CLG
MMP1
UniProt:P03956 MMP1
ELA2
ELANE
UniProt:P08246 ELANE
CLG4A
MMP2
UniProt:P08253 MMP2
MMP3
STMY1
UniProt:P08254 MMP3
MMP7
MPSL1
PUMP1
UniProt:P09237 MMP7
MMP10
STMY2
UniProt:P09238 MMP10
FUR
FURIN
PACE
PCSK3
UniProt:P09958 FURIN
CLG4B
MMP9
UniProt:P14780 MMP9
HME
MMP12
UniProt:P39900 MMP12
MMP14
UniProt:P50281 MMP14
MMP15
UniProt:P51511 MMP15
MMP18
MMP19
RASI
UniProt:Q99542 MMP19
PDI is a chaperone for collagen peptides
Collagen prolyl 4-hydroxylase converts proline to 4-hydroxyproline
Collagen prolyl 3-hydroxylase converts proline to 3-hydroxyproline
Procollagen lysyl hydrolases convert lysine to 5-hydroxylysine
Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2.
Galactosylation of collagen propeptide hydroxylysines by PLOD3
Glucosylation of collagen propeptide hydroxylysines
Association of procollagen chains
Procollagen triple helix formation
Dimerization of procollagen type VI
Tetramerization of procollagen VI
Secretion of collagens
Secretion of transmembrane collagens
Removal of fibrillar collagen N-propeptides
Removal of fibrillar collagen C-propeptides
Formation of collagen fibrils
Formation of collagen networks
Collagen type VII dimerization
Cleavage of collagen VII NC2 region by BMP1
Formation of anchoring fibrils
Collagen type VII binds laminin-322 and collagen IV
Prolysyl oxidase activation
Formation of allysine by LOX
Formation of hydroxyallysine by LOX
Formation of dehydro-lysinonorleucine cross-links
Formation of dehydro-hydroxylysino-norleucine cross-links
Formation of lysino-5-ketonorleucine cross-links
Formation of hydroxylysino-5-ketonorleucine cross-links
Formation of lysyl-pyridinoline cross-links
Formation of hydroxylysyl-pyridinoline cross-links
Formation of lysyl-pyrrole cross-links
Formation of hydroxylysyl-pyrrole cross-links
Formation of histidino-hydroxylysinonorleucine cross-links
Formation of collagen fibres
Collagen XI cross-links with collagen II
Collagen IX is cross-linked to the surface of collagen type II fibrils
Type XII and XIV collagens associate with type I and type II fibrils.
Type X collagen associates with collagen type II fibrils
Hemidesmosome formation
Release of endostatin-like peptides
FN1 dimerizes
Fibronectin dimerizes
Integrin alpha5beta1 binds fibronectin
FN1 aggregation
Fibronectin aggregation
Fibrillin C-terminal processing
Fibrillin-1 binds integrins
Fibrillin microfibril assembly
MFAP2, MFAP5 bind microfibrils
Tropoelastin forms aggregate globules
Tropoelastin associates with microfibrils
Elastin cross-linking by lysyl oxidase
FBLN1, FBLN2 bind fibronectin
Fibulin-1 and -2 bind fibronectin
Fibulin binds elastic fibres
Emilin is found in elastic fibres
LTBP1, LTBP3 bind TGF-Beta
LTBP4 binds TGF-Beta-1
Latent TGF-beta-1 binds integrins
Latent TGF-beta-3 binds integrins
Fibrillins bind BMPs
Fibrillin-1 binds latent TGF-beta
Elastic fibres bind associated proteins
HSPG2 binds multiple ECM components
Perlecan binds multiple ECM components
Dystroglycan binds Laminins and Dystrophin
Dystroglycan binds AGRN and HSPG2
Dystroglycan binds agrin and perlecan
Dystroglycan binds NRXN1
Dystroglycan binds neurexin
NTN4 binds laminins with gamma-1, gamma-3
Netrin-4 bind laminins with gamma-1, gamma -3
DDR1 binds collagens
Discoidin domain receptor 1 binds collagens
DDR2 binds collagens
Discoidin domain receptor 2 binds collagens
Osteopontin binds CD44
SPP1 binds CD44
Syndecan-1 binds Integrin alphaVbeta3
Syndecan-1 binds Integrin alphaVBeta5
Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4)
Syndecan-1 binds THBS1
Syndecan-1 binds collagen types I, III, V
Syndecan-1 binds fibronectin
Syndecan-2 binds CASK
Syndecan-2 binds TRAPPC4
Syndecan-4 binds ACTN1
Syndecan-4 binds PI(4,5)P2
Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG
Syndecans 1, 2 & 4 bind VTN
