CDC2
label: CDC28A
label: CDK1
label: CDKN1
label: P34CDC2
label: UniProt:P06493 CDK1

MMP3
label: STMY1
label: UniProt:P08254 MMP3

ERK2
label: MAPK1
label: PRKM1
label: PRKM2
label: UniProt:P28482 MAPK1

CDK5
label: CDKN5
label: UniProt:Q00535 CDK5

MGLL
label: UniProt:Q99685 MGLL

p-RAF binds 14-3-3 beta/alpha
type: GO_0003674
BFO_0000050: RAF activation
directly activates: Transient dissociation of 14-3-3 upon Ras binding

Transient dissociation of 14-3-3 upon Ras binding
type: GO_0003674
BFO_0000050: RAF activation
directly activates: Stabilisation of RAS:RAF by 14-3-3

Stabilisation of RAS:RAF by 14-3-3
type: GO_0003674
BFO_0000050: RAF activation
directly activates: Stabilisation of RAF by further phosphorylation
directly activates: Catalysis447

Stabilisation of RAF by further phosphorylation
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: RAF activation
directly activates: Activated RAF1 complex binds MEK

Phosphorylated human RAF1 binds to RAS:GTP complex
type: GO_0003674
BFO_0000050: RAF activation
directly activates: RAF1 phosphorylates MEK1
directly activates: RAF1 phosphorylates MEK2
directly activates: Catalysis448
directly activates: Catalysis449

Activated RAF1 complex binds MEK
type: GO_0003674
BFO_0000050: MEK activation
directly activates: RAF1 phosphorylates MEK1
directly activates: RAF1 phosphorylates MEK2
directly activates: Catalysis448
directly activates: Catalysis449

RAF1 phosphorylates MEK1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0016301
BFO_0000050: RAF phosphorylates MEK
directly activates: MEK1 binds ERK-1

RAF1 phosphorylates MEK2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0016301
BFO_0000050: RAF phosphorylates MEK
directly activates: MEK2 binds ERK-2

Adenylate cyclase produces cAMP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0008294
BFO_0000050: PKA activation
directly activates: cAMP induces dissociation of inactive PKA tetramers
directly activates: cAMP hydrolysis by Cam-PDE 1
directly activates: cAMP hydrolysis by PDE 4
directly activates: Catalysis1906
directly activates: Catalysis457
directly activates: Control92
directly activates: Control93

cAMP induces dissociation of inactive PKA tetramers
type: GO_0003674
BFO_0000050: DARPP-32 events
BFO_0000050: PKA activation
directly activates: PKA catalytic subunit translocates to the nucleus
directly activates: BiochemicalReaction1772
directly activates: BiochemicalReaction4565
directly activates: BiochemicalReaction4724
directly activates: BiochemicalReaction5354
directly activates: Catalysis1982
directly activates: Catalysis2086
directly activates: Catalysis2578
directly activates: Catalysis748
directly activates: Control369
directly activates: Control433

PKA catalytic subunit translocates to the nucleus
type: GO_0003674
BFO_0000050: PKA-mediated phosphorylation of CREB
directly activates: PKA phosphorylates CREB
directly activates: BiochemicalReaction5352
directly activates: Catalysis2577
directly activates: Catalysis454
directly activates: Control432

PKA phosphorylates CREB
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: PKA-mediated phosphorylation of CREB
directly activates: Dimerisation of CREB

Dimerisation of CREB
type: GO_0003674
BFO_0000050: PKA-mediated phosphorylation of CREB
BFO_0000050: CaMK IV-mediated phosphorylation of CREB

Calmodulin binds CaMK IV
type: GO_0003674
BFO_0000050: CaMK IV-mediated phosphorylation of CREB
directly activates: CamKIV enters the nucleus

CamKIV enters the nucleus
type: GO_0003674
BFO_0000050: CaMK IV-mediated phosphorylation of CREB
directly activates: CaMK IV autophosphorylation
directly activates: Catalysis455

CaMK IV autophosphorylation
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004683
BFO_0000050: CaMK IV-mediated phosphorylation of CREB

CaMK IV phosphorylates CREB
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004683
BFO_0000050: CaMK IV-mediated phosphorylation of CREB
directly activates: Dimerisation of CREB
directly activates: TemplateReaction23
directly activates: TemplateReactionRegulation31
directly activates: TemplateReactionRegulation32
directly activates: TemplateReactionRegulation33
directly activates: TemplateReactionRegulation34
directly activates: TemplateReactionRegulation35

Calmodulin activates Cam-PDE 1
type: GO_0003674
BFO_0000050: Cam-PDE 1 activation
directly activates: cAMP hydrolysis by Cam-PDE 1
directly activates: Catalysis457

cAMP hydrolysis by Cam-PDE 1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004117
BFO_0000050: Cam-PDE 1 activation

Inhibition of GRK2 by calmodulin
type: GO_0003674
BFO_0000050: Calmodulin induced events

PKC phosphorylates GRK2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004672
BFO_0000050: Calmodulin induced events

Vasopressin receptor type 2 bind vasopressin
type: GO_0003674
BFO_0000050: Vasopressin-like receptors
directly activates: BiochemicalReaction1767
directly activates: Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs

G alpha (s) activates adenylate cyclase
type: GO_0003674
BFO_0000050: G alpha (s) signalling events
directly activates: BiochemicalReaction1771
directly activates: Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate
directly activates: Catalysis1878
directly activates: Catalysis747
directly activates: Control340
directly activates: Control341
directly activates: Control342

Transport of Ca++ from platelet dense tubular system to cytoplasm
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031095
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031095
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031095
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031095
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031095
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031095
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031095
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031095
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031095
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031095
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031095
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031095
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031095
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031095
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031095
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031095
type: GO_0005262
BFO_0000050: Effects of PIP2 hydrolysis
directly activates: Calcium and Diacylglycerol activate CalDAG-GEFs (RasGRPs)
directly activates: BiochemicalReaction2356
directly activates: Calcium binds calmodulin
directly activates: Control159

TP receptor can bind thromboxane
type: GO_0003674
BFO_0000050: Prostanoid ligand receptors
directly activates: BiochemicalReaction2283
directly activates: BiochemicalReaction2284
directly activates: Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13

PIP3 recruits PDK1 and AKT to the membrane
type: GO_0003674
BFO_0000050: G beta:gamma signalling through PI3Kgamma
directly activates: BiochemicalReaction2322

Alpha-2 adrenoceptors bind catecholamines
type: GO_0003674
BFO_0000050: Adrenoceptors
directly activates: Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz

Binding of IP3 to IP3 receptor
type: GO_0003674
BFO_0000050: Effects of PIP2 hydrolysis
directly activates: Transport of Ca++ from platelet dense tubular system to cytoplasm
directly activates: Catalysis1004

Calcium and Diacylglycerol activate CalDAG-GEFs (RasGRPs)
type: GO_0003674
BFO_0000050: Effects of PIP2 hydrolysis
directly activates: BiochemicalReaction850
directly activates: BiochemicalReaction851
directly activates: Catalysis321
directly activates: Catalysis322

Activation of Protein Kinase C novel isoforms
type: GO_0003674
BFO_0000050: Effects of PIP2 hydrolysis

DAG activation of TRPC channels
type: GO_0003674
BFO_0000050: Effects of PIP2 hydrolysis
directly activates: BiochemicalReaction2250
directly activates: Catalysis1006

DAG is metabolized by DAGL to 2-AG
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0047372
BFO_0000050: Arachidonate production from DAG
directly activates: 2-AG hydrolysis to arachidonate by MAGL
directly activates: Catalysis1037

2-AG hydrolysis to arachidonate by MAGL
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0047372
BFO_0000050: Arachidonate production from DAG

