sequestered tissue factor -> tissue factor
formation of TF:F7 complex
tissue factor (TF) + factor VII (F7) -> TF:F7 complex
activation of factor X by TF:F7
factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst)
activation of factor VII
factor VII -> factor VIIa
formation of TF:F7a complex
tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex
activation of factor X by TF:F7a
factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst)
activation of factor IX (TF:F7a catalyst)
factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst)
Inactivation of factor VIIa by TFPI
TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa
Extrinsic Pathway
Generation of extrinsic Factor X activating complex