Cytochrome C Binds to Apaf-1
Cytochrome C:Apaf-1 binds Procaspase-9
Cleavage of Procaspase-9 to Caspase-9
Cleavage of Procaspase-3 by the apoptosome
Cleavage of Procaspase-7 by the apoptosome
SMAC binds XIAP:Caspase-3
SMAC binds XIAP:Caspase-7
SMAC binds XIAP:Caspase-9
Dissociation of Caspase-3 from SMAC:XIAP:Caspase-3
Dissociation of Caspase-7 from SMAC:XIAP:Caspase-7
Dissociation of Caspase-9 from SMAC:XIAP:Caspase-9
Apoptotic factor-mediated response
Cytochrome c-mediated apoptotic response
Formation of apoptosome
Activation of caspases through apoptosome-mediated cleavage
SMAC-mediated apoptotic response
SMAC binds to IAPs
SMAC-mediated dissociation of IAP:caspase complexes