Gene Ontology: Ontology Comparison Report

Files used:

  • file 1 (old): go-2012-01-28.obo; date: 27:01:2012 13:07; CVS revision: 1.2570
  • file 2 (new): go-2012-02-04.obo; date: 03:02:2012 17:53; CVS revision: 1.2587

New terms

ID name namespace
GO:0038083 peptidyl-tyrosine autophosphorylation biological_process
GO:0038084 vascular endothelial growth factor signaling pathway biological_process
GO:0038085 vascular endothelial growth factor binding molecular_function
GO:0038086 VEGF-activated platelet-derived growth factor receptor signaling pathway biological_process
GO:0038087 VEGF-activated platelet-derived growth factor receptor-alpha signaling pathway biological_process
GO:0038088 VEGF-activated platelet-derived growth factor receptor-beta signaling pathway biological_process
GO:0038089 positive regulation of cell migration by vascular endothelial growth factor signaling pathway biological_process
GO:0038090 positive regulation of cell migration by VEGF-activated platelet derived growth factor receptor signaling pathway biological_process
GO:0038091 positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway biological_process
GO:0044488 modulation of voltage-gated sodium channel activity in other organism biological_process
GO:0044489 negative regulation of voltage-gated sodium channel activity in other organism biological_process
GO:0044490 positive regulation of voltage-gated sodium channel activity in other organism biological_process
GO:0044491 positive regulation of molecular function in other organism biological_process
GO:0044492 envenomation resulting in modulation of voltage-gated sodium channel activity in other organism biological_process
GO:0044493 envenomation resulting in negative regulation of voltage-gated sodium channel activity in other organism biological_process
GO:0044494 envenomation resulting in positive regulation of voltage-gated sodium channel activity in other organism biological_process
GO:0044495 modulation of blood pressure in other organism biological_process
GO:0044496 negative regulation of blood pressure in other organism biological_process
GO:0044497 positive regulation of blood pressure in other organism biological_process
GO:0044498 envenomation resulting in modulation of blood pressure in other organism biological_process
GO:0044499 envenomation resulting in positive regulation of blood pressure in other organism biological_process
GO:0044500 envenomation resulting in negative regulation of blood pressure in other organism biological_process
GO:0052869 arachidonic acid omega-hydroxylase activity molecular_function
GO:0052870 tocopherol omega-hydroxylase activity molecular_function
GO:0052871 alpha-tocopherol omega-hydroxylase activity molecular_function
GO:0052872 tocotrienol omega-hydroxylase activity molecular_function
GO:0061424 positive regulation of peroxisome organization by positive regulation of transcription from RNA polymerase II promoter biological_process
GO:0061425 positive regulation of ethanol catabolic process by positive regulation of transcription from RNA polymerase II promoter biological_process
GO:0061426 positive regulation of sulfite transport by positive regulation of transcription from RNA polymerase II promoter biological_process
GO:0061427 negative regulation of ceramide biosynthetic process by negative regulation of transcription from RNA Polymerase II promoter biological_process
GO:0097235 positive regulation of fatty acid beta-oxidation by positive regulation of transcription from RNA polymerase II promoter biological_process
GO:0097236 positive regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation biological_process
GO:0097237 cellular response to toxin biological_process
GO:0097238 cellular response to methylglyoxal biological_process
GO:0097239 positive regulation of transcription from RNA polymerase II promoter in response to methylglyoxal biological_process
GO:1900083 regulation of Sertoli cell proliferation biological_process

Obsoletions

None

Term merges

None

Term changes

Changes in term-related data
File 1 (27:01:2012 13:07, 1.2570) File 2 (03:02:2012 17:53, 1.2587)
GO:0000038 : very long-chain fatty acid metabolic process
name
very long chain fatty acid metabolic process
def
The chemical reactions and pathways involving fatty acids with a chain length of C18 or greater.
is_a
GO:0006631
 name
very long-chain fatty acid metabolic process
def
The chemical reactions and pathways involving any long-chain fatty acid which has a chain length greater than C18.
synonym
"very long chain fatty acid metabolic process" EXACT [GOC:bf]
is_a
GO:0001676
GO:0001579 : medium-chain fatty acid transport
def
The directed movement of medium-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Medium-chain fatty acids are fatty acids with a chain length of between 8 and 12 carbons.
 def
The directed movement of medium-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A medium-chain fatty acid is a fatty acid with a chain length of between C6 and C12.
