KMO
label: UniProt:O15229 KMO

PIG6
label: POX2
label: PRODH
label: UniProt:O43272 PRODH

TPO
label: UniProt:P07202 TPO

PENT
label: PNMT
label: UniProt:P11086 PNMT

ODC1
label: UniProt:P11926 ODC1

AMD
label: AMD1
label: UniProt:P17707 AMD1

SPS1
label: SRM
label: SRML1
label: UniProt:P19623 SRM

SAT
label: SAT1
label: UniProt:P21673 SAT1

CPS1
label: UniProt:P31327 CPS1

HAL
label: HIS
label: UniProt:P42357 HAL

ASMT
label: UniProt:P46597 ASMT

SLC6A8
label: UniProt:P48029 SLC6A8

SMS
label: UniProt:P52788 SMS

DIO3
label: ITDI3
label: TXDI3
label: UniProt:P55073 DIO3

ALDH6A1
label: MMSDH
label: UniProt:Q02252 ALDH6A1

GAMT
label: UniProt:Q14353 GAMT

AANAT
label: SNAT
label: UniProt:Q16613 AANAT

TST
label: UniProt:Q16762 TST

AFMID
label: UniProt:Q63HM1 AFMID

HIBCH
label: UniProt:Q6NVY1 HIBCH

NAGS
label: UniProt:Q8N159 NAGS

NIS
label: SLC5A5
label: UniProt:Q92911 SLC5A5

ADC
label: KIAA1945
label: ODCP
label: UniProt:Q96A70 ADC

AMDHD1
label: HMFT1272
label: UniProt:Q96NU7 AMDHD1

ODC
label: SLC25A21
label: UniProt:Q9BQT8 SLC25A21

AGMAT
label: UniProt:Q9BSE5 AGMAT

MRDI
label: MRI1
label: UNQ6390/PRO21135
label: UniProt:Q9BV20 MRI1

C20orf16
label: SMO
label: SMOX
label: UNQ3039/PRO9854
label: UniProt:Q9NWM0 SMOX

GLXR
label: GRHPR
label: MSTP035
label: UniProt:Q9UBQ7 GRHPR

DIC
label: SLC25A10
label: UniProt:Q9UBX3 SLC25A10

Sulfate is exported to the cytosol in exchange for dicarboxylate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: enabled by
  some values from: DIC
type: Restriction
  on property: enabled by
  some values from: DIC
type: Restriction
  on property: enabled by
  some values from: DIC
type: Restriction
  on property: enabled by
  some values from: DIC
type: Restriction
  on property: enabled by
  some values from: DIC
type: Restriction
  on property: enabled by
  some values from: DIC
type: Restriction
  on property: enabled by
  some values from: DIC
type: Restriction
  on property: enabled by
  some values from: DIC
type: GO_0005310
BFO_0000050: Sulfide oxidation to sulfate

phenylalanine + tetrahydrobiopterin + O2 => tyrosine + 4a-hydroxytetrahydrobiopterin + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004505
BFO_0000050: Phenylalanine and tyrosine catabolism
directly activates: 4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O
directly activates: tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate
directly activates: Catalysis2870
directly activates: Catalysis2872

kynurenine + pyruvate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + alanine [CCBL1]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016212
BFO_0000050: Tryptophan catabolism
directly activates: 4-(2-aminophenyl)-2,4-dioxobutanoate => kynurenate + H2O [cytosolic]

glutamine + H2O => glutamate + NH4+ [GLS]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004359
BFO_0000050: Amino acid synthesis and interconversion (transamination)
directly activates: BiochemicalReaction3688
directly activates: BiochemicalReaction3689
directly activates: Catalysis1645

glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004356
BFO_0000050: Amino acid synthesis and interconversion (transamination)
directly activates: BiochemicalReaction3718
directly activates: Catalysis1673

oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004069
BFO_0000050: Amino acid synthesis and interconversion (transamination)
directly activates: BiochemicalReaction4553
directly activates: 2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix]
directly activates: Catalysis1970
directly activates: Catalysis2866

aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004069
BFO_0000050: Amino acid synthesis and interconversion (transamination)
directly activates: BiochemicalReaction4555
directly activates: Catalysis1972

MTR transfers CH3 group from MeCbl to HCYS
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008705
BFO_0000050: Sulfur amino acid metabolism
directly activates: BiochemicalReaction5600
directly activates: Catalysis2771
label: Methionine is reformed

alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004021
BFO_0000050: Amino acid synthesis and interconversion (transamination)
directly activates: BiochemicalReaction5403
directly activates: Catalysis2599

pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004021
BFO_0000050: Amino acid synthesis and interconversion (transamination)

alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT2]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004021
BFO_0000050: Amino acid synthesis and interconversion (transamination)

pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT2]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004021
BFO_0000050: Amino acid synthesis and interconversion (transamination)

oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004069
BFO_0000050: Amino acid synthesis and interconversion (transamination)
directly activates: ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate
directly activates: Catalysis2894

aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT2]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004069
BFO_0000050: Amino acid synthesis and interconversion (transamination)

ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004587
BFO_0000050: Amino acid synthesis and interconversion (transamination)
directly activates: L-glutamate gamma-semialdehyde <=> L-1-pyrroline-5-carboxylate

glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004587
BFO_0000050: Amino acid synthesis and interconversion (transamination)
directly activates: carbamoyl phosphate + ornithine => citrulline + orthophosphate
directly activates: Catalysis2893

glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: GO_0017084
BFO_0000050: Amino acid synthesis and interconversion (transamination)
directly activates: L-glutamate gamma-semialdehyde <=> L-1-pyrroline-5-carboxylate

