PKA/PKG phosphorylate Rap1GAP2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Rap1 signalling
directly activates: 14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2
directly activates: Control52

14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2
type: GO_0003674
BFO_0000050: Rap1 signalling
directly activates: Rap1 signal termination by Rap1GAPs
directly activates: Catalysis323

Activation of EPACs by cAMP
type: GO_0003674
BFO_0000050: Rap1 signalling
directly activates: Activation of Rap1 by membrane-associated GEFs
directly activates: Catalysis321

Activation of Rap1 by membrane-associated GEFs
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005085
BFO_0000050: Rap1 signalling
directly activates: BiochemicalReaction2324
directly activates: Rap1 signal termination by Rap1GAPs
directly activates: Rap1 sequesters Raf1 to inhibit ERK cascade
directly activates: Catalysis323

Activation of Rap1 by cytosolic GEFs
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0005085
BFO_0000050: Rap1 signalling
directly activates: BiochemicalReaction2324
directly activates: Rap1 signal termination by Rap1GAPs
directly activates: Rap1 sequesters Raf1 to inhibit ERK cascade
directly activates: Catalysis323

Rap1 signal termination by Rap1GAPs
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0005096
BFO_0000050: Rap1 signalling

Rap1 sequesters Raf1 to inhibit ERK cascade
type: GO_0003674
BFO_0000050: Rap1 signalling

Rap1 signalling
type: GO_0008150