GO:0001676 : long-chain fatty acid metabolic process
def
The chemical reactions and pathways involving long-chain fatty acids, aliphatic compounds having a terminal carboxyl group and with a chain length of C12-18.
 def
The chemical reactions and pathways involving long-chain fatty acids, any fatty acid with a chain length of C13 or more. This includes very long-chain fatty acids, which have a chain length of greater than C18.
GO:0001792 : polymeric immunoglobulin receptor activity
def
Combining with a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes via the Fc region to initiate a change in cell activity.
 def
Combining with a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
GO:0001847 : opsonin receptor activity
def
Combining with an opsonin to initiate a change in cell activity.
 def
Combining with an opsonin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
GO:0003674 : molecular_function
disjoint_from
GO:0005575
GO:0008150
GO:0004467 : long-chain fatty acid-CoA ligase activity
def
Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; long-chain fatty acids have chain lengths of C12-18.
 def
Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is any fatty acid with a chain length of C13 or more. This includes very long-chain fatty acids, which have a chain length of greater than C18.
GO:0004875 : complement receptor activity
def
Combining with any component or product of the complement cascade to initiate a change in cell activity.
 def
Combining with any component or product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
GO:0004896 : cytokine receptor activity
def
Combining with a cytokine to initiate a change in cell activity.
 def
Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
GO:0004897 : ciliary neurotrophic factor receptor activity
def
Combining with ciliary neurotrophic factor (CNTF) and transmitting the signal to initiate a change in cell activity.
 def
Combining with ciliary neurotrophic factor (CNTF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
GO:0004900 : erythropoietin receptor activity
def
Combining with erythropoietin to initiate a change in cell activity.
 def
Combining with erythropoietin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
GO:0004902 : granulocyte colony-stimulating factor receptor activity
def
Combining with granulocyte colony-stimulating factor to initiate a change in cell activity.
 def
Combining with granulocyte colony-stimulating factor and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
GO:0004903 : growth hormone receptor activity
def
Combining with growth hormone to initiate a change in cell activity.
 def
Combining with a growth hormone and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
GO:0004904 : interferon receptor activity
def
Combining with an interferon to initiate a change in cell activity.
 def
Combining with an interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
GO:0004918 : interleukin-8 receptor activity
def
Combining with interleukin-8 to initiate a change in cell activity.
 def
Combining with interleukin-8 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
GO:0004950 : chemokine receptor activity
def
Combining with chemokines, small chemoattractant molecules normally used to stimulate leukocytes, to initiate a change in cell activity.
 def
Combining with a chemokine, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Chemokines are small chemoattractant molecules normally used to stimulate leukocytes.
GO:0005021 : vascular endothelial growth factor-activated receptor activity
def
Combining with vascular endothelial growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity.
relationship
part_of GO:0048010
 def
Combining with a vascular endothelial growth factor (VEGF) and transmitting the signal across the plasma membrane to initiate a change in cell activity.
relationship
has_part GO:0038085
part_of GO:0038084
GO:0005024 : transforming growth factor beta-activated receptor activity
def
Combining with transforming growth factor beta to initiate a change in cell activity.
 def
Combining with a transforming growth factor beta (TGFbeta) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
GO:0005056 : tiggrin receptor activity
def
Combining with the extracellular matrix ligand tiggrin to initiate a change in cell activity.
 def
Combining with the extracellular matrix ligand tiggrin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
GO:0005324 : long-chain fatty acid transporter activity
def
Enables the directed movement of long-chain fatty acids into, out of or within a cell, or between cells. Long-chain fatty acids have a chain length of greater than 12 carbons.
 def
Enables the directed movement of long-chain fatty acids into, out of or within a cell, or between cells. A long-chain fatty acid is any fatty acid with a chain length of C13 or more. This includes very long-chain fatty acids, which have a chain length of greater than C18.