DAG kinase produces phosphatidic acid from DAG
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004143
BFO_0000050: Effects of PIP2 hydrolysis

Calcium binds calmodulin
type: GO_0003674
BFO_0000050: CaM pathway
directly activates: Adenylate cyclase produces cAMP
directly activates: Calmodulin binds CaMK IV
directly activates: Calmodulin activates Cam-PDE 1
directly activates: Inhibition of GRK2 by calmodulin
directly activates: BiochemicalReaction1324
directly activates: BiochemicalReaction243
directly activates: Inactive catalytic PP2B is activated by the binding of calmodulin
directly activates: BiochemicalReaction5368
directly activates: Catalysis453
directly activates: Control94
directly activates: Control95
directly activates: Modulation7
directly activates: Modulation8
directly activates: CaMK IV-mediated phosphorylation of CREB

GABAB heterodimeric receptor binds GABA
type: GO_0003674
BFO_0000050: Class C/3 (Metabotropic glutamate/pheromone receptors)

G alpha (i) inhibits adenylate cyclase
type: GO_0003674
BFO_0000050: G alpha (i) signalling events
BFO_0000050: Adenylate cyclase inhibitory pathway
directly activates: G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex
directly activates: Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate
directly activates: Catalysis1878
directly activates: Control340
directly activates: Control341
directly activates: Control342

G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex
type: GO_0003674
BFO_0000050: Adenylate cyclase inhibitory pathway
directly activates: Adenylate cyclase increases the GTPase activity of G alpha-olf
directly activates: Catalysis1704

Adenylate cyclase increases the GTPase activity of G alpha-olf
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0003924
BFO_0000050: Adenylate cyclase inhibitory pathway
directly activates: Adenylate cyclase increases the GTPase activity of Gi alpha
directly activates: Catalysis1705

Adenylate cyclase increases the GTPase activity of Gi alpha
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0003924
BFO_0000050: Adenylate cyclase inhibitory pathway
directly activates: Dissociation of the Gi alpha:G olf complex

Dissociation of the Gi alpha:G olf complex
type: GO_0003674
BFO_0000050: Adenylate cyclase inhibitory pathway

PIP3 binds to RhoA and activates it
type: GO_0003674
BFO_0000050: G beta:gamma signalling through PI3Kgamma

Angiotensin II binds to angiotensin II receptor (types 1 and 2)
type: GO_0003674
BFO_0000050: Peptide ligand-binding receptors
directly activates: Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
directly activates: Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq

Apelin receptor binds to apelin
type: GO_0003674
BFO_0000050: Peptide ligand-binding receptors
directly activates: Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi

Bombesin-like receptors bind bombesin homologues
type: GO_0003674
BFO_0000050: Peptide ligand-binding receptors
directly activates: Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq

Bradykinin receptors B1 and B2 bind to bradykinin
type: GO_0003674
BFO_0000050: Peptide ligand-binding receptors
directly activates: Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
directly activates: Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq

GPR77 binds anaphylatoxins and thier desArginated derivatives
type: GO_0003674
BFO_0000050: Peptide ligand-binding receptors

C5a receptor binds C5a anaphylatoxin
type: GO_0003674
BFO_0000050: Peptide ligand-binding receptors
directly activates: Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi

C3a receptor binds anaphylatoxin C3a
type: GO_0003674
BFO_0000050: Peptide ligand-binding receptors
directly activates: Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi

DARC is a non-specific receptor for many chemokines
type: GO_0003674
BFO_0000050: Peptide ligand-binding receptors

G protein-coupled estrogen receptor 1 binds estrogen non-classically
type: GO_0003674
BFO_0000050: Peptide ligand-binding receptors
directly activates: Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi

GPCR neuropeptide receptor binds neuropeptides B and W
type: GO_0003674
BFO_0000050: Peptide ligand-binding receptors
directly activates: Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi

Nociceptin receptor binds to nociceptin
type: GO_0003674
BFO_0000050: Peptide ligand-binding receptors
directly activates: Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi

Opioid receptors bind opioid peptides
type: GO_0003674
BFO_0000050: Peptide ligand-binding receptors
directly activates: Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi

Receptor CCR10 binds CCL27 and 28 ligands
type: GO_0003674
BFO_0000050: Chemokine receptors bind chemokines
directly activates: Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi

Receptor CCR6 binds CCL20 ligand
type: GO_0003674
BFO_0000050: Chemokine receptors bind chemokines
directly activates: Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi

Receptor CCR7 binds CCL19 and 21 ligands
type: GO_0003674
BFO_0000050: Chemokine receptors bind chemokines
directly activates: Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi

Receptor CCR9 binds CCL25 ligand
type: GO_0003674
BFO_0000050: Chemokine receptors bind chemokines
directly activates: Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi

Receptor CX3C1 binds CX3CL1
type: GO_0003674
BFO_0000050: Chemokine receptors bind chemokines

Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta
type: GO_0003674
BFO_0000050: Chemokine receptors bind chemokines

Receptor CXCR1 binds CXCL6 and CXCL8 ligands
type: GO_0003674
BFO_0000050: Chemokine receptors bind chemokines
directly activates: Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi

Receptor CXCR2 binds ligands CXCL1 to 7
type: GO_0003674
BFO_0000050: Chemokine receptors bind chemokines
directly activates: Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi

Receptor CXCR3 binds ligands CXCL9 to 11
type: GO_0003674
BFO_0000050: Chemokine receptors bind chemokines
directly activates: Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi

Receptors CXCR4 and 7 bind CXCL12 ligand
type: GO_0003674
BFO_0000050: Chemokine receptors bind chemokines
directly activates: Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi

CXCR5 binds CXCL13
type: GO_0003674
BFO_0000050: Chemokine receptors bind chemokines
directly activates: Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi

Receptor CXCR6 binds CXCL16 ligand
type: GO_0003674
BFO_0000050: Chemokine receptors bind chemokines
directly activates: Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi

Receptors CCR1, 2 and 8 bind CCL16 ligand
type: GO_0003674
BFO_0000050: Chemokine receptors bind chemokines
directly activates: Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi

Receptors CCR3, 4 and 5 bind CCL5 ligand
type: GO_0003674
BFO_0000050: Chemokine receptors bind chemokines
directly activates: Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi

Receptor CCBP2 binds most inflammatory CC chemokines
type: GO_0003674
BFO_0000050: Chemokine receptors bind chemokines

Receptor CCR11 binds CCL19, CCL21 & CCL25
type: GO_0003674
BFO_0000050: Chemokine receptors bind chemokines

CCRL2 binds CCL19
type: GO_0003674
BFO_0000050: Chemokine receptors bind chemokines

Somatostatin receptors bind somatostatin
type: GO_0003674
BFO_0000050: Peptide ligand-binding receptors
directly activates: Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi

Tachykinin receptor 1 (NK1) binds to substance P
type: GO_0003674
BFO_0000050: Tachykinin receptors bind tachykinins

Tachykinin receptor 2 (NK2) binds to nuerokinin A
type: GO_0003674
BFO_0000050: Tachykinin receptors bind tachykinins

Tachykinin receptor 3 (NK3) binds to neurokinin B
type: GO_0003674
BFO_0000050: Tachykinin receptors bind tachykinins

Vasopressin receptor type 1 bind vasopressin
type: GO_0003674
BFO_0000050: Vasopressin-like receptors
directly activates: Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq

Oxytocin receptor bind oxytocin
type: GO_0003674
BFO_0000050: Vasopressin-like receptors

Cholecystokinin receptors bind cholecystokinin
type: GO_0003674
BFO_0000050: Peptide ligand-binding receptors

Endothelin receptors bind endothelin
type: GO_0003674
BFO_0000050: Peptide ligand-binding receptors

Melanocortin receptors bind melanocortins
type: GO_0003674
BFO_0000050: Peptide ligand-binding receptors

