KB at the Golgi membrane
directly activates: PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane
directly activates: Catalysis2389
directly activates: Catalysis2390
directly activates: Catalysis2392

PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016303
BFO_0000050: Pathway1215
directly activates: PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane
directly activates: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the Golgi membrane
directly activates: Catalysis2393
directly activates: Catalysis2394

PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: KIAA0851
type: Restriction
  on property: enabled by
  some values from: KIAA0851
type: Restriction
  on property: enabled by
  some values from: KIAA0851
type: Restriction
  on property: enabled by
  some values from: KIAA0851
type: Restriction
  on property: enabled by
  some values from: KIAA0851
type: Restriction
  on property: enabled by
  some values from: KIAA0851
type: Restriction
  on property: enabled by
  some values from: KIAA0851
type: Restriction
  on property: enabled by
  some values from: KIAA0851
type: GO_0004438
BFO_0000050: Pathway1215
directly activates: PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane
directly activates: PI is phosphorylated to PI4P by PI4KB at the Golgi membrane
directly activates: PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane
directly activates: Catalysis2389
directly activates: Catalysis2390
directly activates: Catalysis2392

PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the Golgi membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0000285
BFO_0000050: Pathway1215
directly activates: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane
directly activates: Catalysis2395

PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0043813
BFO_0000050: Pathway1215
directly activates: PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane
directly activates: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the Golgi membrane
directly activates: Catalysis2393
directly activates: Catalysis2394

PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0035005
BFO_0000050: Pathway1215
directly activates: PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane
directly activates: Catalysis2397

PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: TPIP
type: Restriction
  on property: enabled by
  some values from: TPIP
type: Restriction
  on property: enabled by
  some values from: TPIP
type: Restriction
  on property: enabled by
  some values from: TPIP
type: Restriction
  on property: enabled by
  some values from: TPIP
type: Restriction
  on property: enabled by
  some values from: TPIP
type: Restriction
  on property: enabled by
  some values from: TPIP
type: Restriction
  on property: enabled by
  some values from: TPIP
type: GO_0051800
BFO_0000050: Pathway1215
directly activates: PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane
directly activates: PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane
directly activates: PI4P transports from the Golgi membrane to the plasma membrane
directly activates: Catalysis2391
directly activates: Catalysis2396

PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004439
BFO_0000050: Pathway1215
directly activates: PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane
directly activates: PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane
directly activates: PI4P transports from the Golgi membrane to the plasma membrane
directly activates: Catalysis2391
directly activates: Catalysis2396

PI4P transports from the Golgi membrane to the plasma membrane
type: GO_0003674
BFO_0000050: Pathway1216
directly activates: PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane
directly activates: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
directly activates: PI4P is dephosphorylated to PI by SYNJ at the plasma membrane
directly activates: Catalysis2399
directly activates: Catalysis2405
directly activates: Catalysis2416

PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016308
BFO_0000050: Pathway1217
directly activates: BiochemicalReaction4609
directly activates: BiochemicalReaction4610
directly activates: PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane
directly activates: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
directly activates: BiochemicalReaction979
directly activates: Catalysis2022
directly activates: Catalysis2023
directly activates: Catalysis2400
directly activates: Catalysis2401

PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004439
BFO_0000050: Pathway1217
directly activates: PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane
directly activates: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
directly activates: PI4P is dephosphorylated to PI by SYNJ at the plasma membrane
directly activates: Catalysis2399
directly activates: Catalysis2405
directly activates: Catalysis2416

PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0046934
BFO_0000050: Pathway1217
directly activates: PI(3,4,5)P3 is dephosphorylated to PI (4,5)P2 by PTEN at the plasma membrane
directly activates: PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane
directly activates: Catalysis2402
directly activates: Catalysis2404

PI(3,4,5)P3 is dephosphorylated to PI (4,5)P2 by PTEN at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016314
BFO_0000050: Pathway1217
directly activates: BiochemicalReaction4609
directly activates: BiochemicalReaction4610
directly activates: PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane
directly activates: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
directly activates: Catalysis2022
directly activates: Catalysis2023
directly activates: Catalysis2400
directly activates: Catalysis2401

PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0052812
BFO_0000050: Pathway1217
directly activates: PI(3,4,5)P3 is dephosphorylated to PI (4,5)P2 by PTEN at the plasma membrane
directly activates: PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane
directly activates: Catalysis2402
directly activates: Catalysis2404

PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0034485
BFO_0000050: Pathway1217
directly activates: PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane
directly activates: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
directly activates: PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane
directly activates: PI(3,4)P2 is transported from the plasma membrane to the early endosome membrane
directly activates: Catalysis2403
directly activates: Catalysis2406
directly activates: Catalysis2408

PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0035005
BFO_0000050: Pathway1217
directly activates: PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane
directly activates: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
directly activates: PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane
directly activates: PI(3,4)P2 is transported from the plasma membrane to the early endosome membrane
directly activates: Catalysis2403
directly activates: Catalysis2406
directly activates: Catalysis2408

PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0051800
BFO_0000050: Pathway1217
directly activates: PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane
directly activates: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
directly activates: PI4P is dephosphorylated to PI by SYNJ at the plasma membrane
directly activates: Catalysis2399
directly activates: Catalysis2405
directly activates: Catalysis2416

PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0052811
BFO_0000050: Pathway1217
directly activates: PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane
directly activates: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
directly activates: PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane
directly activates: PI(3,4)P2 is transported from the plasma membrane to the early endosome membrane
directly activates: Catalysis2403
directly activates: Catalysis2406
directly activates: Catalysis2408

PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016316
BFO_0000050: Pathway1217
directly activates: PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane
directly activates: PI3P is dephosphorylated to PI by SYNJ/MTM[1] at the plasma membrane
directly activates: PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane
directly activates: Catalysis2407
directly activates: Catalysis2409
directly activates: Catalysis2411

PI3P is dephosphorylated to PI by SYNJ/MTM[1] at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004438
BFO_0000050: Pathway1217
directly activates: PI is hydrolyzed to 1-acyl LPI by PLA2[15]
directly activates: PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane
directly activates: PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane
directly activates: Catalysis2362
directly activates: Catalysis2410
directly activates: Catalysis2415

PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0052810
BFO_0000050: Pathway1217
directly activates: PI5P is phosphorylated to PI(4,5)P2 by PIP4K2A/B at the plasma membrane
directly activates: Catalysis2414

PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0000285
BFO_0000050: Pathway1217
directly activates: PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane
directly activates: PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTM[1] at the plasma membrane
directly activates: Catalysis2412
directly activates: Catalysis2413

PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0043813
BFO_0000050: Pathway1217
directly activates: PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane
directly activates: PI3P is dephosphorylated to PI by SYNJ/MTM[1] at the plasma membrane
directly activates: PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane
directly activates: Catalysis2407
directly activates: Catalysis2409
directly activates: Catalysis2411

PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTM[1] at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0052629
BFO_0000050: Pathway1217
directly activates: PI5P is phosphorylated to PI(4,5)P2 by PIP4K2A/B at the plasma membrane
directly activates: Catalysis2414

PI5P is phosphorylated to PI(4,5)P2 by PIP4K2A/B at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016309
BFO_0000050: Pathway1217
directly activates: BiochemicalReaction4609
directly activates: BiochemicalReaction4610
directly activates: PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane
directly activates: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
directly activates: Catalysis2022
directly activates: Catalysis2023
directly activates: Catalysis2400
directly activates: Catalysis2401

PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004430
BFO_0000050: Pathway1217
directly activates: PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane
directly activates: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
directly activates: PI4P is dephosphorylated to PI by SYNJ at the plasma membrane
directly activates: Catalysis2399
directly activates: Catalysis2405
directly activates: Catalysis2416

PI4P is dephosphorylated to PI by SYNJ at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0034596
BFO_0000050: Pathway1217
directly activates: PI is hydrolyzed to 1-acyl LPI by PLA2[15]
directly activates: PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane
directly activates: PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane
directly activates: Catalysis2362
directly activates: Catalysis2410
directly activates: Catalysis2415

PI(3,4)P2 is transported from the plasma membrane to the early endosome membrane
type: GO_0003674
BFO_0000050: Pathway1218
directly activates: PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane
directly activates: Catalysis2417

PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016316
BFO_0000050: Pathway1219
directly activates: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane
directly activates: PI3P is dephosphorylated to PI by MTM[2] at the early endosome membrane
directly activates: Catalysis2418
directly activates: Catalysis2422

PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031901
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031901
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031901
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031901
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031901
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031901
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031901
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031901
type: GO_0000285
BFO_0000050: Pathway1219
directly activates: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane
directly activates: PI(3,5)P2 is dephosphorylated to PI5P by MTM[2] at the early endosome membrane
directly activates: PI(3,5)P2 transports from the early endosome membrane to the Golgi membrane
directly activates: Catalysis2419
directly activates: Catalysis2420

PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031901
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031901
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031901
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031901
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031901
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031901
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031901
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031901
type: GO_0043813
BFO_0000050: Pathway1219
directly activates: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane
directly activates: PI3P is dephosphorylated to PI by MTM[2] at the early endosome membrane
directly activates: Catalysis2418
directly activates: Catalysis2422

PI(3,5)P2 is dephosphorylated to PI5P by MTM[2] at the early endosome membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0052629
BFO_0000050: Pathway1219

PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016303
BFO_0000050: Pathway1219
directly activates: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane
directly activates: PI3P is dephosphorylated to PI by MTM[2] at the early endosome membrane
directly activates: Catalysis2418
directly activates: Catalysis2422

PI3P is dephosphorylated to PI by MTM[2] at the early endosome membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004438
BFO_0000050: Pathway1219
directly activates: PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane
directly activates: PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane
directly activates: Catalysis2421
directly activates: Catalysis2423

PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004430
BFO_0000050: Pathway1219
directly activates: PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane
directly activates: Catalysis2424

PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0035005
BFO_0000050: Pathway1219
directly activates: PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane
directly activates: Catalysis2417

PI(3,5)P2 transports from the early endosome membrane to the Golgi membrane
type: GO_0003674
BFO_0000050: Pathway1220
directly activates: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane
directly activates: Presence of PI(3,5)P2 stimulates the maturation of the early endosome into the late endosome
directly activates: Catalysis2395

Presence of PI(3,5)P2 stimulates the maturation of the early endosome into the late endosome
type: GO_0003674
BFO_0000050: Pathway1221
directly activates: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane
directly activates: PI(3,5)P2 is dephosphorylated to PI5P by MTM[3] at the late endosome membrane
directly activates: PI(3,5)P2 transports from the late endosome membrane to the Golgi membrane
directly activates: Catalysis2426
directly activates: Catalysis2427

PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the late endosome membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031902
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031902
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031902
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031902
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031902
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031902
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031902
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031902
type: GO_0000285
BFO_0000050: Pathway1222
directly activates: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane
directly activates: PI(3,5)P2 is dephosphorylated to PI5P by MTM[3] at the late endosome membrane
directly activates: PI(3,5)P2 transports from the late endosome membrane to the Golgi membrane
directly activates: Catalysis2426
directly activates: Catalysis2427

PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031902
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031902
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031902
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031902
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031902
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031902
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031902
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031902
type: GO_0043813
BFO_0000050: Pathway1222
directly activates: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the late endosome membrane
directly activates: PI3P is dephosphorylated to PI by MTM[3] at the late endosome membrane
directly activates: Catalysis2425
directly activates: Catalysis2430

PI(3,5)P2 is dephosphorylated to PI5P by MTM[3] at the late endosome membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0052629
BFO_0000050: Pathway1222

PI is phosphorylated to PI5P by PIKFYVE at the late endosome membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031902
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031902
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031902
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031902
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031902
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031902
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031902
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031902
type: GO_0052810
BFO_0000050: Pathway1222

PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016303
BFO_0000050: Pathway1222
directly activates: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the late endosome membrane
directly activates: PI3P is dephosphorylated to PI by MTM[3] at the late endosome membrane
directly activates: Catalysis2425
directly activates: Catalysis2430

PI3P is dephosphorylated to PI by MTM[3] at the late endosome membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004438
BFO_0000050: Pathway1222
directly activates: PI is phosphorylated to PI5P by PIKFYVE at the late endosome membrane
directly activates: PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane
directly activates: Catalysis2428
directly activates: Catalysis2429

PI(3,5)P2 transports from the late endosome membrane to the Golgi membrane
type: GO_0003674
BFO_0000050: Pathway1223
directly activates: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane
directly activates: Catalysis2395

Activation of alpha-linolenic acid to alpha-linolenoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004467
BFO_0000050: Pathway1225
directly activates: Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA
directly activates: Catalysis2432

Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: FADS2
type: Restriction
  on property: enabled by
  some values from: FADS2
type: Restriction
  on property: enabled by
  some values from: FADS2
type: Restriction
  on property: enabled by
  some values from: FADS2
type: GO_0016213
BFO_0000050: Pathway1225
directly activates: Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA
directly activates: Catalysis2433

Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: GO_0009922
BFO_0000050: Pathway1225
directly activates: Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA
directly activates: Catalysis2434

Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: FADS1
type: Restriction
  on property: enabled by
  some values from: FADS1
type: Restriction
  on property: enabled by
  some values from: FADS1
type: Restriction
  on property: enabled by
  some values from: FADS1
type: GO_0045485
BFO_0000050: Pathway1225
directly activates: Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA
directly activates: Catalysis2435

Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0009922
BFO_0000050: Pathway1225
directly activates: Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA
directly activates: Catalysis2436

Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: GO_0009922
BFO_0000050: Pathway1225
directly activates: Desaturation of tetracosapentaenoyl-CoA to tetracosahexaenoyl-CoA
directly activates: Catalysis2437

Desaturation of tetracosapentaenoyl-CoA to tetracosahexaenoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: FADS2
type: Restriction
  on property: enabled by
  some values from: FADS2
type: Restriction
  on property: enabled by
  some values from: FADS2
type: Restriction
  on property: enabled by
  some values from: FADS2
type: GO_0016213
BFO_0000050: Pathway1225
directly activates: Translocation of tetracosahexaenoyl-CoA to peroxisomes
directly activates: Catalysis2438

Translocation of tetracosahexaenoyl-CoA to peroxisomes
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: Restriction
  on property: enabled by
  some values from: ABCD1
type: Restriction
  on property: enabled by
  some values from: ABCD1
type: Restriction
  on property: enabled by
  some values from: ABCD1
type: Restriction
  on property: enabled by
  some values from: ABCD1
type: GO_0005324
BFO_0000050: Pathway1225
directly activates: Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA
directly activates: Catalysis2439

Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0003997
BFO_0000050: Pathway1225
directly activates: Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA
directly activates: Catalysis2440

Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0016508
BFO_0000050: Pathway1225
directly activates: Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA
directly activates: Catalysis2441

Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0016508
BFO_0000050: Pathway1225
directly activates: Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx)
directly activates: Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase
directly activates: Catalysis2442
directly activates: Catalysis2443

Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: enabled by
  some values from: SCP2
type: Restriction
  on property: enabled by
  some values from: SCP2
type: Restriction
  on property: enabled by
  some values from: SCP2
type: Restriction
  on property: enabled by
  some values from: SCP2
type: GO_0050632
BFO_0000050: Pathway1225
directly activates: Conversion of DHA-CoA to docosahexaenoic acid (DHA)
directly activates: Catalysis2444

Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: enabled by
  some values from: ACAA
type: Restriction
  on property: enabled by
  some values from: ACAA
type: Restriction
  on property: enabled by
  some values from: ACAA
type: Restriction
  on property: enabled by
  some values from: ACAA
type: GO_0008775
BFO_0000050: Pathway1225
directly activates: Conversion of DHA-CoA to docosahexaenoic acid (DHA)
directly activates: Catalysis2444

Conversion of DHA-CoA to docosahexaenoic acid (DHA)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: enabled by
  some values from: ACOT8
type: Restriction
  on property: enabled by
  some values from: ACOT8
type: Restriction
  on property: enabled by
  some values from: ACOT8
type: Restriction
  on property: enabled by
  some values from: ACOT8
type: GO_0003986
BFO_0000050: Pathway1225
directly activates: Retranslocation of DHA back to ER

Retranslocation of DHA back to ER
type: GO_0003674
BFO_0000050: Pathway1225

Activation of linoleic acid to linoleoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004467
BFO_0000050: Pathway1226
directly activates: Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA
directly activates: Catalysis2446

Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: FADS2
type: Restriction
  on property: enabled by
  some values from: FADS2
type: Restriction
  on property: enabled by
  some values from: FADS2
type: Restriction
  on property: enabled by
  some values from: FADS2
type: GO_0016213
BFO_0000050: Pathway1226
directly activates: Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA
directly activates: Catalysis2447

Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: GO_0009922
BFO_0000050: Pathway1226
directly activates: Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA
directly activates: Catalysis2448

Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: FADS1
type: Restriction
  on property: enabled by
  some values from: FADS1
type: Restriction
  on property: enabled by
  some values from: FADS1
type: Restriction
  on property: enabled by
  some values from: FADS1
type: GO_0045485
BFO_0000050: Pathway1226
directly activates: Elongation of arachidonyl-CoA to docosatetraenoyl-CoA
directly activates: Catalysis2449

Elongation of arachidonyl-CoA to docosatetraenoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0009922
BFO_0000050: Pathway1226
directly activates: Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA
directly activates: Catalysis2450
label: arachidonoyl-CoA + malonyl-CoA => 3-oxo-(7,10,13,16)-docosatetraenoyl-CoA + CO2 + CoASH [ELOVL5]

Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: GO_0009922
BFO_0000050: Pathway1226
directly activates: Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA
directly activates: Catalysis2451

Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: FADS2
type: Restriction
  on property: enabled by
  some values from: FADS2
type: Restriction
  on property: enabled by
  some values from: FADS2
type: Restriction
  on property: enabled by
  some values from: FADS2
type: GO_0016213
BFO_0000050: Pathway1226
directly activates: Translocation of tetracosapentaenoyl-CoA to peroxisomes
directly activates: Catalysis2452

Translocation of tetracosapentaenoyl-CoA to peroxisomes
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: Restriction
  on property: enabled by
  some values from: ABCD1
type: Restriction
  on property: enabled by
  some values from: ABCD1
type: Restriction
  on property: enabled by
  some values from: ABCD1
type: Restriction
  on property: enabled by
  some values from: ABCD1
type: GO_0005324
BFO_0000050: Pathway1226
directly activates: Peroxisomal beta-oxidation of tetracosapentaenoyl-CoA to Docosapentaenoyl-CoA

Peroxisomal beta-oxidation of tetracosapentaenoyl-CoA to Docosapentaenoyl-CoA
type: GO_0003674
BFO_0000050: Pathway1226
directly activates: Translocation of DPA to the ER

Translocation of DPA to the ER
type: GO_0003674
BFO_0000050: Pathway1226

Arachidonate diffuses across the ER membrane
type: GO_0003674
BFO_0000050: Pathway1227
directly activates: BiochemicalReaction5222
directly activates: BiochemicalReaction5242
directly activates: BiochemicalReaction5245
directly activates: BiochemicalReaction5246
directly activates: BiochemicalReaction5248
directly activates: BiochemicalReaction5250
directly activates: BiochemicalReaction5256
directly activates: BiochemicalReaction5261
directly activates: BiochemicalReaction5262
directly activates: Catalysis2472
directly activates: Catalysis2490
directly activates: Catalysis2493
directly activates: Catalysis2494
directly activates: Catalysis2496
directly activates: Catalysis2498
directly activates: Catalysis2504
directly activates: Catalysis2509
directly activates: Catalysis2510

PTGS2 dimer binds celecoxib
type: GO_0003674
BFO_0000050: Pathway1228

Aspirin acetylates PTGS1
type: GO_0003674
BFO_0000050: Pathway1228

Aspirin acetylates PTGS2
type: GO_0003674
BFO_0000050: Pathway1228
directly activates: BiochemicalReaction5245
directly activates: Catalysis2493

Arachidonic acid is oxidised to PGG2 by PTGS1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004666
BFO_0000050: Pathway1227
BFO_0000050: Pathway1228
directly activates: PGG2 is reduced to PGH2 by PTGS1
directly activates: Catalysis2455
label: Arachidonic acid oxidised to PGG2

Arachidonic acid is oxidised to PGG2 by PTGS2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004666
BFO_0000050: Pathway1227
BFO_0000050: Pathway1228
directly activates: PGG2 is reduced to PGH2 by PTGS2
directly activates: Catalysis2456
label: Arachidonic acid oxidised to PGG2

PGG2 is reduced to PGH2 by PTGS1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004601
BFO_0000050: Pathway1227
BFO_0000050: Pathway1228
directly activates: PGH2 diffuses from the endoplasmic reticulum lumen to the cytosol
directly activates: BiochemicalReaction5206
directly activates: BiochemicalReaction5215
directly activates: BiochemicalReaction5217
directly activates: BiochemicalReaction5220
directly activates: Catalysis2462
directly activates: Catalysis2467
directly activates: Catalysis2468
directly activates: Catalysis2470
label: Peroxidative reduction of PGG2 to PGH2

PGG2 is reduced to PGH2 by PTGS2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004601
BFO_0000050: Pathway1227
BFO_0000050: Pathway1228
directly activates: PGH2 diffuses from the endoplasmic reticulum lumen to the cytosol
directly activates: BiochemicalReaction5206
directly activates: BiochemicalReaction5215
directly activates: BiochemicalReaction5217
directly activates: BiochemicalReaction5220
directly activates: Catalysis2462
directly activates: Catalysis2467
directly activates: Catalysis2468
directly activates: Catalysis2470
label: Peroxidative reduction of PGG2 to PGH2

PGH2 diffuses from the endoplasmic reticulum lumen to the cytosol
type: GO_0003674
BFO_0000050: Pathway1228
directly activates: PGH2 is reduced to PGF2a by AKR1C3
directly activates: BiochemicalReaction5198
directly activates: BiochemicalReaction5199
directly activates: BiochemicalReaction5200
directly activates: Catalysis2457
directly activates: Catalysis2458
directly activates: Catalysis2459
directly activates: Catalysis2460

PGH2 is reduced to PGF2a by AKR1C3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0036130
BFO_0000050: Pathway1228