GO:0005575 : cellular_component
disjoint_from
GO:0003674
 disjoint_from
GO:0008150
GO:0008046 : axon guidance receptor activity
def
Combining with an extracellular messenger that results in a change in cellular activity involved in axon guidance.
 def
Combining with an extracellular messenger and transmitting the signal from one side of the membrane to the other to results in a change in cellular activity involved in axon guidance.
GO:0008066 : glutamate receptor activity
def
Combining with glutamate to initiate a change in cell activity.
 def
Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
GO:0008150 : biological_process
disjoint_from
GO:0003674
GO:0005575
GO:0008281 : sulfonylurea receptor activity
def
Combining with sulfonylurea to initiate a change in cell activity.
 def
Combining with sulfonylurea, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
GO:0008288 : boss receptor activity
def
Combining with the protein bride of sevenless (boss) to initiate a change in cell activity.
 def
Combining with a protein bride of sevenless (boss) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.
GO:0008922 : long-chain fatty acid [acyl-carrier-protein] ligase activity
def
Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein].
 def
Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]. A long-chain fatty acid is any fatty acid with a chain length of C13 or more. This includes very long-chain fatty acids, which have a chain length of greater than C18.
GO:0009884 : cytokinin receptor activity
def
Combining with a cytokinin to initiate a change in cell activity.
 def
Combining with a cytokinin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
GO:0015464 : acetylcholine receptor activity
def
Combining with acetylcholine to initiate a change in cell activity.
 def
Combining with acetylcholine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
GO:0015483 : long-chain fatty acid transporting porin activity
def
Catalysis of the transfer of long-chain fatty acids from one side of the membrane to the other. Long-chain fatty acids have a chain length of greater than 12 carbons. This transporter is a porin and so enables the energy independent passage of substances, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.
 def
Catalysis of the transfer of long-chain fatty acids from one side of the membrane to the other. Long-chain fatty acids are any fatty acid with a chain length of C13 or more. This includes very long-chain fatty acids, which have a chain length of greater than C18. This transporter is a porin and so enables the energy independent passage of substances, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.
GO:0015635 : short-chain fatty acid transporter activity
def
Enables the directed movement of short-chain fatty acids into, out of or within a cell, or between cells. Short-chain fatty acids have a chain length of less than 8 carbons.
 def
Enables the directed movement of short-chain fatty acids into, out of or within a cell, or between cells. Short-chain fatty acids are fatty acids with a chain length of less than C6.
GO:0015636 : short-chain fatty acid uptake transporter activity
def
Enables the directed movement of short-chain fatty acids into a cell or organelle. Short-chain fatty acids have a chain length of less than 8 carbons.
 def
Enables the directed movement of short-chain fatty acids into a cell or organelle. Short-chain fatty acids are fatty acids with a chain length of less than C6.
GO:0015909 : long-chain fatty acid transport
def
The directed movement of long-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A long-chain fatty acid is an aliphatic compound with a terminal carboxyl group and with a chain length greater than C12.
 def
The directed movement of long-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A long-chain fatty acid is any fatty acid with a chain length of C13 or more. This includes very long-chain fatty acids, which have a chain length of greater than C18.
GO:0015910 : peroxisomal long-chain fatty acid import
def
The directed movement of long-chain fatty acids into a peroxisome.
 def
The directed movement of long-chain fatty acids into a peroxisome. A long-chain fatty acid is any fatty acid with a chain length of C13 or more. This includes very long-chain fatty acids, which have a chain length of greater than C18.
GO:0015911 : plasma membrane long-chain fatty acid transport
def
The directed movement of long-chain fatty acids across the plasma membrane.
 def
The directed movement of long-chain fatty acids across the plasma membrane. A long-chain fatty acid is any fatty acid with a chain length of C13 or more. This includes very long-chain fatty acids, which have a chain length of greater than C18.
GO:0015912 : short-chain fatty acid transport
def
The directed movement of short-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Short-chain fatty acids are fatty acids with a chain length of less than 8 carbons.
 def
The directed movement of short-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Short-chain fatty acids are fatty acids with a chain length of less than C6.
