CDC2
label: CDC28A
label: CDK1
label: CDKN1
label: P34CDC2
label: UniProt:P06493 CDK1

PLC1
label: PLCG1
label: UniProt:P19174 PLCG1

Active PLCG1 hydrolyses PIP2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: PLC1
type: Restriction
  on property: enabled by
  some values from: PLC1
type: Restriction
  on property: enabled by
  some values from: PLC1
type: Restriction
  on property: enabled by
  some values from: PLC1
type: GO_0004435
BFO_0000050: DAG and IP3 signaling
directly activates: DAG stimulates protein kinase C-delta
directly activates: BiochemicalReaction2349
directly activates: BiochemicalReaction4612
directly activates: BiochemicalReaction4621
directly activates: BiochemicalReaction4666
directly activates: BiochemicalReaction4667
directly activates: IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel
directly activates: Catalysis2025
directly activates: Catalysis2062
directly activates: Catalysis2063
directly activates: Catalysis438
directly activates: Control91

DAG stimulates protein kinase C-delta
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004697
BFO_0000050: DAG and IP3 signaling
directly activates: BiochemicalReaction1245
directly activates: Catalysis439

Dimerization of DAP12
type: GO_0003674
BFO_0000050: DAP12 interactions
directly activates: Interaction of DAP12 and KIR2DS1
directly activates: Interaction of DAP12 and KIR2DS2
directly activates: Interaction of DAP12 and KIR2DS4
directly activates: Interaction of DAP12 and KIR2DS5
directly activates: Interaction of DAP12 and KIR3DS1
directly activates: Interaction of DAP12 and MDL-1
directly activates: DAP12 interacts with NKG2C
directly activates: Interaction of DAP12 and NKG2D
directly activates: Interaction of DAP12 and NKp44
directly activates: Interaction of DAP12 and SIRP beta
directly activates: Interaction of DAP12 and TREM1
directly activates: Interaction of DAP12 and TREM2
directly activates: Interaction of SIGLEC14/15/16 and DAP12
directly activates: Interaction of DAP12 and IREM2
directly activates: Interaction of DAP12 and CLM7

Interaction of DAP12 and KIR2DS1
type: GO_0003674
BFO_0000050: DAP12 interactions

Interaction of DAP12 and KIR2DS2
type: GO_0003674
BFO_0000050: DAP12 interactions

Interaction of DAP12 and KIR2DS4
type: GO_0003674
BFO_0000050: DAP12 interactions

Interaction of DAP12 and KIR2DS5
type: GO_0003674
BFO_0000050: DAP12 interactions

Interaction of DAP12 and KIR3DS1
type: GO_0003674
BFO_0000050: DAP12 interactions

Interaction of DAP12 and MDL-1
type: GO_0003674
BFO_0000050: DAP12 interactions

DAP12 interacts with NKG2C
type: GO_0003674
BFO_0000050: DAP12 interactions

Interaction of DAP12 and NKG2D
type: GO_0003674
BFO_0000050: DAP12 interactions

Interaction of DAP12 and NKp44
type: GO_0003674
BFO_0000050: DAP12 interactions

Interaction of DAP12 and SIRP beta
type: GO_0003674
BFO_0000050: DAP12 interactions

Interaction of DAP12 and TREM1
type: GO_0003674
BFO_0000050: DAP12 interactions

Interaction of DAP12 and TREM2
type: GO_0003674
BFO_0000050: DAP12 interactions

Interaction of SIGLEC14/15/16 and DAP12
type: GO_0003674
BFO_0000050: DAP12 interactions

Interaction of DAP12 and IREM2
type: GO_0003674
BFO_0000050: DAP12 interactions

Interaction of DAP12 and CLM7
type: GO_0003674
BFO_0000050: DAP12 interactions

Phosphorylation of DAP12
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004713
BFO_0000050: DAP12 signaling
directly activates: Recruitment of SYK to p-DAP12

Recruitment of SYK to p-DAP12
type: GO_0003674
BFO_0000050: DAP12 signaling
directly activates: Phosphorylation of SYK
directly activates: Catalysis443

