LIG1
label: UniProt:P18858 LIG1

UniProt:P30291 WEE1
label: WEE1

CDC25A
label: UniProt:P30304 CDC25A

FEN1
label: RAD2
label: UniProt:P39748 FEN1

PLK
label: PLK1
label: UniProt:P53350 PLK1

DYRK
label: DYRK1A
label: MNB
label: MNBH
label: UniProt:Q13627 DYRK1A

ESP1
label: ESPL1
label: KIAA0165
label: UniProt:Q14674 ESPL1

GW
label: GWL
label: MASTL
label: THC2
label: UniProt:Q96GX5 MASTL

MYT1
label: PKMYT1
label: UniProt:Q99640 PKMYT1

C20orf154
label: MCM8
label: UniProt:Q9UJA3 MCM8

CDC6 association with ORC:origin complexes mediated by MCM8
type: GO_0003674
BFO_0000050: CDC6 association with the ORC:origin complex
directly activates: Free CDT1 associates with CDC6:ORC:origin complexes

The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1
type: GO_0003674
BFO_0000050: Association of licensing factors with the pre-replicative complex
BFO_0000050: CDT1 association with the CDC6:ORC:origin complex
directly activates: Ubiquitinated geminin is degraded by the proteasome
directly activates: Free CDT1 associates with CDC6:ORC:origin complexes
directly activates: Catalysis3

Ubiquitinated geminin is degraded by the proteasome
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004175
BFO_0000050: CDT1 association with the CDC6:ORC:origin complex

Free CDT1 associates with CDC6:ORC:origin complexes
type: GO_0003674
BFO_0000050: CDT1 association with the CDC6:ORC:origin complex

Mcm2-7 associates with the Cdt1:CDC6:ORC:origin complex, forming the pre-replicative complex (preRC)
type: GO_0003674
BFO_0000050: Assembly of the pre-replicative complex
directly activates: Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7
directly activates: MCM2-7 mediated fork unwinding
directly activates: MCM8 mediated fork unwinding
directly activates: Catalysis12
directly activates: Catalysis13

Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7
type: GO_0003674
BFO_0000050: Activation of the pre-replicative complex
directly activates: Cdt1 is displaced from the pre-replicative complex.
directly activates: CDK and DDK associate with the Mcm10:pre-replicative complex

Cdt1 is displaced from the pre-replicative complex.
type: GO_0003674
BFO_0000050: Removal of licensing factors from origins
BFO_0000050: Activation of the pre-replicative complex
directly activates: Cdt1 associates with geminin

CDK and DDK associate with the Mcm10:pre-replicative complex
type: GO_0003674
BFO_0000050: Activation of the pre-replicative complex
directly activates: Mcm2-7 is phosphorylated by DDK
directly activates: Cdc45 associates with the pre-replicative complex at the origin
directly activates: Catalysis4

Mcm2-7 is phosphorylated by DDK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Activation of the pre-replicative complex

Inactivation of Cyclin E:Cdk2 complexes by p27/p21
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004861
BFO_0000050: Cyclin E associated events during G1/S transition
directly activates: Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21
directly activates: Catalysis831

Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes
type: Restriction
  on property: enabled by
  some values from: UniProt:P30291 WEE1
type: Restriction
  on property: enabled by
  some values from: UniProt:P30291 WEE1
type: Restriction
  on property: enabled by
  some values from: UniProt:P30291 WEE1
type: Restriction
  on property: enabled by
  some values from: UniProt:P30291 WEE1
type: Restriction
  on property: enabled by
  some values from: UniProt:P30291 WEE1
type: Restriction
  on property: enabled by
  some values from: UniProt:P30291 WEE1
type: Restriction
  on property: enabled by
  some values from: UniProt:P30291 WEE1
type: Restriction
  on property: enabled by
  some values from: UniProt:P30291 WEE1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Cyclin A/B1 associated events during G2/M transition
directly activates: Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm
directly activates: Control139

Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes
type: GO_0003674
BFO_0000050: Cyclin A/B1 associated events during G2/M transition
directly activates: Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus
directly activates: Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25
directly activates: Catalysis864

Inactivation of APC/C via CDC20 sequestration
type: GO_0003674
BFO_0000050: Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components

Formation of the MCC complex
type: GO_0003674
BFO_0000050: Inactivation of APC/C via direct inhibition of the APC/C complex
directly activates: Binding of the MCC complex to the APC/C complex

Binding of the MCC complex to the APC/C complex
type: GO_0003674
BFO_0000050: Inactivation of APC/C via direct inhibition of the APC/C complex
directly activates: Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1
directly activates: BiochemicalReaction2520
directly activates: BiochemicalReaction3794

Phosphorylation of LIN52 component of MuvB by DYRK1A
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: DYRK
type: Restriction
  on property: enabled by
  some values from: DYRK
type: Restriction
  on property: enabled by
  some values from: DYRK
type: Restriction
  on property: enabled by
  some values from: DYRK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004672
BFO_0000050: G0 and Early G1
directly activates: p130 (RBL2) associates with MuvB to form DREAM complex

p130 (RBL2) associates with MuvB to form DREAM complex
type: GO_0003674
BFO_0000050: G0 and Early G1
directly activates: Transcription of E2F targets under negative control by DREAM complex
directly activates: Control134

Transcription of E2F targets under negative control by DREAM complex
type: GO_0003674
BFO_0000050: G0 and Early G1

HDAC1 + p107(RBL1):E2F4:DP1 => HDAC1-p107(RBL2):E2F4:DP1
type: GO_0003674
BFO_0000050: G0 and Early G1
directly activates: Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
directly activates: Control135
directly activates: Control136
label: Recruitment of HDAC1 by p107 (RBL1)

HDAC1 + p130(RBL2):E2F4/5:DP1 => HDAC1-p130(RBL2):E2F4/5:DP1
type: GO_0003674
BFO_0000050: G0 and Early G1
directly activates: Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
directly activates: Control135
directly activates: Control136
label: Recruitment of HDAC1 by p130 (RBL2)

Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
type: GO_0003674
BFO_0000050: G0 and Early G1

p107 (RBL1) binds CyclinE/A:CDK2
type: GO_0003674
BFO_0000050: G0 and Early G1

p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2
type: GO_0003674
BFO_0000050: G0 and Early G1

p130 (RBL2) binds Cyclin E/A:CDK2
type: GO_0003674
BFO_0000050: G0 and Early G1

p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2
type: GO_0003674
BFO_0000050: G0 and Early G1

Formation of Cyclin D:Cdk4/6 complexes
type: GO_0003674
BFO_0000050: Cyclin D associated events in G1
directly activates: Translocation of Cyclin D:Cdk4/6 complexes from the cytoplasm to the nucleus

Translocation of Cyclin D:Cdk4/6 complexes from the cytoplasm to the nucleus
type: GO_0003674
BFO_0000050: Cyclin D associated events in G1
directly activates: Phosphorylation of Cyclin D:Cdk4/6 complexes
directly activates: Catalysis824

Phosphorylation of Cyclin D:Cdk4/6 complexes
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Cyclin D associated events in G1
directly activates: Cyclin D:Cdk4/6 mediated phosphorylation of Rb and dissociation of phospho-Rb from the E2F1/2/3:DP-1 complexes
directly activates: Catalysis825

Cyclin D:Cdk4/6 mediated phosphorylation of Rb and dissociation of phospho-Rb from the E2F1/2/3:DP-1 complexes
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004693
BFO_0000050: Cyclin D associated events in G1
directly activates: G1/S-Specific Transcription
directly activates: Ubiquitin-dependent degradation of Cyclin D1
directly activates: CDC6 protein is synthesized under the control of E2F transcription factors
directly activates: TemplateReaction150
directly activates: TemplateReaction152
directly activates: TemplateReactionRegulation1
directly activates: TemplateReactionRegulation174
directly activates: TemplateReactionRegulation176

Association of INK4A with Cdk4/6
type: GO_0003674
BFO_0000050: Cyclin D associated events in G1

Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004693
BFO_0000050: Cyclin D associated events in G1
directly activates: Dephosphorylation of p107 (RBL1) by PP2A
directly activates: Catalysis827

Dephosphorylation of p107 (RBL1) by PP2A
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004721
BFO_0000050: Cyclin D associated events in G1
label: Dephosphorylation of p107 by PP2A

Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004693
BFO_0000050: Cyclin D associated events in G1
directly activates: Dephosphorylation of p107 by PP2A
directly activates: Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex
directly activates: Catalysis829

Dephosphorylation of p107 by PP2A
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004721
BFO_0000050: Cyclin D associated events in G1
label: Dephosphorylation of p130 (RBL2) by PP2A

Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex
type: GO_0003674
BFO_0000050: Cyclin D associated events in G1
directly activates: Ubiquitination of p130 (RBL2) by SCF (Skp2)
directly activates: Catalysis830

Ubiquitination of p130 (RBL2) by SCF (Skp2)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004842
BFO_0000050: Cyclin D associated events in G1

Formation of Cyclin E:Cdk2 complexes
type: GO_0003674
BFO_0000050: Cyclin E associated events during G1/S transition
directly activates: Translocation of Cyclin E:Cdk2 complex to the nucleus

Translocation of Cyclin E:Cdk2 complex to the nucleus
type: GO_0003674
BFO_0000050: Cyclin E associated events during G1/S transition
directly activates: Inactivation of Cyclin E:Cdk2 complexes by p27/p21
directly activates: Phosphorylation of Cyclin E:Cdk2 complexes by Wee-1
directly activates: CAK-mediated phosphorylation of Cyclin E:Cdk2
directly activates: Catalysis808
directly activates: Catalysis834
directly activates: Catalysis838

Translocation of p21 to the nucleus
type: GO_0003674
BFO_0000050: Cyclin E associated events during G1/S transition
BFO_0000050: Cyclin A:Cdk2-associated events at S phase entry
directly activates: Inactivation of Cyclin E:Cdk2 complexes by p27/p21
directly activates: Inactivation of Cyclin A:Cdk2 complexes by p27/p21
directly activates: Catalysis808
directly activates: Catalysis845

Translocation of p27 to the nucleoplasm
type: GO_0003674
BFO_0000050: Cyclin E associated events during G1/S transition
BFO_0000050: Cyclin A:Cdk2-associated events at S phase entry
directly activates: Inactivation of Cyclin E:Cdk2 complexes by p27/p21
directly activates: Inactivation of Cyclin A:Cdk2 complexes by p27/p21
directly activates: Catalysis808
directly activates: Catalysis845

Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004693
BFO_0000050: SCF(Skp2)-mediated degradation of p27/p21
directly activates: Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex

Association of Cks1 with SCF(Skp2) complex
type: GO_0003674
BFO_0000050: SCF(Skp2)-mediated degradation of p27/p21
directly activates: Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex

Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex
type: GO_0003674
BFO_0000050: SCF(Skp2)-mediated degradation of p27/p21
directly activates: Ubiquitination of phospho-p27/p21
directly activates: Catalysis832

Ubiquitination of phospho-p27/p21
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004842
BFO_0000050: SCF(Skp2)-mediated degradation of p27/p21
directly activates: Degradation of ubiquitinated p27/p21 by the 26S proteasome
directly activates: Catalysis833

Degradation of ubiquitinated p27/p21 by the 26S proteasome
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004175
BFO_0000050: SCF(Skp2)-mediated degradation of p27/p21
directly activates: CAK-mediated phosphorylation of Cyclin E:Cdk2
directly activates: CAK-mediated phosphorylation of Cyclin A:Cdk2
directly activates: Catalysis838
directly activates: Catalysis843

Phosphorylation of Cyclin E:Cdk2 complexes by Wee-1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: UniProt:P30291 WEE1
type: Restriction
  on property: enabled by
  some values from: UniProt:P30291 WEE1
type: Restriction
  on property: enabled by
  some values from: UniProt:P30291 WEE1
type: Restriction
  on property: enabled by
  some values from: UniProt:P30291 WEE1
type: Restriction
  on property: enabled by
  some values from: UniProt:P30291 WEE1
type: Restriction
  on property: enabled by
  some values from: UniProt:P30291 WEE1
type: Restriction
  on property: enabled by
  some values from: UniProt:P30291 WEE1
type: Restriction
  on property: enabled by
  some values from: UniProt:P30291 WEE1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Cyclin E associated events during G1/S transition
directly activates: Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A
directly activates: Catalysis837

Cdc45 associates with the pre-replicative complex at the origin
type: GO_0003674
BFO_0000050: Activation of the pre-replicative complex
directly activates: DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin

Phosphorylation of Cyclin E1:Cdk2 complexes by Myt1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: MYT1
type: Restriction
  on property: enabled by
  some values from: MYT1
type: Restriction
  on property: enabled by
  some values from: MYT1
type: Restriction
  on property: enabled by
  some values from: MYT1
type: Restriction
  on property: enabled by
  some values from: MYT1
type: Restriction
  on property: enabled by
  some values from: MYT1
type: Restriction
  on property: enabled by
  some values from: MYT1
type: Restriction
  on property: enabled by
  some values from: MYT1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Cyclin E associated events during G1/S transition

Phosphorylation of Cyclin E2:Cdk2 complexes by Myt1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: MYT1
type: Restriction
  on property: enabled by
  some values from: MYT1
type: Restriction
  on property: enabled by
  some values from: MYT1
type: Restriction
  on property: enabled by
  some values from: MYT1
type: Restriction
  on property: enabled by
  some values from: MYT1
type: Restriction
  on property: enabled by
  some values from: MYT1
type: Restriction
  on property: enabled by
  some values from: MYT1
type: Restriction
  on property: enabled by
  some values from: MYT1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Cyclin E associated events during G1/S transition

Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: CDC25A
type: Restriction
  on property: enabled by
  some values from: CDC25A
type: Restriction
  on property: enabled by
  some values from: CDC25A
type: Restriction
  on property: enabled by
  some values from: CDC25A
type: Restriction
  on property: enabled by
  some values from: CDC25A
type: Restriction
  on property: enabled by
  some values from: CDC25A
type: Restriction
  on property: enabled by
  some values from: CDC25A
type: Restriction
  on property: enabled by
  some values from: CDC25A
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004721
BFO_0000050: Cyclin E associated events during G1/S transition
directly activates: Inactivation of Cyclin E:Cdk2 complexes by p27/p21
directly activates: BiochemicalReaction1841
directly activates: CAK-mediated phosphorylation of Cyclin E:Cdk2
directly activates: Catalysis808
directly activates: Catalysis809
directly activates: Catalysis838
directly activates: Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes

CAK-mediated phosphorylation of Cyclin E:Cdk2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Cyclin E associated events during G1/S transition
directly activates: Association of Rb with Cyclin E:Cdk2 complexes
directly activates: Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes

Association of Rb with Cyclin E:Cdk2 complexes
type: GO_0003674
BFO_0000050: Cyclin E associated events during G1/S transition
directly activates: Cyclin E:Cdk2-mediated phosphorylation of Rb
directly activates: Catalysis839

Cyclin E:Cdk2-mediated phosphorylation of Rb
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004693
BFO_0000050: Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes

Detection of damage during initiation of DNA synthesis in S-phase
type: GO_0003674
BFO_0000050: Inhibition of replication initiation of damaged DNA by RB1/E2F1
directly activates: PP2A mediated localization of RB1 protein in chromatin
directly activates: Catalysis840

PP2A mediated localization of RB1 protein in chromatin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004721
BFO_0000050: Inhibition of replication initiation of damaged DNA by RB1/E2F1
directly activates: Replication initiation regulation by Rb1/E2F1

Replication initiation regulation by Rb1/E2F1
type: GO_0003674
BFO_0000050: Inhibition of replication initiation of damaged DNA by RB1/E2F1

Activation of Cyclin B/Cdk1 by Cdc25a (string) protein
type: GO_0003674
BFO_0000050: E2F-enabled inhibition of pre-replication complex formation
directly activates: Association of Cyclin B/Cdk1 with replicative origin inhibits pre-RC formation