GO:0015913 : short-chain fatty acid import
def
The directed movement of short-chain fatty acids into a cell or organelle. Short-chain fatty acids are fatty acids with a chain length of less than 8 carbons.
 def
The directed movement of short-chain fatty acids into a cell or organelle. Short-chain fatty acids are fatty acids with a chain length of less than C6.
GO:0016167 : glial cell-derived neurotrophic factor receptor activity
def
Combining with glial cell line-derived neurotrophic factor to initiate a change in cell activity.
 def
Combining with glial cell line-derived neurotrophic factor and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
GO:0016493 : C-C chemokine receptor activity
def
Combining with a C-C chemokine to initiate a change in cell activity. C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif.
 def
Combining with a C-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif.
GO:0016494 : C-X-C chemokine receptor activity
def
Combining with a C-X-C chemokine to initiate a change in cell activity. A C-X-C chemokine has a single amino acid between the first two cysteines of the characteristic four cysteine motif.
 def
Combining with a C-X-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A C-X-C chemokine has a single amino acid between the first two cysteines of the characteristic four cysteine motif.
GO:0016495 : C-X3-C chemokine receptor activity
def
Combining with a C-X3-C chemokine to initiate a change in cell activity. A C-X3-C chemokine has three amino acids between the first two cysteines of the characteristic four-cysteine motif.
 def
Combining with a C-X3-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A C-X3-C chemokine has three amino acids between the first two cysteines of the characteristic four-cysteine motif.
GO:0016502 : nucleotide receptor activity
def
Combining with a nucleotide to initiate a change in cell activity. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule.
 def
Combining with a nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule.
GO:0016509 : long-chain-3-hydroxyacyl-CoA dehydrogenase activity
def
Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD(P)+ = 3-oxoacyl-CoA + NAD(P)H + H+, where the acyl group is a long-chain fatty acid residue. Long-chain fatty acids have a chain length of between 12 and 18 carbons.
 def
Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD(P)+ = 3-oxoacyl-CoA + NAD(P)H + H+, where the acyl group is a long-chain fatty acid residue. A long-chain fatty acid is any fatty acid with a chain length of C13 or more. This includes very long-chain fatty acids, which have a chain length of greater than C18.
GO:0016524 : latrotoxin receptor activity
def
Combining with alpha-latrotoxin, a potent presynaptic neurotoxin, to initiate a change in cell activity.
 def
Combining with alpha-latrotoxin, a potent presynaptic neurotoxin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
GO:0016917 : GABA receptor activity
def
Combining with gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to initiate a change in cell activity.
 def
Combining with gamma-aminobutyric acid (GABA), and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. (GABA, 4-aminobutyrate) is an amino acid which acts as a neurotransmitter in some organisms.
GO:0017002 : activin-activated receptor activity
def
Combining with activin, one of two gonadal glycoproteins related to transforming growth factor beta, to initiate a change in cell activity.
 def
Combining with activin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Activin is one of two gonadal glycoproteins related to transforming growth factor beta.
GO:0017099 : very-long-chain-acyl-CoA dehydrogenase activity
def
Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a very long chain fatty acid residue.
is_a
GO:0003995
 def
Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a very long chain fatty acid residue. A very long-chain fatty acid is a long-chain fatty acid which has a chain length greater than C18.
is_a
GO:0004466
GO:0017154 : semaphorin receptor activity
def
Combining with a semaphorin to initiate a change in cell activity.
 def
Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
GO:0019626 : short-chain fatty acid catabolic process
def
The chemical reactions and pathways resulting in the breakdown of fatty acids with a chain length of less than 8 carbons.
 def
The chemical reactions and pathways resulting in the breakdown of fatty acids with a chain length of less than C6.
