IBP1
label: IGFBP1
label: UniProt:P08833 IGFBP1

IBP3
label: IGFBP3
label: UniProt:P17936 IGFBP3

BP2
label: IBP2
label: IGFBP2
label: UniProt:P18065 IGFBP2

IBP4
label: IGFBP4
label: UniProt:P22692 IGFBP4

IBP6
label: IGFBP6
label: UniProt:P24592 IGFBP6

IBP5
label: IGFBP5
label: UniProt:P24593 IGFBP5

PAPPA
label: UniProt:Q13219 PAPPA

Formation of the IGF:IGFBP-1 Complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: enabled by
  some values from: IBP1
type: GO_0005515
BFO_0000050: Regulation of IGF Activity by IGFBP

Formation of the IGF:IGFBP-2 Complex
type: Restriction
  on property: enabled by
  some values from: BP2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0005515
BFO_0000050: Regulation of IGF Activity by IGFBP

Formation of the IGF:IGFBP-3:ALS Complex
type: Restriction
  on property: enabled by
  some values from: IBP3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0005515
BFO_0000050: Regulation of IGF Activity by IGFBP
directly activates: Proteolysis of the IGF:IGFBP-3:ALS Complex by Cathepsin G
directly activates: Proteolysis of the IGF:IGFBP-3:ALS Complex by Matrix Metalloproteinase
directly activates: Proteolysis of the IGF:IGFBP-3:ALS Complex by Plasmin
directly activates: Proteolysis of the IGF:IGFBP-3:ALS Complex by Prostate-specific Antigen
directly activates: Proteolysis of the IGF:IGFBP-3:ALS Complex by Thrombin
directly activates: Catalysis1619
directly activates: Catalysis1620
directly activates: Catalysis1621
directly activates: Catalysis1622
directly activates: Catalysis1623

Formation of the IGF:IGFBP-4 Complex
type: Restriction
  on property: enabled by
  some values from: IBP4
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0005515
BFO_0000050: Regulation of IGF Activity by IGFBP
directly activates: Proteolysis of the IGF:IGFBP-4 Complex by PAPP-A
directly activates: Catalysis1624

Formation of the IGF:IGFBP-5:ALS Complex
type: Restriction
  on property: enabled by
  some values from: IBP5
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0005515
BFO_0000050: Regulation of IGF Activity by IGFBP
directly activates: Proteolysis of the IGF:IGFBP-5:ALS Complex by PAPP-A2
directly activates: Catalysis1625

Formation of the IGF:IGFBP-6 Complex
type: Restriction
  on property: enabled by
  some values from: IBP6
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0005515
BFO_0000050: Regulation of IGF Activity by IGFBP

Proteolysis of the IGF:IGFBP-3:ALS Complex by Cathepsin G
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004252
BFO_0000050: Regulation of IGF Activity by IGFBP

Proteolysis of the IGF:IGFBP-3:ALS Complex by Matrix Metalloproteinase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004222
BFO_0000050: Regulation of IGF Activity by IGFBP

Proteolysis of the IGF:IGFBP-3:ALS Complex by Plasmin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Regulation of IGF Activity by IGFBP

Proteolysis of the IGF:IGFBP-3:ALS Complex by Prostate-specific Antigen
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Regulation of IGF Activity by IGFBP

Proteolysis of the IGF:IGFBP-3:ALS Complex by Thrombin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Regulation of IGF Activity by IGFBP

Proteolysis of the IGF:IGFBP-4 Complex by PAPP-A
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: enabled by
  some values from: PAPPA
type: GO_0004222
BFO_0000050: Regulation of IGF Activity by IGFBP

Proteolysis of the IGF:IGFBP-5:ALS Complex by PAPP-A2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004222
BFO_0000050: Regulation of IGF Activity by IGFBP

Regulation of IGF Activity by IGFBP
type: GO_0008150
label: Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)