L-glutamate gamma-semialdehyde <=> L-1-pyrroline-5-carboxylate
type: GO_0003674
BFO_0000050: Amino acid synthesis and interconversion (transamination)
directly activates: L-1-pyrroline-5-carboxylate + NADPH + H+ => proline + NADP+
directly activates: Catalysis2828

L-1-pyrroline-5-carboxylate + NADPH + H+ => proline + NADP+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004735
BFO_0000050: Amino acid synthesis and interconversion (transamination)

aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004066
BFO_0000050: Amino acid synthesis and interconversion (transamination)
directly activates: BiochemicalReaction296
directly activates: Catalysis111
directly activates: Control14

alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004353
BFO_0000050: Amino acid synthesis and interconversion (transamination)

glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004353
BFO_0000050: Amino acid synthesis and interconversion (transamination)

glutamine + pyruvate => 2-oxoglutaramate + alanine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0047945
BFO_0000050: Amino acid synthesis and interconversion (transamination)

3-phosphoglycerate is dehydrogenated
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004617
BFO_0000050: Serine biosynthesis
directly activates: 3-phosphonooxypyruvic acid + L-glutamate = O-phospho-L-serine + 2-oxoglutarate
directly activates: Catalysis2834

3-phosphonooxypyruvic acid + L-glutamate = O-phospho-L-serine + 2-oxoglutarate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004648
BFO_0000050: Serine biosynthesis
directly activates: phosphoserine is dephosphorylated
directly activates: Catalysis2835

phosphoserine is dephosphorylated
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004647
BFO_0000050: Serine biosynthesis

leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004084
BFO_0000050: Branched-chain amino acid catabolism
directly activates: BiochemicalReaction3689
directly activates: Catalysis1645

a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004084
BFO_0000050: Branched-chain amino acid catabolism

leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004084
BFO_0000050: Branched-chain amino acid catabolism
directly activates: Oxidative decarboxylation of branched-chain alpha-keto acids
directly activates: Catalysis2840

a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004084
BFO_0000050: Branched-chain amino acid catabolism

Oxidative decarboxylation of branched-chain alpha-keto acids
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0003826
BFO_0000050: Branched-chain amino acid catabolism
directly activates: isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2
directly activates: alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2
directly activates: isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2
directly activates: Catalysis2841
directly activates: Catalysis2845
directly activates: Catalysis2850
label: a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+

isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0008470
BFO_0000050: Branched-chain amino acid catabolism
directly activates: beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA]
directly activates: Catalysis2842

beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004485
BFO_0000050: Branched-chain amino acid catabolism
directly activates: beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA
directly activates: Catalysis2844

beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004485
BFO_0000050: Branched-chain amino acid catabolism

beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004490
BFO_0000050: Branched-chain amino acid catabolism

alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0003995
BFO_0000050: Branched-chain amino acid catabolism
directly activates: tiglyl-CoA + H2O <=> alpha-methyl-beta-hydroxybutyryl-CoA
directly activates: Catalysis2846

tiglyl-CoA + H2O <=> alpha-methyl-beta-hydroxybutyryl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004300
BFO_0000050: Branched-chain amino acid catabolism
directly activates: alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+
directly activates: Catalysis2847

alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0003857
BFO_0000050: Branched-chain amino acid catabolism
directly activates: alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA
directly activates: Catalysis2849

alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0003857
BFO_0000050: Branched-chain amino acid catabolism

alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0003985
BFO_0000050: Branched-chain amino acid catabolism
directly activates: BiochemicalReaction4802
directly activates: BiochemicalReaction5407
directly activates: Catalysis2164
directly activates: Catalysis2603

isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0003995
BFO_0000050: Branched-chain amino acid catabolism
directly activates: methacrylyl-CoA + H2O <=> beta-hydroxyisobutyryl-CoA
directly activates: Catalysis2851

methacrylyl-CoA + H2O <=> beta-hydroxyisobutyryl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004300
BFO_0000050: Branched-chain amino acid catabolism
directly activates: beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA
directly activates: Catalysis2852

beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA
type: Restriction
  on property: enabled by
  some values from: HIBCH
type: Restriction
  on property: enabled by
  some values from: HIBCH
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0003860
BFO_0000050: Branched-chain amino acid catabolism
directly activates: beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+
directly activates: Catalysis2853

beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0008442
BFO_0000050: Branched-chain amino acid catabolism
directly activates: methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+
directly activates: Catalysis2855

methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0008442
BFO_0000050: Branched-chain amino acid catabolism

methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+
type: Restriction
  on property: enabled by
  some values from: ALDH6A1
type: Restriction
  on property: enabled by
  some values from: ALDH6A1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004491
BFO_0000050: Branched-chain amino acid catabolism
directly activates: BiochemicalReaction4802
directly activates: Catalysis2164

histidine => urocanate + NH4+
type: Restriction
  on property: enabled by
  some values from: HAL
type: Restriction
  on property: enabled by
  some values from: HAL
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004397
BFO_0000050: Histidine catabolism
directly activates: urocanate + H2O => 4-imidazolone-5-propionate
directly activates: Catalysis2857

urocanate + H2O => 4-imidazolone-5-propionate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016153
BFO_0000050: Histidine catabolism
directly activates: 4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+
directly activates: Catalysis2858

4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+
type: Restriction
  on property: enabled by
  some values from: AMDHD1
type: Restriction
  on property: enabled by
  some values from: AMDHD1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016812
BFO_0000050: Histidine catabolism
directly activates: N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate
directly activates: Catalysis2859

N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0030412
BFO_0000050: Histidine catabolism

