KIAA0361
PFAS
UniProt:O15067 PFAS
ADA
ADA1
UniProt:P00813 ADA
GART
PGFT
PRGS
UniProt:P22102 GART
GMPS
UniProt:P49915 GMPS
AIRP
FKSG85
NT5C1B
UniProt:Q96P26 NT5C1B
Formation of phosphoribosyl pyrophosphate amidotransferase tetramer
Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate
PRPP + H2O + L-Glutamine => 5-Phosphoribosylamine + L-Glutamate + PPi
5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi
5-phosphoribosylamine + glycine + ATP => 5-phosphoribosylglycinamide (GAR) + ADP + orthophosphate
5-phosphoribosylglycinamide (GAR) + 10-formyl-tetrahydrofolate => 5'-phosphoribosylformylglycinamide (FGAR) + tetrahydrofolate
GAR + 10-Formyl-THF => FGAR + THF
5'-phosphoribosylformylglycinamide (FGAR) + L-glutamine + ATP + H2O => 5'-phosphoribosylformylglycinamidine (FGAM) + L-glutamate + adenosine 5'-diphosphate + orthophosphate
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi
5'-phosphoribosylformylglycinamidine (FGAM) + ATP => 5'-phosphoribosyl-5-aminoimidazole (AIR) + ADP + orthophosphate
FGAM + ATP => AIR + ADP + Pi
5'-phosphoribosyl-5-aminoimidazole (AIR) + CO2 <=> 5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR)
AIR + CO2 => CAIR
5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR) + L-aspartate + ATP => 5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) + ADP + orthophosphate
CAIR + Aspartate + ATP => SAICAR + ADP + Pi
5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) <=> 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + fumarate
SAICAR => AICAR + Fumarate
5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + 10-formyltetrahydrofolate => 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) + tetrahydrofolate
AICAR + 10-Formyl-THF => FAICAR + THF
5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) <=> inosine 5'-monophosphate + H2O
FAICAR => IMP + H2O
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2]
inosine 5'-monophosphate (IMP) + NAD+ + H2O => xanthosine 5'-monophosphate (XMP) + NADH + H+
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate
xanthosine 5'-monophosphate (XMP) + L-glutamine + ATP + H2O => guanosine 5'-monophosphate (GMP) + L-glutamate + adenosine 5'-monophosphate (AMP) + pyrophosphate
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]
inosine 5'-monophosphate + L-aspartate + GTP => adenylosuccinate + guanosine 5'-diphosphate + orthophosphate
Adenylosuccinate => AMP + Fumarate
adenylosuccinate => adenosine 5'-monophosphate + fumarate
(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH3 [ADA]
(2'-deoxy)adenosine + ATP => (d)AMP + ADP [ADK]
deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP [DCK]
dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP [DGUOK]
AMP + H2O => IMP + NH3 [AMPD]
Deamination of N6-methyl-AMP to form IMP
N6-methyl-AMP + H2O => IMP + methylamine
guanine + (deoxy)ribose 1-phosphate <=> (deoxy)guanosine + orthophosphate [NP]
hypoxanthine + (deoxy)ribose 1-phosphate <=> (deoxy)inosine + orthophosphate [NP]
Adenine + PRPP => AMP + PPi
guanine or hypoxanthine + PRPP => GMP or IMP + PPi [HPRT1]
GMP + NADPH + H+ => IMP + NADP+ + NH4+ [GMPR,GMPR2]
AMP, dAMP, GMP, or IMP + H2O => adenosine, deoxyadenosine, guanosine, or inosine + orthophosphate [NT5E]
(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate [NT5C2]
AMP + H2O => adenosine + orthophosphate [NT5C1B]
(2'-deoxy)purine nucleoside 5'-monophosphate + H2O => (2'-deoxy)purine nucleoside + orthophosphate [NT5C1A]
(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate [NT5C1A]
(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate [NT5C]
(deoxy)guanosine + orthophosphate <=> guanine + (deoxy)ribose 1-phosphate [NP]
(deoxy)inosine + orthophosphate <=> hypoxanthine + (deoxy)ribose 1-phosphate [NP]
Guanine + H2O => Xanthine + NH3
Hypoxanthine + H2O + O2 => Xanthine + H2O2
Xanthine + H2O + O2 => Urate + H2O2
2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O
2 H2O2 => O2 + 2 H2O
Purine metabolism
Purine ribonucleoside monophosphate biosynthesis
Purine salvage
Purine catabolism