PKA/PKG phosphorylate Rap1GAP2
14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2
Activation of EPACs by cAMP
Activation of Rap1 by membrane-associated GEFs
Activation of Rap1 by cytosolic GEFs
Rap1 signal termination by Rap1GAPs
Rap1 sequesters Raf1 to inhibit ERK cascade
Rap1 signalling