Association of Cyclin B/Cdk1 with replicative origin inhibits pre-RC formation
type: GO_0003674
BFO_0000050: E2F-enabled inhibition of pre-replication complex formation

Formation of Cyclin A:Cdk2 complexes
type: GO_0003674
BFO_0000050: Cyclin A:Cdk2-associated events at S phase entry
directly activates: Translocation of Cyclin A:Cdk2 complexes to the nucleus

Translocation of Cyclin A:Cdk2 complexes to the nucleus
type: GO_0003674
BFO_0000050: Cyclin A:Cdk2-associated events at S phase entry
directly activates: Phosphorylation of Cyclin A:Cdk2 at Tyr 15
directly activates: Inactivation of Cyclin A:Cdk2 complexes by p27/p21
directly activates: Catalysis841
directly activates: Catalysis845

Phosphorylation of Cyclin A:Cdk2 at Tyr 15
type: Restriction
  on property: enabled by
  some values from: UniProt:P30291 WEE1
type: Restriction
  on property: enabled by
  some values from: UniProt:P30291 WEE1
type: Restriction
  on property: enabled by
  some values from: UniProt:P30291 WEE1
type: Restriction
  on property: enabled by
  some values from: UniProt:P30291 WEE1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Cyclin A:Cdk2-associated events at S phase entry
directly activates: Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2
directly activates: Catalysis842

Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004721
BFO_0000050: Cyclin A:Cdk2-associated events at S phase entry
directly activates: CAK-mediated phosphorylation of Cyclin A:Cdk2
directly activates: Catalysis843

CAK-mediated phosphorylation of Cyclin A:Cdk2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Cyclin A:Cdk2-associated events at S phase entry
directly activates: Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2
directly activates: Association of Cyclin A:Cdk2 with Cdh1
directly activates: Catalysis846

Cyclin A:Cdk2 mediated phosphorylation of p27/p21
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004693
BFO_0000050: Cyclin A:Cdk2-associated events at S phase entry

Inactivation of Cyclin A:Cdk2 complexes by p27/p21
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004861
BFO_0000050: Cyclin A:Cdk2-associated events at S phase entry
directly activates: Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21
directly activates: Cyclin A:Cdk2 mediated phosphorylation of p27/p21
directly activates: Catalysis831
directly activates: Catalysis844

Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Cyclin A:Cdk2-associated events at S phase entry

Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Ubiquitin-dependent degradation of Cyclin D1

Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm
type: GO_0003674
BFO_0000050: Ubiquitin-dependent degradation of Cyclin D1

Relocalization of nuclearly localized Cyclin D1 to the cytoplasm
type: GO_0003674
BFO_0000050: Ubiquitin-dependent degradation of Cyclin D1

Ubiquitination of Cyclin D1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004842
BFO_0000050: Ubiquitin-dependent degradation of Cyclin D1
directly activates: Proteasome mediated degradation of Cyclin D1
directly activates: Catalysis849

Proteasome mediated degradation of Cyclin D1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004175
BFO_0000050: Ubiquitin-dependent degradation of Cyclin D1

Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0008080
BFO_0000050: Establishment of Sister Chromatid Cohesion
directly activates: CDCA5 (Sororin) enables cohesion of sister chromosomal arms

Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0008080
BFO_0000050: Establishment of Sister Chromatid Cohesion
directly activates: CDCA5 (Sororin) enables cohesion of sister centromeres

CDCA5 (Sororin) enables cohesion of sister chromosomal arms
type: GO_0003674
BFO_0000050: Establishment of Sister Chromatid Cohesion
directly activates: CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms
directly activates: Catalysis885

CDCA5 (Sororin) enables cohesion of sister centromeres
type: GO_0003674
BFO_0000050: Establishment of Sister Chromatid Cohesion
directly activates: Kinetochore assembly

Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3
type: GO_0003674
BFO_0000050: G2 Phase
directly activates: Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160)
directly activates: Catalysis852

Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004693
BFO_0000050: G2 Phase

Formation of Cyclin A:Cdc2 complexes
type: GO_0003674
BFO_0000050: Cyclin A/B1 associated events during G2/M transition
directly activates: Myt-1 mediated phosphorylation of Cyclin A:Cdc2
directly activates: Catalysis853

Myt-1 mediated phosphorylation of Cyclin A:Cdc2
type: Restriction
  on property: enabled by
  some values from: MYT1
type: Restriction
  on property: enabled by
  some values from: MYT1
type: Restriction
  on property: enabled by
  some values from: MYT1
type: Restriction
  on property: enabled by
  some values from: MYT1
type: Restriction
  on property: enabled by
  some values from: MYT1
type: Restriction
  on property: enabled by
  some values from: MYT1
type: Restriction
  on property: enabled by
  some values from: MYT1
type: Restriction
  on property: enabled by
  some values from: MYT1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016301
BFO_0000050: Cyclin A/B1 associated events during G2/M transition
directly activates: Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus

Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus
type: GO_0003674
BFO_0000050: Cyclin A/B1 associated events during G2/M transition
directly activates: CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes
directly activates: Catalysis854

CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Cyclin A/B1 associated events during G2/M transition
directly activates: Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes
directly activates: Catalysis855

Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes
type: Restriction
  on property: enabled by
  some values from: UniProt:P30291 WEE1
type: Restriction
  on property: enabled by
  some values from: UniProt:P30291 WEE1
type: Restriction
  on property: enabled by
  some values from: UniProt:P30291 WEE1
type: Restriction
  on property: enabled by
  some values from: UniProt:P30291 WEE1
type: Restriction
  on property: enabled by
  some values from: UniProt:P30291 WEE1
type: Restriction
  on property: enabled by
  some values from: UniProt:P30291 WEE1
type: Restriction
  on property: enabled by
  some values from: UniProt:P30291 WEE1
type: Restriction
  on property: enabled by
  some values from: UniProt:P30291 WEE1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Cyclin A/B1 associated events during G2/M transition
directly activates: Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes
directly activates: Catalysis856

Translocation of active Cdc25C to the nucleus
type: GO_0003674
BFO_0000050: Cyclin A/B1 associated events during G2/M transition
directly activates: Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes
directly activates: Catalysis856

Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004721
BFO_0000050: Cyclin A/B1 associated events during G2/M transition
directly activates: Phosphorylation of proteins involved in G2/M transition by active Cyclin A2:Cdc2 complexes
directly activates: Catalysis858
directly activates: Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes

Phosphorylation of proteins involved in G2/M transition by active Cyclin A1:Cdc2 complexes
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004693
BFO_0000050: Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes

Phosphorylation of proteins involved in G2/M transition by active Cyclin A2:Cdc2 complexes
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004693
BFO_0000050: Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes

Formation of Cyclin B:Cdc2 complexes
type: GO_0003674
BFO_0000050: Cyclin A/B1 associated events during G2/M transition
directly activates: Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes

Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus
type: GO_0003674
BFO_0000050: Cyclin A/B1 associated events during G2/M transition
directly activates: CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes
directly activates: Catalysis859

CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Cyclin A/B1 associated events during G2/M transition
directly activates: Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes
directly activates: Phosphorylation of Cyclin B1 in the CRS domain
directly activates: Catalysis819
directly activates: Catalysis861

Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm
type: GO_0003674
BFO_0000050: Cyclin A/B1 associated events during G2/M transition
directly activates: Dephosphorylation of cytoplasmic Cyclin B1:phospho-Cdc2 (Thr 14, Tyr 15) complexes by Cdc25 phosphatases
directly activates: Catalysis860

Translocation of Cdc25B to the cytoplasm
type: GO_0003674
BFO_0000050: Cyclin A/B1 associated events during G2/M transition
directly activates: Dephosphorylation of cytoplasmic Cyclin B1:phospho-Cdc2 (Thr 14, Tyr 15) complexes by Cdc25 phosphatases
directly activates: Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25
directly activates: Catalysis860
directly activates: Catalysis864