Syndecans 1, 2, 4, (3) bind FGF2
Syndecans 2, (4) bind TGFB1
TNC binds Syndecan-3
SLRPs bind TGF Beta
Small Leucine-rich Repeat Proteogycans bind TGF beta
DCN binds collagens
Decorin binds collagens
BGN binds Collagen types I, VI, (IX)
Biglycan binds Collagen types I, VI, (IX)
BGN binds Collagen types II, III
Biglycan binds Collagen type II, III
VTN binds collagens I, IV and VI
Vitronectin binds collagens I, IV and VI
VTN binds collagens II, III and V
Vitronectin binds collagens II, III and V
VTN binds integrins
Vitronectin binds integrins
VTN binds Plasminogen activator inhibitor- 1
VTN binds SERPINE1
AGRN binds Alpha-dystroglycan
AGRN binds LRP4:MUSK
AGRN binds Laminins with gamma-1 subunit
Agrin binds Laminins with gamma-1 subunit
AGRN binds NCAM1, PTPRS
AGRN binds Beta amyloid fibril via GAG chains
SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+
TNC binds TNC-binding integrins
Tenascins C, R, (X, N) bind lecticans
Tenascins C, R, (X, N) bind the fibronectin matrix
COMP binds collagen, fibronectin, aggrecan and matrilins
Aggrecan binds Hyaluronan and HAPLN1
Initial activation of proMMP1
Autocatalytic activation of MMP1
Full activation of MMP1
proMMP9 binds TIMP1
MMP14 (MT1-MMP) binds TIMP2
MMP14:TIMP2 binds proMMP2
Initial activation of proMMP2 by MMP1, 7
Initial activation of proMMP2 by MMP14
Autocatalytic activation of proMMP2
Autocatalytic activation of bound proMMP2
Initial activation of proMMP3
Autocatalytic activation of MMP3
Activation of proMMP7 by MMP3
Initial activation of proMMP7 by trypsin
Autocatalytic activation of MMP7
Activation of proMMP8
Initial activation of proMMP9 by MMPs
Activation of MMP9 intermediate form by MMPs
Activation of proMMP9 by proteases
Activation of proMMP10
Activation of proMMP11 by FURIN
Initial activation of proMMP13 by plasmin and trypsin
Initial activation of proMMP13 by MMP3
Initial activation of proMMP13 by MMP14 (MT1-MMP)
Autocatalytic activation of proMMP13
Activation of MT-MMPs by FURIN
MT-MMPs are sorted to the plasma membrane
Collagen type I degradation by MMP1,2,8,13, PRSS2
Collagen type I degradation by MMP14
Collagen type I degradation by MMP15
Collagen type II degradation by MMP1,3,8,13,PRSS2
Collagen type II degradation by MMP14
Collagen type II degradation by MMP15
Collagen type III degradation by MMP1,8,9,13
Collagen type III degradation by MMP10
Collagen type III degradation by MMP14
Collagen type III degradation by MMP15
Collagen type IV degradation by MMP2,3,4,9,10,12
Collagen type V degradation by MMP2,9,10
Collagen type VI degradation by MMP2,9,11
Collagen type VII degradation by MMP1,2,3
Collagen type VIII degradation by MMP1
Collagen type VIII degradation by ELANE
Collagen type IX degradation by MMP3,13
Collagen type X degradation by MMP1,2
Collagen type X degradation by MMP3, 13
Collagen type XI degradation by MMP1,2,3,9
Collagen type XII degradation by MMP12
Collagen type XIV degradation by MMP9,13
Collagen type XV restin release
Collagen type XVI degradation by MMP9
Collagen type XVIII endostatin release
Collagen type XIII ectodomain shedding
Collagen type XVII ectodomain shedding
Collagen type XXIII ectodomain shedding
Collagen type XXV ectomain shedding
Endostatin degradation by cathepsins
Collagen type XIX degradation
Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13
Gelatin degradation by MMP19
Extracellular matrix organization
Collagen formation
Collagen biosynthesis and modifying enzymes
Assembly of collagen fibrils and other multimeric structures
Anchoring fibril formation
Crosslinking of collagen fibrils
Fibronectin matrix formation
Elastic fibre formation
Molecules associated with elastic fibres
Non-integrin membrane-ECM interactions
Syndecan interactions
ECM proteoglycans
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Degradation of collagen