Histidine is decarboxylated to histamine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0001694
type: GO_0004398
BFO_0000050: Histidine catabolism

lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0047130
BFO_0000050: Lysine catabolism
directly activates: saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+
directly activates: Catalysis2862

saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0047131
BFO_0000050: Lysine catabolism
directly activates: alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+
directly activates: Catalysis2863

alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004043
BFO_0000050: Lysine catabolism
directly activates: alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate
directly activates: Catalysis2864

alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0047536
BFO_0000050: Lysine catabolism

alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0047536
BFO_0000050: Lysine catabolism

2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: enabled by
  some values from: ODC
type: Restriction
  on property: enabled by
  some values from: ODC
type: GO_0015139
BFO_0000050: Lysine catabolism
directly activates: aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1]
directly activates: alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate
directly activates: Oxidative decarboxylation of alpha-ketoadipate to glutaryl CoA by alpha-ketoglutarate dehydrogenase
directly activates: Catalysis1971
directly activates: Catalysis2865
directly activates: Catalysis2867
label: Exchange of cytosolic 2-oxoadipate for mitochondrial 2-oxoglutarate

Oxidative decarboxylation of alpha-ketoadipate to glutaryl CoA by alpha-ketoglutarate dehydrogenase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0034602
BFO_0000050: Lysine catabolism
directly activates: glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2
directly activates: Catalysis2868
label: alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+

glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004361
BFO_0000050: Lysine catabolism
directly activates: BiochemicalReaction4794
directly activates: Catalysis2150

phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0047312
BFO_0000050: Phenylalanine and tyrosine catabolism

4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008124
BFO_0000050: Phenylalanine and tyrosine catabolism
directly activates: q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+
directly activates: Catalysis2871

q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004155
BFO_0000050: Phenylalanine and tyrosine catabolism
directly activates: phenylalanine + tetrahydrobiopterin + O2 => tyrosine + 4a-hydroxytetrahydrobiopterin + H2O
directly activates: Catalysis1288
directly activates: Control221

tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004838
BFO_0000050: Phenylalanine and tyrosine catabolism
directly activates: p-hydroxyphenylpyruvate + O2 => homogentisate + CO2
directly activates: Catalysis2874

p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004838
BFO_0000050: Phenylalanine and tyrosine catabolism

p-hydroxyphenylpyruvate + O2 => homogentisate + CO2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003868
BFO_0000050: Phenylalanine and tyrosine catabolism
directly activates: homogentisate + O2 => maleylacetoacetate
directly activates: Catalysis2875

homogentisate + O2 => maleylacetoacetate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004411
BFO_0000050: Phenylalanine and tyrosine catabolism
directly activates: maleylacetoacetate => fumarylacetoacetate
directly activates: Catalysis2876

maleylacetoacetate => fumarylacetoacetate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016034
BFO_0000050: Phenylalanine and tyrosine catabolism
directly activates: fumarylacetoacetate => fumarate + acetoacetate
directly activates: Catalysis2877

fumarylacetoacetate => fumarate + acetoacetate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004334
BFO_0000050: Phenylalanine and tyrosine catabolism

proline => L-1-pyrroline-5-carboxylate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: enabled by
  some values from: PIG6
type: Restriction
  on property: enabled by
  some values from: PIG6
type: GO_0004657
BFO_0000050: Proline catabolism
directly activates: L-1-pyrroline-5-carboxylate <=> L-glutamate gamma-semialdehyde

L-1-pyrroline-5-carboxylate <=> L-glutamate gamma-semialdehyde
type: GO_0003674
BFO_0000050: Proline catabolism
directly activates: glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT]
directly activates: L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+
directly activates: Catalysis2826
directly activates: Catalysis2879

L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0003842
BFO_0000050: Proline catabolism

tryptophan + O2 => N-formylkynurenine [TDO]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004833
BFO_0000050: Tryptophan catabolism
directly activates: N-formylkynurenine + H2O => kynurenine + formate
directly activates: Catalysis2883

tryptophan + O2 => N-formylkynurenine [IDO]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004833
BFO_0000050: Tryptophan catabolism
directly activates: N-formylkynurenine + H2O => kynurenine + formate
directly activates: Catalysis2883

tryptophan + O2 => N-formylkynurenine [IDO2]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004833
BFO_0000050: Tryptophan catabolism

N-formylkynurenine + H2O => kynurenine + formate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: AFMID
type: Restriction
  on property: enabled by
  some values from: AFMID
type: GO_0004061
BFO_0000050: Tryptophan catabolism
directly activates: kynurenine + pyruvate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + alanine [CCBL1]
directly activates: kynurenine + pyruvate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + alanine [CCBL2]
directly activates: kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O
directly activates: Catalysis1292
directly activates: Catalysis2884
directly activates: Catalysis2885
directly activates: Control222

kynurenine + pyruvate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + alanine [CCBL2]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016212
BFO_0000050: Tryptophan catabolism
directly activates: 4-(2-aminophenyl)-2,4-dioxobutanoate => kynurenate + H2O [cytosolic]

4-(2-aminophenyl)-2,4-dioxobutanoate => kynurenate + H2O [cytosolic]
type: GO_0003674
BFO_0000050: Tryptophan catabolism
label: 4-(2-aminophenyl)-2,4-dioxobutanoate => kynurenic acid + H2O [cytosolic]

kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: KMO
type: Restriction
  on property: enabled by
  some values from: KMO
type: GO_0004502
BFO_0000050: Tryptophan catabolism
directly activates: 3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine
directly activates: Catalysis2886

3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0030429
BFO_0000050: Tryptophan catabolism
directly activates: 3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde
directly activates: Catalysis2887

