EIF4B
label: UniProt:P23588 EIF4B

EIF4H
label: KIAA0038
label: UniProt:Q15056 EIF4H
label: WBSCR1
label: WSCR1

Release of 40S and 60S subunits from the 80S ribosome
type: GO_0003674
BFO_0000050: Formation of a pool of free 40S subunits
directly activates: eIF3 and eIF1A bind to the 40S subunit
directly activates: The 60S subunit joins the translation initiation complex

eIF3 and eIF1A bind to the 40S subunit
type: GO_0003674
BFO_0000050: Formation of a pool of free 40S subunits
directly activates: Formation of the ternary complex, and subsequently, the 43S complex

De novo formation of eIF2:GTP
type: GO_0003674
BFO_0000050: Formation of the ternary complex, and subsequently, the 43S complex
directly activates: Met-tRNAi binds to eIF2:GTP to form the ternary complex
directly activates: Control44

Met-tRNAi binds to eIF2:GTP to form the ternary complex
type: GO_0003674
BFO_0000050: Formation of the ternary complex, and subsequently, the 43S complex
directly activates: Formation of the 43S pre-initiation complex

Formation of the 43S pre-initiation complex
type: GO_0003674
BFO_0000050: Formation of the ternary complex, and subsequently, the 43S complex

Release of eIF4E from the inactive eIF4E:4E-BP complex
type: GO_0003674
BFO_0000050: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
directly activates: Formation of the cap-binding eIF4F complex

Formation of the cap-binding eIF4F complex
type: GO_0003674
BFO_0000050: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
directly activates: eIF4F binds to mRNP

eIF4F binds to mRNP
type: GO_0003674
BFO_0000050: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
directly activates: Cap-bound mRNA is activated by helicases
directly activates: Catalysis212
directly activates: Catalysis213
directly activates: Catalysis214

Cap-bound mRNA is activated by helicases
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003724
type: GO_0004386
BFO_0000050: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
directly activates: Formation of translation initiation complexes containing mRNA that does not circularize
directly activates: Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation
directly activates: Translation initiation complex formation

Formation of translation initiation complexes containing mRNA that does not circularize
type: GO_0003674
BFO_0000050: Translation initiation complex formation

Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation
type: GO_0003674
BFO_0000050: Translation initiation complex formation
directly activates: Pathway88

Ribosomal scanning
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003743
BFO_0000050: Ribosomal scanning and start codon recognition
directly activates: Start codon recognition
directly activates: Catalysis216

Start codon recognition
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003743
BFO_0000050: Ribosomal scanning and start codon recognition
directly activates: eIF2:GTP is hydrolyzed, eIFs are released
directly activates: Control46

eIF2:GTP is hydrolyzed, eIFs are released
type: GO_0003674
BFO_0000050: GTP hydrolysis and joining of the 60S ribosomal subunit
directly activates: The 60S subunit joins the translation initiation complex
directly activates: Formation of eIF2:GDP:eIF2B intermediate

eIF5B:GTP is hydrolyzed and released
type: GO_0003674
BFO_0000050: GTP hydrolysis and joining of the 60S ribosomal subunit
directly activates: BiochemicalReaction607

The 60S subunit joins the translation initiation complex
type: GO_0003674
BFO_0000050: GTP hydrolysis and joining of the 60S ribosomal subunit
directly activates: eIF5B:GTP is hydrolyzed and released

Formation of eIF2:GDP:eIF2B intermediate
type: GO_0003674
BFO_0000050: Recycling of eIF2:GDP
directly activates: eIF2 activation
directly activates: Catalysis217

eIF2 activation
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003743
BFO_0000050: Recycling of eIF2:GDP
directly activates: Met-tRNAi binds to eIF2:GTP to form the ternary complex
directly activates: Control44

Cap-dependent Translation Initiation
type: GO_0008150

Formation of a pool of free 40S subunits
type: GO_0008150
BFO_0000050: Cap-dependent Translation Initiation

Formation of the ternary complex, and subsequently, the 43S complex
type: GO_0008150
BFO_0000050: Cap-dependent Translation Initiation

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
type: GO_0008150
BFO_0000050: Cap-dependent Translation Initiation

Translation initiation complex formation
type: GO_0008150
BFO_0000050: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

Ribosomal scanning and start codon recognition
type: GO_0008150
BFO_0000050: Cap-dependent Translation Initiation

GTP hydrolysis and joining of the 60S ribosomal subunit
type: GO_0008150
BFO_0000050: Cap-dependent Translation Initiation

Recycling of eIF2:GDP
type: GO_0008150
BFO_0000050: Cap-dependent Translation Initiation