PRDM9 Binds Recombination Hotspot Motifs in DNA
type: GO_0003674
BFO_0000050: Meiotic Recombination
directly activates: Trimethylation of Histone H3 by PRDM9
directly activates: Catalysis1722

Trimethylation of Histone H3 by PRDM9
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0042800
BFO_0000050: Meiotic Recombination
directly activates: Formation of Double-strand Break in DNA by SPO11
directly activates: Catalysis1723

Formation of Double-strand Break in DNA by SPO11
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016888
BFO_0000050: Meiotic Recombination
directly activates: BiochemicalReaction2070
directly activates: BiochemicalReaction2071
directly activates: Removal of SPO11 and Resection of 5' Ends of DNA
directly activates: Catalysis1724
directly activates: Catalysis1725

Removal of SPO11 and Resection of 5' Ends of DNA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004520
type: GO_0008296
BFO_0000050: Meiotic Recombination
directly activates: Formation of Early Recombination Nodule
directly activates: Control302
directly activates: Control303

Formation of Early Recombination Nodule
type: GO_0003674
BFO_0000050: Meiotic Recombination
directly activates: Formation of Meiotic Heteroduplex
directly activates: Catalysis1726
directly activates: Control304
label: Formation of Meiotic Single-stranded DNA Invasion Complex

Formation of Meiotic Heteroduplex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0000150
BFO_0000050: Meiotic Recombination
directly activates: Formation of Meiotic Holliday Junction
label: Meiotic Strand Invasion

Formation of Meiotic Holliday Junction
type: GO_0003674
BFO_0000050: Meiotic Recombination
directly activates: Resolution of Meiotic Holliday Junction
label: Formation of Meiotic Recombination Intermediate

Resolution of Meiotic Holliday Junction
type: GO_0003674
BFO_0000050: Meiotic Recombination

Meiotic Recombination
type: GO_0008150