ACTH specifically binds with melanocortin receptor 2
type: GO_0003674
BFO_0000050: Peptide ligand-binding receptors

Prolactin-releasing hormone receptor binds PRH
type: GO_0003674
BFO_0000050: Peptide ligand-binding receptors

Neuropeptide Y receptors can bind neuropeptide Y-related peptides
type: GO_0003674
BFO_0000050: Peptide ligand-binding receptors

Neurotensin receptors can bind neurotensins
type: GO_0003674
BFO_0000050: Peptide ligand-binding receptors

Galanin receptors can bind galanin
type: GO_0003674
BFO_0000050: Peptide ligand-binding receptors

The Kiss receptor GPR54 binds kisspeptin
type: GO_0003674
BFO_0000050: Peptide ligand-binding receptors

Proteinase-activated receptors can bind thrombin
type: GO_0003674
BFO_0000050: Peptide ligand-binding receptors

Orexin 1 receptor can bind orexin-A neuropeptide
type: GO_0003674
BFO_0000050: Orexin and neuropeptides FF and QRFP bind to their respective receptors

Orexin 2 receptor can bind orexin-B neuropeptide
type: GO_0003674
BFO_0000050: Orexin and neuropeptides FF and QRFP bind to their respective receptors

Two NPFF receptors can bind neuropeptide FF
type: GO_0003674
BFO_0000050: Orexin and neuropeptides FF and QRFP bind to their respective receptors

The orphan QRFP receptor can bind neuropeptide QRFP
type: GO_0003674
BFO_0000050: Orexin and neuropeptides FF and QRFP bind to their respective receptors

MLNR (GPR38) is a receptor for motilin
type: GO_0003674
BFO_0000050: Peptide ligand-binding receptors
directly activates: Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq

FPR is a receptor for formyl peptides
type: GO_0003674
BFO_0000050: Formyl peptide receptors bind formyl peptides and many other ligands
directly activates: Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi

FPRL1 receptor binds a wide range of ligands
type: GO_0003674
BFO_0000050: Formyl peptide receptors bind formyl peptides and many other ligands
directly activates: Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi

FPRL2 receptor binds a wide range of ligands
type: GO_0003674
BFO_0000050: Formyl peptide receptors bind formyl peptides and many other ligands
directly activates: Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi

Thyrotropin-releasing hormone receptor binds thyrotropin
type: GO_0003674
BFO_0000050: Peptide ligand-binding receptors
directly activates: Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq

Neuropeptide S receptor binds neuropeptide S
type: GO_0003674
BFO_0000050: Peptide ligand-binding receptors
directly activates: Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs
directly activates: Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq

Prokineticin receptors bind prokineticin
type: GO_0003674
BFO_0000050: Peptide ligand-binding receptors
directly activates: Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq

Relaxin receptor 1 binds relaxin 2 and 3
type: GO_0003674
BFO_0000050: Relaxin receptors
directly activates: Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs

Relaxin receptor 2 binds relaxin 2 and INSL3
type: GO_0003674
BFO_0000050: Relaxin receptors
directly activates: Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs

Relaxin 3 receptor 1 binds relaxin 3
type: GO_0003674
BFO_0000050: Relaxin receptors
directly activates: Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi

Relaxin 3 receptor 2 binds relaxin 3 and INSL5
type: GO_0003674
BFO_0000050: Relaxin receptors
directly activates: Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi

Urotensin-2 receptor binds urotensin-2 and 2B
type: GO_0003674
BFO_0000050: Peptide ligand-binding receptors
directly activates: Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq

GHSR is a receptor for ghrelin
type: GO_0003674
BFO_0000050: Peptide ligand-binding receptors
directly activates: Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq

Melanin-concentrating hormone receptors bind MCH
type: GO_0003674
BFO_0000050: Peptide ligand-binding receptors
directly activates: Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi

Neuromedin-U receptors bind neuromedins U, S
type: GO_0003674
BFO_0000050: Peptide ligand-binding receptors
directly activates: Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
directly activates: Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq

NMUR2 binds neuromedin-S
type: GO_0003674
BFO_0000050: Peptide ligand-binding receptors
directly activates: Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
directly activates: Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq

M2 and M4 receptors bind acetylcholine
type: GO_0003674
BFO_0000050: Muscarinic acetylcholine receptors
directly activates: Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi

M1, M3 and M5 receptors bind acetylcholine
type: GO_0003674
BFO_0000050: Muscarinic acetylcholine receptors
directly activates: Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq

Alpha-1 adrenoceptors bind catecholamines
type: GO_0003674
BFO_0000050: Adrenoceptors
directly activates: Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
directly activates: Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13

Beta adrenoceptors bind catecholamines
type: GO_0003674
BFO_0000050: Adrenoceptors
directly activates: Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs

D1-like dopamine receptors bind to dopamine
type: GO_0003674
BFO_0000050: Dopamine receptors
directly activates: Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs

D2-like dopamine receptors bind to dopamine
type: GO_0003674
BFO_0000050: Dopamine receptors
directly activates: Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi

H1 receptor binds histamine
type: GO_0003674
BFO_0000050: Histamine receptors
directly activates: Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq

H2 receptor binds histamine
type: GO_0003674
BFO_0000050: Histamine receptors
directly activates: Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs

H3 and H4 receptors binds histamine
type: GO_0003674
BFO_0000050: Histamine receptors
directly activates: Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi

5-HT1 and 5A receptors can bind serotonin
type: GO_0003674
BFO_0000050: Serotonin receptors
directly activates: Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi

5-HT2 receptor can bind serotonin
type: GO_0003674
BFO_0000050: Serotonin receptors
directly activates: Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq

5-HT4, 6 and 7 receptors can bind serotonin
type: GO_0003674
BFO_0000050: Serotonin receptors
directly activates: Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs

Trace amine-associated receptors can bind trace amines
type: GO_0003674
BFO_0000050: Amine ligand-binding receptors
directly activates: Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs

Follicle-stimulating hormone receptor can bind FSH
type: GO_0003674
BFO_0000050: Hormone ligand-binding receptors
directly activates: Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs

Gonadotropin-releasing hormone receptors can bind GNRH I and II
type: GO_0003674
BFO_0000050: Hormone ligand-binding receptors
directly activates: Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq

Luteinizing hormone receptor can bind LH
type: GO_0003674
BFO_0000050: Hormone ligand-binding receptors
directly activates: Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs

Thyroid-stimulating hormone receptor can bind TSH
type: GO_0003674
BFO_0000050: Hormone ligand-binding receptors
directly activates: Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs

EP1 receptor can bind PGE2
type: GO_0003674
BFO_0000050: Prostanoid ligand receptors

EP2 and EP4 receptors can bind PGE2
type: GO_0003674
BFO_0000050: Prostanoid ligand receptors

EP3 receptor can bind PGE2
type: GO_0003674
BFO_0000050: Prostanoid ligand receptors

FP receptor can bind PGF2-alpha
type: GO_0003674
BFO_0000050: Prostanoid ligand receptors

IP receptor can bind prostacyclin
type: GO_0003674
BFO_0000050: Prostanoid ligand receptors
directly activates: Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs

DP1 receptor can bind PGD2
type: GO_0003674
BFO_0000050: Prostanoid ligand receptors

DP2 receptor can bind PGD2
type: GO_0003674
BFO_0000050: Prostanoid ligand receptors

BLT receptors can bind LTB4
type: GO_0003674
BFO_0000050: Leukotriene receptors

CysLT receptors can bind cysteinyl leukotrienes
type: GO_0003674
BFO_0000050: Leukotriene receptors

UDP/CysLT receptor can bind cysteinyl leukotrienes
type: GO_0003674
BFO_0000050: Leukotriene receptors

Oxoeicosanoid receptor can bind oxoeicosanoid
type: GO_0003674
BFO_0000050: Eicosanoid ligand-binding receptors