GO:0019763 : immunoglobulin receptor activity
def
Combining with the Fc region of an immunoglobulin protein to initiate a change in cell activity.
 def
Combining with the Fc region of an immunoglobulin protein and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
GO:0020005 : symbiont-containing vacuole membrane
is_a
GO:0005774
GO:0020006 : symbiont-containing vacuolar membrane network
is_a
GO:0044425
GO:0044437
GO:0021798 : forebrain dorsal/ventral pattern formation
synonym
"forebrain dorsal-ventral pattern formation" EXACT []
GO:0030297 : transmembrane receptor protein tyrosine kinase activator activity
relationship
part_of GO:0007171
GO:0030369 : ICAM-3 receptor activity
def
Combining with ICAM-3, intercellular adhesion molecule 3, to initiate a change in cell activity. ICAM-3, or CD50, are constitutively expressed on monocytes, granulocytes and lymphocytes; on physiological stimulation, they become transiently phosphorylated on serine residues.
 def
Combining with ICAM-3, intercellular adhesion molecule 3, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. ICAM-3, or CD50, are constitutively expressed on monocytes, granulocytes and lymphocytes; on physiological stimulation, they become transiently phosphorylated on serine residues.
GO:0031955 : short-chain fatty acid-CoA ligase activity
def
Catalysis of the reaction: ATP + a short-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; short-chain fatty acids have chain lengths of less than 8 carbons.
 def
Catalysis of the reaction: ATP + a short-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; short-chain fatty acids are fatty acids with a chain length of less than C6.
GO:0031956 : medium-chain fatty acid-CoA ligase activity
def
Catalysis of the reaction: ATP + a medium-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; medium-chain fatty acids have chain lengths of C8-12.
 def
Catalysis of the reaction: ATP + a medium-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; a medium-chain fatty acid is any fatty acid with a chain length of between C6 and C12.
GO:0031957 : very long-chain fatty acid-CoA ligase activity
def
Catalysis of the reaction: ATP + a very-long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; very-long-chain fatty acids have chain lengths of greater than C18.
is_a
GO:0015645
 def
Catalysis of the reaction: ATP + a very-long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; a very long-chain fatty acid is a long-chain fatty acid which has a chain length greater than C18.
is_a
GO:0004467
GO:0032501 : multicellular organismal process
disjoint_from
GO:0051704
GO:0034188 : apolipoprotein A-I receptor activity
def
Combining with apolipoprotein A-I and transmitting the signal to initiate a change in cell activity.
 def
Combining with apolipoprotein A-I and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
GO:0035336 : long-chain fatty-acyl-CoA metabolic process
def
The chemical reactions and pathways involving long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths ranging from C12-18.
 def
The chemical reactions and pathways involving long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more.
GO:0035338 : long-chain fatty-acyl-CoA biosynthetic process
def
The chemical reactions and pathways resulting in the formation of a long-chain fatty-acyl-CoA any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths ranging from C12-18.
 def
The chemical reactions and pathways resulting in the formation of a long-chain fatty-acyl-CoA any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more.
GO:0035380 : very long-chain-3-hydroxyacyl-CoA dehydrogenase activity
def
Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD(P)+ = 3-oxoacyl-CoA + NAD(P)H + H+, where the acyl group is a very long-chain fatty acid residue. Very-long-chain fatty acids have a chain length of greater than 18 carbons.
is_a
GO:0016616
 def
Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD(P)+ = 3-oxoacyl-CoA + NAD(P)H + H+, where the acyl group is a very long-chain fatty acid residue. A very long-chain fatty acid is a long-chain fatty acid which has a chain length greater than C18.
is_a
GO:0016509
GO:0035586 : purinergic receptor activity
def
Combining with a purine or purine derivative (purine nucleoside or purine nucleotide) to initiate a change in cell activity.
 def
Combining with a purine or purine derivative (purine nucleoside or purine nucleotide) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule.
GO:0035790 : platelet-derived growth factor receptor-alpha signaling pathway
def
The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor-alpha binding to one of its physiological ligands.
 def
A series of molecular signals initiated by the binding of a ligand to an alpha-type platelet-derived growth factor receptor (PDGFalpha) on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.
GO:0035791 : platelet-derived growth factor receptor-beta signaling pathway
def
The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor-beta binding to one of its physiological ligands.
 def
A series of molecular signals initiated by the binding of a ligand to a beta-type platelet-derived growth factor receptor (PDGFbeta) on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.
