Pyruvate + NADH + H+ <=> (S)-Lactate + NAD+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004459
BFO_0000050: Cori Cycle (interconversion of glucose and lactate)

lactate + H+ [cytosol] <=> lactate + H+ [extracellular]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0015129
BFO_0000050: Cori Cycle (interconversion of glucose and lactate)

lactate + H+ [extracellular] <=> lactate + H+ [cytosol]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0015129
BFO_0000050: Cori Cycle (interconversion of glucose and lactate)

(S)-Lactate + NAD+ <=> Pyruvate + NADH + H+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004459
BFO_0000050: Cori Cycle (interconversion of glucose and lactate)
directly activates: Cytosolic PYR is transported to the mitochondrial matrix by MPC1:MPC2
directly activates: Catalysis2599

Cytosolic PYR is transported to the mitochondrial matrix by MPC1:MPC2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: GO_0050833
BFO_0000050: Cori Cycle (interconversion of glucose and lactate)
directly activates: BiochemicalReaction4548
directly activates: Oxidative decarboxylation of pyruvate to acetyl CoA by pyruvate dehydrogenase
directly activates: Catalysis1965
directly activates: Catalysis2600
directly activates: Control367
label: PYR + H+ (cytosol) => PYR + H+ (mitochondrial matrix)

Oxidative decarboxylation of pyruvate to acetyl CoA by pyruvate dehydrogenase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004738
BFO_0000050: Cori Cycle (interconversion of glucose and lactate)
directly activates: BiochemicalReaction5407
directly activates: BiochemicalReaction5940
directly activates: BiochemicalReaction5941
directly activates: BiochemicalReaction5942
directly activates: BiochemicalReaction5962
directly activates: BiochemicalReaction5964
directly activates: BiochemicalReaction5966
directly activates: Catalysis2603
directly activates: Catalysis3074
directly activates: Catalysis3075
directly activates: Catalysis3076
directly activates: Catalysis3094
directly activates: Catalysis3096
directly activates: Catalysis3098
label: pyruvate + CoASH + NAD+ => acetylCoA + CO2 + NADH + H+

Inactivation of PDC by phosphorylation of PDC E1 alpha component
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004740
BFO_0000050: Regulation of pyruvate dehydrogenase (PDH) complex
directly activates: Activation of PDC by dephosphorylation of phospho-E1 alpha component
directly activates: Catalysis2602
directly activates: Control443
label: PDK-catalyzed phosphorylation (inactivation) of PDC E1 alpha subunit

Activation of PDC by dephosphorylation of phospho-E1 alpha component
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004741
BFO_0000050: Regulation of pyruvate dehydrogenase (PDH) complex
directly activates: Oxidative decarboxylation of pyruvate to acetyl CoA by pyruvate dehydrogenase
directly activates: Inactivation of PDC by phosphorylation of PDC E1 alpha component
directly activates: Catalysis2600
directly activates: Catalysis2601
directly activates: Control440
directly activates: Control441
directly activates: Control442
label: PDP-catalyzed dephosphorylation (activation) of phospho E1 alpha subunit

Cori Cycle (interconversion of glucose and lactate)
type: GO_0008150
label: Pyruvate metabolism

Regulation of pyruvate dehydrogenase (PDH) complex
type: GO_0008150
BFO_0000050: Cori Cycle (interconversion of glucose and lactate)