P2Y1 receptor can bind to ADP
type: GO_0003674
BFO_0000050: P2Y receptors
directly activates: Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq

P2Y2 receptor binds ATP and UTP
type: GO_0003674
BFO_0000050: P2Y receptors
directly activates: Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq

P2Y4 receptor can bind to UTP
type: GO_0003674
BFO_0000050: P2Y receptors
directly activates: Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi

P2Y5 receptor can bind to LPA
type: GO_0003674
BFO_0000050: P2Y receptors
directly activates: Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq

P2Y6 receptor can bind to UDP
type: GO_0003674
BFO_0000050: P2Y receptors
directly activates: Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq

P2Y9 receptor can bind to LPA
type: GO_0003674
BFO_0000050: P2Y receptors
directly activates: Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq

P2Y10 receptor can bind to LPA
type: GO_0003674
BFO_0000050: P2Y receptors
directly activates: Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq

P2Y11 receptor can bind to ATP
type: GO_0003674
BFO_0000050: P2Y receptors

P2Y12 receptor can bind to ADP
type: GO_0003674
BFO_0000050: P2Y receptors
directly activates: Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi

P2Y13 receptor can bind ADP
type: GO_0003674
BFO_0000050: P2Y receptors
directly activates: Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi

P2Y14 receptor can bind to UDP-glucose
type: GO_0003674
BFO_0000050: P2Y receptors
directly activates: Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi

The UDP/CysLT (P2Y17) receptor can bind UTP
type: GO_0003674
BFO_0000050: P2Y receptors

A1 and A3 receptors bind adenosine
type: GO_0003674
BFO_0000050: Adenosine P1 receptors
directly activates: Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi

A2a and A2b receptors bind adenosine
type: GO_0003674
BFO_0000050: Adenosine P1 receptors
directly activates: Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs
directly activates: Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi

HCAR2 binds HCAR2 ligands
type: GO_0003674
BFO_0000050: Class A/1 (Rhodopsin-like receptors)
BFO_0000050: Hydroxycarboxylic acid-binding receptors
directly activates: Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi

HCAR1 binds L-lactate
type: GO_0003674
BFO_0000050: Hydroxycarboxylic acid-binding receptors
directly activates: Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
label: HCAR1 binds LACT

HCAR3 binds HCAR3 ligands
type: GO_0003674
BFO_0000050: Hydroxycarboxylic acid-binding receptors
directly activates: Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi

Cannabinoid receptors can bind cannabinoids
type: GO_0003674
BFO_0000050: Class A/1 (Rhodopsin-like receptors)
directly activates: Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi

PAF receptor binds platelet activating factor
type: GO_0003674
BFO_0000050: Class A/1 (Rhodopsin-like receptors)

Melatonin receptors can bind melatonin
type: GO_0003674
BFO_0000050: Class A/1 (Rhodopsin-like receptors)

LPA-binding receptors bind LPA
type: GO_0003674
BFO_0000050: Lysosphingolipid and LPA receptors

S1P-binding receptors bind S1P
type: GO_0003674
BFO_0000050: Lysosphingolipid and LPA receptors

Light stimulates opsin receptors
type: GO_0003674
BFO_0000050: Opsins
directly activates: Opsins that act as GEFs for G alpha-t
directly activates: Catalysis1882

Melanospin is stimulated by light
type: GO_0003674
BFO_0000050: Opsins
directly activates: Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq

Receptor FFAR1 binds free fatty acids
type: GO_0003674
BFO_0000050: Free fatty acid receptors
directly activates: Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq

Receptor FFAR2 binds carboxylates
type: GO_0003674
BFO_0000050: Free fatty acid receptors
directly activates: Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq

Receptor FFAR3 binds carboxylates
type: GO_0003674
BFO_0000050: Free fatty acid receptors
directly activates: Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq

GPR120 is a receptor for unsaturated long-chain free fatty acids
type: GO_0003674
BFO_0000050: Free fatty acid receptors

GPR31 is a receptor for 12(S)-HETE
type: GO_0003674
BFO_0000050: Free fatty acid receptors

GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors
type: GO_0003674
BFO_0000050: Class A/1 (Rhodopsin-like receptors)
directly activates: Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq

G-protein coupled bile acid receptor binds lithocholic acid
type: GO_0003674
BFO_0000050: Class A/1 (Rhodopsin-like receptors)
directly activates: Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs

N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine
type: GO_0003674
BFO_0000050: Class A/1 (Rhodopsin-like receptors)
directly activates: Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi

Zinc is an agonist of GPR39
type: GO_0003674
BFO_0000050: Class A/1 (Rhodopsin-like receptors)

OXGR1 binds 2OG
type: GO_0003674
BFO_0000050: Class A/1 (Rhodopsin-like receptors)
directly activates: Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi

SUCNR1 binds SUCCA
type: GO_0003674
BFO_0000050: Class A/1 (Rhodopsin-like receptors)
directly activates: Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
label: SUCNR1 binds succinate

Calcitonin receptor binds calcitonin
type: GO_0003674
BFO_0000050: Calcitonin-like ligand receptors
directly activates: Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs

Amylin receptors can bind Amylin
type: GO_0003674
BFO_0000050: Calcitonin-like ligand receptors
directly activates: Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs

CGRP receptor can bind calcitonin gene-related peptides
type: GO_0003674
BFO_0000050: Calcitonin-like ligand receptors
directly activates: Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs

The adrenomedullin receptor can bind adrenomedullin and intermedin
type: GO_0003674
BFO_0000050: Calcitonin-like ligand receptors
directly activates: Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs

Corticotropin-releasing hormone receptor can bind CRH
type: GO_0003674
BFO_0000050: Class B/2 (Secretin family receptors)
directly activates: Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs

GIP receptor binds gastric inhibitory peptide
type: GO_0003674
BFO_0000050: Glucagon-type ligand receptors
directly activates: Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs

Glucagon binds to Glucagon receptor
type: GO_0003674
BFO_0000050: Glucagon-type ligand receptors
directly activates: Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs
directly activates: Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
directly activates: BiochemicalReaction5351
directly activates: Catalysis2576

Binding of Glucagon-like Peptide-1 by Glucagon-like Peptide-1 Receptor
type: GO_0003674
BFO_0000050: Glucagon-type ligand receptors
directly activates: Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs
directly activates: BiochemicalReaction5337

Glucagon-like receptor 2 binds GLP2
type: GO_0003674
BFO_0000050: Glucagon-type ligand receptors
directly activates: Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs

GHRH receptor binds GHRH
type: GO_0003674
BFO_0000050: Glucagon-type ligand receptors
directly activates: Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs

The PACAP receptor binds PACAP
type: GO_0003674
BFO_0000050: Glucagon-type ligand receptors
directly activates: Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs

Secretin receptor binds secretin
type: GO_0003674
BFO_0000050: Glucagon-type ligand receptors
directly activates: Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs

Parathyroid hormone receptor can bind parathyroid hormone
type: GO_0003674
BFO_0000050: Class B/2 (Secretin family receptors)
directly activates: Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs

Patched binds Smoothened
type: GO_0003674
BFO_0000050: Class B/2 (Secretin family receptors)

Frizzled receptors bind Wnts
type: GO_0003674
BFO_0000050: Class B/2 (Secretin family receptors)

EGF-TM7 receptors bind chondroitin sulphate
type: GO_0003674
BFO_0000050: Class B/2 (Secretin family receptors)

CD97 binds CD55
type: GO_0003674
BFO_0000050: Class B/2 (Secretin family receptors)

Metabotropic glutamate receptors bind glutamate
type: GO_0003674
BFO_0000050: Class C/3 (Metabotropic glutamate/pheromone receptors)
directly activates: Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq

Calcium-sensing receptor binds calcium
type: GO_0003674
BFO_0000050: Class C/3 (Metabotropic glutamate/pheromone receptors)
directly activates: Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
directly activates: Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq

GPRC6A can bind L-alpha amino acids and calcium
type: GO_0003674
BFO_0000050: Class C/3 (Metabotropic glutamate/pheromone receptors)

T1R1/T1R3 dimer is the umami taste receptor
type: GO_0003674
BFO_0000050: Class C/3 (Metabotropic glutamate/pheromone receptors)

T1R2/T1R3 dimer is a sweet taste receptor
type: GO_0003674
BFO_0000050: Class C/3 (Metabotropic glutamate/pheromone receptors)

T2Rs bind bitter-tasting compounds
type: GO_0003674
BFO_0000050: Class C/3 (Metabotropic glutamate/pheromone receptors)
directly activates: Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi

Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs
type: GO_0003674
BFO_0000050: G alpha (s) signalling events
directly activates: Liganded Gs-activating GPCR acts as a GEF for Gs
directly activates: Catalysis1877

Liganded Gs-activating GPCR acts as a GEF for Gs
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005085
BFO_0000050: G alpha (s) signalling events
directly activates: The Ligand:GPCR:Gs complex dissociates
directly activates: Gbeta:gamma recruits PI3K gamma
directly activates: Gbeta:gamma activation of PLC beta

The Ligand:GPCR:Gs complex dissociates
type: GO_0003674
BFO_0000050: G alpha (s) signalling events
directly activates: G alpha (s) activates adenylate cyclase
directly activates: G alpha (s) auto-inactivates by hydrolysing GTP to GDP
directly activates: Catalysis1880

Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004016
BFO_0000050: G alpha (s) signalling events
BFO_0000050: G alpha (i) signalling events
BFO_0000050: G alpha (z) signalling events
directly activates: cAMP degradation by Phosphodiesterases
directly activates: Catalysis1879

cAMP degradation by Phosphodiesterases
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004115
BFO_0000050: G alpha (s) signalling events

G alpha (s) auto-inactivates by hydrolysing GTP to GDP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0003924
BFO_0000050: G alpha (s) signalling events
directly activates: Inactive G alpha (s) reassociates with G beta:gamma

Inactive G alpha (s) reassociates with G beta:gamma
type: GO_0003674
BFO_0000050: G alpha (s) signalling events

Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
type: GO_0003674
BFO_0000050: G alpha (i) signalling events
directly activates: Liganded Gi-activating GPCR acts as a GEF for Gi
directly activates: Catalysis1881

Liganded Gi-activating GPCR acts as a GEF for Gi
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005085
BFO_0000050: G alpha (i) signalling events
directly activates: The Ligand:GPCR:Gi complex dissociates
directly activates: G alpha (z) inhibits adenylate cyclase
directly activates: G alpha (z) auto-inactivates by hydrolysing GTP to GDP
directly activates: G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF)
directly activates: LARG activation by G alpha 12/13
directly activates: G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP
directly activates: Gbeta:gamma recruits PI3K gamma
directly activates: Gbeta:gamma activation of PLC beta
directly activates: Catalysis1886
directly activates: Catalysis1893
directly activates: Control344

The Ligand:GPCR:Gi complex dissociates
type: GO_0003674
BFO_0000050: G alpha (i) signalling events
directly activates: G alpha (i) inhibits adenylate cyclase
directly activates: G alpha (i) auto-inactivates by hydrolysing GTP to GDP
directly activates: Catalysis1883
directly activates: Control343

Opsins that act as GEFs for G alpha-t
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005085
BFO_0000050: G alpha (i) signalling events

G alpha (i) auto-inactivates by hydrolysing GTP to GDP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0003924
BFO_0000050: G alpha (i) signalling events
directly activates: Inactive G alpha (i) reassociates with G beta:gamma

Inactive G alpha (i) reassociates with G beta:gamma
type: GO_0003674
BFO_0000050: G alpha (i) signalling events

Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz
type: GO_0003674
BFO_0000050: G alpha (z) signalling events
directly activates: Liganded Gz-activating GPCR acts as a GEF for Gz
directly activates: Catalysis1884

Liganded Gz-activating GPCR acts as a GEF for Gz
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005085
BFO_0000050: G alpha (z) signalling events
directly activates: The Ligand:GPCR:Gz complex dissociates

The Ligand:GPCR:Gz complex dissociates
type: GO_0003674
BFO_0000050: G alpha (z) signalling events
directly activates: G alpha (z) inhibits adenylate cyclase
directly activates: G alpha (z) auto-inactivates by hydrolysing GTP to GDP
directly activates: Catalysis1886
directly activates: Control344

G alpha (z) inhibits adenylate cyclase
type: GO_0003674
BFO_0000050: G alpha (z) signalling events
directly activates: Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate
directly activates: Catalysis1878
directly activates: Control340
directly activates: Control341
directly activates: Control342

Gz is a substrate for PKC
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004697
BFO_0000050: G alpha (z) signalling events

G alpha (z) auto-inactivates by hydrolysing GTP to GDP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0003924
BFO_0000050: G alpha (z) signalling events
directly activates: Inactive G alpha (z) reassociates with G beta:gamma

Inactive G alpha (z) reassociates with G beta:gamma
type: GO_0003674
BFO_0000050: G alpha (z) signalling events

Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
type: GO_0003674
BFO_0000050: G alpha (q) signalling events
directly activates: Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
directly activates: Catalysis1887

Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005085
BFO_0000050: G alpha (q) signalling events
directly activates: The Ligand:GPCR:Gq complex dissociates
directly activates: Gbeta:gamma recruits PI3K gamma
directly activates: Gbeta:gamma activation of PLC beta

The Ligand:GPCR:Gq complex dissociates
type: GO_0003674
BFO_0000050: G alpha (q) signalling events
directly activates: GRK2 sequesters activated Gq
directly activates: GRK5 sequesters activated Gq
directly activates: G alpha (q) binds to Trio family RhoGEFs
directly activates: PLC beta is activated by G alpha (q)
directly activates: G alpha (q) inhibits PI3K alpha
directly activates: G alpha (q) auto-inactivates by hydrolysing GTP to GDP
directly activates: Catalysis1889
directly activates: Control345

GRK2 sequesters activated Gq
type: GO_0003674
BFO_0000050: G alpha (q) signalling events

GRK5 sequesters activated Gq
type: GO_0003674
BFO_0000050: G alpha (q) signalling events

G alpha (q) binds to Trio family RhoGEFs
type: GO_0003674
BFO_0000050: G alpha (q) signalling events

PLC beta is activated by G alpha (q)
type: GO_0003674
BFO_0000050: G alpha (q) signalling events
directly activates: PLC beta-mediated PIP2 hydrolysis
directly activates: Catalysis1888

G alpha (q) inhibits PI3K alpha
type: GO_0003674
BFO_0000050: G alpha (q) signalling events

PLC beta-mediated PIP2 hydrolysis
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004629
BFO_0000050: G alpha (q) signalling events
directly activates: Binding of IP3 to IP3 receptor
directly activates: Calcium and Diacylglycerol activate CalDAG-GEFs (RasGRPs)
directly activates: Activation of Protein Kinase C novel isoforms
directly activates: DAG activation of TRPC channels
directly activates: DAG is metabolized by DAGL to 2-AG
directly activates: DAG kinase produces phosphatidic acid from DAG
directly activates: BiochemicalReaction2356
directly activates: Activation of Protein kinase C, alpha type by Diacylglycerol
directly activates: IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel
directly activates: Catalysis1036
directly activates: Catalysis1038
directly activates: Control159

G alpha (q) auto-inactivates by hydrolysing GTP to GDP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0003924
BFO_0000050: G alpha (q) signalling events
directly activates: Inactive G alpha (q) reassociates with G beta:gamma

