CLG
label: MMP1
label: UniProt:P03956 MMP1

ELA2
label: ELANE
label: UniProt:P08246 ELANE

CLG4A
label: MMP2
label: UniProt:P08253 MMP2

MMP3
label: STMY1
label: UniProt:P08254 MMP3

MMP7
label: MPSL1
label: PUMP1
label: UniProt:P09237 MMP7

MMP10
label: STMY2
label: UniProt:P09238 MMP10

FUR
label: FURIN
label: PACE
label: PCSK3
label: UniProt:P09958 FURIN

CLG4B
label: MMP9
label: UniProt:P14780 MMP9

HME
label: MMP12
label: UniProt:P39900 MMP12

MMP14
label: UniProt:P50281 MMP14

MMP15
label: UniProt:P51511 MMP15

MMP18
label: MMP19
label: RASI
label: UniProt:Q99542 MMP19

PDI is a chaperone for collagen peptides
type: GO_0003674
BFO_0000050: Collagen biosynthesis and modifying enzymes

Collagen prolyl 4-hydroxylase converts proline to 4-hydroxyproline
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005788
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005788
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005788
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005788
type: GO_0004656
BFO_0000050: Collagen biosynthesis and modifying enzymes

Collagen prolyl 3-hydroxylase converts proline to 3-hydroxyproline
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005788
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005788
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005788
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005788
type: GO_0019797
BFO_0000050: Collagen biosynthesis and modifying enzymes

Procollagen lysyl hydrolases convert lysine to 5-hydroxylysine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0008475
BFO_0000050: Collagen biosynthesis and modifying enzymes
directly activates: Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2.
directly activates: Galactosylation of collagen propeptide hydroxylysines by PLOD3
directly activates: Catalysis931
directly activates: Catalysis932

Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2.
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005788
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005788
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005788
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005788
type: GO_0050211
BFO_0000050: Collagen biosynthesis and modifying enzymes
directly activates: Glucosylation of collagen propeptide hydroxylysines
directly activates: Catalysis933

Galactosylation of collagen propeptide hydroxylysines by PLOD3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0050211
BFO_0000050: Collagen biosynthesis and modifying enzymes
directly activates: Glucosylation of collagen propeptide hydroxylysines
directly activates: Catalysis933

Glucosylation of collagen propeptide hydroxylysines
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0033823
BFO_0000050: Collagen biosynthesis and modifying enzymes

Association of procollagen chains
type: GO_0003674
BFO_0000050: Collagen biosynthesis and modifying enzymes

Procollagen triple helix formation
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005788
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005788
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005788
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005788
type: GO_0003755
BFO_0000050: Collagen biosynthesis and modifying enzymes

Dimerization of procollagen type VI
type: GO_0003674
BFO_0000050: Collagen biosynthesis and modifying enzymes
directly activates: Tetramerization of procollagen VI

Tetramerization of procollagen VI
type: GO_0003674
BFO_0000050: Collagen biosynthesis and modifying enzymes

Secretion of collagens
type: GO_0003674
BFO_0000050: Collagen biosynthesis and modifying enzymes

Secretion of transmembrane collagens
type: GO_0003674
BFO_0000050: Collagen biosynthesis and modifying enzymes

Removal of fibrillar collagen N-propeptides
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004222
BFO_0000050: Collagen biosynthesis and modifying enzymes
directly activates: Removal of fibrillar collagen C-propeptides
directly activates: Catalysis936
directly activates: Control151

Removal of fibrillar collagen C-propeptides
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004222
BFO_0000050: Collagen biosynthesis and modifying enzymes

Formation of collagen fibrils
type: GO_0003674
BFO_0000050: Assembly of collagen fibrils and other multimeric structures
directly activates: Formation of collagen fibres

Formation of collagen networks
type: GO_0003674
BFO_0000050: Assembly of collagen fibrils and other multimeric structures

Collagen type VII dimerization
type: GO_0003674
BFO_0000050: Anchoring fibril formation
directly activates: Cleavage of collagen VII NC2 region by BMP1
directly activates: Catalysis937