Phosphorylation of SYK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: DAP12 signaling
directly activates: p85 regulatory unit of PI3K binds p-6Y-SYK
directly activates: Phosphorylation of LAT by p-SYK
directly activates: Catalysis445

p85 regulatory unit of PI3K binds p-6Y-SYK
type: GO_0003674
BFO_0000050: DAP12 signaling
directly activates: PI3K phosphorylates PIP2 to PIP3
directly activates: Catalysis444

PI3K phosphorylates PIP2 to PIP3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0046934
BFO_0000050: DAP12 signaling

Phosphorylation of LAT by p-SYK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: DAP12 signaling

Recruitment of GRB2:SOS to p-5Y-LAT
type: GO_0003674
BFO_0000050: DAP12 signaling
directly activates: SOS mediated nucleotide exchange of RAS (SHC)
directly activates: Catalysis446

Recruitment of GADS:SLP-76 to p-5Y-LAT
type: GO_0003674
BFO_0000050: DAP12 signaling
directly activates: Phosphorylation of SLP-76 by p-SYK
directly activates: BiochemicalReaction1310
directly activates: Catalysis450
directly activates: Catalysis466

Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT
type: GO_0003674
BFO_0000050: DAP12 signaling
directly activates: Recruitment of GADS:SLP-76 to p-5Y-LAT

SOS mediated nucleotide exchange of RAS (SHC)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005088
BFO_0000050: DAP12 signaling
directly activates: RAF/MAP kinase cascade

p-RAF binds 14-3-3 beta/alpha
type: GO_0003674
BFO_0000050: RAF activation
directly activates: Transient dissociation of 14-3-3 upon Ras binding

Transient dissociation of 14-3-3 upon Ras binding
type: GO_0003674
BFO_0000050: RAF activation
directly activates: Stabilisation of RAS:RAF by 14-3-3

Stabilisation of RAS:RAF by 14-3-3
type: GO_0003674
BFO_0000050: RAF activation
directly activates: Stabilisation of RAF by further phosphorylation
directly activates: Catalysis447

Stabilisation of RAF by further phosphorylation
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: RAF activation
directly activates: Activated RAF1 complex binds MEK

Phosphorylated human RAF1 binds to RAS:GTP complex
type: GO_0003674
BFO_0000050: RAF activation
directly activates: RAF1 phosphorylates MEK1
directly activates: RAF1 phosphorylates MEK2
directly activates: Catalysis448
directly activates: Catalysis449

Activated RAF1 complex binds MEK
type: GO_0003674
BFO_0000050: MEK activation
directly activates: RAF1 phosphorylates MEK1
directly activates: RAF1 phosphorylates MEK2
directly activates: Catalysis448
directly activates: Catalysis449

RAF1 phosphorylates MEK1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0016301
BFO_0000050: RAF phosphorylates MEK
directly activates: MEK1 binds ERK-1

RAF1 phosphorylates MEK2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0016301
BFO_0000050: RAF phosphorylates MEK
directly activates: MEK2 binds ERK-2

Phosphorylation of SLP-76 by p-SYK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: DAP12 signaling
directly activates: Recruitment of VAV and BTK to p-SLP-76

Recruitment of VAV and BTK to p-SLP-76
type: GO_0003674
BFO_0000050: DAP12 signaling
directly activates: Phosphorylation of BTK by p-SYK
directly activates: Phosphorylation and activation of VAV2/VAV3 by SYK
directly activates: Catalysis451
directly activates: Catalysis459

Phosphorylation of BTK by p-SYK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: DAP12 signaling
directly activates: Phosphorylation of PLC-gamma by p-BTK/p-SYK
directly activates: Catalysis452

Phosphorylation of PLC-gamma by p-BTK/p-SYK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: DAP12 signaling
directly activates: Release of p-PLCG1

Release of p-PLCG1
type: GO_0003674
BFO_0000050: DAP12 signaling

Adenylate cyclase produces cAMP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0008294
BFO_0000050: PKA activation
directly activates: cAMP induces dissociation of inactive PKA tetramers
directly activates: cAMP hydrolysis by Cam-PDE 1
directly activates: BiochemicalReaction4409
directly activates: Catalysis1906
directly activates: Catalysis457
directly activates: Control92
directly activates: Control93

cAMP induces dissociation of inactive PKA tetramers
type: GO_0003674
BFO_0000050: PKA activation
directly activates: PKA catalytic subunit translocates to the nucleus
directly activates: BiochemicalReaction1772
directly activates: BiochemicalReaction4565
directly activates: BiochemicalReaction4724
directly activates: BiochemicalReaction5354
directly activates: Catalysis1982
directly activates: Catalysis2086
directly activates: Catalysis2578
directly activates: Catalysis748
directly activates: Control369
directly activates: Control433

