Gene Ontology Definition Changes
Files used:
- file 1 (old): 20:01:2012 15:15, cvs revision 1.2535
- file 2 (new): 27:01:2012 13:07, cvs revision 1.2570
- Database: unknown DB type, unknown DB release name
Terms with changed definitions
GO:0000161 : MAPK cascade involved in osmosensory signaling pathway
(was MAPKKK cascade involved in osmosensory signaling pathway)
OLD: MAPKKK cascade involved in signal transduction in response to change in osmotic conditions.
NEW: A MAPK cascade involved in signal transduction in response to change in osmotic conditions.
GO:0000165 : MAPK cascade
(was MAPKKK cascade)
OLD: A series of protein phosphorylation events catalyzed by MAP kinases, by which a signal is passed on to downstream components within a cell. The MAPKKK cascade begins with phosphorylation of a MAPKK by a MAPKKK, and ends with phosphorylation of a downstream target by MAPK.
NEW: An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
GO:0000196 : MAPK cascade involved in cell wall biogenesis
(was MAPKKK cascade involved in cell wall biogenesis)
OLD: A MAPKKK cascade culminating in the phosphorylation and activation of a MAP kinase that occurs in the context of cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells.
NEW: A MAPK cascade that contributes to cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells.
GO:0003705 : sequence-specific distal enhancer binding RNA polymerase II transcription factor activity
OLD: Functions to initiate or regulate RNA polymerase II transcription by binding a distal enhancer region of DNA.
NEW: Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II.
GO:0004708 : MAP kinase kinase activity
OLD: Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in MAP kinases. It is a dual-specificity mitogen-activated protein kinase kinase and requires activation by the serine/threonine kinase, MAP kinase kinase kinase.
NEW: Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate.
GO:0004709 : MAP kinase kinase kinase activity
OLD: Catalysis of the phosphorylation and activation of MAP kinase kinases; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases.
NEW: Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases.
GO:0007243 : intracellular protein kinase cascade
OLD: A series of reactions that occur within the cell, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound.
NEW: A series of reactions in which a signal is passed on to downstream proteins within the cell by sequential protein phosphorylation and activation of the cascade components.
GO:0007254 : JNK cascade
OLD: A cascade of protein kinase activities, culminating in the phosphorylation and activation of a member of the JUN kinase subfamily of stress-activated protein kinases, which in turn are a subfamily of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress.
NEW: An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
GO:0035420 : MAPK cascade involved in innate immune response
(was MAPKKK cascade involved in innate immune response)
OLD: A MAPKKK cascade culminating in the phosphorylation and activation of a MAP kinase that occurs in the context of an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens.
NEW: A MAPK cascade that contributes to an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens.
GO:0042730 : fibrinolysis
OLD: An ongoing process that solubilizes fibrin, chiefly by the proteolytic action of plasmin, resulting in the removal of small blood clots.
NEW: A process that solubilizes fibrin in the bloodstream of a multicellular organism, chiefly by the proteolytic action of plasmin.
GO:0043408 : regulation of MAPK cascade
(was regulation of MAPKKK cascade)
OLD: Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade.
NEW: Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade.
GO:0070371 : ERK1 and ERK2 cascade
OLD: A cascade of protein kinase activities, culminating in the phosphorylation and activation of either the ERK1 or ERK2 kinases, which in turn are a subfamily of mitogen-activated protein (MAP) kinases.
NEW: An intracellular protein kinase cascade containing at least ERK1 or ERK2 (MAPKs), a MEK (a MAPKK) and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
GO:0070375 : ERK5 cascade
(was BMK cascade)
OLD: A cascade of protein kinase activities, culminating in the phosphorylation and activation of big MAP kinase (BMK1/ERK5), which is a type of mitogen-activated protein (MAP) kinase.
NEW: An intracellular protein kinase cascade containing at least ERK5 (also called BMK1; a MAPK), a MEK (a MAPKK) and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
0 annotations
GO:0070376 : regulation of ERK5 cascade
(was regulation of BMK cascade)
OLD: Any process that modulates the frequency, rate or extent of signal transduction mediated by the BMK cascade.
NEW: Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK5 cascade.
0 annotations
GO:0070377 : negative regulation of ERK5 cascade
(was negative regulation of BMK cascade)
OLD: Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the BMK cascade.
NEW: Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK5 cascade.
0 annotations
GO:0070378 : positive regulation of ERK5 cascade
(was positive regulation of BMK cascade)
OLD: Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the BMK cascade.
NEW: Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK5 cascade.
GO:0071507 : MAPK cascade involved in conjugation with cellular fusion
(was MAPKKK cascade involved in conjugation with cellular fusion)
OLD: A MAPKKK cascade culminating in the phosphorylation and activation of a MAP kinase that occurs in the context of conjugation with cellular fusion.
NEW: A MAPK cascade that contributes to conjugation with cellular fusion.