GO:0035940 : negative regulation of peptidase activity in other organism
is_a
GO:0035821
 is_a
GO:0044362
GO:0036041 : long-chain fatty acid binding
def
Interacting selectively and non-covalently with a long-chain fatty acid. A long-chain fatty acid is an aliphatic compound with a terminal carboxyl group and with a chain length of C12-18.
 def
Interacting selectively and non-covalently with a long-chain fatty acid. A long-chain fatty acid is any fatty acid with a chain length of C13 or more. This includes very long-chain fatty acids, which have a chain length of greater than C18.
GO:0036042 : long-chain fatty acyl-CoA binding
def
Interacting selectively and non-covalently with a long-chain fatty acyl-CoA. A long-chain fatty acyl-CoA is any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths ranging from C12-18.
 def
Interacting selectively and non-covalently with a long-chain fatty acyl-CoA. A long-chain fatty acyl-CoA is any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more.
GO:0038021 : leptin receptor activity
def
Combining with the fat-cell specific hormone leptin to initiate a change in cell activity.
 def
Combining with the fat-cell specific hormone leptin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
GO:0038033 : positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
name
vascular endothelial growth factor receptor signaling pathway involved in endothelial cell chemotaxis
def
The series of molecular signals generated as a consequence of vascular endothelial growth factor receptor binding to one of its physiological ligands, which contributes to the directed movement of an endothelial cell guided by a specific chemical concentration gradient.
synonym
"VEGF signaling involved in migration of endothelial cells" RELATED [GOC:bf]
"VEGF-mediated chemotactic endothelial cell migration" RELATED [GOC:bf, PMID:21245381]
"VEGFR signaling pathway involved in endothelial cell migration" EXACT [GOC:bf]
relationship
part_of GO:0035767
 name
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
def
A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a VEGFR on the surface of a cell, which activates or increases the frequency, rate or extent of endothelial cell chemotaxis.
synonym
"positive regulation of endothelial cell chemotaxis by VEGF/VEGFR signaling pathway" EXACT [GOC:bf]
"vascular endothelial growth factor receptor signaling pathway involved in endothelial cell chemotaxis" RELATED [GOC:bf]
"VEGF-mediated chemotactic endothelial cell migration" BROAD [GOC:bf, PMID:21245381]
"VEGF-VEGFR-induced endothelial cell chemotaxis" EXACT [GOC:bf]
is_a
GO:0038089
GO:2001028
GO:0042758 : long-chain fatty acid catabolic process
def
The chemical reactions and pathways resulting in the breakdown of long-chain fatty acids, aliphatic compounds having a terminal carboxyl group and with a chain length of C12-18.
 def
The chemical reactions and pathways resulting in the breakdown of long-chain fatty acids, any fatty acid with a chain length of C13 or more. This includes very long-chain fatty acids, which have a chain length of greater than C18.
GO:0042759 : long-chain fatty acid biosynthetic process
def
The chemical reactions and pathways resulting in the formation of long-chain fatty acids, aliphatic compounds having a terminal carboxyl group and with a chain length of C12-18.
 def
The chemical reactions and pathways resulting in the formation of long-chain fatty acids, any fatty acid with a chain length of C13 or more. This includes very long-chain fatty acids, which have a chain length of greater than C18.
GO:0042760 : very long-chain fatty acid catabolic process
def
The chemical reactions and pathways resulting in the breakdown of fatty acids with a chain length of C18 or greater.
is_a
GO:0009062
 def
The chemical reactions and pathways resulting in the breakdown of a long-chain fatty acid which has a chain length greater than C18.
is_a
GO:0042758
GO:0042761 : very long-chain fatty acid biosynthetic process
def
The chemical reactions and pathways resulting in the formation of fatty acids with a chain length of C18 or greater.
is_a
GO:0006633
 def
The chemical reactions and pathways resulting in the formation of a long-chain fatty acid which has a chain length greater than C18.
is_a
GO:0042759
GO:0043296 : apical junction complex
def
A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in invertebrates is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability.
 def
A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in some invertebrates, such as Drosophila, is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability.