PKA catalytic subunit translocates to the nucleus
type: GO_0003674
BFO_0000050: PKA-mediated phosphorylation of CREB
directly activates: PKA phosphorylates CREB
directly activates: BiochemicalReaction5352
directly activates: Catalysis2577
directly activates: Catalysis454
directly activates: Control432

PKA phosphorylates CREB
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: PKA-mediated phosphorylation of CREB
directly activates: Dimerisation of CREB

Dimerisation of CREB
type: GO_0003674
BFO_0000050: PKA-mediated phosphorylation of CREB
BFO_0000050: CaMK IV-mediated phosphorylation of CREB

Calmodulin binds CaMK IV
type: GO_0003674
BFO_0000050: CaMK IV-mediated phosphorylation of CREB
directly activates: CamKIV enters the nucleus

CamKIV enters the nucleus
type: GO_0003674
BFO_0000050: CaMK IV-mediated phosphorylation of CREB
directly activates: CaMK IV autophosphorylation
directly activates: Catalysis455

CaMK IV autophosphorylation
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004683
BFO_0000050: CaMK IV-mediated phosphorylation of CREB

CaMK IV phosphorylates CREB
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004683
BFO_0000050: CaMK IV-mediated phosphorylation of CREB
directly activates: Dimerisation of CREB
directly activates: TemplateReaction23
directly activates: TemplateReactionRegulation31
directly activates: TemplateReactionRegulation32
directly activates: TemplateReactionRegulation33
directly activates: TemplateReactionRegulation34
directly activates: TemplateReactionRegulation35

Calmodulin activates Cam-PDE 1
type: GO_0003674
BFO_0000050: Cam-PDE 1 activation
directly activates: cAMP hydrolysis by Cam-PDE 1
directly activates: Catalysis457

cAMP hydrolysis by Cam-PDE 1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004117
BFO_0000050: Cam-PDE 1 activation

Inhibition of GRK2 by calmodulin
type: GO_0003674
BFO_0000050: Calmodulin induced events

PKC phosphorylates GRK2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004672
BFO_0000050: Calmodulin induced events

Phosphorylation and activation of VAV2/VAV3 by SYK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: DAP12 signaling
directly activates: Activation of RAC1 by VAV2/3
directly activates: Catalysis460

Activation of RAC1 by VAV2/3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005085
BFO_0000050: DAP12 signaling

Calcium binds calmodulin
type: GO_0003674
BFO_0000050: CaM pathway
directly activates: Adenylate cyclase produces cAMP
directly activates: Calmodulin binds CaMK IV
directly activates: Calmodulin activates Cam-PDE 1
directly activates: Inhibition of GRK2 by calmodulin
directly activates: BiochemicalReaction1324
directly activates: BiochemicalReaction243
directly activates: BiochemicalReaction4415
directly activates: BiochemicalReaction5368
directly activates: Catalysis453
directly activates: Control94
directly activates: Control95
directly activates: Modulation7
directly activates: Modulation8
directly activates: CaMK IV-mediated phosphorylation of CREB

PIP3 recruits PDPK1 to the membrane
type: GO_0003674
BFO_0000050: PIP3 activates AKT signaling

PIP3 recruits AKT to the membrane
type: GO_0003674
BFO_0000050: PIP3 activates AKT signaling

TORC2 (mTOR) phosphorylates AKT at S473
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: PIP3 activates AKT signaling
directly activates: BiochemicalReaction684
directly activates: AKT phosphorylates BAD
directly activates: AKT phosphorylates GSK3
directly activates: AKT phosphorylates caspase-9
directly activates: AKT phosphorylates MDM2
directly activates: AKT phosphorylates IKKalpha
directly activates: AKT phosphorylates p21Cip1 and p27Kip1
directly activates: AKT phosphorylates TSC2, inhibiting it
directly activates: AKT phosphorylates AKT1S1 (PRAS40)
directly activates: Catalysis252
directly activates: Catalysis282
directly activates: Catalysis283
directly activates: Catalysis284
directly activates: Catalysis285
directly activates: Catalysis286
directly activates: Catalysis287
directly activates: Catalysis288
directly activates: Catalysis289