Cleavage of collagen VII NC2 region by BMP1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Anchoring fibril formation
directly activates: Formation of anchoring fibrils

Formation of anchoring fibrils
type: GO_0003674
BFO_0000050: Anchoring fibril formation
directly activates: Collagen type VII binds laminin-322 and collagen IV

Collagen type VII binds laminin-322 and collagen IV
type: GO_0003674
BFO_0000050: Anchoring fibril formation

Prolysyl oxidase activation
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004222
BFO_0000050: Crosslinking of collagen fibrils
directly activates: Formation of allysine by LOX
directly activates: Formation of hydroxyallysine by LOX
directly activates: Catalysis939
directly activates: Catalysis940

Formation of allysine by LOX
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004720
BFO_0000050: Crosslinking of collagen fibrils
directly activates: Formation of dehydro-lysinonorleucine cross-links
directly activates: Formation of dehydro-hydroxylysino-norleucine cross-links
directly activates: Crosslinking of collagen fibrils

Formation of hydroxyallysine by LOX
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004720
BFO_0000050: Crosslinking of collagen fibrils
directly activates: Formation of lysino-5-ketonorleucine cross-links
directly activates: Formation of hydroxylysino-5-ketonorleucine cross-links

Formation of dehydro-lysinonorleucine cross-links
type: GO_0003674
BFO_0000050: Crosslinking of collagen fibrils

Formation of dehydro-hydroxylysino-norleucine cross-links
type: GO_0003674
BFO_0000050: Crosslinking of collagen fibrils
directly activates: Formation of histidino-hydroxylysinonorleucine cross-links

Formation of lysino-5-ketonorleucine cross-links
type: GO_0003674
BFO_0000050: Crosslinking of collagen fibrils
directly activates: Formation of lysyl-pyridinoline cross-links
directly activates: Formation of lysyl-pyrrole cross-links

Formation of hydroxylysino-5-ketonorleucine cross-links
type: GO_0003674
BFO_0000050: Crosslinking of collagen fibrils
directly activates: Formation of hydroxylysyl-pyridinoline cross-links
directly activates: Formation of hydroxylysyl-pyrrole cross-links

Formation of lysyl-pyridinoline cross-links
type: GO_0003674
BFO_0000050: Crosslinking of collagen fibrils

Formation of hydroxylysyl-pyridinoline cross-links
type: GO_0003674
BFO_0000050: Crosslinking of collagen fibrils

Formation of lysyl-pyrrole cross-links
type: GO_0003674
BFO_0000050: Crosslinking of collagen fibrils

Formation of hydroxylysyl-pyrrole cross-links
type: GO_0003674
BFO_0000050: Crosslinking of collagen fibrils

Formation of histidino-hydroxylysinonorleucine cross-links
type: GO_0003674
BFO_0000050: Crosslinking of collagen fibrils

Formation of collagen fibres
type: GO_0003674
BFO_0000050: Assembly of collagen fibrils and other multimeric structures

Collagen XI cross-links with collagen II
type: GO_0003674
BFO_0000050: Assembly of collagen fibrils and other multimeric structures

Collagen IX is cross-linked to the surface of collagen type II fibrils
type: GO_0003674
BFO_0000050: Assembly of collagen fibrils and other multimeric structures

Type XII and XIV collagens associate with type I and type II fibrils.
type: GO_0003674
BFO_0000050: Assembly of collagen fibrils and other multimeric structures

Type X collagen associates with collagen type II fibrils
type: GO_0003674
BFO_0000050: Assembly of collagen fibrils and other multimeric structures

Hemidesmosome formation
type: GO_0003674
BFO_0000050: Assembly of collagen fibrils and other multimeric structures

Release of endostatin-like peptides
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004175
BFO_0000050: Assembly of collagen fibrils and other multimeric structures

FN1 dimerizes
type: GO_0003674
BFO_0000050: Fibronectin matrix formation
directly activates: Integrin alpha5beta1 binds fibronectin
directly activates: Control152
label: Fibronectin dimerizes