3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0000334
BFO_0000050: Tryptophan catabolism
directly activates: BiochemicalReaction5624
directly activates: 2-amino-3-carboxymuconate semialdehyde => 2-aminomuconate semialdehyde + CO2
directly activates: Catalysis2888

2-amino-3-carboxymuconate semialdehyde => 2-aminomuconate semialdehyde + CO2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016831
BFO_0000050: Tryptophan catabolism
directly activates: 2-aminomuconate semialdehyde + NAD+ + H2O => aminomuconate + NADH + H+
directly activates: Catalysis2889

2-aminomuconate semialdehyde + NAD+ + H2O => aminomuconate + NADH + H+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0047102
BFO_0000050: Tryptophan catabolism

kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0016212
BFO_0000050: Tryptophan catabolism
directly activates: 4-(2-aminophenyl)-2,4-dioxobutanoate => kynurenate + H2O [mitochondrial]

4-(2-aminophenyl)-2,4-dioxobutanoate => kynurenate + H2O [mitochondrial]
type: GO_0003674
BFO_0000050: Tryptophan catabolism
label: 4-(2-aminophenyl)-2,4-dioxobutanoate => kynurenic acid + H2O [mitochondrial]

glutamate + acetyl CoA => N-acetyl glutamate + CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: NAGS
type: Restriction
  on property: enabled by
  some values from: NAGS
type: GO_0004042
BFO_0000050: Urea cycle
directly activates: 2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate
directly activates: Catalysis2892
directly activates: Control482
directly activates: Modulation30

2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: CPS1
type: Restriction
  on property: enabled by
  some values from: CPS1
type: GO_0004087
BFO_0000050: Urea cycle
directly activates: carbamoyl phosphate + ornithine => citrulline + orthophosphate
directly activates: Catalysis2893
label: 2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial]

carbamoyl phosphate + ornithine => citrulline + orthophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004585
BFO_0000050: Urea cycle
directly activates: ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic)
directly activates: Catalysis2898

ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004055
BFO_0000050: Urea cycle
directly activates: BiochemicalReaction296
directly activates: argininosuccinate <=> fumarate + arginine
directly activates: Catalysis111
directly activates: Catalysis2895
directly activates: Control14

argininosuccinate <=> fumarate + arginine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004056
BFO_0000050: Urea cycle
directly activates: arginine + H2O => ornithine + urea [ARG1]
directly activates: Catalysis2896

arginine + H2O => ornithine + urea [ARG1]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004053
BFO_0000050: Urea cycle
directly activates: ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic)
directly activates: Catalysis2898

arginine + H2O => ornithine + urea [ARG2]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004053
BFO_0000050: Urea cycle

ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: GO_0000064
BFO_0000050: Urea cycle
directly activates: ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT]
directly activates: carbamoyl phosphate + ornithine => citrulline + orthophosphate
directly activates: ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate
directly activates: Catalysis2825
directly activates: Catalysis2893
directly activates: Catalysis2894

trimethyllysine + alpha-ketoglutarate + O2 => beta-hydroxy-trimethyllysine + succinate + CO2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0050353
BFO_0000050: Carnitine synthesis
directly activates: beta-hydroxy-trimethyllysine => gamma-butyrobetaine aldehyde + glycine
directly activates: Catalysis2900

beta-hydroxy-trimethyllysine => gamma-butyrobetaine aldehyde + glycine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004372
BFO_0000050: Carnitine synthesis
directly activates: gamma-butyrobetaine semialdehyde + NAD+ => gamma-butyrobetaine + NADH + H+
directly activates: BiochemicalReaction5822
directly activates: Catalysis2901
directly activates: Catalysis2969
directly activates: Control487

gamma-butyrobetaine semialdehyde + NAD+ => gamma-butyrobetaine + NADH + H+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004028
BFO_0000050: Carnitine synthesis
directly activates: gamma-butyrobetaine + alpha-ketoglutarate + O2 => carnitine + succinate + CO2
directly activates: Catalysis2902

gamma-butyrobetaine + alpha-ketoglutarate + O2 => carnitine + succinate + CO2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008336
BFO_0000050: Carnitine synthesis

arginine + glycine => ornithine + guanidoacetate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005758
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005758
type: GO_0015068
BFO_0000050: Creatine metabolism
directly activates: guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine
directly activates: Catalysis2904

guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: GAMT
type: Restriction
  on property: enabled by
  some values from: GAMT
type: GO_0008168
BFO_0000050: Creatine metabolism
directly activates: creatine + ATP => phosphocreatine + ADP [CKB,CKM]
directly activates: creatine + ATP => phosphocreatine + ADP [CK octamer]
directly activates: Catalysis2905
directly activates: Catalysis2906

creatine + ATP => phosphocreatine + ADP [CKB,CKM]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004111
BFO_0000050: Creatine metabolism
directly activates: phosphocreatine + H2O => creatinine + orthophosphate

creatine + ATP => phosphocreatine + ADP [CK octamer]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: GO_0004111
BFO_0000050: Creatine metabolism
directly activates: phosphocreatine + H2O => creatinine + orthophosphate

phosphocreatine + H2O => creatinine + orthophosphate
type: GO_0003674
BFO_0000050: Creatine metabolism

Creatine transport across the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: SLC6A8
type: Restriction
  on property: enabled by
  some values from: SLC6A8
type: GO_0005309
BFO_0000050: Creatine metabolism
directly activates: creatine + ATP => phosphocreatine + ADP [CKB,CKM]
directly activates: creatine + ATP => phosphocreatine + ADP [CK octamer]
directly activates: Catalysis2905
directly activates: Catalysis2906

