SRC
label: SRC1
label: UniProt:P12931-1 SRC

ERK2
label: MAPK1
label: PRKM1
label: PRKM2
label: UniProt:P28482 MAPK1

Phosphorylation of L1 by SRC
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: SRC
type: GO_0004713
BFO_0000050: Recycling pathway of L1
directly activates: L1 binds ERM family members

L1 binds ERM family members
type: GO_0003674
BFO_0000050: Recycling pathway of L1
directly activates: L1 trans-homophilic interaction

L1 trans-homophilic interaction
type: GO_0003674
BFO_0000050: Recycling pathway of L1
directly activates: Linkage of L1 with treadmilling F-actin

Linkage of L1 with treadmilling F-actin
type: GO_0003674
BFO_0000050: Recycling pathway of L1
directly activates: Dephosphorylation of pL1 (Y1176)
directly activates: Catalysis3200

Shootin-1 links L1 and retrograde actin flow
type: GO_0003674
BFO_0000050: Recycling pathway of L1

Dephosphorylation of pL1 (Y1176)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004725
BFO_0000050: Recycling pathway of L1
directly activates: L1 binds to AP-2 Clathrin complex

L1 binds to AP-2 Clathrin complex
type: GO_0003674
BFO_0000050: Recycling pathway of L1
directly activates: Formation of clathrin coated vesicle
directly activates: Transport of L1 into endosomes
directly activates: Catalysis3201

Formation of clathrin coated vesicle
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0003924
BFO_0000050: Recycling pathway of L1

Interaction of NUMB with L1
type: GO_0003674
BFO_0000050: Recycling pathway of L1

Transport of L1 into endosomes
type: GO_0003674
BFO_0000050: Recycling pathway of L1
directly activates: Phosphorylation of L1 by p90rsk
directly activates: Phosphorylation of L1 by ERK
directly activates: Transport of L1 from C-domain to P-domain
directly activates: Catalysis3202
directly activates: Catalysis3203

Phosphorylation of L1 by p90rsk
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Recycling pathway of L1

Phosphorylation of L1 by ERK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: ERK2
type: GO_0016301
BFO_0000050: Recycling pathway of L1

Transport of L1 from C-domain to P-domain
type: GO_0003674
BFO_0000050: Recycling pathway of L1
directly activates: Reinsertion of L1 into the plasma membrane

Reinsertion of L1 into the plasma membrane
type: GO_0003674
BFO_0000050: Recycling pathway of L1
directly activates: Phosphorylation of L1 by SRC
directly activates: Catalysis3199

Recycling pathway of L1
type: GO_0008150