Integrin alpha5beta1 binds fibronectin
type: GO_0003674
BFO_0000050: Fibronectin matrix formation
directly activates: FN1 aggregation

FN1 aggregation
type: GO_0003674
BFO_0000050: Fibronectin matrix formation
label: Fibronectin aggregation

Fibrillin C-terminal processing
type: Restriction
  on property: enabled by
  some values from: FUR
type: Restriction
  on property: enabled by
  some values from: FUR
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004252
BFO_0000050: Elastic fibre formation
directly activates: Fibrillin-1 binds integrins
directly activates: Fibrillin microfibril assembly

Fibrillin-1 binds integrins
type: GO_0003674
BFO_0000050: Elastic fibre formation

Fibrillin microfibril assembly
type: GO_0003674
BFO_0000050: Elastic fibre formation
directly activates: MFAP2, MFAP5 bind microfibrils
directly activates: Tropoelastin associates with microfibrils
directly activates: Elastic fibres bind associated proteins

MFAP2, MFAP5 bind microfibrils
type: GO_0003674
BFO_0000050: Elastic fibre formation

Tropoelastin forms aggregate globules
type: GO_0003674
BFO_0000050: Elastic fibre formation
directly activates: Tropoelastin associates with microfibrils

Tropoelastin associates with microfibrils
type: GO_0003674
BFO_0000050: Elastic fibre formation
directly activates: Elastin cross-linking by lysyl oxidase
directly activates: Catalysis943

Elastin cross-linking by lysyl oxidase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004720
BFO_0000050: Elastic fibre formation

FBLN1, FBLN2 bind fibronectin
type: GO_0003674
BFO_0000050: Molecules associated with elastic fibres
label: Fibulin-1 and -2 bind fibronectin

Fibulin binds elastic fibres
type: GO_0003674
BFO_0000050: Molecules associated with elastic fibres

Emilin is found in elastic fibres
type: GO_0003674
BFO_0000050: Molecules associated with elastic fibres

LTBP1, LTBP3 bind TGF-Beta
type: GO_0003674
BFO_0000050: Molecules associated with elastic fibres

LTBP4 binds TGF-Beta-1
type: GO_0003674
BFO_0000050: Molecules associated with elastic fibres

Latent TGF-beta-1 binds integrins
type: GO_0003674
BFO_0000050: Molecules associated with elastic fibres

Latent TGF-beta-3 binds integrins
type: GO_0003674
BFO_0000050: Molecules associated with elastic fibres

Fibrillins bind BMPs
type: GO_0003674
BFO_0000050: Molecules associated with elastic fibres

Fibrillin-1 binds latent TGF-beta
type: GO_0003674
BFO_0000050: Molecules associated with elastic fibres

Elastic fibres bind associated proteins
type: GO_0003674
BFO_0000050: Molecules associated with elastic fibres

HSPG2 binds multiple ECM components
type: GO_0003674
BFO_0000050: Non-integrin membrane-ECM interactions
label: Perlecan binds multiple ECM components

Dystroglycan binds Laminins and Dystrophin
type: GO_0003674
BFO_0000050: Non-integrin membrane-ECM interactions

Dystroglycan binds AGRN and HSPG2
type: GO_0003674
BFO_0000050: Non-integrin membrane-ECM interactions
label: Dystroglycan binds agrin and perlecan

Dystroglycan binds NRXN1
type: GO_0003674
BFO_0000050: Non-integrin membrane-ECM interactions
label: Dystroglycan binds neurexin

NTN4 binds laminins with gamma-1, gamma-3
type: GO_0003674
BFO_0000050: Non-integrin membrane-ECM interactions
label: Netrin-4 bind laminins with gamma-1, gamma -3

DDR1 binds collagens
type: GO_0003674
BFO_0000050: Non-integrin membrane-ECM interactions
label: Discoidin domain receptor 1 binds collagens

DDR2 binds collagens
type: GO_0003674
BFO_0000050: Non-integrin membrane-ECM interactions
label: Discoidin domain receptor 2 binds collagens