Arginine<=>Agmatine+CO2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: ADC
type: Restriction
  on property: enabled by
  some values from: ADC
type: Restriction
  on property: enabled by
  some values from: ADC
type: Restriction
  on property: enabled by
  some values from: ADC
type: GO_0008792
BFO_0000050: Agmatine biosynthesis

Agmatine + H2O <=> putrescine + urea
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005739
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005739
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005739
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005739
type: Restriction
  on property: enabled by
  some values from: AGMAT
type: Restriction
  on property: enabled by
  some values from: AGMAT
type: Restriction
  on property: enabled by
  some values from: AGMAT
type: Restriction
  on property: enabled by
  some values from: AGMAT
type: GO_0008783
BFO_0000050: Agmatine biosynthesis

ornithine => putrescine + CO2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: ODC1
type: Restriction
  on property: enabled by
  some values from: ODC1
type: GO_0004586
BFO_0000050: Metabolism of polyamines
directly activates: Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine
directly activates: Catalysis2912

S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: AMD
type: Restriction
  on property: enabled by
  some values from: AMD
type: GO_0004014
BFO_0000050: Metabolism of polyamines
directly activates: Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine
directly activates: dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine
directly activates: Catalysis2912
directly activates: Catalysis2913

Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: SPS1
type: Restriction
  on property: enabled by
  some values from: SPS1
type: GO_0004766
BFO_0000050: Metabolism of polyamines
directly activates: dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine
directly activates: MTA is cleaved and phosphorylated
directly activates: Catalysis2913
directly activates: Catalysis2919

dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: SMS
type: Restriction
  on property: enabled by
  some values from: SMS
type: GO_0016768
BFO_0000050: Metabolism of polyamines
directly activates: MTA is cleaved and phosphorylated
directly activates: Catalysis2919

Spermidine => N-acetylated spermidine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: SAT
type: Restriction
  on property: enabled by
  some values from: SAT
type: Restriction
  on property: enabled by
  some values from: SAT
type: Restriction
  on property: enabled by
  some values from: SAT
type: GO_0004145
BFO_0000050: Interconversion of polyamines
directly activates: N-acetylated spermidine (cytosol)=>N-acetylated spermidine (peroxisomal)

N-acetylated spermidine (cytosol)=>N-acetylated spermidine (peroxisomal)
type: GO_0003674
BFO_0000050: Interconversion of polyamines
directly activates: N-acetylspermidine is oxidized to putrescine
directly activates: Catalysis2915

N-acetylspermidine is oxidized to putrescine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0052904
BFO_0000050: Interconversion of polyamines

Spermine => N-acetylated spermine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: SAT
type: Restriction
  on property: enabled by
  some values from: SAT
type: Restriction
  on property: enabled by
  some values from: SAT
type: Restriction
  on property: enabled by
  some values from: SAT
type: GO_0004145
BFO_0000050: Interconversion of polyamines
directly activates: N-acetylated spermine (cytosol)=>N-acetylated spermine (peroxisomal)

N-acetylated spermine (cytosol)=>N-acetylated spermine (peroxisomal)
type: GO_0003674
BFO_0000050: Interconversion of polyamines
directly activates: N-acetylspermine is oxidised to spermidine
directly activates: Catalysis2917

N-acetylspermine is oxidised to spermidine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0052904
BFO_0000050: Interconversion of polyamines

Spermine is oxidized to spermidine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: C20orf16
type: Restriction
  on property: enabled by
  some values from: C20orf16
type: Restriction
  on property: enabled by
  some values from: C20orf16
type: Restriction
  on property: enabled by
  some values from: C20orf16
type: GO_0052901
BFO_0000050: Interconversion of polyamines

MTA is cleaved and phosphorylated
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0017061
BFO_0000050: Methionine salvage pathway
directly activates: Methylthio-ribose-P = Methylthio-ribulose-P
directly activates: Catalysis2920

Methylthio-ribose-P = Methylthio-ribulose-P
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: MRDI
type: Restriction
  on property: enabled by
  some values from: MRDI
type: Restriction
  on property: enabled by
  some values from: MRDI
type: Restriction
  on property: enabled by
  some values from: MRDI
type: Restriction
  on property: enabled by
  some values from: MRDI
type: Restriction
  on property: enabled by
  some values from: MRDI
type: Restriction
  on property: enabled by
  some values from: MRDI
type: Restriction
  on property: enabled by
  some values from: MRDI
type: GO_0046523
BFO_0000050: Methionine salvage pathway
directly activates: Dehydration of methylthio-ribulose-P
directly activates: Catalysis2922

Methylthio-ribulose-P = Methylthio-ribose-P
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: MRDI
type: Restriction
  on property: enabled by
  some values from: MRDI
type: Restriction
  on property: enabled by
  some values from: MRDI
type: Restriction
  on property: enabled by
  some values from: MRDI
type: Restriction
  on property: enabled by
  some values from: MRDI
type: Restriction
  on property: enabled by
  some values from: MRDI
type: Restriction
  on property: enabled by
  some values from: MRDI
type: Restriction
  on property: enabled by
  some values from: MRDI
type: GO_0046523
BFO_0000050: Methionine salvage pathway

Dehydration of methylthio-ribulose-P
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0019509
type: GO_0046570
BFO_0000050: Methionine salvage pathway
directly activates: Acireductone is created
directly activates: Catalysis2923

Acireductone is created
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0043874
BFO_0000050: Methionine salvage pathway
directly activates: Acireductone is oxidized to MOB
directly activates: Catalysis2924

Acireductone is oxidized to MOB
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0010309
BFO_0000050: Methionine salvage pathway
directly activates: Transamination of MOB to methionine
directly activates: Catalysis2925

Transamination of MOB to methionine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008483
type: GO_0019509
BFO_0000050: Methionine salvage pathway

