MSK1
RPS6KA5
UniProt:O75582 RPS6KA5
CDC2
CDC28A
CDK1
CDKN1
P34CDC2
UniProt:P06493 CDK1
MAPKAPK2
UniProt:P49137 MAPKAPK2
BMK1
ERK5
MAPK7
PRKM7
UniProt:Q13164 MAPK7
RNF85
TRAF6
UniProt:Q9Y4K3 TRAF6
Pellino binds hp-IRAK1:TRAF6
IRAK1 phosphorylates Pellino
Pellino ubiquitinates hp-IRAK1
NEMO subunit of IKK complex binds to activated IRAK1
IRAK2 induces TRAF6 oligomerization
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2
Activated TRAF6 synthesizes unanchored polyubiquitin chains
Activated TRAF6:p-IRAK2 interacts with TAK1 complex
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3
TRAF6 binds MEKK1
Activated TAK1 mediates phosphorylation of the IKK Complex
Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex
Released NFkB complex is transported to nucleus
Activated TAK1 phosphorylates MKK4/MKK7
Phosphorylation of human JNKs by activated MKK4/MKK7
Activated human JNKs migrate to nucleoplasm
activated human TAK1 phosphorylates MKK3/MKK6
phosphorylated MKK3/MKK6 migrates to nucleus
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3
Active p38 MAPK phosphorylates MAPKAPK2 or 3
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3
Inactivation of MEK1 by p34cdc2
MEK1 binds ERK-1
MEK1 phosphorylates ERK-1
Dissociation of phospho-ERK-1:MEK1
Dimerisation of phospho-ERK-1
Nuclear translocation of phospho-ERK-1 dimer
MEK2 binds ERK-2
MEK2 phosphorylates ERK-2
Dissociation of phospho-ERK-2:MEK2
Dimerisation of phospho-ERK-2
Nuclear translocation of phospho-ERK-2 dimer
ERK1/2 activates ELK1
ERK1/2 phosphorylates MSK1
p38MAPK phosphorylates MSK1
ERK1/2/5 activate RSK1/2/3
ERK5 activates the transcription factor MEF2
ERKs are inactivated by protein phosphatase 2A
ERKs are inactivated by dual-specific phosphatases (DUSPs)
MSK1 activates CREB
MSK1 activates ATF1
RSK1/2/3 phosphorylates CREB at Serine 133
MAPKAPK2 phosphorylates CREB at Serine 133
Phosphorylated MAPKs phosphorylate ATF-2
Activated JNKs phosphorylate c-JUN
c-FOS activation by phospho ERK1/2
Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.
Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.
TRAM:TLR4:MD2:LPS:CD14 recruits TRIF (TICAM1)
Viral dsRNA:TLR3 recruits TRIF (TICAM1)
Negative regulator SARM binds to TRIF
TRAF3 binds to TRIF:activated TLR3/4 complex
Auto-ubiquitination of TRAF3
Recruitment of TBK1/IKK epsilon to K63-poly-Ub-TRAF3:TRIF:activated TLR3/TLR4 followed by their phosphorylation
IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR
Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex
Dimerization of phosphorylated IRF3/IRF7
Dimerized phospho-IRF3/IRF7 is transported to the nucleus
TRIF:activated TLR3/TLR4 complex recruits RIP1
K63-linked ubiquitination of RIP1 bound to the activated TLR complex
Nemo subunit of IKK complex binds polyubiquinated RIP1
TLR3/4-induced ripoptosome assembly
Caspase-8 processing
RIP3 binds TRIF to mediate necroptosis
Activated TLR3/4:TRIF recruits TRAF6
Auto ubiquitination of TRAF6 bound to the activated TLR complex
Activated TLR:TRIF:K63-pUb-TRAF6 recruits TAK1complex
Activation of TAK1 complex bound to activated TLR
Phosphorylated TAK1 leaves activated TLR receptor complex
Activated TLR2/4 interacts with MAL(TIRAP)
Activated TLR2/4:MAL interacts with BTK
MAL is phosphorylated by BTK
MyD88 forms a complex with MAL:activated TLR2/4
MyD88 oligomerization within the complex of activated TLR:Mal:MyD88
IRAK4 binds to the activated TLR receptor:Mal:MyD88 complex
IRAK4 autophosphorylation in the complex with activated TLR:MyD88:Mal
IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:Mal complex
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:Mal:activated TLR complex
First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal
Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal
Multiple IRAK1 autophosphorylation steps
TRAF6 binds to hp- IRAK1
TRAF6 binds to p-IRAK2
Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:Mal:p-IRAK4 complex
Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:Mal:p-IRAK4 complex
IRAK1 recruits IKK complex
IRAK2 mediated activation of TAK1 complex
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
MAP kinase activation in TLR cascade
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
activated TAK1 mediates p38 MAPK activation
ERK activation
ERK1 activation
ERK2 activation
MAPK targets/ Nuclear events mediated by MAP kinases
ERK/MAPK targets
ERKs are inactivated
CREB phosphorylation
Activation of the AP-1 family of transcription factors
MyD88-independent cascade
TRIF-mediated TLR3/TLR4 signaling
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
IKK complex recruitment mediated by RIP1
TRIF-mediated programmed cell death
TRAF6 mediated induction of TAK1 complex
Activated TLR4 signalling
MyD88:Mal cascade initiated on plasma membrane