CDC2
CDC28A
CDK1
CDKN1
P34CDC2
UniProt:P06493 CDK1
PLC1
PLCG1
UniProt:P19174 PLCG1
Active PLCG1 hydrolyses PIP2
DAG stimulates protein kinase C-delta
Dimerization of DAP12
Interaction of DAP12 and KIR2DS1
Interaction of DAP12 and KIR2DS2
Interaction of DAP12 and KIR2DS4
Interaction of DAP12 and KIR2DS5
Interaction of DAP12 and KIR3DS1
Interaction of DAP12 and MDL-1
DAP12 interacts with NKG2C
Interaction of DAP12 and NKG2D
Interaction of DAP12 and NKp44
Interaction of DAP12 and SIRP beta
Interaction of DAP12 and TREM1
Interaction of DAP12 and TREM2
Interaction of SIGLEC14/15/16 and DAP12
Interaction of DAP12 and IREM2
Interaction of DAP12 and CLM7
Phosphorylation of DAP12
Recruitment of SYK to p-DAP12
Phosphorylation of SYK
p85 regulatory unit of PI3K binds p-6Y-SYK
PI3K phosphorylates PIP2 to PIP3
Phosphorylation of LAT by p-SYK
Recruitment of GRB2:SOS to p-5Y-LAT
Recruitment of GADS:SLP-76 to p-5Y-LAT
Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT
SOS mediated nucleotide exchange of RAS (SHC)
p-RAF binds 14-3-3 beta/alpha
Transient dissociation of 14-3-3 upon Ras binding
Stabilisation of RAS:RAF by 14-3-3
Stabilisation of RAF by further phosphorylation
Phosphorylated human RAF1 binds to RAS:GTP complex
Activated RAF1 complex binds MEK
RAF1 phosphorylates MEK1
RAF1 phosphorylates MEK2
Phosphorylation of SLP-76 by p-SYK
Recruitment of VAV and BTK to p-SLP-76
Phosphorylation of BTK by p-SYK
Phosphorylation of PLC-gamma by p-BTK/p-SYK
Release of p-PLCG1
Adenylate cyclase produces cAMP
cAMP induces dissociation of inactive PKA tetramers
PKA catalytic subunit translocates to the nucleus
PKA phosphorylates CREB
Dimerisation of CREB
Calmodulin binds CaMK IV
CamKIV enters the nucleus
CaMK IV autophosphorylation
CaMK IV phosphorylates CREB
Calmodulin activates Cam-PDE 1
cAMP hydrolysis by Cam-PDE 1
Inhibition of GRK2 by calmodulin
PKC phosphorylates GRK2
Phosphorylation and activation of VAV2/VAV3 by SYK
Activation of RAC1 by VAV2/3
Calcium binds calmodulin
PIP3 recruits PDPK1 to the membrane
PIP3 recruits AKT to the membrane
TORC2 (mTOR) phosphorylates AKT at S473
AKT binds PDPK1
PDPK1 phosphorylates AKT at T308
IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel
Release of calcium from intracellular stores by IP3 receptor activation
AKT phosphorylates BAD
AKT phosphorylates GSK3
AKT phosphorylates caspase-9
AKT phosphorylates MDM2
AKT phosphorylates IKKalpha
AKT phosphorylates p21Cip1 and p27Kip1
AKT phosphorylates TSC2, inhibiting it
AKT phosphorylates AKT1S1 (PRAS40)
AKT translocates to the nucleus
AKT phosphorylates CREB1
AKT can phosphorylate forkhead box transcription factors
AKT can phosphorylate RSK
AKT can phosphorylate NR4A1 (NUR77)
PTEN dephosphorylates PIP3
THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
PHLPP dephosphorylates S473 in AKT
PDPK1 binds PIP2
MIR26A microRNAs bind PTEN mRNA
PTEN mRNA translation negatively regulated by microRNAs
Inactivation of MEK1 by p34cdc2
MEK1 binds ERK-1
MEK1 phosphorylates ERK-1
Dissociation of phospho-ERK-1:MEK1
Dimerisation of phospho-ERK-1
Nuclear translocation of phospho-ERK-1 dimer
MEK2 binds ERK-2
MEK2 phosphorylates ERK-2
Dissociation of phospho-ERK-2:MEK2
Dimerisation of phospho-ERK-2
Nuclear translocation of phospho-ERK-2 dimer
PIP3 activates AKT signaling
AKT phosphorylates targets in the cytosol
AKT phosphorylates targets in the nucleus
Negative regulation of the PI3K/AKT network
ERK activation
ERK1 activation
ERK2 activation
DAP12 interactions
DAP12 signaling
RAF/MAP kinase cascade
RAF activation
MEK activation
RAF phosphorylates MEK
DAG and IP3 signaling
CaM pathway
Calmodulin induced events
PKA-mediated phosphorylation of CREB
PKA activation
CaMK IV-mediated phosphorylation of CREB
Cam-PDE 1 activation