Osteopontin binds CD44
type: GO_0003674
BFO_0000050: Non-integrin membrane-ECM interactions
label: SPP1 binds CD44

Syndecan-1 binds Integrin alphaVbeta3
type: GO_0003674
BFO_0000050: Syndecan interactions

Syndecan-1 binds Integrin alphaVBeta5
type: GO_0003674
BFO_0000050: Syndecan interactions

Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4)
type: GO_0003674
BFO_0000050: Syndecan interactions

Syndecan-1 binds THBS1
type: GO_0003674
BFO_0000050: Syndecan interactions

Syndecan-1 binds collagen types I, III, V
type: GO_0003674
BFO_0000050: Syndecan interactions

Syndecan-1 binds fibronectin
type: GO_0003674
BFO_0000050: Syndecan interactions

Syndecan-2 binds CASK
type: GO_0003674
BFO_0000050: Syndecan interactions

Syndecan-2 binds TRAPPC4
type: GO_0003674
BFO_0000050: Syndecan interactions

Syndecan-4 binds ACTN1
type: GO_0003674
BFO_0000050: Syndecan interactions

Syndecan-4 binds PI(4,5)P2
type: GO_0003674
BFO_0000050: Syndecan interactions
directly activates: Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG

Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG
type: GO_0003674
BFO_0000050: Syndecan interactions

Syndecans 1, 2 & 4 bind VTN
type: GO_0003674
BFO_0000050: Syndecan interactions

Syndecans 1, 2, 4, (3) bind FGF2
type: GO_0003674
BFO_0000050: Syndecan interactions

Syndecans 2, (4) bind TGFB1
type: GO_0003674
BFO_0000050: Syndecan interactions

TNC binds Syndecan-3
type: GO_0003674
BFO_0000050: Syndecan interactions

SLRPs bind TGF Beta
type: GO_0003674
BFO_0000050: ECM proteoglycans
label: Small Leucine-rich Repeat Proteogycans bind TGF beta

DCN binds collagens
type: GO_0003674
BFO_0000050: ECM proteoglycans
label: Decorin binds collagens

BGN binds Collagen types I, VI, (IX)
type: GO_0003674
BFO_0000050: ECM proteoglycans
label: Biglycan binds Collagen types I, VI, (IX)

BGN binds Collagen types II, III
type: GO_0003674
BFO_0000050: ECM proteoglycans
label: Biglycan binds Collagen type II, III

VTN binds collagens I, IV and VI
type: GO_0003674
BFO_0000050: ECM proteoglycans
label: Vitronectin binds collagens I, IV and VI

VTN binds collagens II, III and V
type: GO_0003674
BFO_0000050: ECM proteoglycans
label: Vitronectin binds collagens II, III and V

VTN binds integrins
type: GO_0003674
BFO_0000050: ECM proteoglycans
label: Vitronectin binds integrins

VTN binds Plasminogen activator inhibitor- 1
type: GO_0003674
BFO_0000050: ECM proteoglycans
label: VTN binds SERPINE1

AGRN binds Alpha-dystroglycan
type: GO_0003674
BFO_0000050: ECM proteoglycans

AGRN binds LRP4:MUSK
type: GO_0003674
BFO_0000050: ECM proteoglycans

AGRN binds Laminins with gamma-1 subunit
type: GO_0003674
BFO_0000050: ECM proteoglycans
label: Agrin binds Laminins with gamma-1 subunit

AGRN binds NCAM1, PTPRS
type: GO_0003674
BFO_0000050: ECM proteoglycans

AGRN binds Beta amyloid fibril via GAG chains
type: GO_0003674
BFO_0000050: ECM proteoglycans

SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+
type: GO_0003674
BFO_0000050: ECM proteoglycans

TNC binds TNC-binding integrins
type: GO_0003674
BFO_0000050: ECM proteoglycans

Tenascins C, R, (X, N) bind lecticans
type: GO_0003674
BFO_0000050: ECM proteoglycans