GO:0046459 : short-chain fatty acid metabolic process
def
The chemical reactions and pathways involving fatty acids with a chain length of less than 8 carbons.
 def
The chemical reactions and pathways involving fatty acids with a chain length of less than C6.
GO:0047474 : long-chain fatty acid luciferin component ligase activity
def
Catalysis of the reaction: protein + an acid + ATP = an acyl-protein thiolester + diphosphate + AMP.
 def
Catalysis of the reaction: protein + an acid + ATP = an acyl-protein thiolester + diphosphate + AMP. A long-chain fatty acid is any fatty acid with a chain length of C13 or more. This includes very long-chain fatty acids, which have a chain length of greater than C18.
GO:0048010 : vascular endothelial growth factor receptor signaling pathway
def
The series of molecular signals generated as a consequence of vascular endothelial growth factor receptor binding to one of its physiological ligands.
is_a
GO:0035924
 def
Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.
comment
In GO, a gene product with 'vascular endothelial growth factor-activated receptor activity ; GO:0005021' necessarily binds VEGF to transduce a signal. In contrast, the VEGFR refers to PR:000001971. To represent cross-talk between ligands and receptors, signaling pathways in GO are starting to be named after the receptor and/or the signal. GO:0048010 is for annotation of any pathway in which a ligand (VEGF or an alternative growth factor) binds and activates a VEGFR (PR:000001971). For annotation of signaling pathways where a VEGF binds to a cell surface receptor (VEGFR, PDGFR etc.), consider 'vascular endothelial growth factor signaling pathway ; GO:0038084'.
GO:0048756 : sieve cell differentiation
GO:0051595 : response to methylglyoxal
def
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylglyoxal stimulus.
 def
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylglyoxal stimulus. Methylglyoxal is a 2-oxoaldehyde derived from propanal.
is_a
GO:0010033
GO:0051704 : multi-organism process
disjoint_from
GO:0032501
GO:0051790 : short-chain fatty acid biosynthetic process
def
The chemical reactions and pathways resulting in the formation of fatty acids with a chain length of less than 8 carbons.
 def
The chemical reactions and pathways resulting in the formation of fatty acids with a chain length of less than C6.
GO:0051791 : medium-chain fatty acid metabolic process
def
The chemical reactions and pathways involving medium-chain fatty acids, aliphatic compounds having a terminal carboxyl group and with a chain length of C8-12.
 def
The chemical reactions and pathways involving medium-chain fatty acids, any fatty acid with a chain length of between C6 and C12.
GO:0051792 : medium-chain fatty acid biosynthetic process
def
The chemical reactions and pathways resulting in the formation of fatty acids with a chain length of between 8 and 12 carbons.
 def
The chemical reactions and pathways resulting in the formation of any fatty acid with a chain length of between C6 and C12.
GO:0051793 : medium-chain fatty acid catabolic process
def
The chemical reactions and pathways resulting in the breakdown of fatty acids with a chain length of between 8 and 12 carbons.
 def
The chemical reactions and pathways resulting in the breakdown of any fatty acid with a chain length of between C6 and C12.
GO:0052817 : very long chain acyl-CoA hydrolase activity
def
Catalysis of the reaction: H2O + a very long chain acyl-CoA = a very long chain carboxylate + CoA. A very long chain is a chain of greater than 18 carbons in length.
is_a
GO:0047617
 def
Catalysis of the reaction: H2O + a very long chain acyl-CoA = a very long chain carboxylate + CoA. A very long chain has chain length greater than C18.
is_a
GO:0052816
GO:0052868 : protein-lysine lysyltransferase activity
def
Catalysis of the reaction: protein-lysine + protein-lysine = protein N6-(lysyl)-L-lysine+ protein. This reaction is the addition of lysine group from one protein to a lysine residue in a second protein, producing N6-(lysyl)-L-lysine.
 def
Catalysis of the reaction: protein-lysine + protein-lysine = protein N6-(lysyl)-L-lysine + protein. This reaction is the addition of lysine group from one protein to a lysine residue in a second protein, producing N6-(lysyl)-L-lysine.
