LIG1
label: UniProt:P18858 LIG1

FEN1
label: RAD2
label: UniProt:P39748 FEN1

The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0000722
type: GO_0003899
BFO_0000050: Telomere C-strand synthesis initiation
directly activates: The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere
directly activates: Catalysis922

The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0000722
type: GO_0003887
BFO_0000050: Telomere C-strand synthesis initiation
directly activates: RFC binding displaces Pol Alpha on the C-strand of the telomere

RFC binding displaces Pol Alpha on the C-strand of the telomere
type: GO_0000722
BFO_0000050: Polymerase switching on the C-strand of the telomere
directly activates: Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere

Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere
type: GO_0000722
BFO_0000050: Polymerase switching on the C-strand of the telomere
directly activates: RFC dissociates after sliding clamp formation on the C-strand of the telomere

RFC dissociates after sliding clamp formation on the C-strand of the telomere
type: GO_0000722
BFO_0000050: Polymerase switching on the C-strand of the telomere
directly activates: Formation of Processive Complex on the C-strand of the telomere

Formation of Processive Complex on the C-strand of the telomere
type: GO_0000722
BFO_0000050: Polymerase switching on the C-strand of the telomere
directly activates: Formation of C-strand Okazaki fragments
directly activates: Catalysis923

Formation of C-strand Okazaki fragments
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0000722
type: GO_0003887
BFO_0000050: Processive synthesis on the C-strand of the telomere
directly activates: Formation of the Flap Intermediate on the C-strand

Formation of the Flap Intermediate on the C-strand
type: GO_0000722
BFO_0000050: Processive synthesis on the C-strand of the telomere
directly activates: RPA binds to the Flap on the C-strand
directly activates: Removal of the Flap Intermediate from the C-strand

RPA binds to the Flap on the C-strand
type: GO_0000722
BFO_0000050: Removal of the Flap Intermediate from the C-strand
directly activates: Recruitment of Dna2 endonuclease to the C strand

Recruitment of Dna2 endonuclease to the C strand
type: GO_0000722
BFO_0000050: Removal of the Flap Intermediate from the C-strand
directly activates: Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand

Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand
type: GO_0000722
BFO_0000050: Removal of the Flap Intermediate from the C-strand
directly activates: Removal of remaining Flap from the C-strand
directly activates: Catalysis924

Removal of remaining Flap from the C-strand
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0000722
type: GO_0017108
BFO_0000050: Removal of the Flap Intermediate from the C-strand

Joining of adjacent Okazaki fragments of the C-strand
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0000722
type: GO_0003909
BFO_0000050: Processive synthesis on the C-strand of the telomere
directly activates: Disassociation of Processive Complex and Completed Telomere End

Disassociation of Processive Complex and Completed Telomere End
type: GO_0000723
BFO_0000050: Telomere C-strand (Lagging Strand) Synthesis
directly activates: BiochemicalReaction2066
directly activates: BiochemicalReaction2067

Telomere C-strand (Lagging Strand) Synthesis
type: GO_0008150

Telomere C-strand synthesis initiation
type: GO_0008150
BFO_0000050: Telomere C-strand (Lagging Strand) Synthesis

Polymerase switching on the C-strand of the telomere
type: GO_0008150
BFO_0000050: Telomere C-strand (Lagging Strand) Synthesis

Processive synthesis on the C-strand of the telomere
type: GO_0008150
BFO_0000050: Telomere C-strand (Lagging Strand) Synthesis

Removal of the Flap Intermediate from the C-strand
type: GO_0008150
BFO_0000050: Processive synthesis on the C-strand of the telomere