Inactive G alpha (q) reassociates with G beta:gamma
type: GO_0003674
BFO_0000050: G alpha (q) signalling events

Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13
type: GO_0003674
BFO_0000050: G alpha (12/13) signalling events
directly activates: Liganded G12/13-activating GPCR acts as a GEF for G12/13
directly activates: Catalysis1890

Liganded G12/13-activating GPCR acts as a GEF for G12/13
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005085
BFO_0000050: G alpha (12/13) signalling events
directly activates: The Ligand:GPCR:G12/13 complex dissociates

The Ligand:GPCR:G12/13 complex dissociates
type: GO_0003674
BFO_0000050: G alpha (12/13) signalling events
directly activates: G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF)
directly activates: LARG activation by G alpha 12/13
directly activates: G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP
directly activates: Catalysis1893

G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF)
type: GO_0003674
BFO_0000050: G alpha (12/13) signalling events
directly activates: p115-RhoGEF activation of Rac1
directly activates: GEFs activate RhoA,B,C
directly activates: Catalysis1891
directly activates: Catalysis1892

p115-RhoGEF activation of Rac1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005085
BFO_0000050: G alpha (12/13) signalling events
directly activates: Rac1 activation of PI3K

Rac1 activation of PI3K
type: GO_0003674
BFO_0000050: G alpha (12/13) signalling events
directly activates: BiochemicalReaction2320
directly activates: Catalysis1027

GEFs activate RhoA,B,C
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0005089
BFO_0000050: G alpha (12/13) signalling events
directly activates: ROCK activation by Rho

ROCK activation by Rho
type: GO_0003674
BFO_0000050: G alpha (12/13) signalling events
directly activates: BiochemicalReaction6113
directly activates: BiochemicalReaction6114
directly activates: Catalysis3170
directly activates: Catalysis3171

LARG activation by G alpha 12/13
type: GO_0003674
BFO_0000050: G alpha (12/13) signalling events
directly activates: GEFs activate RhoA,B,C
directly activates: LARG binds plexin B1
directly activates: Catalysis1892

LARG binds plexin B1
type: GO_0003674
BFO_0000050: G alpha (12/13) signalling events

G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0003924
BFO_0000050: G alpha (12/13) signalling events
directly activates: Inactive G alpha (12/13) reassociates with G beta:gamma

Inactive G alpha (12/13) reassociates with G beta:gamma
type: GO_0003674
BFO_0000050: G alpha (12/13) signalling events

Gbeta:gamma recruits PI3K gamma
type: GO_0003674
BFO_0000050: G beta:gamma signalling through PI3Kgamma
directly activates: G beta:gamma activated PI3Kgamma converts PIP2 to PIP3
directly activates: Catalysis1894

G beta:gamma activated PI3Kgamma converts PIP2 to PIP3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0046934
BFO_0000050: G beta:gamma signalling through PI3Kgamma
directly activates: PIP3 recruits PDK1 and AKT to the membrane
directly activates: PIP3 binds to RhoA and activates it
directly activates: BiochemicalReaction679
directly activates: BiochemicalReaction680
directly activates: Control158

Gbeta:gamma activation of PLC beta
type: GO_0003674
BFO_0000050: G beta:gamma signalling through PLC beta
directly activates: PLC beta-mediated PIP2 hydrolysis
directly activates: Catalysis1895

PLC beta-mediated PIP2 hydrolysis
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004629
BFO_0000050: G beta:gamma signalling through PLC beta
directly activates: Binding of IP3 to IP3 receptor
directly activates: Calcium and Diacylglycerol activate CalDAG-GEFs (RasGRPs)
directly activates: Activation of Protein Kinase C novel isoforms
directly activates: DAG activation of TRPC channels
directly activates: DAG is metabolized by DAGL to 2-AG
directly activates: DAG kinase produces phosphatidic acid from DAG
directly activates: BiochemicalReaction2356
directly activates: IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel
directly activates: Catalysis1036
directly activates: Catalysis1038
directly activates: Control159

G Protein trimer formation (olfactory)
type: GO_0003674
BFO_0000050: Olfactory Signaling Pathway

Olfactory Receptor - G Protein olfactory trimer complex formation
type: GO_0003674
BFO_0000050: Olfactory Signaling Pathway

Opioid binds MOR
type: GO_0003674
BFO_0000050: Opioid Signalling
directly activates: The high affinity receptor complex binds to G-protein
directly activates: Catalysis1896

The high affinity receptor complex binds to G-protein
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004930
BFO_0000050: G-protein activation
directly activates: The receptor:G-protein complex releases GDP

The receptor:G-protein complex releases GDP
type: GO_0003674
BFO_0000050: G-protein activation
directly activates: The receptor:G-protein complex binds GTP
directly activates: Catalysis1897

The receptor:G-protein complex binds GTP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005525
BFO_0000050: G-protein activation
directly activates: The receptor:G-protein complex dissociates

The receptor:G-protein complex dissociates
type: GO_0003674
BFO_0000050: G-protein activation
directly activates: G-protein alpha subunit is inactivated
directly activates: Catalysis1898

G-protein alpha subunit is inactivated
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0003924
BFO_0000050: G-protein activation
directly activates: G-protein beta-gamma subunits rebind the alpha-GDP subunit

G-protein beta-gamma subunits rebind the alpha-GDP subunit
type: GO_0003674
BFO_0000050: G-protein activation
directly activates: The high affinity receptor complex binds to G-protein
directly activates: Catalysis1896

Opioid dissociates from MOR
type: GO_0003674
BFO_0000050: Opioid Signalling
directly activates: Opioid binds MOR

Activation of PLC beta-1/4
type: GO_0003674
BFO_0000050: PLC beta mediated events
directly activates: PIP2 hydrolysis
directly activates: Inactivation of PLC beta
directly activates: Catalysis1899

PIP2 hydrolysis
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004435
BFO_0000050: PLC beta mediated events
directly activates: IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel

Inactivation of PLC beta
type: GO_0003674
BFO_0000050: PLC beta mediated events

Phosphorylation of cPLA2 by ERK-2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: ERK2
type: Restriction
  on property: enabled by
  some values from: ERK2
type: Restriction
  on property: enabled by
  some values from: ERK2
type: Restriction
  on property: enabled by
  some values from: ERK2
type: Restriction
  on property: enabled by
  some values from: ERK2
type: Restriction
  on property: enabled by
  some values from: ERK2
type: Restriction
  on property: enabled by
  some values from: ERK2
type: Restriction
  on property: enabled by
  some values from: ERK2
type: Restriction
  on property: enabled by
  some values from: ERK2
type: Restriction
  on property: enabled by
  some values from: ERK2
type: Restriction
  on property: enabled by
  some values from: ERK2
type: Restriction
  on property: enabled by
  some values from: ERK2
type: Restriction
  on property: enabled by
  some values from: ERK2
type: Restriction
  on property: enabled by
  some values from: ERK2
type: Restriction
  on property: enabled by
  some values from: ERK2
type: Restriction
  on property: enabled by
  some values from: ERK2
type: Restriction
  on property: enabled by
  some values from: ERK2
type: Restriction
  on property: enabled by
  some values from: ERK2
type: Restriction
  on property: enabled by
  some values from: ERK2
type: Restriction
  on property: enabled by
  some values from: ERK2
type: Restriction
  on property: enabled by
  some values from: ERK2
type: Restriction
  on property: enabled by
  some values from: ERK2
type: Restriction
  on property: enabled by
  some values from: ERK2
type: Restriction
  on property: enabled by
  some values from: ERK2
type: Restriction
  on property: enabled by
  some values from: ERK2
type: Restriction
  on property: enabled by
  some values from: ERK2
type: Restriction
  on property: enabled by
  some values from: ERK2
type: Restriction
  on property: enabled by
  some values from: ERK2
type: Restriction
  on property: enabled by
  some values from: ERK2
type: Restriction
  on property: enabled by
  some values from: ERK2
type: Restriction
  on property: enabled by
  some values from: ERK2
type: Restriction
  on property: enabled by
  some values from: ERK2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016301
BFO_0000050: phospho-PLA2 pathway
directly activates: Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase

Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase
type: GO_0003674
BFO_0000050: phospho-PLA2 pathway
directly activates: Hydrolysis of phosphatidylcholine
directly activates: Catalysis1901

Hydrolysis of phosphatidylcholine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0047498
BFO_0000050: phospho-PLA2 pathway
directly activates: BiochemicalReaction5188
directly activates: BiochemicalReaction5192
directly activates: BiochemicalReaction5193
directly activates: BiochemicalReaction5258
directly activates: BiochemicalReaction5259
directly activates: BiochemicalReaction5260
directly activates: Catalysis2453
directly activates: Catalysis2454
directly activates: Catalysis2506
directly activates: Catalysis2507
directly activates: Catalysis2508

Galpha-olf:GTP binds to adenylate cyclase and activates it
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0007190
type: GO_0008179
BFO_0000050: Adenylate cyclase activating pathway
directly activates: Adenylate cyclase converts ATP into cyclic AMP
directly activates: Catalysis1903

Adenylate cyclase converts ATP into cyclic AMP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004016
BFO_0000050: Adenylate cyclase activating pathway
directly activates: Adenylaye cyclase increases the GTPase activity of G alpha-olf
directly activates: cAMP hydrolysis by PDE 4
directly activates: Catalysis1904
directly activates: Catalysis1906

Adenylaye cyclase increases the GTPase activity of G alpha-olf
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0003924
BFO_0000050: Adenylate cyclase activating pathway
directly activates: The G alpha-olf:GDP:Adenylate cyclase complex dissociates

The G alpha-olf:GDP:Adenylate cyclase complex dissociates
type: GO_0003674
BFO_0000050: Adenylate cyclase activating pathway

PKA phosphorylates PDE4B
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004691
BFO_0000050: DARPP-32 events
directly activates: cAMP hydrolysis by PDE 4
directly activates: Catalysis1906

cAMP hydrolysis by PDE 4
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004115
BFO_0000050: DARPP-32 events

PKA phosphorylates DARPP-32 on Thr34
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004691
BFO_0000050: DARPP-32 events
directly activates: DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function
directly activates: Catalysis1908

DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008599
BFO_0000050: DARPP-32 events

CDK5 phosphorylates DARPP-32 on Thr75
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: CDK5
type: Restriction
  on property: enabled by
  some values from: CDK5
type: Restriction
  on property: enabled by
  some values from: CDK5
type: Restriction
  on property: enabled by
  some values from: CDK5
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004693
BFO_0000050: DARPP-32 events
directly activates: DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function
directly activates: DARPP-32 is dephosphorylated on Thr75 by PP2A
directly activates: Catalysis1910
directly activates: Catalysis1911

DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004862
BFO_0000050: DARPP-32 events

DARPP-32 is dephosphorylated on Thr75 by PP2A
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004722
BFO_0000050: DARPP-32 events

Inactive catalytic PP2B is activated by the binding of calmodulin
type: GO_0003674
BFO_0000050: DARPP-32 events

DARPP-32 is dephosphorylated on Thr34 by PP2B
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004722
BFO_0000050: DARPP-32 events

Gastrin binds to CCK-B receptor
type: GO_0003674
BFO_0000050: Gastrin-CREB signalling pathway via PKC and MAPK
directly activates: Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq

Activation of Protein kinase C, alpha type by Diacylglycerol
type: GO_0003674
BFO_0000050: EGFR Transactivation by Gastrin
directly activates: BiochemicalReaction5334
directly activates: Catalysis2568
directly activates: Activated PKC-alpha can activate MMP3

Active MMP3 can cleave pro-HBEGF to form active HBEGF
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: enabled by
  some values from: MMP3
type: Restriction
  on property: enabled by
  some values from: MMP3
type: Restriction
  on property: enabled by
  some values from: MMP3
type: Restriction
  on property: enabled by
  some values from: MMP3
type: GO_0004222
BFO_0000050: EGFR Transactivation by Gastrin
directly activates: Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor

Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor
type: GO_0003674
BFO_0000050: EGFR Transactivation by Gastrin
directly activates: GRB2:SOS1 binds to HBEGF:p-Y-EGFR

GRB2:SOS1 binds to HBEGF:p-Y-EGFR
type: GO_0003674
BFO_0000050: EGFR Transactivation by Gastrin
directly activates: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
directly activates: Catalysis1914

SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005088
BFO_0000050: EGFR Transactivation by Gastrin

IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel
type: GO_0003674
BFO_0000050: PLC beta mediated events
directly activates: Release of calcium from intracellular stores by IP3 receptor activation
directly activates: Catalysis272
directly activates: Control50

Release of calcium from intracellular stores by IP3 receptor activation
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0005261
BFO_0000050: PLC beta mediated events
directly activates: Calcium binds calmodulin
directly activates: BiochemicalReaction5350
directly activates: BiochemicalReaction717
directly activates: BiochemicalReaction722
directly activates: Catalysis2575
directly activates: Catalysis273
directly activates: Control428
directly activates: Control429
directly activates: Control430
directly activates: Control431
directly activates: Ca-dependent events

Inactivation of MEK1 by p34cdc2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: GO_0004674
BFO_0000050: ERK1 activation

MEK1 binds ERK-1
type: GO_0003674
BFO_0000050: ERK1 activation
directly activates: MEK1 phosphorylates ERK-1
directly activates: Catalysis344
directly activates: Control57

MEK1 phosphorylates ERK-1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: ERK1 activation
directly activates: Dissociation of phospho-ERK-1:MEK1

Dissociation of phospho-ERK-1:MEK1
type: GO_0003674
BFO_0000050: ERK1 activation
directly activates: Dimerisation of phospho-ERK-1

Dimerisation of phospho-ERK-1
type: GO_0003674
BFO_0000050: ERK1 activation
directly activates: Nuclear translocation of phospho-ERK-1 dimer

Nuclear translocation of phospho-ERK-1 dimer
type: GO_0000189
BFO_0000050: ERK1 activation
directly activates: BiochemicalReaction905
directly activates: BiochemicalReaction906
directly activates: ERK1/2/5 activate RSK1/2/3
directly activates: Catalysis346
directly activates: Catalysis347
directly activates: Catalysis349

MEK2 binds ERK-2
type: GO_0003674
BFO_0000050: ERK2 activation
directly activates: MEK2 phosphorylates ERK-2
directly activates: Catalysis345

MEK2 phosphorylates ERK-2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: ERK2 activation
directly activates: Dissociation of phospho-ERK-2:MEK2

Dissociation of phospho-ERK-2:MEK2
type: GO_0003674
BFO_0000050: ERK2 activation
directly activates: Dimerisation of phospho-ERK-2

Dimerisation of phospho-ERK-2
type: GO_0003674
BFO_0000050: ERK2 activation
directly activates: Nuclear translocation of phospho-ERK-2 dimer

Nuclear translocation of phospho-ERK-2 dimer
type: GO_0000189
BFO_0000050: ERK2 activation
directly activates: BiochemicalReaction905
directly activates: BiochemicalReaction906
directly activates: ERK1/2/5 activate RSK1/2/3
directly activates: Catalysis346
directly activates: Catalysis347
directly activates: Catalysis349

ERK1/2/5 activate RSK1/2/3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: Gastrin-CREB signalling pathway via PKC and MAPK
directly activates: RSK1/2/3 phosphorylates CREB at Serine 133
directly activates: Catalysis355

