ART1
UniProt:P52961 ART1
Pre-pro-defensins are cleaved to remove the signal peptide
Pro-HNP1-4 are cleaved to biologically active defensin
HNP1-4 are stored in primary neutrophil granules
HNP1-4 are released into phagocytic vacuoles
pro-defensin alpha 5 is stored in Paneth cell granules
pro-defensin alpha 5 is secreted
pro-HD5 is cleaved by trypsin
Alpha-defensins form biologically active dimers
Alpha-defensin dimers adsorb onto microbial membrane anionic phospholipids
Alpha-defensin dimers multimerize to form a pore complex
HNP1-3 bind gp120
HNP1-3 bind CD4
ADP-Ribosylation of HNP-1
Beta-defensins are secreted
Beta-defensins bind microbial membranes causing disruption
Beta-defensins 1, 4A and 103 bind CCR6
Beta-defensins 4A and 103 bind CCR2
Beta defensin 103 activates TLR1:TLR2
Binding of defensins to lipid II
Defensins
Alpha-defensins
Beta defensins