Tenascins C, R, (X, N) bind the fibronectin matrix
type: GO_0003674
BFO_0000050: ECM proteoglycans

COMP binds collagen, fibronectin, aggrecan and matrilins
type: GO_0003674
BFO_0000050: ECM proteoglycans

Aggrecan binds Hyaluronan and HAPLN1
type: GO_0003674
BFO_0000050: ECM proteoglycans

Initial activation of proMMP1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Activation of Matrix Metalloproteinases
directly activates: Autocatalytic activation of MMP1
directly activates: Catalysis945

Autocatalytic activation of MMP1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: enabled by
  some values from: CLG
type: Restriction
  on property: enabled by
  some values from: CLG
type: Restriction
  on property: enabled by
  some values from: CLG
type: Restriction
  on property: enabled by
  some values from: CLG
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Activation of Matrix Metalloproteinases
directly activates: Full activation of MMP1
directly activates: Catalysis946

Full activation of MMP1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Activation of Matrix Metalloproteinases
directly activates: Initial activation of proMMP2 by MMP1, 7
directly activates: Catalysis947

proMMP9 binds TIMP1
type: GO_0003674
BFO_0000050: Activation of Matrix Metalloproteinases

MMP14 (MT1-MMP) binds TIMP2
type: GO_0003674
BFO_0000050: Activation of Matrix Metalloproteinases
directly activates: MMP14:TIMP2 binds proMMP2

MMP14:TIMP2 binds proMMP2
type: GO_0003674
BFO_0000050: Activation of Matrix Metalloproteinases
directly activates: Initial activation of proMMP2 by MMP14
directly activates: Catalysis948

Initial activation of proMMP2 by MMP1, 7
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Activation of Matrix Metalloproteinases
directly activates: Autocatalytic activation of proMMP2
directly activates: Catalysis949
directly activates: Control153

Initial activation of proMMP2 by MMP14
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004252
BFO_0000050: Activation of Matrix Metalloproteinases
directly activates: Autocatalytic activation of bound proMMP2
directly activates: Catalysis950

Autocatalytic activation of proMMP2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: enabled by
  some values from: CLG4A
type: Restriction
  on property: enabled by
  some values from: CLG4A
type: Restriction
  on property: enabled by
  some values from: CLG4A
type: Restriction
  on property: enabled by
  some values from: CLG4A
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Activation of Matrix Metalloproteinases

Autocatalytic activation of bound proMMP2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004252
BFO_0000050: Activation of Matrix Metalloproteinases

Initial activation of proMMP3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Activation of Matrix Metalloproteinases
directly activates: Autocatalytic activation of MMP3
directly activates: Catalysis952

Autocatalytic activation of MMP3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: enabled by
  some values from: MMP3
type: Restriction
  on property: enabled by
  some values from: MMP3
type: Restriction
  on property: enabled by
  some values from: MMP3
type: Restriction
  on property: enabled by
  some values from: MMP3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Activation of Matrix Metalloproteinases
directly activates: Activation of proMMP7 by MMP3
directly activates: Catalysis953

Activation of proMMP7 by MMP3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Activation of Matrix Metalloproteinases

Initial activation of proMMP7 by trypsin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Activation of Matrix Metalloproteinases
directly activates: Autocatalytic activation of MMP7
directly activates: Catalysis955
directly activates: Control154

Autocatalytic activation of MMP7
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: enabled by
  some values from: MMP7
type: Restriction
  on property: enabled by
  some values from: MMP7
type: Restriction
  on property: enabled by
  some values from: MMP7
type: Restriction
  on property: enabled by
  some values from: MMP7
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Activation of Matrix Metalloproteinases

Activation of proMMP8
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Activation of Matrix Metalloproteinases

Initial activation of proMMP9 by MMPs
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Activation of Matrix Metalloproteinases
directly activates: Activation of MMP9 intermediate form by MMPs
directly activates: Catalysis958

Activation of MMP9 intermediate form by MMPs
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Activation of Matrix Metalloproteinases

