Pyruvate + NADH + H+ <=> (S)-Lactate + NAD+
lactate + H+ [cytosol] <=> lactate + H+ [extracellular]
lactate + H+ [extracellular] <=> lactate + H+ [cytosol]
(S)-Lactate + NAD+ <=> Pyruvate + NADH + H+
Cytosolic PYR is transported to the mitochondrial matrix by MPC1:MPC2
PYR + H+ (cytosol) => PYR + H+ (mitochondrial matrix)
Oxidative decarboxylation of pyruvate to acetyl CoA by pyruvate dehydrogenase
pyruvate + CoASH + NAD+ => acetylCoA + CO2 + NADH + H+
Inactivation of PDC by phosphorylation of PDC E1 alpha component
PDK-catalyzed phosphorylation (inactivation) of PDC E1 alpha subunit
Activation of PDC by dephosphorylation of phospho-E1 alpha component
PDP-catalyzed dephosphorylation (activation) of phospho E1 alpha subunit
Cori Cycle (interconversion of glucose and lactate)
Pyruvate metabolism
Regulation of pyruvate dehydrogenase (PDH) complex