Interaction of Tie2 with Ang1
type: GO_0003674
BFO_0000050: Tie2 Signaling
directly activates: Dimerization of Tie2/Ang1 complex

Dimerization of Tie2/Ang1 complex
type: GO_0003674
BFO_0000050: Tie2 Signaling
directly activates: Trans-phosphorylation of Tie2
directly activates: Catalysis1075

Trans-phosphorylation of Tie2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Tie2 Signaling
directly activates: Interaction of Tie2 and p85 of PI3K
directly activates: Interaction of Tie2 and Grb2
directly activates: Interaction of Tie2 and Shc1
directly activates: Interaction of Tie2 and Dok-2
directly activates: Interaction of Tie2 and Shp2
directly activates: Interaction of Tie2 and Grb7
directly activates: Interaction of Tie2 and Grb14

Interaction of Tie2 and p85 of PI3K
type: GO_0003674
BFO_0000050: Tie2 Signaling

Interaction of Tie2 and Grb2
type: GO_0003674
BFO_0000050: Tie2 Signaling
directly activates: Interaction of SOS-1 to Tie2 bound Grb2

Interaction of SOS-1 to Tie2 bound Grb2
type: GO_0003674
BFO_0000050: Tie2 Signaling
directly activates: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)
directly activates: Catalysis1076

Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005088
BFO_0000050: Tie2 Signaling

Interaction of Tie2 and Shc1
type: GO_0003674
BFO_0000050: Tie2 Signaling

Interaction of Tie2 and Dok-2
type: GO_0003674
BFO_0000050: Tie2 Signaling

Interaction of Tie2 with Ang2
type: GO_0003674
BFO_0000050: Tie2 Signaling

Interaction of Tie2 and Ang4
type: GO_0003674
BFO_0000050: Tie2 Signaling

Interaction of Tie2 and Shp2
type: GO_0003674
BFO_0000050: Tie2 Signaling

Interaction of Tie2 and Grb7
type: GO_0003674
BFO_0000050: Tie2 Signaling

Interaction of Tie2 and Grb14
type: GO_0003674
BFO_0000050: Tie2 Signaling

Tie2 Signaling
type: GO_0008150