EIF4B
UniProt:P23588 EIF4B
EIF4H
KIAA0038
UniProt:Q15056 EIF4H
WBSCR1
WSCR1
Release of 40S and 60S subunits from the 80S ribosome
eIF3 and eIF1A bind to the 40S subunit
De novo formation of eIF2:GTP
Met-tRNAi binds to eIF2:GTP to form the ternary complex
Formation of the 43S pre-initiation complex
Release of eIF4E from the inactive eIF4E:4E-BP complex
Formation of the cap-binding eIF4F complex
eIF4F binds to mRNP
Cap-bound mRNA is activated by helicases
Formation of translation initiation complexes containing mRNA that does not circularize
Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation
Ribosomal scanning
Start codon recognition
eIF2:GTP is hydrolyzed, eIFs are released
eIF5B:GTP is hydrolyzed and released
The 60S subunit joins the translation initiation complex
Formation of eIF2:GDP:eIF2B intermediate
eIF2 activation
Cap-dependent Translation Initiation
Formation of a pool of free 40S subunits
Formation of the ternary complex, and subsequently, the 43S complex
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Translation initiation complex formation
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit
Recycling of eIF2:GDP