RSK1/2/3 phosphorylates CREB at Serine 133
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: Gastrin-CREB signalling pathway via PKC and MAPK

Signaling by GPCR
type: GO_0008150

GPCR ligand binding
type: GO_0008150
BFO_0000050: Signaling by GPCR

Class A/1 (Rhodopsin-like receptors)
type: GO_0008150
BFO_0000050: GPCR ligand binding

Peptide ligand-binding receptors
type: GO_0008150
BFO_0000050: Class A/1 (Rhodopsin-like receptors)

Chemokine receptors bind chemokines
type: GO_0008150
BFO_0000050: Peptide ligand-binding receptors

Tachykinin receptors bind tachykinins
type: GO_0008150
BFO_0000050: Peptide ligand-binding receptors

Vasopressin-like receptors
type: GO_0008150
BFO_0000050: Peptide ligand-binding receptors

Orexin and neuropeptides FF and QRFP bind to their respective receptors
type: GO_0008150
BFO_0000050: Peptide ligand-binding receptors

Formyl peptide receptors bind formyl peptides and many other ligands
type: GO_0008150
BFO_0000050: Peptide ligand-binding receptors

Relaxin receptors
type: GO_0008150
BFO_0000050: Peptide ligand-binding receptors

Amine ligand-binding receptors
type: GO_0008150
BFO_0000050: Class A/1 (Rhodopsin-like receptors)

Muscarinic acetylcholine receptors
type: GO_0008150
BFO_0000050: Amine ligand-binding receptors

Adrenoceptors
type: GO_0008150
BFO_0000050: Amine ligand-binding receptors

Dopamine receptors
type: GO_0008150
BFO_0000050: Amine ligand-binding receptors

Histamine receptors
type: GO_0008150
BFO_0000050: Amine ligand-binding receptors

Serotonin receptors
type: GO_0008150
BFO_0000050: Amine ligand-binding receptors

Hormone ligand-binding receptors
type: GO_0008150
BFO_0000050: Class A/1 (Rhodopsin-like receptors)

Eicosanoid ligand-binding receptors
type: GO_0008150
BFO_0000050: Class A/1 (Rhodopsin-like receptors)

Prostanoid ligand receptors
type: GO_0008150
BFO_0000050: Eicosanoid ligand-binding receptors

Leukotriene receptors
type: GO_0008150
BFO_0000050: Eicosanoid ligand-binding receptors

Nucleotide-like (purinergic) receptors
type: GO_0008150
BFO_0000050: Class A/1 (Rhodopsin-like receptors)

P2Y receptors
type: GO_0008150
BFO_0000050: Nucleotide-like (purinergic) receptors

Adenosine P1 receptors
type: GO_0008150
BFO_0000050: Nucleotide-like (purinergic) receptors

Hydroxycarboxylic acid-binding receptors
type: GO_0008150
BFO_0000050: Class A/1 (Rhodopsin-like receptors)

Lysosphingolipid and LPA receptors
type: GO_0008150
BFO_0000050: Class A/1 (Rhodopsin-like receptors)

Opsins
type: GO_0008150
BFO_0000050: Class A/1 (Rhodopsin-like receptors)

Free fatty acid receptors
type: GO_0008150
BFO_0000050: Class A/1 (Rhodopsin-like receptors)

Class B/2 (Secretin family receptors)
type: GO_0008150
BFO_0000050: GPCR ligand binding

Calcitonin-like ligand receptors
type: GO_0008150
BFO_0000050: Class B/2 (Secretin family receptors)

Glucagon-type ligand receptors
type: GO_0008150
BFO_0000050: Class B/2 (Secretin family receptors)

Class C/3 (Metabotropic glutamate/pheromone receptors)
type: GO_0008150
BFO_0000050: GPCR ligand binding

GPCR downstream signaling
type: GO_0008150
BFO_0000050: Signaling by GPCR

G alpha (s) signalling events
type: GO_0008150
BFO_0000050: GPCR downstream signaling

G alpha (i) signalling events
type: GO_0008150
BFO_0000050: GPCR downstream signaling

G alpha (z) signalling events
type: GO_0008150
BFO_0000050: GPCR downstream signaling

G alpha (q) signalling events
type: GO_0008150
BFO_0000050: GPCR downstream signaling
BFO_0000050: Gastrin-CREB signalling pathway via PKC and MAPK

G alpha (12/13) signalling events
type: GO_0008150
BFO_0000050: GPCR downstream signaling

G-protein beta:gamma signalling
type: GO_0008150
BFO_0000050: GPCR downstream signaling

G beta:gamma signalling through PI3Kgamma
type: GO_0008150
BFO_0000050: G-protein beta:gamma signalling

G beta:gamma signalling through PLC beta
type: GO_0008150
BFO_0000050: G-protein beta:gamma signalling

Olfactory Signaling Pathway
type: GO_0008150
BFO_0000050: GPCR downstream signaling

Opioid Signalling
type: GO_0008150
BFO_0000050: Signaling by GPCR

G-protein activation
type: GO_0008150
BFO_0000050: Opioid Signalling

G-protein mediated events
type: GO_0008150
BFO_0000050: Opioid Signalling

PLC beta mediated events
type: GO_0008150
BFO_0000050: G-protein mediated events

Ca-dependent events
type: GO_0008150
BFO_0000050: PLC beta mediated events

phospho-PLA2 pathway
type: GO_0008150
BFO_0000050: Ca-dependent events

Adenylate cyclase activating pathway
type: GO_0008150
BFO_0000050: G-protein mediated events

DARPP-32 events
type: GO_0008150
BFO_0000050: Opioid Signalling

Gastrin-CREB signalling pathway via PKC and MAPK
type: GO_0008150
BFO_0000050: Signaling by GPCR

EGFR Transactivation by Gastrin
type: GO_0008150
BFO_0000050: Gastrin-CREB signalling pathway via PKC and MAPK

ERK activation
type: GO_0008150
BFO_0000050: RAF/MAP kinase cascade

ERK1 activation
type: GO_0008150
BFO_0000050: ERK activation

ERK2 activation
type: GO_0008150
BFO_0000050: ERK activation

RAF/MAP kinase cascade
type: GO_0008150
BFO_0000050: Gastrin-CREB signalling pathway via PKC and MAPK

RAF activation
type: GO_0008150
BFO_0000050: RAF/MAP kinase cascade

MEK activation
type: GO_0008150
BFO_0000050: RAF/MAP kinase cascade

RAF phosphorylates MEK
type: GO_0008150
BFO_0000050: MEK activation

CaM pathway
type: GO_0008150
BFO_0000050: Ca-dependent events

Calmodulin induced events
type: GO_0008150
BFO_0000050: CaM pathway

PKA-mediated phosphorylation of CREB
type: GO_0008150
BFO_0000050: Calmodulin induced events

PKA activation
type: GO_0008150
BFO_0000050: PKA-mediated phosphorylation of CREB

CaMK IV-mediated phosphorylation of CREB
type: GO_0008150
BFO_0000050: Calmodulin induced events

Cam-PDE 1 activation
type: GO_0008150
BFO_0000050: Calmodulin induced events

Effects of PIP2 hydrolysis
type: GO_0008150
BFO_0000050: G alpha (q) signalling events

Arachidonate production from DAG
type: GO_0008150
BFO_0000050: Effects of PIP2 hydrolysis

Adenylate cyclase inhibitory pathway
type: GO_0008150
BFO_0000050: G-protein mediated events

Activated PKC-alpha can activate MMP3
type: GO_0003674
BFO_0000050: EGFR Transactivation by Gastrin
directly activates: Active MMP3 can cleave pro-HBEGF to form active HBEGF
directly activates: Catalysis1913