Dephosphorylation of cytoplasmic Cyclin B1:phospho-Cdc2 (Thr 14, Tyr 15) complexes by Cdc25 phosphatases
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004721
BFO_0000050: Cyclin A/B1 associated events during G2/M transition
directly activates: Phosphorylation of Cyclin B1 in the CRS domain
directly activates: Catalysis861

Phosphorylation of Cyclin B1 in the CRS domain
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016301
BFO_0000050: Cyclin A/B1 associated events during G2/M transition
directly activates: Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes

Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes
type: GO_0003674
BFO_0000050: Cyclin A/B1 associated events during G2/M transition
directly activates: Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases
directly activates: Catalysis862

Translocation of Cdc25 to the nucleus
type: GO_0003674
BFO_0000050: Cyclin A/B1 associated events during G2/M transition
directly activates: Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases
directly activates: Catalysis862

Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004721
BFO_0000050: Cyclin A/B1 associated events during G2/M transition
directly activates: Phosphorylation of M phase proteins by active Cyclin B1:Cdc2 complexes
directly activates: CDK1 phosphorylates MASTL
directly activates: Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2
directly activates: Phosphorylation of Cdh1 by Cyclin B1:Cdc2
directly activates: Free APC/C phosphorylated by Cyclin B:Cdc2
directly activates: Association of Cyclin B:Cdc2 with Cdc20:APC/C complex
directly activates: Catalysis863
directly activates: Catalysis876
directly activates: Catalysis905
directly activates: Catalysis909
directly activates: Catalysis911

Phosphorylation of M phase proteins by active Cyclin B1:Cdc2 complexes
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004693
BFO_0000050: Cyclin A/B1 associated events during G2/M transition

Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004721
BFO_0000050: Cyclin B2 mediated events
directly activates: Phosphorylation of proteins involved in G2/M transition by active Cyclin B2:Cdc2 complexes
directly activates: Catalysis865

Phosphorylation of proteins involved in G2/M transition by active Cyclin B2:Cdc2 complexes
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004693
BFO_0000050: Cyclin B2 mediated events

PLK1 phosphorylates OPTN
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Regulation of PLK1 Activity at G2/M Transition
directly activates: Phosphorylated OPTN translocates to the nucleus

Phosphorylated OPTN translocates to the nucleus
type: GO_0003674
BFO_0000050: Regulation of PLK1 Activity at G2/M Transition

Cytosolic PLK1 translocates to the nucleus
type: GO_0003674
BFO_0000050: Regulation of PLK1 Activity at G2/M Transition

Myosin phosphatase dephosphorylates PLK1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004722
BFO_0000050: Regulation of PLK1 Activity at G2/M Transition

Inactivation of Wee1 kinase
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
type: GO_0051726
BFO_0000050: Polo-like kinase mediated events
directly activates: Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes
directly activates: Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases
directly activates: Catalysis856
directly activates: Catalysis862

Activation of Cdc25C
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
type: GO_0051726
BFO_0000050: Polo-like kinase mediated events
directly activates: Translocation of Cdc25 to the nucleus
directly activates: Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25
directly activates: Catalysis864

Inactivation of Myt1 kinase
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
type: GO_0051726
BFO_0000050: Polo-like kinase mediated events
directly activates: Dephosphorylation of cytoplasmic Cyclin B1:phospho-Cdc2 (Thr 14, Tyr 15) complexes by Cdc25 phosphatases
directly activates: Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25
directly activates: Catalysis860
directly activates: Catalysis864

Recruitment of CDK11p58 to the centrosomes
type: GO_0003674
BFO_0000050: Recruitment of mitotic centrosome proteins and complexes

Recruitment of Plk1 to centrosomes
type: GO_0003674
BFO_0000050: Recruitment of mitotic centrosome proteins and complexes

Cyclin B/Cdk1 mediate phosphorylation of NuMA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004693
BFO_0000050: Recruitment of NuMA to mitotic centrosomes

Translocation of NuMA to the centrosomes
type: GO_0003674
BFO_0000050: Recruitment of NuMA to mitotic centrosomes

Association of NuMA with microtubules
type: GO_0003674
BFO_0000050: Recruitment of NuMA to mitotic centrosomes

Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome
type: GO_0003674
BFO_0000050: Recruitment of mitotic centrosome proteins and complexes

Loss of C-Nap-1 from centrosomes
type: GO_0003674
BFO_0000050: Loss of proteins required for interphase microtubule organizationÂ from the centrosome

Plk1-mediated phosphorylation of Nlp
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Loss of Nlp from mitotic centrosomes
directly activates: Dissociation of Phospho-Nlp from the centrosome

Dissociation of Phospho-Nlp from the centrosome
type: GO_0003674
BFO_0000050: Loss of Nlp from mitotic centrosomes

Phosphorylation of GORASP1, GOLGA2 and RAB1A by CDK1:CCNB
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004693
BFO_0000050: Golgi Cisternae Pericentriolar Stack Reorganization

GOLGA2 phosphorylated by CDK1 is unable to promote fusion of ER to Golgi transport vesicles with cis-Golgi
type: GO_0003674
BFO_0000050: Golgi Cisternae Pericentriolar Stack Reorganization

Recruitment of PLK1 to phosphorylated GORASP1 (GRASP65)
type: GO_0003674
BFO_0000050: Golgi Cisternae Pericentriolar Stack Reorganization

Activation of the Anaphase Promoting Complex (APC) by PLK1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0007092
type: GO_0016301
BFO_0000050: Golgi Cisternae Pericentriolar Stack Reorganization
label: PLK1 phosphorylates GORASP1

MAPK3-3 or MAPK1 phosphorylate GORASP2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Golgi Cisternae Pericentriolar Stack Reorganization

GORASP1 phosphorylated by PLK1 and GORASP2 phosphorylated by MAPK3-3/MAPK1 are unable to promote Golgi cisternae stacking
type: GO_0003674
BFO_0000050: Golgi Cisternae Pericentriolar Stack Reorganization

CDK1 phosphorylates MASTL
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004693
BFO_0000050: MASTL Facilitates Mitotic Progression
directly activates: MASTL (GWL) phosphorylates ARPP19
directly activates: MASTL phosphorylates ENSA
directly activates: Catalysis877
directly activates: Catalysis878

MASTL (GWL) phosphorylates ARPP19
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: GW
type: Restriction
  on property: enabled by
  some values from: GW
type: Restriction
  on property: enabled by
  some values from: GW
type: Restriction
  on property: enabled by
  some values from: GW
type: Restriction
  on property: enabled by
  some values from: GW
type: Restriction
  on property: enabled by
  some values from: GW
type: Restriction
  on property: enabled by
  some values from: GW
type: Restriction
  on property: enabled by
  some values from: GW
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: MASTL Facilitates Mitotic Progression
directly activates: p-S62-ARPP19/p-S67-ENSA binds PP2A-PPP2R2D

MASTL phosphorylates ENSA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: GW
type: Restriction
  on property: enabled by
  some values from: GW
type: Restriction
  on property: enabled by
  some values from: GW
type: Restriction
  on property: enabled by
  some values from: GW
type: Restriction
  on property: enabled by
  some values from: GW
type: Restriction
  on property: enabled by
  some values from: GW
type: Restriction
  on property: enabled by
  some values from: GW
type: Restriction
  on property: enabled by
  some values from: GW
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: MASTL Facilitates Mitotic Progression
directly activates: p-S62-ARPP19/p-S67-ENSA binds PP2A-PPP2R2D

p-S62-ARPP19/p-S67-ENSA binds PP2A-PPP2R2D
type: GO_0003674
BFO_0000050: MASTL Facilitates Mitotic Progression

CDK1:CCNB phosphorylates NEK9
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004693
BFO_0000050: Activation of NIMA Kinases NEK9, NEK6, NEK7
directly activates: PLK1 phosphorylates NEK9
directly activates: Catalysis880

PLK1 phosphorylates NEK9
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Activation of NIMA Kinases NEK9, NEK6, NEK7
directly activates: NEK9 binds NEK6/NEK7 in the cytosol

