activated human TAK1 phosphorylates MKK3/MKK6
phosphorylated MKK3/MKK6 migrates to nucleus
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3
Active p38 MAPK phosphorylates MAPKAPK2 or 3
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3
activated TAK1 mediates p38 MAPK activation