Activation of proMMP9 by proteases
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Activation of Matrix Metalloproteinases

Activation of proMMP10
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Activation of Matrix Metalloproteinases

Activation of proMMP11 by FURIN
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: FUR
type: Restriction
  on property: enabled by
  some values from: FUR
type: Restriction
  on property: enabled by
  some values from: FUR
type: Restriction
  on property: enabled by
  some values from: FUR
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0004252
BFO_0000050: Activation of Matrix Metalloproteinases

Initial activation of proMMP13 by plasmin and trypsin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Activation of Matrix Metalloproteinases
directly activates: Autocatalytic activation of proMMP13
directly activates: Catalysis965
directly activates: Control156

Initial activation of proMMP13 by MMP3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Activation of Matrix Metalloproteinases
directly activates: Autocatalytic activation of proMMP13
directly activates: Catalysis965
directly activates: Control156

Initial activation of proMMP13 by MMP14 (MT1-MMP)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004252
BFO_0000050: Activation of Matrix Metalloproteinases
directly activates: Autocatalytic activation of proMMP13
directly activates: Catalysis965
directly activates: Control156

Autocatalytic activation of proMMP13
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Activation of Matrix Metalloproteinases

Activation of MT-MMPs by FURIN
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: FUR
type: Restriction
  on property: enabled by
  some values from: FUR
type: Restriction
  on property: enabled by
  some values from: FUR
type: Restriction
  on property: enabled by
  some values from: FUR
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0004252
BFO_0000050: Activation of Matrix Metalloproteinases
directly activates: MMP14 (MT1-MMP) binds TIMP2

MT-MMPs are sorted to the plasma membrane
type: GO_0003674
BFO_0000050: Activation of Matrix Metalloproteinases

Collagen type I degradation by MMP1,2,8,13, PRSS2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Degradation of collagen
directly activates: Catalysis995
directly activates: Catalysis996
directly activates: Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13
directly activates: Gelatin degradation by MMP19

Collagen type I degradation by MMP14
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: MMP14
type: Restriction
  on property: enabled by
  some values from: MMP14
type: Restriction
  on property: enabled by
  some values from: MMP14
type: Restriction
  on property: enabled by
  some values from: MMP14
type: GO_0004252
BFO_0000050: Degradation of collagen
directly activates: Catalysis995
directly activates: Catalysis996
directly activates: Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13
directly activates: Gelatin degradation by MMP19

Collagen type I degradation by MMP15
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: MMP15
type: Restriction
  on property: enabled by
  some values from: MMP15
type: Restriction
  on property: enabled by
  some values from: MMP15
type: Restriction
  on property: enabled by
  some values from: MMP15
type: GO_0004252
BFO_0000050: Degradation of collagen
directly activates: Catalysis995
directly activates: Catalysis996
directly activates: Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13
directly activates: Gelatin degradation by MMP19

Collagen type II degradation by MMP1,3,8,13,PRSS2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Degradation of collagen
directly activates: Catalysis995
directly activates: Catalysis996
directly activates: Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13
directly activates: Gelatin degradation by MMP19

Collagen type II degradation by MMP14
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: MMP14
type: Restriction
  on property: enabled by
  some values from: MMP14
type: Restriction
  on property: enabled by
  some values from: MMP14
type: Restriction
  on property: enabled by
  some values from: MMP14
type: GO_0004252
BFO_0000050: Degradation of collagen
directly activates: Catalysis995
directly activates: Catalysis996
directly activates: Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13
directly activates: Gelatin degradation by MMP19

Collagen type II degradation by MMP15
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: MMP15
type: Restriction
  on property: enabled by
  some values from: MMP15
type: Restriction
  on property: enabled by
  some values from: MMP15
type: Restriction
  on property: enabled by
  some values from: MMP15
type: GO_0004252
BFO_0000050: Degradation of collagen

Collagen type III degradation by MMP1,8,9,13
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Degradation of collagen
directly activates: Catalysis995
directly activates: Catalysis996
directly activates: Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13
directly activates: Gelatin degradation by MMP19

