ART1
label: UniProt:P52961 ART1

Pre-pro-defensins are cleaved to remove the signal peptide
type: GO_0003674
BFO_0000050: Defensins
directly activates: Pro-HNP1-4 are cleaved to biologically active defensin
directly activates: pro-defensin alpha 5 is stored in Paneth cell granules

Pro-HNP1-4 are cleaved to biologically active defensin
type: GO_0003674
BFO_0000050: Alpha-defensins
directly activates: HNP1-4 are stored in primary neutrophil granules

HNP1-4 are stored in primary neutrophil granules
type: GO_0003674
BFO_0000050: Alpha-defensins
directly activates: HNP1-4 are released into phagocytic vacuoles

HNP1-4 are released into phagocytic vacuoles
type: GO_0003674
BFO_0000050: Alpha-defensins
directly activates: Alpha-defensins form biologically active dimers
directly activates: HNP1-3 bind gp120
directly activates: HNP1-3 bind CD4
directly activates: ADP-Ribosylation of HNP-1
directly activates: Catalysis412

pro-defensin alpha 5 is stored in Paneth cell granules
type: GO_0003674
BFO_0000050: Alpha-defensins
directly activates: pro-defensin alpha 5 is secreted

pro-defensin alpha 5 is secreted
type: GO_0003674
BFO_0000050: Alpha-defensins
directly activates: pro-HD5 is cleaved by trypsin
directly activates: Catalysis411

pro-HD5 is cleaved by trypsin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0008236
BFO_0000050: Alpha-defensins
directly activates: Alpha-defensins form biologically active dimers

Alpha-defensins form biologically active dimers
type: GO_0003674
BFO_0000050: Alpha-defensins
directly activates: Alpha-defensin dimers adsorb onto microbial membrane anionic phospholipids

Alpha-defensin dimers adsorb onto microbial membrane anionic phospholipids
type: GO_0003674
BFO_0000050: Alpha-defensins
directly activates: Alpha-defensin dimers multimerize to form a pore complex

Alpha-defensin dimers multimerize to form a pore complex
type: GO_0003674
BFO_0000050: Alpha-defensins

HNP1-3 bind gp120
type: GO_0003674
BFO_0000050: Alpha-defensins

HNP1-3 bind CD4
type: GO_0003674
BFO_0000050: Alpha-defensins

ADP-Ribosylation of HNP-1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: ART1
type: Restriction
  on property: enabled by
  some values from: ART1
type: GO_0006471
BFO_0000050: Alpha-defensins

Beta-defensins are secreted
type: GO_0003674
BFO_0000050: Beta defensins
directly activates: Beta-defensins bind microbial membranes causing disruption

Beta-defensins bind microbial membranes causing disruption
type: GO_0003674
BFO_0000050: Beta defensins

Beta-defensins 1, 4A and 103 bind CCR6
type: GO_0003674
BFO_0000050: Beta defensins

Beta-defensins 4A and 103 bind CCR2
type: GO_0003674
BFO_0000050: Beta defensins

Beta defensin 103 activates TLR1:TLR2
type: GO_0003674
BFO_0000050: Beta defensins

Binding of defensins to lipid II
type: GO_0003674
BFO_0000050: Defensins

Defensins
type: GO_0008150

Alpha-defensins
type: GO_0008150
BFO_0000050: Defensins

Beta defensins
type: GO_0008150
BFO_0000050: Defensins