NEC2
label: PCSK2
label: UniProt:P16519 PCSK2

KIF5B
label: KNS
label: KNS1
label: UniProt:P33176 KIF5B

RAB27
label: RAB27A
label: UniProt:P51159 RAB27A

SLC30A6
label: UniProt:Q6NXT4 SLC30A6
label: ZNT6

SLC30A7
label: UniProt:Q8NEW0 SLC30A7
label: ZNT7
label: ZNTL2

SLC30A5
label: UNQ863/PRO1879
label: UniProt:Q8TAD4 SLC30A5
label: ZNT5
label: ZNTL1
label: ZTL1

ERO1L
label: UNQ434/PRO865
label: UniProt:Q96HE7 ERO1L

MYH12
label: MYO5A
label: UniProt:Q9Y4I1 MYO5A

Oxidation of Cysteine to Cystine in Proinsulin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005788
type: Restriction
  on property: enabled by
  some values from: ERO1L
type: GO_0015036
BFO_0000050: Insulin Processing
directly activates: Translocation of Cystine-bonded Proinsulin from the Endoplasmic Reticulum to the Golgi

Translocation of Cystine-bonded Proinsulin from the Endoplasmic Reticulum to the Golgi
type: GO_0003674
BFO_0000050: Insulin Processing
directly activates: Formation of Proinsulin-Zinc-Calcium Complex
directly activates: Catalysis1574
directly activates: Catalysis1575
directly activates: Catalysis1576

Formation of Proinsulin-Zinc-Calcium Complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0005385
BFO_0000050: Insulin Processing
directly activates: Transport of Proinsulin-Zinc-Calcium Complex to Immature Secretory Granule

Transport of Proinsulin-Zinc-Calcium Complex to Immature Secretory Granule
type: GO_0003674
BFO_0000050: Insulin Processing
directly activates: Processing of Proinsulin to Insulin
directly activates: Catalysis1577
directly activates: Catalysis1578
directly activates: Catalysis1579

Processing of Proinsulin to Insulin
type: Restriction
  on property: enabled by
  some values from: NEC2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0034774
type: Restriction
  on property: BFO_0000066
  some values from: GO_0034774
type: Restriction
  on property: BFO_0000066
  some values from: GO_0030667
type: GO_0004181
type: GO_0004252
BFO_0000050: Insulin Processing
directly activates: Translocation of Insulin Secretory Granules to Cell Cortex
directly activates: Catalysis1580

Translocation of Insulin Secretory Granules to Cell Cortex
type: Restriction
  on property: enabled by
  some values from: KIF5B
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003777
BFO_0000050: Insulin Processing
directly activates: Traversal of the cortical actin network and docking at plasma membrane
directly activates: Catalysis1581
directly activates: Catalysis1582
directly activates: Catalysis1583

Traversal of the cortical actin network and docking at plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0000146
type: GO_0000149
type: GO_0005515
BFO_0000050: Insulin Processing
directly activates: BiochemicalReaction5350
directly activates: Catalysis2575
directly activates: Control428
directly activates: Control429
directly activates: Control430
directly activates: Control431

Exocyst complex formation
type: GO_0003674
BFO_0000050: Insulin Processing
directly activates: Traversal of the cortical actin network and docking at plasma membrane
directly activates: Catalysis1581
directly activates: Catalysis1582
directly activates: Catalysis1583

Insulin Processing
type: GO_0008150