ATM
UniProt:Q13315 ATM
COP1
RFWD2
RNF200
UniProt:Q8NHY2 RFWD2
Phosphorylation of p53 at ser-15 by ATM kinase
Phosphorylation of MDM2 at serine-395 by ATM kinase
Phosphorylation of COP1 at Ser-387 by ATM
Dissociation of the COP1-p53 complex
Translocation of COP1 from the nucleus to the cytoplasm
Autoubiquitination of phospho-COP1(Ser-387 )
Proteasome mediated degradation of COP1
Inactivation of Cyclin E:Cdk2 complexes by p27/p21
p53-Dependent G1 DNA Damage Response
Stabilization of p53
Autodegradation of the E3 ubiquitin ligase COP1
Transcriptional activation of p53 responsive genes
Transcriptional activation of cell cycle inhibitor p21
Transcriptional activation of p21 by p53 after DNA damage