AKT binds PDPK1
type: GO_0003674
BFO_0000050: PIP3 activates AKT signaling

PDPK1 phosphorylates AKT at T308
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004674
BFO_0000050: PIP3 activates AKT signaling
directly activates: AKT phosphorylates BAD
directly activates: AKT phosphorylates GSK3
directly activates: AKT phosphorylates caspase-9
directly activates: AKT phosphorylates MDM2
directly activates: AKT phosphorylates IKKalpha
directly activates: AKT phosphorylates p21Cip1 and p27Kip1
directly activates: AKT phosphorylates TSC2, inhibiting it
directly activates: AKT phosphorylates AKT1S1 (PRAS40)
directly activates: Catalysis282
directly activates: Catalysis283
directly activates: Catalysis284
directly activates: Catalysis285
directly activates: Catalysis286
directly activates: Catalysis287
directly activates: Catalysis288
directly activates: Catalysis289

IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel
type: GO_0003674
BFO_0000050: DAG and IP3 signaling
directly activates: Release of calcium from intracellular stores by IP3 receptor activation
directly activates: Catalysis272
directly activates: Control50

Release of calcium from intracellular stores by IP3 receptor activation
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0005261
BFO_0000050: DAG and IP3 signaling
directly activates: Calcium binds calmodulin
directly activates: BiochemicalReaction5350
directly activates: BiochemicalReaction717
directly activates: BiochemicalReaction722
directly activates: Catalysis2575
directly activates: Catalysis273
directly activates: Control428
directly activates: Control429
directly activates: Control430
directly activates: Control431
directly activates: Pathway1104

PI3K phosphorylates PIP2 to PIP3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0046934
BFO_0000050: PIP3 activates AKT signaling

AKT phosphorylates BAD
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: AKT phosphorylates targets in the cytosol
directly activates: BiochemicalReaction6004

AKT phosphorylates GSK3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: AKT phosphorylates targets in the cytosol

AKT phosphorylates caspase-9
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: AKT phosphorylates targets in the cytosol

AKT phosphorylates MDM2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: AKT phosphorylates targets in the cytosol

AKT phosphorylates IKKalpha
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: AKT phosphorylates targets in the cytosol

AKT phosphorylates p21Cip1 and p27Kip1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: AKT phosphorylates targets in the cytosol

AKT phosphorylates TSC2, inhibiting it
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: AKT phosphorylates targets in the cytosol

AKT phosphorylates AKT1S1 (PRAS40)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: AKT phosphorylates targets in the cytosol

AKT translocates to the nucleus
type: GO_0003674
BFO_0000050: PIP3 activates AKT signaling
directly activates: AKT phosphorylates CREB1
directly activates: AKT can phosphorylate forkhead box transcription factors
directly activates: AKT can phosphorylate RSK
directly activates: AKT can phosphorylate NR4A1 (NUR77)
directly activates: Catalysis290
directly activates: Catalysis291
directly activates: Catalysis292
directly activates: Catalysis293

AKT phosphorylates CREB1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: AKT phosphorylates targets in the nucleus

AKT can phosphorylate forkhead box transcription factors
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: AKT phosphorylates targets in the nucleus

AKT can phosphorylate RSK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: AKT phosphorylates targets in the nucleus

AKT can phosphorylate NR4A1 (NUR77)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: AKT phosphorylates targets in the nucleus

PTEN dephosphorylates PIP3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016314
BFO_0000050: Negative regulation of the PI3K/AKT network
directly activates: BiochemicalReaction3944
directly activates: Catalysis1796

THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
type: GO_0003674
BFO_0000050: Negative regulation of the PI3K/AKT network

PHLPP dephosphorylates S473 in AKT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004722
BFO_0000050: Negative regulation of the PI3K/AKT network

PDPK1 binds PIP2
type: GO_0003674
BFO_0000050: PIP3 activates AKT signaling
directly activates: BiochemicalReaction3238