Collagen type III degradation by MMP10
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: enabled by
  some values from: MMP10
type: Restriction
  on property: enabled by
  some values from: MMP10
type: Restriction
  on property: enabled by
  some values from: MMP10
type: Restriction
  on property: enabled by
  some values from: MMP10
type: GO_0004252
BFO_0000050: Degradation of collagen
directly activates: Catalysis995
directly activates: Catalysis996
directly activates: Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13
directly activates: Gelatin degradation by MMP19

Collagen type III degradation by MMP14
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: MMP14
type: Restriction
  on property: enabled by
  some values from: MMP14
type: Restriction
  on property: enabled by
  some values from: MMP14
type: Restriction
  on property: enabled by
  some values from: MMP14
type: GO_0004252
BFO_0000050: Degradation of collagen
directly activates: Catalysis995
directly activates: Catalysis996
directly activates: Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13
directly activates: Gelatin degradation by MMP19

Collagen type III degradation by MMP15
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: MMP15
type: Restriction
  on property: enabled by
  some values from: MMP15
type: Restriction
  on property: enabled by
  some values from: MMP15
type: Restriction
  on property: enabled by
  some values from: MMP15
type: GO_0004252
BFO_0000050: Degradation of collagen

Collagen type IV degradation by MMP2,3,4,9,10,12
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Degradation of collagen
directly activates: Catalysis995
directly activates: Catalysis996
directly activates: Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13
directly activates: Gelatin degradation by MMP19

Collagen type V degradation by MMP2,9,10
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Degradation of collagen
directly activates: Catalysis995
directly activates: Catalysis996
directly activates: Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13
directly activates: Gelatin degradation by MMP19

Collagen type VI degradation by MMP2,9,11
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Degradation of collagen
directly activates: Catalysis995
directly activates: Catalysis996
directly activates: Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13
directly activates: Gelatin degradation by MMP19

Collagen type VII degradation by MMP1,2,3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Degradation of collagen
directly activates: Catalysis995
directly activates: Catalysis996
directly activates: Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13
directly activates: Gelatin degradation by MMP19

Collagen type VIII degradation by MMP1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: enabled by
  some values from: CLG
type: Restriction
  on property: enabled by
  some values from: CLG
type: Restriction
  on property: enabled by
  some values from: CLG
type: Restriction
  on property: enabled by
  some values from: CLG
type: GO_0004252
BFO_0000050: Degradation of collagen
directly activates: Catalysis995
directly activates: Catalysis996
directly activates: Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13
directly activates: Gelatin degradation by MMP19

Collagen type VIII degradation by ELANE
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: enabled by
  some values from: ELA2
type: Restriction
  on property: enabled by
  some values from: ELA2
type: Restriction
  on property: enabled by
  some values from: ELA2
type: Restriction
  on property: enabled by
  some values from: ELA2
type: GO_0004252
BFO_0000050: Degradation of collagen
directly activates: Catalysis995
directly activates: Catalysis996
directly activates: Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13
directly activates: Gelatin degradation by MMP19

Collagen type IX degradation by MMP3,13
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Degradation of collagen
directly activates: Catalysis995
directly activates: Catalysis996
directly activates: Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13
directly activates: Gelatin degradation by MMP19

Collagen type X degradation by MMP1,2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Degradation of collagen
directly activates: Catalysis995
directly activates: Catalysis996
directly activates: Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13
directly activates: Gelatin degradation by MMP19

Collagen type X degradation by MMP3, 13
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Degradation of collagen
directly activates: Catalysis995
directly activates: Catalysis996
directly activates: Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13
directly activates: Gelatin degradation by MMP19

Collagen type XI degradation by MMP1,2,3,9
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Degradation of collagen
directly activates: Catalysis995
directly activates: Catalysis996
directly activates: Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13
directly activates: Gelatin degradation by MMP19