Antizyme OAZ binds to Ornithine decarboxylase
type: GO_0003674
BFO_0000050: Regulation of ornithine decarboxylase (ODC)

26S proteosome degrades ODC holoenzyme complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004175
BFO_0000050: Regulation of ornithine decarboxylase (ODC)

Antizyme inhibitor binds to OAZ and stablizes ODC complex
type: GO_0003674
BFO_0000050: Regulation of ornithine decarboxylase (ODC)

NQO1 interaction with ODC
type: GO_0003674
BFO_0000050: Regulation of ornithine decarboxylase (ODC)

Tyrosine is hydroxylated to dopa
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004511
BFO_0000050: Catecholamine biosynthesis
directly activates: Dopa is decarboxylated to dopamine
directly activates: Catalysis2928

Dopa is decarboxylated to dopamine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004058
BFO_0000050: Catecholamine biosynthesis
directly activates: BiochemicalReaction3678
directly activates: Dopamine translocates to a secretory vesicle
directly activates: Catalysis1636

Dopamine translocates to a secretory vesicle
type: GO_0003674
BFO_0000050: Catecholamine biosynthesis
directly activates: Dopamine is oxidised to noradrenaline
directly activates: Catalysis2929

Dopamine is oxidised to noradrenaline
type: Restriction
  on property: BFO_0000066
  some values from: GO_0034774
type: Restriction
  on property: BFO_0000066
  some values from: GO_0034774
type: Restriction
  on property: BFO_0000066
  some values from: GO_0034774
type: Restriction
  on property: BFO_0000066
  some values from: GO_0034774
type: GO_0004500
BFO_0000050: Catecholamine biosynthesis
directly activates: Noradrenaline translocates to the cytosol

Noradrenaline translocates to the cytosol
type: GO_0003674
BFO_0000050: Catecholamine biosynthesis
directly activates: Noradrenaline is converted to adrenaline
directly activates: Catalysis2930

Noradrenaline is converted to adrenaline
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: PENT
type: Restriction
  on property: enabled by
  some values from: PENT
type: Restriction
  on property: enabled by
  some values from: PENT
type: Restriction
  on property: enabled by
  some values from: PENT
type: GO_0004603
BFO_0000050: Catecholamine biosynthesis

Iodide is taken up by thyroid epithelial cells
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: NIS
type: Restriction
  on property: enabled by
  some values from: NIS
type: Restriction
  on property: enabled by
  some values from: NIS
type: Restriction
  on property: enabled by
  some values from: NIS
type: GO_0015111
BFO_0000050: Thyroxine biosynthesis

Iodide is organified
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: TPO
type: Restriction
  on property: enabled by
  some values from: TPO
type: Restriction
  on property: enabled by
  some values from: TPO
type: Restriction
  on property: enabled by
  some values from: TPO
type: GO_0004601
BFO_0000050: Thyroxine biosynthesis
directly activates: Tyrosine is monoiodinated
directly activates: Tyrosine is diiodinated
directly activates: Catalysis2933
directly activates: Catalysis2935

Tyrosine is monoiodinated
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: TPO
type: Restriction
  on property: enabled by
  some values from: TPO
type: Restriction
  on property: enabled by
  some values from: TPO
type: Restriction
  on property: enabled by
  some values from: TPO
type: GO_0004601
BFO_0000050: Thyroxine biosynthesis
directly activates: Monoiodinated tyrosine can be deiodinated
directly activates: DIT and MIT combine to form triiodothyronine
directly activates: Catalysis2934
directly activates: Catalysis2937
directly activates: Control483

Monoiodinated tyrosine can be deiodinated
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0016491
BFO_0000050: Thyroxine biosynthesis
directly activates: Tyrosine is monoiodinated
directly activates: Catalysis2933

Tyrosine is diiodinated
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: TPO
type: Restriction
  on property: enabled by
  some values from: TPO
type: Restriction
  on property: enabled by
  some values from: TPO
type: Restriction
  on property: enabled by
  some values from: TPO
type: GO_0004601
BFO_0000050: Thyroxine biosynthesis
directly activates: Diiodinated tyrosine can be deiodinated
directly activates: DIT and MIT combine to form triiodothyronine
directly activates: Two DITs combine to form thyroxine
directly activates: Catalysis2936
directly activates: Catalysis2937
directly activates: Catalysis2938
directly activates: Control483
directly activates: Control484

Diiodinated tyrosine can be deiodinated
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0016491
BFO_0000050: Thyroxine biosynthesis
directly activates: Tyrosine is diiodinated
directly activates: Catalysis2935

DIT and MIT combine to form triiodothyronine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: TPO
type: Restriction
  on property: enabled by
  some values from: TPO
type: Restriction
  on property: enabled by
  some values from: TPO
type: Restriction
  on property: enabled by
  some values from: TPO
type: GO_0004601
BFO_0000050: Thyroxine biosynthesis

Two DITs combine to form thyroxine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: TPO
type: Restriction
  on property: enabled by
  some values from: TPO
type: Restriction
  on property: enabled by
  some values from: TPO
type: Restriction
  on property: enabled by
  some values from: TPO
type: GO_0004601
BFO_0000050: Thyroxine biosynthesis
directly activates: Thyroxine is deiodinated to triiodothyronine
directly activates: Catalysis2939

Thyroxine is deiodinated to triiodothyronine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004800
BFO_0000050: Regulation of thyroid hormone activity