NEK9 binds NEK6/NEK7 in the cytosol
type: GO_0003674
BFO_0000050: Activation of NIMA Kinases NEK9, NEK6, NEK7
directly activates: NEK9 phosphorylates NEK6/NEK7
directly activates: Catalysis881

NEK9 phosphorylates NEK6/NEK7
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Activation of NIMA Kinases NEK9, NEK6, NEK7

CDK1 phosphorylates NUP98
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004693
BFO_0000050: Nuclear Pore Complex (NPC) Disassembly

NEK6/NEK7 phosphorylates NUP98
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Nuclear Pore Complex (NPC) Disassembly

VRK1/VRK2 phosphorylate BANF1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: Clearance of Nuclear Envelope Membranes from Chromatin

Kinetochore capture of astral microtubules
type: GO_0003674
BFO_0000050: Mitotic Prometaphase
directly activates: Kinetochore assembly

CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004693
BFO_0000050: Resolution of Sister Chromatid Cohesion
directly activates: Phosphorylation of cohesin by PLK1 at chromosomal arms
directly activates: Catalysis886

Phosphorylation of cohesin by PLK1 at chromosomal arms
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
type: GO_0007062
BFO_0000050: Resolution of Sister Chromatid Cohesion
directly activates: Resolution of sister chromatids

Resolution of sister chromatids
type: GO_0003674
BFO_0000050: Resolution of Sister Chromatid Cohesion
directly activates: Deacetylation of cohesin
directly activates: Catalysis887

Deacetylation of cohesin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004407
BFO_0000050: Resolution of Sister Chromatid Cohesion

Kinetochore assembly
type: GO_0003674
BFO_0000050: Resolution of Sister Chromatid Cohesion
directly activates: CDK1 phosphorylates CDCA5 (Sororin) at centromeres
directly activates: Catalysis888

CDK1 phosphorylates CDCA5 (Sororin) at centromeres
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004693
BFO_0000050: Resolution of Sister Chromatid Cohesion
directly activates: Phosphorylation of cohesin by PLK1 at centromeres
directly activates: Catalysis889

Phosphorylation of cohesin by PLK1 at centromeres
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
type: GO_0007062
BFO_0000050: Resolution of Sister Chromatid Cohesion
directly activates: PP2A-B56 dephosphorylates centromeric cohesin
directly activates: Catalysis890

PP2A-B56 dephosphorylates centromeric cohesin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000775
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000775
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000775
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000775
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000775
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000775
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000775
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000775
type: GO_0004722
BFO_0000050: Resolution of Sister Chromatid Cohesion

CK2 phosphorylates condensin I subunits
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016301
BFO_0000050: Condensation of Prometaphase Chromosomes
directly activates: Dephosphorylation of CK2-modified condensin I
directly activates: Catalysis892

Dephosphorylation of CK2-modified condensin I
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004721
BFO_0000050: Condensation of Prometaphase Chromosomes
directly activates: CDK1 phosphorylates condensin I
directly activates: Catalysis893

CDK1 phosphorylates condensin I
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004693
BFO_0000050: Condensation of Prometaphase Chromosomes
directly activates: Phosphorylated condensin I promotes condensation of prometaphase chromosomes
directly activates: Control145

Phosphorylated condensin I promotes condensation of prometaphase chromosomes
type: GO_0003674
BFO_0000050: Condensation of Prometaphase Chromosomes

Down Regulation of Emi1 through Phosphorylation of Emi1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
type: GO_0007092
BFO_0000050: Mitotic Metaphase/Anaphase Transition

Association of Securin with Cdc20:APC/C complex
type: GO_0003674
BFO_0000050: Separation of Sister Chromatids
BFO_0000050: APC/C:Cdc20 mediated degradation of Securin
directly activates: Ubiquitination of Securin by phospho-APC/C:Cdc20 complex
directly activates: Catalysis895

DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin
type: GO_0003674
BFO_0000050: Activation of the pre-replicative complex
directly activates: DNA polymerase alpha:primase binds at the origin
directly activates: DNA polymerase epsilon binds at the origin
directly activates: Control1
directly activates: Control2

Ubiquitination of Securin by phospho-APC/C:Cdc20 complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004842
type: GO_0042787
BFO_0000050: Separation of Sister Chromatids
BFO_0000050: APC/C:Cdc20 mediated degradation of Securin
directly activates: Degradation of multiubiquitinated Securin
directly activates: Catalysis896

Degradation of multiubiquitinated Securin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004175
BFO_0000050: Separation of Sister Chromatids
BFO_0000050: APC/C:Cdc20 mediated degradation of Securin
directly activates: Autocleavage of ESPL1 (Separase)
directly activates: Dissociation of Cdc20 from APC/C complex
directly activates: Catalysis897

PTTG1 (Securin) sequesters ESPL1 (Separase)
type: GO_0003674
BFO_0000050: Separation of Sister Chromatids
label: Securin sequesters Separase

Autocleavage of ESPL1 (Separase)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: ESP1
type: Restriction
  on property: enabled by
  some values from: ESP1
type: Restriction
  on property: enabled by
  some values from: ESP1
type: Restriction
  on property: enabled by
  some values from: ESP1
type: Restriction
  on property: enabled by
  some values from: ESP1
type: Restriction
  on property: enabled by
  some values from: ESP1
type: Restriction
  on property: enabled by
  some values from: ESP1
type: Restriction
  on property: enabled by
  some values from: ESP1
type: Restriction
  on property: enabled by
  some values from: ESP1
type: Restriction
  on property: enabled by
  some values from: ESP1
type: Restriction
  on property: enabled by
  some values from: ESP1
type: Restriction
  on property: enabled by
  some values from: ESP1
type: Restriction
  on property: enabled by
  some values from: ESP1
type: Restriction
  on property: enabled by
  some values from: ESP1
type: Restriction
  on property: enabled by
  some values from: ESP1
type: Restriction
  on property: enabled by
  some values from: ESP1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008234
BFO_0000050: Separation of Sister Chromatids
label: Autocleavage of Separin

ESPL1 (Separase) cleaves centromeric cohesin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008234
BFO_0000050: Separation of Sister Chromatids

Separation of sister chromatids
type: GO_0003674
BFO_0000050: Separation of Sister Chromatids
directly activates: Deacetylation of cleaved cohesin
directly activates: Catalysis899

Deacetylation of cleaved cohesin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004407
BFO_0000050: Separation of Sister Chromatids

ANKLE2 binds VRK1 or VRK2
type: GO_0003674
BFO_0000050: Initiation of Nuclear Envelope Reformation

PP2A dephosphorylates BANF1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004722
BFO_0000050: Initiation of Nuclear Envelope Reformation
directly activates: BANF1 binds chromatin, EMD/TMPO/LEMD3/LEMD2 and lamins

BANF1 binds chromatin, EMD/TMPO/LEMD3/LEMD2 and lamins
type: GO_0003674
BFO_0000050: Initiation of Nuclear Envelope Reformation

Regulation of KIF23 (MKLP1) by phosphorylation
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: Mitotic Telophase/Cytokinesis

Regulation of KIF20A (MKL2) by phosphorylation
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: Mitotic Telophase/Cytokinesis

Regulation of NUDC by phosphorylation
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: Mitotic Telophase/Cytokinesis

Cohesin binds PDS5 and WAPAL
type: GO_0003674
BFO_0000050: Cohesin Loading onto Chromatin
directly activates: Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2

Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2
type: GO_0003674
BFO_0000050: Cohesin Loading onto Chromatin
directly activates: Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2
directly activates: Catalysis850

Association of Cyclin A:Cdk2 with Cdh1
type: GO_0003674
BFO_0000050: Regulation of APC/C activators between G1/S and early anaphase
directly activates: Phosphorylation of Cdh1 by Cyclin A:Cdk2
directly activates: Catalysis904

Phosphorylation of Cdh1 by Cyclin A:Cdk2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004693
type: GO_0051436
BFO_0000050: Regulation of APC/C activators between G1/S and early anaphase
directly activates: Dissociation of phospho-Cdh1 from the APC/C complex
directly activates: Dephosphorylation of phospho-Cdh1
directly activates: Catalysis913