Collagen type XII degradation by MMP12
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: enabled by
  some values from: HME
type: Restriction
  on property: enabled by
  some values from: HME
type: Restriction
  on property: enabled by
  some values from: HME
type: Restriction
  on property: enabled by
  some values from: HME
type: GO_0004252
BFO_0000050: Degradation of collagen
directly activates: Catalysis995
directly activates: Catalysis996
directly activates: Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13
directly activates: Gelatin degradation by MMP19

Collagen type XIV degradation by MMP9,13
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Degradation of collagen
directly activates: Catalysis995
directly activates: Catalysis996
directly activates: Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13
directly activates: Gelatin degradation by MMP19

Collagen type XV restin release
type: GO_0003674
BFO_0000050: Degradation of collagen

Collagen type XVI degradation by MMP9
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: enabled by
  some values from: CLG4B
type: Restriction
  on property: enabled by
  some values from: CLG4B
type: Restriction
  on property: enabled by
  some values from: CLG4B
type: Restriction
  on property: enabled by
  some values from: CLG4B
type: GO_0004252
BFO_0000050: Degradation of collagen
directly activates: Catalysis995
directly activates: Catalysis996
directly activates: Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13
directly activates: Gelatin degradation by MMP19

Collagen type XVIII endostatin release
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Degradation of collagen

Collagen type XIII ectodomain shedding
type: GO_0003674
BFO_0000050: Degradation of collagen

Collagen type XVII ectodomain shedding
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004252
BFO_0000050: Degradation of collagen

Collagen type XXIII ectodomain shedding
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: FUR
type: Restriction
  on property: enabled by
  some values from: FUR
type: Restriction
  on property: enabled by
  some values from: FUR
type: Restriction
  on property: enabled by
  some values from: FUR
type: GO_0004252
BFO_0000050: Degradation of collagen

Collagen type XXV ectomain shedding
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: FUR
type: Restriction
  on property: enabled by
  some values from: FUR
type: Restriction
  on property: enabled by
  some values from: FUR
type: Restriction
  on property: enabled by
  some values from: FUR
type: GO_0004252
BFO_0000050: Degradation of collagen

Endostatin degradation by cathepsins
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Degradation of collagen

Collagen type XIX degradation
type: GO_0003674
BFO_0000050: Degradation of collagen

Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Degradation of collagen

Gelatin degradation by MMP19
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: enabled by
  some values from: MMP18
type: Restriction
  on property: enabled by
  some values from: MMP18
type: Restriction
  on property: enabled by
  some values from: MMP18
type: Restriction
  on property: enabled by
  some values from: MMP18
type: GO_0004252
BFO_0000050: Degradation of collagen

Extracellular matrix organization
type: GO_0008150

Collagen formation
type: GO_0008150
BFO_0000050: Extracellular matrix organization

Collagen biosynthesis and modifying enzymes
type: GO_0008150
BFO_0000050: Collagen formation

Assembly of collagen fibrils and other multimeric structures
type: GO_0008150
BFO_0000050: Collagen formation

Anchoring fibril formation
type: GO_0008150
BFO_0000050: Assembly of collagen fibrils and other multimeric structures

Crosslinking of collagen fibrils
type: GO_0008150
BFO_0000050: Assembly of collagen fibrils and other multimeric structures

Fibronectin matrix formation
type: GO_0008150
BFO_0000050: Extracellular matrix organization

Elastic fibre formation
type: GO_0008150
BFO_0000050: Extracellular matrix organization

Molecules associated with elastic fibres
type: GO_0008150
BFO_0000050: Elastic fibre formation

Non-integrin membrane-ECM interactions
type: GO_0008150
BFO_0000050: Extracellular matrix organization

Syndecan interactions
type: GO_0008150
BFO_0000050: Non-integrin membrane-ECM interactions

ECM proteoglycans
type: GO_0008150
BFO_0000050: Extracellular matrix organization

Degradation of the extracellular matrix
type: GO_0008150
BFO_0000050: Extracellular matrix organization

Activation of Matrix Metalloproteinases
type: GO_0008150
BFO_0000050: Degradation of the extracellular matrix

Degradation of collagen
type: GO_0008150
BFO_0000050: Degradation of the extracellular matrix