Thyroxine is deiodinated to reverse triiodothyronine (RT3)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: DIO3
type: Restriction
  on property: enabled by
  some values from: DIO3
type: Restriction
  on property: enabled by
  some values from: DIO3
type: Restriction
  on property: enabled by
  some values from: DIO3
type: Restriction
  on property: enabled by
  some values from: DIO3
type: Restriction
  on property: enabled by
  some values from: DIO3
type: Restriction
  on property: enabled by
  some values from: DIO3
type: Restriction
  on property: enabled by
  some values from: DIO3
type: GO_0004800
BFO_0000050: Regulation of thyroid hormone activity

Tryptophan is hydroxylated
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004510
BFO_0000050: Serotonin and melatonin biosynthesis
directly activates: Decarboxylation of 5-hydroxytryptophan forms serotonin
directly activates: Catalysis2942

Decarboxylation of 5-hydroxytryptophan forms serotonin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004058
BFO_0000050: Serotonin and melatonin biosynthesis
directly activates: BiochemicalReaction3682
directly activates: N-acetylation of serotonin
directly activates: Catalysis1640
directly activates: Catalysis2943

N-acetylation of serotonin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: AANAT
type: Restriction
  on property: enabled by
  some values from: AANAT
type: Restriction
  on property: enabled by
  some values from: AANAT
type: Restriction
  on property: enabled by
  some values from: AANAT
type: GO_0004059
BFO_0000050: Serotonin and melatonin biosynthesis
directly activates: Methylation of N-acetyl-5-HT to form melatonin
directly activates: Catalysis2944

Methylation of N-acetyl-5-HT to form melatonin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: ASMT
type: Restriction
  on property: enabled by
  some values from: ASMT
type: Restriction
  on property: enabled by
  some values from: ASMT
type: Restriction
  on property: enabled by
  some values from: ASMT
type: GO_0008172
BFO_0000050: Serotonin and melatonin biosynthesis

Synthesis of glyoxylate from hydroxyproline
type: GO_0003674
BFO_0000050: Glyoxylate metabolism
directly activates: glyoxylate + NADPH + H+ => glycolate + NADP+
directly activates: Catalysis2948

glycine + O2 => glyoxylate + H2O2 + NH4+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0003884
BFO_0000050: Glyoxylate metabolism
directly activates: BiochemicalReaction5478
directly activates: glyoxylate + alanine => glycine + pyruvate [peroxisome]
directly activates: glyoxylate + NADPH + H+ => glycolate + NADP+
directly activates: Conversion of glyoxylate to oxalate
directly activates: Catalysis2666
directly activates: Catalysis2946
directly activates: Catalysis2948
directly activates: Catalysis2950

glyoxylate + alanine => glycine + pyruvate [peroxisome]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0008453
BFO_0000050: Glyoxylate metabolism
directly activates: glycine + O2 => glyoxylate + H2O2 + NH4+
directly activates: Catalysis2945

glyoxylate + alanine => glycine + pyruvate [mitochondrial matrix]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0008453
BFO_0000050: Glyoxylate metabolism

glyoxylate + NADPH + H+ => glycolate + NADP+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: enabled by
  some values from: GLXR
type: Restriction
  on property: enabled by
  some values from: GLXR
type: GO_0030267
BFO_0000050: Glyoxylate metabolism

glycolate + O2 => glyoxylate + H2O2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0008891
BFO_0000050: Glyoxylate metabolism
directly activates: BiochemicalReaction5478
directly activates: glyoxylate + alanine => glycine + pyruvate [peroxisome]
directly activates: Conversion of glyoxylate to oxalate
directly activates: Catalysis2666
directly activates: Catalysis2946
directly activates: Catalysis2950

Conversion of glyoxylate to oxalate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0047969
BFO_0000050: Glyoxylate metabolism
directly activates: BiochemicalReaction5478
directly activates: Catalysis2666

SAM is sythesized from methionine's reaction with ATP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004478
BFO_0000050: Sulfur amino acid metabolism
directly activates: S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2
directly activates: BiochemicalReaction5916
directly activates: BiochemicalReaction5917
directly activates: BiochemicalReaction5918
directly activates: BiochemicalReaction5919
directly activates: Catalysis2911
directly activates: Catalysis3054
directly activates: Catalysis3055
directly activates: Catalysis3056
directly activates: Catalysis3057

S-adenoylhomocysteine is hydrolyzed
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004013
BFO_0000050: Sulfur amino acid metabolism
directly activates: MTR transfers CH3 group from MeCbl to HCYS
directly activates: Remethylation of homocysteine via betaine degradation
directly activates: Cystathionine is formed from homocysteine and serine
directly activates: Catalysis2773
directly activates: Catalysis2953
directly activates: Catalysis2954

Remethylation of homocysteine via betaine degradation
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0047150
BFO_0000050: Sulfur amino acid metabolism

Cystathionine is formed from homocysteine and serine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004122
BFO_0000050: Cysteine formation from homocysteine
directly activates: Cleavage of cystathionine into cysteine
directly activates: Catalysis2955

Cleavage of cystathionine into cysteine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004123
BFO_0000050: Cysteine formation from homocysteine
directly activates: Cysteine is oxidized
directly activates: Catalysis2960

Glutamate and cysteine combine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004357
BFO_0000050: Sulfur amino acid metabolism
directly activates: BiochemicalReaction5921
directly activates: BiochemicalReaction5922
directly activates: Catalysis3059
directly activates: Catalysis3060
directly activates: Control489

A dipeptidase cleaves cysteinylglycine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004180
BFO_0000050: Sulfur amino acid metabolism
directly activates: Glutamate and cysteine combine
directly activates: BiochemicalReaction5922
directly activates: Catalysis2956
directly activates: Catalysis3060
directly activates: Control489

Homocysteine is degraded to oxobutanoate and H2S
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0047982
BFO_0000050: Degradation of cysteine and homocysteine