MIR26A microRNAs bind PTEN mRNA
type: GO_0003674
BFO_0000050: PIP3 activates AKT signaling

PTEN mRNA translation negatively regulated by microRNAs
type: GO_0003674
BFO_0000050: PIP3 activates AKT signaling

Inactivation of MEK1 by p34cdc2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: ERK1 activation

MEK1 binds ERK-1
type: GO_0003674
BFO_0000050: ERK1 activation
directly activates: MEK1 phosphorylates ERK-1
directly activates: Catalysis344
directly activates: Control57

MEK1 phosphorylates ERK-1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: ERK1 activation
directly activates: Dissociation of phospho-ERK-1:MEK1

Dissociation of phospho-ERK-1:MEK1
type: GO_0003674
BFO_0000050: ERK1 activation
directly activates: Dimerisation of phospho-ERK-1

Dimerisation of phospho-ERK-1
type: GO_0003674
BFO_0000050: ERK1 activation
directly activates: Nuclear translocation of phospho-ERK-1 dimer

Nuclear translocation of phospho-ERK-1 dimer
type: GO_0000189
BFO_0000050: ERK1 activation
directly activates: BiochemicalReaction905
directly activates: BiochemicalReaction906
directly activates: BiochemicalReaction908
directly activates: Catalysis346
directly activates: Catalysis347
directly activates: Catalysis349

MEK2 binds ERK-2
type: GO_0003674
BFO_0000050: ERK2 activation
directly activates: MEK2 phosphorylates ERK-2
directly activates: Catalysis345

MEK2 phosphorylates ERK-2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: ERK2 activation
directly activates: Dissociation of phospho-ERK-2:MEK2

Dissociation of phospho-ERK-2:MEK2
type: GO_0003674
BFO_0000050: ERK2 activation
directly activates: Dimerisation of phospho-ERK-2

Dimerisation of phospho-ERK-2
type: GO_0003674
BFO_0000050: ERK2 activation
directly activates: Nuclear translocation of phospho-ERK-2 dimer

Nuclear translocation of phospho-ERK-2 dimer
type: GO_0000189
BFO_0000050: ERK2 activation
directly activates: BiochemicalReaction905
directly activates: BiochemicalReaction906
directly activates: BiochemicalReaction908
directly activates: Catalysis346
directly activates: Catalysis347
directly activates: Catalysis349

PIP3 activates AKT signaling
type: GO_0008150
BFO_0000050: DAP12 signaling

AKT phosphorylates targets in the cytosol
type: GO_0008150
BFO_0000050: PIP3 activates AKT signaling

AKT phosphorylates targets in the nucleus
type: GO_0008150
BFO_0000050: PIP3 activates AKT signaling

Negative regulation of the PI3K/AKT network
type: GO_0008150
BFO_0000050: PIP3 activates AKT signaling

ERK activation
type: GO_0008150
BFO_0000050: RAF/MAP kinase cascade

ERK1 activation
type: GO_0008150
BFO_0000050: ERK activation

ERK2 activation
type: GO_0008150
BFO_0000050: ERK activation

DAP12 interactions
type: GO_0008150

DAP12 signaling
type: GO_0008150
BFO_0000050: DAP12 interactions

RAF/MAP kinase cascade
type: GO_0008150
BFO_0000050: DAP12 signaling

RAF activation
type: GO_0008150
BFO_0000050: RAF/MAP kinase cascade

MEK activation
type: GO_0008150
BFO_0000050: RAF/MAP kinase cascade

RAF phosphorylates MEK
type: GO_0008150
BFO_0000050: MEK activation

DAG and IP3 signaling
type: GO_0008150
BFO_0000050: DAP12 signaling

CaM pathway
type: GO_0008150
BFO_0000050: DAG and IP3 signaling

Calmodulin induced events
type: GO_0008150
BFO_0000050: CaM pathway

PKA-mediated phosphorylation of CREB
type: GO_0008150
BFO_0000050: Calmodulin induced events

PKA activation
type: GO_0008150
BFO_0000050: PKA-mediated phosphorylation of CREB

CaMK IV-mediated phosphorylation of CREB
type: GO_0008150
BFO_0000050: Calmodulin induced events

Cam-PDE 1 activation
type: GO_0008150
BFO_0000050: Calmodulin induced events