CDC2
CDC28A
CDK1
CDKN1
P34CDC2
UniProt:P06493 CDK1
SRC
SRC1
UniProt:P12931-1 SRC
p-RAF binds 14-3-3 beta/alpha
Transient dissociation of 14-3-3 upon Ras binding
Stabilisation of RAS:RAF by 14-3-3
Stabilisation of RAF by further phosphorylation
Phosphorylated human RAF1 binds to RAS:GTP complex
Activated RAF1 complex binds MEK
RAF1 phosphorylates MEK1
RAF1 phosphorylates MEK2
GRB2:SOS binds to SHC-P
SOS mediated nucleotide exchange of RAS (SHC)
SHC binds to the activated TrkA receptor
SHC, complexed with TrkA, is tyrosine-phosphorylated
Phospho-Shc dissociates from the TrkA receptor
Ral-GDS binds to Ras-GTP
Guanine nucleotide exchange on RAL
Activation of SRC by RAL-GTP
Binding and activation of MAP Kinase
MAP kinase activates MAPKAPK2, MAPKAPK3 and MSK1
Inactivation of MEK1 by p34cdc2
MEK1 binds ERK-1
MEK1 phosphorylates ERK-1
Dissociation of phospho-ERK-1:MEK1
Dimerisation of phospho-ERK-1
Nuclear translocation of phospho-ERK-1 dimer
MEK2 binds ERK-2
MEK2 phosphorylates ERK-2
Dissociation of phospho-ERK-2:MEK2
Dimerisation of phospho-ERK-2
Nuclear translocation of phospho-ERK-2 dimer
Signalling to RAS
Feedback control in the MAPK signaling module
p38MAPK events
ERK activation
ERK1 activation
ERK2 activation
RAF/MAP kinase cascade
RAF activation
MEK activation
RAF phosphorylates MEK