Cysteine is degraded to serine and H2S
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0080146
BFO_0000050: Degradation of cysteine and homocysteine
directly activates: SQR oxidizes sulfide to bound persulfide
directly activates: Catalysis2965

Cysteine is oxidized
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0017172
type: GO_0019448
BFO_0000050: Degradation of cysteine and homocysteine
directly activates: CSAD decarboxylates 3-sulfinoalanine to hypotaurine
directly activates: Catalysis2961

CSAD decarboxylates 3-sulfinoalanine to hypotaurine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004782
BFO_0000050: Degradation of cysteine and homocysteine
directly activates: Oxidation of hypotaurine to taurine
directly activates: Catalysis2962

Oxidation of hypotaurine to taurine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0047822
BFO_0000050: Degradation of cysteine and homocysteine

Excess homocysteine yields homolanthionine and H2S
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016846
BFO_0000050: Degradation of cysteine and homocysteine

Excess cysteine yields lanthionine and H2S
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0080146
BFO_0000050: Degradation of cysteine and homocysteine

SQR oxidizes sulfide to bound persulfide
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: GO_0070224
BFO_0000050: Sulfide oxidation to sulfate
directly activates: Persulfide sulfur is dioxygenated
directly activates: Persulfide sulfur is transferred onto sulfite
directly activates: Catalysis2966
directly activates: Catalysis2967

Persulfide sulfur is dioxygenated
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0050313
BFO_0000050: Sulfide oxidation to sulfate
directly activates: Persulfide sulfur is transferred onto sulfite
directly activates: Sulfite is oxidized to sulfate
directly activates: Catalysis2967
directly activates: Catalysis2968

Persulfide sulfur is transferred onto sulfite
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: TST
type: Restriction
  on property: enabled by
  some values from: TST
type: Restriction
  on property: enabled by
  some values from: TST
type: Restriction
  on property: enabled by
  some values from: TST
type: Restriction
  on property: enabled by
  some values from: TST
type: Restriction
  on property: enabled by
  some values from: TST
type: Restriction
  on property: enabled by
  some values from: TST
type: Restriction
  on property: enabled by
  some values from: TST
type: GO_0016783
BFO_0000050: Sulfide oxidation to sulfate
directly activates: Thiosulfate can transfer its sulfate to glutathione

Thiosulfate can transfer its sulfate to glutathione
type: GO_0003674
BFO_0000050: Sulfide oxidation to sulfate

Sulfite is oxidized to sulfate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0008482
BFO_0000050: Sulfide oxidation to sulfate
directly activates: Sulfate is exported to the cytosol in exchange for dicarboxylate
directly activates: Thiosulfate can transfer its sulfate to glutathione
directly activates: Catalysis635

Amino acid and derivative metabolism
type: GO_0008150
label: Metabolism of amino acids and derivatives

Amino acid synthesis and interconversion (transamination)
type: GO_0008150
BFO_0000050: Amino acid and derivative metabolism

Serine biosynthesis
type: GO_0008150
BFO_0000050: Amino acid synthesis and interconversion (transamination)

Branched-chain amino acid catabolism
type: GO_0008150
BFO_0000050: Amino acid and derivative metabolism

Histidine catabolism
type: GO_0008150
BFO_0000050: Amino acid and derivative metabolism

Lysine catabolism
type: GO_0008150
BFO_0000050: Amino acid and derivative metabolism

Phenylalanine and tyrosine catabolism
type: GO_0008150
BFO_0000050: Amino acid and derivative metabolism

Proline catabolism
type: GO_0008150
BFO_0000050: Amino acid and derivative metabolism

Tryptophan catabolism
type: GO_0008150
BFO_0000050: Amino acid and derivative metabolism

Urea cycle
type: GO_0008150
BFO_0000050: Amino acid and derivative metabolism
label: Urea synthesis

Carnitine synthesis
type: GO_0008150
BFO_0000050: Amino acid and derivative metabolism

Creatine metabolism
type: GO_0008150
BFO_0000050: Amino acid and derivative metabolism

Metabolism of polyamines
type: GO_0008150
BFO_0000050: Amino acid and derivative metabolism

Agmatine biosynthesis
type: GO_0008150
BFO_0000050: Metabolism of polyamines

Interconversion of polyamines
type: GO_0008150
BFO_0000050: Metabolism of polyamines

Methionine salvage pathway
type: GO_0008150
BFO_0000050: Metabolism of polyamines
BFO_0000050: Sulfur amino acid metabolism

Regulation of ornithine decarboxylase (ODC)
type: GO_0008150
BFO_0000050: Amino acid and derivative metabolism

Amine-derived hormones
type: GO_0008150
BFO_0000050: Amino acid and derivative metabolism

Catecholamine biosynthesis
type: GO_0008150
BFO_0000050: Amine-derived hormones

Thyroxine biosynthesis
type: GO_0008150
BFO_0000050: Amine-derived hormones

Regulation of thyroid hormone activity
type: GO_0008150
BFO_0000050: Thyroxine biosynthesis

Serotonin and melatonin biosynthesis
type: GO_0008150
BFO_0000050: Amine-derived hormones

Glyoxylate metabolism
type: GO_0008150
BFO_0000050: Amino acid and derivative metabolism

Sulfur amino acid metabolism
type: GO_0008150
BFO_0000050: Amino acid and derivative metabolism

Cysteine formation from homocysteine
type: GO_0008150
BFO_0000050: Sulfur amino acid metabolism

Degradation of cysteine and homocysteine
type: GO_0008150
BFO_0000050: Sulfur amino acid metabolism

Sulfide oxidation to sulfate
type: GO_0008150
BFO_0000050: Degradation of cysteine and homocysteine