Dissociation of phospho-Cdh1 from the APC/C complex
type: GO_0051436
BFO_0000050: Regulation of APC/C activators between G1/S and early anaphase

Association of Emi1 with Cdh1
type: GO_0051436
BFO_0000050: Regulation of APC/C activators between G1/S and early anaphase
directly activates: Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2
directly activates: Phosphorylation of the Emi1 DSGxxS degron by Plk1
directly activates: Catalysis905
directly activates: Catalysis906
directly activates: Phosphorylation of Emi1

Association of Emi1 with Cdc20
type: GO_0051436
BFO_0000050: Regulation of APC/C activators between G1/S and early anaphase
directly activates: Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2
directly activates: Phosphorylation of the Emi1 DSGxxS degron by Plk1
directly activates: Catalysis905
directly activates: Catalysis906
directly activates: Phosphorylation of Emi1

Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004693
BFO_0000050: Phosphorylation of Emi1
directly activates: Phosphorylated Emi1 binds the beta-TrCP in the SCF complex

Phosphorylation of the Emi1 DSGxxS degron by Plk1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: GO_0004674
BFO_0000050: Phosphorylation of Emi1
directly activates: Phosphorylated Emi1 binds the beta-TrCP in the SCF complex

Phosphorylated Emi1 binds the beta-TrCP in the SCF complex
type: GO_0003674
BFO_0000050: SCF-beta-TrCP mediated degradation of Emi1
directly activates: Ubiquitination of Emi1 by SCF-beta-TrCP
directly activates: Catalysis907

Ubiquitination of Emi1 by SCF-beta-TrCP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004842
BFO_0000050: SCF-beta-TrCP mediated degradation of Emi1
directly activates: SCF-mediated degradation of Emi1
directly activates: Catalysis908

SCF-mediated degradation of Emi1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004175
BFO_0000050: SCF-beta-TrCP mediated degradation of Emi1
directly activates: Phosphorylation of Cdh1 by Cyclin B1:Cdc2
directly activates: Catalysis909

Phosphorylation of Cdh1 by Cyclin B1:Cdc2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004693
type: GO_0051436
BFO_0000050: Regulation of APC/C activators between G1/S and early anaphase
directly activates: Dephosphorylation of phospho-Cdh1
directly activates: Catalysis913

Free APC/C phosphorylated by Plk1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: GO_0004674
BFO_0000050: Phosphorylation of the APC/C

Free APC/C phosphorylated by Cyclin B:Cdc2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004693
BFO_0000050: Phosphorylation of the APC/C

Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1
type: GO_0051437
BFO_0000050: APC/C:Cdc20 mediated degradation of mitotic proteins
directly activates: Association of Securin with Cdc20:APC/C complex
directly activates: Association of Cyclin B:Cdc2 with Cdc20:APC/C complex

Association of Cyclin B:Cdc2 with Cdc20:APC/C complex
type: GO_0003674
BFO_0000050: APC/C:Cdc20 mediated degradation of Cyclin B
directly activates: Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex
directly activates: Catalysis912

Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004842
type: GO_0042787
BFO_0000050: APC/C:Cdc20 mediated degradation of Cyclin B
directly activates: Degradation of multiubiquitinated Cyclin B

Degradation of multiubiquitinated Cyclin B
type: GO_0003674
BFO_0000050: APC/C:Cdc20 mediated degradation of Cyclin B
directly activates: Dissociation of Cdc20 from APC/C complex

Dephosphorylation of phospho-Cdh1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004721
BFO_0000050: Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
directly activates: Association of Cdh1 with the APC/C

Dissociation of Cdc20 from APC/C complex
type: GO_0003674
BFO_0000050: Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
directly activates: Association of Cdh1 with the APC/C

Association of Cdh1 with the APC/C
type: GO_0003674
BFO_0000050: Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
directly activates: Association of cell cycle proteins with the APC/C:Cdh1 complex

Association of cell cycle proteins with the APC/C:Cdh1 complex
type: GO_0003674
BFO_0000050: APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
directly activates: Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex
directly activates: Catalysis914

Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004842
type: GO_0042787
BFO_0000050: APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
directly activates: Degradation of multiubiquitinated cell cycle proteins
directly activates: Multiubiquitination of APC/C-associated Cdh1
directly activates: Catalysis915
directly activates: Catalysis917

Degradation of multiubiquitinated cell cycle proteins
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004175
BFO_0000050: APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1

APC/C:Cdh1-mediated degradation of Skp2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004175
BFO_0000050: APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1

Multiubiquitination of APC/C-associated Cdh1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004842
type: GO_0042787
BFO_0000050: Autodegradation of Cdh1 by Cdh1:APC/C
directly activates: Degradation of multiubiquitinated Cdh1
directly activates: Catalysis918

Degradation of multiubiquitinated Cdh1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004175
BFO_0000050: Autodegradation of Cdh1 by Cdh1:APC/C

DNA polymerase alpha:primase binds at the origin
type: GO_0003674
BFO_0000050: Activation of the pre-replicative complex
directly activates: The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin
directly activates: Catalysis5

DNA polymerase epsilon binds at the origin
type: GO_0003674
BFO_0000050: Activation of the pre-replicative complex

The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003899
BFO_0000050: DNA replication initiation
directly activates: The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin
directly activates: Catalysis6

The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003887
BFO_0000050: DNA replication initiation
directly activates: Detection of damage during initiation of DNA synthesis in S-phase
directly activates: RFC binding displaces Pol Alpha

Orc1 is phosphorylated by cyclin A/CDK2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Orc1 removal from chromatin
directly activates: Phosphorylated Orc1 is ubiquitinated while still associated with chromatin

Phosphorylated Orc1 is ubiquitinated while still associated with chromatin
type: GO_0003674
BFO_0000050: Orc1 removal from chromatin
directly activates: Ubiquitinated Orc1 enters the cytosol

Ubiquitinated Orc1 enters the cytosol
type: GO_0003674
BFO_0000050: Orc1 removal from chromatin
directly activates: Ubiquitinated Orc1 is degraded by the proteasome
directly activates: Catalysis8

Ubiquitinated Orc1 is degraded by the proteasome
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004175
BFO_0000050: Orc1 removal from chromatin

Cdc6 protein is phosphorylated by CDK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: CDK-mediated phosphorylation and removal of Cdc6
directly activates: Phosphorylated Cdc6 is exported from the nucleus

Phosphorylated Cdc6 is exported from the nucleus
type: GO_0003674
BFO_0000050: CDK-mediated phosphorylation and removal of Cdc6
directly activates: Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex
directly activates: Catalysis10

Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004175
BFO_0000050: CDK-mediated phosphorylation and removal of Cdc6
directly activates: Ubiquitinated Cdc6 is degraded by the proteasome
directly activates: Catalysis11

Ubiquitinated Cdc6 is degraded by the proteasome
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004175
BFO_0000050: CDK-mediated phosphorylation and removal of Cdc6

Mcm4,6,7 trimer forms and associates with the replication fork
type: GO_0003674
BFO_0000050: Switching of origins to a post-replicative state
BFO_0000050: Removal of licensing factors from origins
label: Rearrangement and mobilization of Mcm2-7

MCM2-7 mediated fork unwinding
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004386
BFO_0000050: Unwinding of DNA

MCM8 mediated fork unwinding
type: Restriction
  on property: enabled by
  some values from: C20orf154
type: Restriction
  on property: enabled by
  some values from: C20orf154
type: Restriction
  on property: enabled by
  some values from: C20orf154
type: Restriction
  on property: enabled by
  some values from: C20orf154
type: Restriction
  on property: enabled by
  some values from: C20orf154
type: Restriction
  on property: enabled by
  some values from: C20orf154
type: Restriction
  on property: enabled by
  some values from: C20orf154
type: Restriction
  on property: enabled by
  some values from: C20orf154
type: Restriction
  on property: enabled by
  some values from: C20orf154
type: Restriction
  on property: enabled by
  some values from: C20orf154
type: Restriction
  on property: enabled by
  some values from: C20orf154
type: Restriction
  on property: enabled by
  some values from: C20orf154
type: Restriction
  on property: enabled by
  some values from: C20orf154
type: Restriction
  on property: enabled by
  some values from: C20orf154
type: Restriction
  on property: enabled by
  some values from: C20orf154
type: Restriction
  on property: enabled by
  some values from: C20orf154
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004386
BFO_0000050: Unwinding of DNA

