Binding of ligand-responsive EGFR mutants to chaperoning proteins HSP90 and CDC37
type: GO_0003674
BFO_0000050: Signaling by constitutively active EGFR
directly activates: Binding of EGF to ligand-responsive EGFR mutants
directly activates: Spontaneous dimerization of ligand-responsive EGFR mutants

Binding of EGF to ligand-responsive EGFR mutants
type: GO_0003674
BFO_0000050: Signaling by constitutively active EGFR
directly activates: EGF-induced dimerization of ligand-responsive EGFR mutants

EGF-induced dimerization of ligand-responsive EGFR mutants
type: GO_0003674
BFO_0000050: Signaling by constitutively active EGFR
directly activates: Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers
directly activates: Non-covalent tyrosine kinase inhibitors bind and inactivate sensitive ligand-responsive EGFR cancer mutants
directly activates: Catalysis1220

Spontaneous dimerization of ligand-responsive EGFR mutants
type: GO_0003674
BFO_0000050: Signaling by constitutively active EGFR
directly activates: Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers
directly activates: Non-covalent tyrosine kinase inhibitors bind and inactivate sensitive ligand-responsive EGFR cancer mutants
directly activates: Catalysis1220

Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Signaling by constitutively active EGFR
directly activates: Binding of GRB2:SOS1 complex to phosphorylated EGFR mutants
directly activates: Binding of SHC1 to p-EGFR mutants
directly activates: Binding of GRB2:GAB1:PIK3R1 complex to p-EGFR mutants
directly activates: PLC-gamma 1 binds to p-EGFR mutants
directly activates: Binding of CBL to phosphorylated ligand-responsive EGFR mutants

EGFRvIII mutant binds chaperone proteins HSP90 and CDC37.
type: GO_0003674
BFO_0000050: Signaling by constitutively active EGFR
directly activates: Ligand-independent dimerization of EGFRvIII mutant

Ligand-independent dimerization of EGFRvIII mutant
type: GO_0003674
BFO_0000050: Signaling by constitutively active EGFR
directly activates: Trans-autophosphorylation of EGFRvIII mutant dimers
directly activates: Catalysis1221

Trans-autophosphorylation of EGFRvIII mutant dimers
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Signaling by constitutively active EGFR
directly activates: Binding of GRB2:SOS1 complex to phosphorylated EGFR mutants
directly activates: Binding of SHC1 to p-EGFR mutants
directly activates: Binding of GRB2:GAB1:PIK3R1 complex to p-EGFR mutants
directly activates: PLC-gamma 1 binds to p-EGFR mutants

Binding of GRB2:SOS1 complex to phosphorylated EGFR mutants
type: GO_0003674
BFO_0000050: Signaling by constitutively active EGFR
directly activates: SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFR mutants)
directly activates: Catalysis1222
label: Binding of GRB2:SOS1 to p-EGFR mutants

SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFR mutants)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005088
BFO_0000050: Signaling by constitutively active EGFR

Binding of SHC1 to p-EGFR mutants
type: GO_0003674
BFO_0000050: Signaling by constitutively active EGFR
directly activates: Phosphorylation of SHC1 by p-EGFR mutants
directly activates: Catalysis1223

Phosphorylation of SHC1 by p-EGFR mutants
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Signaling by constitutively active EGFR
directly activates: Phosphorylated SHC1 in complex with p-EGFR mutants recruits GRB2:SOS1 complex

Phosphorylated SHC1 in complex with p-EGFR mutants recruits GRB2:SOS1 complex
type: GO_0003674
BFO_0000050: Signaling by constitutively active EGFR
directly activates: SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFR mutants)
directly activates: Catalysis1224

SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFR mutants)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005088
BFO_0000050: Signaling by constitutively active EGFR

Binding of GRB2:GAB1:PIK3R1 complex to p-EGFR mutants
type: GO_0003674
BFO_0000050: Signaling by constitutively active EGFR
directly activates: Binding of PI3K p110 subunit alpha (PIK3CA) to complex of GRB2:GAB1:PIK3R1 and p-EGFR mutants

Binding of PI3K p110 subunit alpha (PIK3CA) to complex of GRB2:GAB1:PIK3R1 and p-EGFR mutants
type: GO_0003674
BFO_0000050: Signaling by constitutively active EGFR
directly activates: Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFR mutants
directly activates: Catalysis1225

Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFR mutants
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0046934
BFO_0000050: Signaling by constitutively active EGFR

PLC-gamma 1 binds to p-EGFR mutants
type: GO_0003674
BFO_0000050: Signaling by constitutively active EGFR
directly activates: Phosphorylation of PLC-gamma 1 by p-EGFR mutants
directly activates: Catalysis1226

Phosphorylation of PLC-gamma 1 by p-EGFR mutants
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Signaling by constitutively active EGFR
directly activates: Dissociation of phosphorylated PLC-gamma 1 from p-EGFR mutants

Dissociation of phosphorylated PLC-gamma 1 from p-EGFR mutants
type: GO_0003674
BFO_0000050: Signaling by constitutively active EGFR

Binding of CBL to phosphorylated ligand-responsive EGFR mutants
type: GO_0003674
BFO_0000050: Signaling by constitutively active EGFR
directly activates: Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants
directly activates: Catalysis1227

Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Signaling by constitutively active EGFR
directly activates: Inefficient ubiquitination of ligand-responsive EGFR mutants by phosphorylated CBL
directly activates: Catalysis1228
directly activates: Control205

Inefficient ubiquitination of ligand-responsive EGFR mutants by phosphorylated CBL
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004842
BFO_0000050: Signaling by constitutively active EGFR

HSP90 is inactivated by binding to benzaquinoid ansamycins
type: GO_0003674
BFO_0000050: Signaling by constitutively active EGFR

Non-covalent tyrosine kinase inhibitors bind and inactivate sensitive ligand-responsive EGFR cancer mutants
type: GO_0003674
BFO_0000050: Signaling by constitutively active EGFR
directly activates: Covalent tyrosine kinase inhibitors bind and inactivate EGFR kinase domain mutant dimers resistant to non-covalent tyrosine kinase inhibitors

Covalent tyrosine kinase inhibitors bind and inactivate EGFR kinase domain mutant dimers resistant to non-covalent tyrosine kinase inhibitors
type: GO_0003674
BFO_0000050: Signaling by constitutively active EGFR

Covalent tyrosine kinase inhibitors bind and inhibit wild-type EGF:EGFR dimers
type: GO_0003674
BFO_0000050: Signaling by constitutively active EGFR

Inactivation of over-expressed wild type EGFR by Cetuximab recombinant antibody
type: GO_0003674
BFO_0000050: Signaling by constitutively active EGFR

Signaling by constitutively active EGFR
type: GO_0008150