GO:0061399 : positive regulation of transcription from RNA polymerase II promoter in response to cobalt ion
def
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to an cobalt ion stimulus.
 def
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to a cobalt ion stimulus.
GO:0070991 : medium-chain-acyl-CoA dehydrogenase activity
def
Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a medium-chain fatty acid residue.
 def
Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a medium-chain fatty acid residue. A medium chain fatty acid is any fatty acid with a chain length of between C6 and C12.
GO:0097193 : intrinsic apoptotic signaling pathway
def
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, growth factor withdrawal, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP).
 def
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP).
GO:0097199 : cysteine-type endopeptidase activity involved in apoptotic signaling pathway
synonym
"initiator caspase" NARROW []
 synonym
"apical caspase activity" NARROW []
"initiator caspase activity" NARROW []
GO:0097200 : cysteine-type endopeptidase activity involved in execution phase of apoptosis
synonym
"effector caspase" NARROW []
 synonym
"effector caspase activity" NARROW []
"executioner caspase activity" NARROW []
GO:0097217 : sieve area
comment
Part of a sieve element (PO:0025406).
GO:0097218 : sieve plate
comment
Typical of angiosperms. Part of sieve tube member (PO:0000289).
GO:1900013 : cellular response to potassium ion involved in chemotaxis to cAMP
intersection_of
GO:0035865
part_of GO:0043327
GO:1900014 : cellular response to calcium ion involved in chemotaxis to cAMP
is_a
GO:0071277
intersection_of
GO:0071277
part_of GO:0043327
relationship
part_of GO:0043327
GO:1900060 : negative regulation of ceramide biosynthetic process
def
Any process that stops, prevents or reduces the frequency, rate or extent of ceramide biosynthetic process.
 def
Any process that stops, prevents or reduces the frequency, rate or extent of a ceramide biosynthetic process.
GO:1900073 : regulation of neuromuscular synaptic transmission
GO:1900074 : negative regulation of neuromuscular synaptic transmission
GO:1900075 : positive regulation of neuromuscular synaptic transmission
GO:2000303 : regulation of ceramide biosynthetic process
def
Any process that modulates the frequency, rate or extent of ceramide biosynthetic process.
 def
Any process that modulates the frequency, rate or extent of a ceramide biosynthetic process.
GO:2001267 : regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
synonym
"regulation of initiator caspase" RELATED [GOC:obol]
 synonym
"regulation of initiator caspase activity" NARROW [GOC:obol]
GO:2001268 : negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
synonym
"negative regulation of initiator caspase" RELATED [GOC:obol]
 synonym
"negative regulation of initiator caspase activity" NARROW [GOC:obol]
GO:2001269 : positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
synonym
"positive regulation of initiator caspase" RELATED [GOC:obol]
 synonym
"positive regulation of initiator caspase activity" NARROW [GOC:obol]
GO:2001270 : regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
synonym
"regulation of effector caspase" RELATED [GOC:obol]
 synonym
"regulation of effector caspase activity" NARROW [GOC:obol]
GO:2001271 : negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
synonym
"negative regulation of effector caspase" RELATED [GOC:obol]
 synonym
"negative regulation of effector caspase activity" NARROW [GOC:obol]
GO:2001272 : positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
synonym
"positive regulation of effector caspase" RELATED [GOC:obol]
 synonym
"positive regulation of effector caspase activity" NARROW [GOC:obol]

File Stats

Term counts for the old and new files
Ontology Old file New file Change
molecular function 9233
9233 (100.0%) defined 		9238
9238 (100.0%) defined 		+5
cellular component 2960
2960 (100.0%) defined 		2960
2960 (100.0%) defined 		0
biological process 21916
21916 (100.0%) defined 		21946
21946 (100.0%) defined 		+30
Obsolete 1611
(4.5% of total)		 1612
(4.5% of total)		 +1 (+0.1%)
Totals 34109
34109 (100.0%) defined
35720 inc. obsoletes 		34144
34144 (100.0%) defined
35756 inc. obsoletes 		+36 (+0.1%)

Ontology report info