Formation of GINS complex
type: GO_0003674
BFO_0000050: Unwinding of DNA
directly activates: MCM8 mediated fork unwinding
directly activates: Catalysis13

Multiple proteins are localized at replication fork
type: GO_0003674
BFO_0000050: Unwinding of DNA

RFC binding displaces Pol Alpha
type: GO_0003674
BFO_0000050: Polymerase switching
directly activates: Loading of PCNA - Sliding Clamp Formation

Loading of PCNA - Sliding Clamp Formation
type: GO_0003674
BFO_0000050: Polymerase switching
directly activates: RFC dissociates after sliding clamp formation

Orc3 associates with Orc2 constitutively bound at origins of replication
type: GO_0003674
BFO_0000050: Assembly of the ORC complex at the origin of replication
directly activates: Orc5 associates with Orc3:Orc2:origin complexes

RFC dissociates after sliding clamp formation
type: GO_0003674
BFO_0000050: Polymerase switching
directly activates: Formation of Processive Complex

Formation of Processive Complex
type: GO_0003674
BFO_0000050: Polymerase switching

Processive synthesis on the leading strand
type: GO_0003674
BFO_0000050: Leading Strand Synthesis

Formation of Okazaki fragments
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003887
BFO_0000050: Processive synthesis on the lagging strand
directly activates: Formation of the Flap Intermediate

Formation of the Flap Intermediate
type: GO_0003674
BFO_0000050: Processive synthesis on the lagging strand
directly activates: RPA binds to the Flap
directly activates: Removal of the Flap Intermediate

RPA binds to the Flap
type: GO_0003674
BFO_0000050: Removal of the Flap Intermediate
directly activates: Recruitment of Dna2 endonuclease

Recruitment of Dna2 endonuclease
type: GO_0003674
BFO_0000050: Removal of the Flap Intermediate
directly activates: Removal of RNA primer and dissociation of RPA and Dna2

Removal of RNA primer and dissociation of RPA and Dna2
type: GO_0003674
BFO_0000050: Removal of the Flap Intermediate
directly activates: Removal of remaining Flap
directly activates: Catalysis15

Removal of remaining Flap
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0017108
BFO_0000050: Removal of the Flap Intermediate

Joining of adjacent Okazaki fragments
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003909
BFO_0000050: Processive synthesis on the lagging strand

Orc5 associates with Orc3:Orc2:origin complexes
type: GO_0003674
BFO_0000050: Assembly of the ORC complex at the origin of replication
directly activates: Orc4 associates with Orc5:Orc3:Orc2:origin complexes

Cdt1 associates with geminin
type: GO_0003674
BFO_0000050: Removal of licensing factors from origins

Orc4 associates with Orc5:Orc3:Orc2:origin complexes
type: GO_0003674
BFO_0000050: Assembly of the ORC complex at the origin of replication
directly activates: Orc1 associates with Orc4:Orc5:Orc3:Orc2:origin complexes

Orc1 associates with Orc4:Orc5:Orc3:Orc2:origin complexes
type: GO_0003674
BFO_0000050: Association of licensing factors with the pre-replicative complex
BFO_0000050: Assembly of the ORC complex at the origin of replication
directly activates: Orc6 associates with Orc1:Orc4:Orc5:Orc3:Orc2:origin complexes, forming ORC:origin complexes

Orc6 associates with Orc1:Orc4:Orc5:Orc3:Orc2:origin complexes, forming ORC:origin complexes
type: GO_0003674
BFO_0000050: Assembly of the ORC complex at the origin of replication
directly activates: Association of Cyclin B/Cdk1 with replicative origin inhibits pre-RC formation

Association of MCM8 with ORC:origin complex
type: GO_0003674
BFO_0000050: Assembly of the pre-replicative complex
directly activates: CDC6 association with ORC:origin complexes mediated by MCM8
directly activates: CDC6 association with the ORC:origin complex

DNA replication initiation
type: GO_0008150
BFO_0000050: Synthesis of DNA

Switching of origins to a post-replicative state
type: GO_0008150
BFO_0000050: Synthesis of DNA

Orc1 removal from chromatin
type: GO_0008150
BFO_0000050: Switching of origins to a post-replicative state
BFO_0000050: Removal of licensing factors from origins

CDK-mediated phosphorylation and removal of Cdc6
type: GO_0008150
BFO_0000050: Switching of origins to a post-replicative state
BFO_0000050: Removal of licensing factors from origins

DNA strand elongation
type: GO_0008150
BFO_0000050: Synthesis of DNA

Unwinding of DNA
type: GO_0008150
BFO_0000050: DNA strand elongation

Leading Strand Synthesis
type: GO_0008150
BFO_0000050: DNA strand elongation

Polymerase switching
type: GO_0008150
BFO_0000050: Leading Strand Synthesis
BFO_0000050: Lagging Strand Synthesis

Lagging Strand Synthesis
type: GO_0008150
BFO_0000050: DNA strand elongation

Processive synthesis on the lagging strand
type: GO_0008150
BFO_0000050: Lagging Strand Synthesis

M/G1 Transition
type: GO_0008150
BFO_0000050: Cell Cycle, Mitotic

Removal of the Flap Intermediate
type: GO_0008150
BFO_0000050: Processive synthesis on the lagging strand

Regulation of DNA replication
type: GO_0008150
BFO_0000050: Cell Cycle, Mitotic

Association of licensing factors with the pre-replicative complex
type: GO_0008150
BFO_0000050: Regulation of DNA replication

Removal of licensing factors from origins
type: GO_0008150
BFO_0000050: Regulation of DNA replication

DNA Replication Pre-Initiation
type: GO_0008150
BFO_0000050: M/G1 Transition

Assembly of the pre-replicative complex
type: GO_0008150
BFO_0000050: DNA Replication Pre-Initiation

Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
type: GO_0008150
BFO_0000050: Regulation of APC/C activators between G1/S and early anaphase

Inactivation of APC/C via direct inhibition of the APC/C complex
type: GO_0008150
BFO_0000050: Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components

Cell Cycle, Mitotic
type: GO_0008150

Mitotic G1-G1/S phases
type: GO_0008150
BFO_0000050: Cell Cycle, Mitotic

G0 and Early G1
type: GO_0008150
BFO_0000050: Mitotic G1-G1/S phases

G1 Phase
type: GO_0008150
BFO_0000050: Mitotic G1-G1/S phases

Cyclin D associated events in G1
type: GO_0008150
BFO_0000050: G1 Phase

G1/S Transition
type: GO_0008150
BFO_0000050: Mitotic G1-G1/S phases

Cyclin E associated events during G1/S transition
type: GO_0008150
BFO_0000050: G1/S Transition

SCF(Skp2)-mediated degradation of p27/p21
type: GO_0008150
BFO_0000050: Cyclin E associated events during G1/S transition
BFO_0000050: Cyclin A:Cdk2-associated events at S phase entry

Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
type: GO_0008150
BFO_0000050: Cyclin E associated events during G1/S transition

Ubiquitin-Dependent Degradation of Cyclin E
type: GO_0003674
BFO_0000050: Cyclin E associated events during G1/S transition

G1/S-Specific Transcription
type: GO_0008150
BFO_0000050: G1/S Transition

E2F mediated regulation of DNA replication
type: GO_0008150
BFO_0000050: G1/S Transition

Inhibition of replication initiation of damaged DNA by RB1/E2F1
type: GO_0008150
BFO_0000050: E2F mediated regulation of DNA replication

E2F-enabled inhibition of pre-replication complex formation
type: GO_0008150
BFO_0000050: E2F mediated regulation of DNA replication

S Phase
type: GO_0008150
BFO_0000050: Cell Cycle, Mitotic

Cyclin A:Cdk2-associated events at S phase entry
type: GO_0008150
BFO_0000050: S Phase

Ubiquitin-dependent degradation of Cyclin D
type: GO_0008150
BFO_0000050: S Phase

Ubiquitin-dependent degradation of Cyclin D1
type: GO_0008150
BFO_0000050: Ubiquitin-dependent degradation of Cyclin D

Establishment of Sister Chromatid Cohesion
type: GO_0008150
BFO_0000050: S Phase

Mitotic G2-G2/M phases
type: GO_0008150
BFO_0000050: Cell Cycle, Mitotic

G2 Phase
type: GO_0008150
BFO_0000050: Mitotic G2-G2/M phases

G2/M Transition
type: GO_0008150
BFO_0000050: Mitotic G2-G2/M phases

Cyclin A/B1 associated events during G2/M transition
type: GO_0008150
BFO_0000050: G2/M Transition

Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes
type: GO_0008150
BFO_0000050: Cyclin A/B1 associated events during G2/M transition

Cyclin B2 mediated events
type: GO_0008150
BFO_0000050: G2/M Transition

Regulation of PLK1 Activity at G2/M Transition
type: GO_0008150
BFO_0000050: G2/M Transition

Polo-like kinase mediated events
type: GO_0008150
BFO_0000050: G2/M Transition

Centrosome maturation
type: GO_0008150
BFO_0000050: G2/M Transition

Recruitment of mitotic centrosome proteins and complexes
type: GO_0008150
BFO_0000050: Centrosome maturation

Recruitment of NuMA to mitotic centrosomes
type: GO_0008150
BFO_0000050: Recruitment of mitotic centrosome proteins and complexes

Loss of proteins required for interphase microtubule organizationÂ from the centrosome
type: GO_0008150
BFO_0000050: Centrosome maturation

Loss of Nlp from mitotic centrosomes
type: GO_0008150
BFO_0000050: Loss of proteins required for interphase microtubule organizationÂ from the centrosome

M Phase
type: GO_0008150
BFO_0000050: Cell Cycle, Mitotic

Mitotic Prophase
type: GO_0008150
BFO_0000050: M Phase

Golgi Cisternae Pericentriolar Stack Reorganization
type: GO_0008150
BFO_0000050: Mitotic Prophase

MASTL Facilitates Mitotic Progression
type: GO_0008150
BFO_0000050: Mitotic Prophase

Nuclear Envelope Breakdown
type: GO_0008150
BFO_0000050: Mitotic Prophase

Activation of NIMA Kinases NEK9, NEK6, NEK7
type: GO_0008150
BFO_0000050: Nuclear Envelope Breakdown

Nuclear Pore Complex (NPC) Disassembly
type: GO_0008150
BFO_0000050: Nuclear Envelope Breakdown

Clearance of Nuclear Envelope Membranes from Chromatin
type: GO_0008150
BFO_0000050: Nuclear Envelope Breakdown

Mitotic Prometaphase
type: GO_0008150
BFO_0000050: M Phase

Resolution of Sister Chromatid Cohesion
type: GO_0008150
BFO_0000050: Mitotic Prometaphase

Condensation of Prometaphase Chromosomes
type: GO_0008150
BFO_0000050: Mitotic Prometaphase

Mitotic Metaphase and Anaphase
type: GO_0008150
BFO_0000050: M Phase

Mitotic Metaphase
type: GO_0000089
BFO_0000050: Mitotic Metaphase and Anaphase
directly activates: Pathway434

Mitotic Metaphase/Anaphase Transition
type: GO_0008150
BFO_0000050: Mitotic Metaphase and Anaphase

Mitotic Anaphase
type: GO_0008150
BFO_0000050: Mitotic Metaphase and Anaphase

Separation of Sister Chromatids
type: GO_0008150
BFO_0000050: Mitotic Anaphase

Nuclear Envelope Reassembly
type: GO_0008150
BFO_0000050: Mitotic Anaphase

Initiation of Nuclear Envelope Reformation
type: GO_0008150
BFO_0000050: Nuclear Envelope Reassembly

Mitotic Telophase/Cytokinesis
type: GO_0008150
BFO_0000050: M Phase
label: cell division

Cohesin Loading onto Chromatin
type: GO_0008150
BFO_0000050: Mitotic Telophase/Cytokinesis

Regulation of mitotic cell cycle
type: GO_0008150
BFO_0000050: Cell Cycle, Mitotic

APC/C-mediated degradation of cell cycle proteins
type: GO_0008150
BFO_0000050: Regulation of mitotic cell cycle

Regulation of APC/C activators between G1/S and early anaphase
type: GO_0008150
BFO_0000050: APC/C-mediated degradation of cell cycle proteins

Phosphorylation of Emi1
type: GO_0008150
BFO_0000050: Regulation of APC/C activators between G1/S and early anaphase

SCF-beta-TrCP mediated degradation of Emi1
type: GO_0008150
BFO_0000050: Regulation of APC/C activators between G1/S and early anaphase

Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
type: GO_0008150
BFO_0000050: APC/C-mediated degradation of cell cycle proteins

Phosphorylation of the APC/C
type: GO_0008150
BFO_0000050: Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins

APC/C:Cdc20 mediated degradation of mitotic proteins
type: GO_0008150
BFO_0000050: Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins

APC/C:Cdc20 mediated degradation of Cyclin B
type: GO_0008150
BFO_0000050: APC/C:Cdc20 mediated degradation of mitotic proteins

Assembly of the ORC complex at the origin of replication
type: GO_0008150
BFO_0000050: Assembly of the pre-replicative complex

APC/C:Cdc20 mediated degradation of Securin
type: GO_0008150
BFO_0000050: APC/C:Cdc20 mediated degradation of mitotic proteins

Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
type: GO_0008150
BFO_0000050: APC/C-mediated degradation of cell cycle proteins

APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
type: GO_0008150
BFO_0000050: APC/C-mediated degradation of cell cycle proteins

Autodegradation of Cdh1 by Cdh1:APC/C
type: GO_0008150
BFO_0000050: APC/C-mediated degradation of cell cycle proteins

CDC6 association with the ORC:origin complex
type: GO_0008150
BFO_0000050: Assembly of the pre-replicative complex

CDT1 association with the CDC6:ORC:origin complex
type: GO_0008150
BFO_0000050: Assembly of the pre-replicative complex

Activation of the pre-replicative complex
type: GO_0008150
BFO_0000050: DNA Replication Pre-Initiation
BFO_0000050: G1/S Transition

Synthesis of DNA
type: GO_0008150
BFO_0000050: S Phase

CDC6 protein is synthesized under the control of E2F transcription factors
type: GO_0003674
BFO_0000050: Association of licensing factors with the pre-replicative complex
BFO_0000050: CDC6 association with the ORC:origin complex
directly activates: CDC6 association with ORC:origin complexes mediated by MCM8

Activation of Cdc25A by c-myc
type: GO_0003674
BFO_0000050: Cyclin E associated events during G1/S transition
BFO_0000050: Cyclin A:Cdk2-associated events at S phase entry
directly activates: Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A
directly activates: Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2
directly activates: Catalysis837
directly activates: Catalysis842

Activation of E2F target genes at G1/S
type: GO_0003674
BFO_0000050: G1/S-Specific Transcription
BFO_0000050: E2F mediated regulation of DNA replication
directly activates: Formation of Cyclin E:Cdk2 complexes
directly activates: Cdc45 associates with the pre-replicative complex at the origin
directly activates: Activation of Cyclin B/Cdk1 by Cdc25a (string) protein
directly activates: Association of Emi1 with Cdh1
directly activates: DNA polymerase alpha:primase binds at the origin
directly activates: Orc1 associates with Orc4:Orc5:Orc3:Orc2:origin complexes
directly activates: Control1