KIAA0361
label: PFAS
label: UniProt:O15067 PFAS

ADA
label: ADA1
label: UniProt:P00813 ADA

GART
label: PGFT
label: PRGS
label: UniProt:P22102 GART

GMPS
label: UniProt:P49915 GMPS

AIRP
label: FKSG85
label: NT5C1B
label: UniProt:Q96P26 NT5C1B

Formation of phosphoribosyl pyrophosphate amidotransferase tetramer
type: GO_0003674
BFO_0000050: Purine ribonucleoside monophosphate biosynthesis

Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer
type: GO_0003674
BFO_0000050: Purine ribonucleoside monophosphate biosynthesis

5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004044
BFO_0000050: Purine ribonucleoside monophosphate biosynthesis
directly activates: BiochemicalReaction296
directly activates: 5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi
directly activates: Catalysis111
directly activates: Catalysis2631
directly activates: Control14
label: PRPP + H2O + L-Glutamine => 5-Phosphoribosylamine + L-Glutamate + PPi

5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: GART
type: Restriction
  on property: enabled by
  some values from: GART
type: GO_0004637
BFO_0000050: Purine ribonucleoside monophosphate biosynthesis
directly activates: 5-phosphoribosylglycinamide (GAR) + 10-formyl-tetrahydrofolate => 5'-phosphoribosylformylglycinamide (FGAR) + tetrahydrofolate
directly activates: Catalysis2632
label: 5-phosphoribosylamine + glycine + ATP => 5-phosphoribosylglycinamide (GAR) + ADP + orthophosphate

5-phosphoribosylglycinamide (GAR) + 10-formyl-tetrahydrofolate => 5'-phosphoribosylformylglycinamide (FGAR) + tetrahydrofolate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: GART
type: Restriction
  on property: enabled by
  some values from: GART
type: GO_0004644
BFO_0000050: Purine ribonucleoside monophosphate biosynthesis
directly activates: 5'-phosphoribosylformylglycinamide (FGAR) + L-glutamine + ATP + H2O => 5'-phosphoribosylformylglycinamidine (FGAM) + L-glutamate + adenosine 5'-diphosphate + orthophosphate
directly activates: Catalysis2633
label: GAR + 10-Formyl-THF => FGAR + THF

5'-phosphoribosylformylglycinamide (FGAR) + L-glutamine + ATP + H2O => 5'-phosphoribosylformylglycinamidine (FGAM) + L-glutamate + adenosine 5'-diphosphate + orthophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: KIAA0361
type: Restriction
  on property: enabled by
  some values from: KIAA0361
type: GO_0004642
BFO_0000050: Purine ribonucleoside monophosphate biosynthesis
directly activates: 5'-phosphoribosylformylglycinamidine (FGAM) + ATP => 5'-phosphoribosyl-5-aminoimidazole (AIR) + ADP + orthophosphate
directly activates: Catalysis2634
label: FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi

5'-phosphoribosylformylglycinamidine (FGAM) + ATP => 5'-phosphoribosyl-5-aminoimidazole (AIR) + ADP + orthophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: GART
type: Restriction
  on property: enabled by
  some values from: GART
type: GO_0004641
BFO_0000050: Purine ribonucleoside monophosphate biosynthesis
directly activates: 5'-phosphoribosyl-5-aminoimidazole (AIR) + CO2 <=> 5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR)
directly activates: Catalysis2635
label: FGAM + ATP => AIR + ADP + Pi

5'-phosphoribosyl-5-aminoimidazole (AIR) + CO2 <=> 5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004638
BFO_0000050: Purine ribonucleoside monophosphate biosynthesis
directly activates: 5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR) + L-aspartate + ATP => 5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) + ADP + orthophosphate
directly activates: Catalysis2636
label: AIR + CO2 => CAIR

5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR) + L-aspartate + ATP => 5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) + ADP + orthophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004639
BFO_0000050: Purine ribonucleoside monophosphate biosynthesis
directly activates: 5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) <=> 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + fumarate
directly activates: Catalysis2637
label: CAIR + Aspartate + ATP => SAICAR + ADP + Pi

5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) <=> 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + fumarate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004018
BFO_0000050: Purine ribonucleoside monophosphate biosynthesis
directly activates: 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + 10-formyltetrahydrofolate => 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) + tetrahydrofolate
directly activates: Catalysis2638
label: SAICAR => AICAR + Fumarate

5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + 10-formyltetrahydrofolate => 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) + tetrahydrofolate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004643
BFO_0000050: Purine ribonucleoside monophosphate biosynthesis
directly activates: 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) <=> inosine 5'-monophosphate + H2O
directly activates: Catalysis2639
label: AICAR + 10-Formyl-THF => FAICAR + THF

5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) <=> inosine 5'-monophosphate + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003937
BFO_0000050: Purine ribonucleoside monophosphate biosynthesis
directly activates: IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2]
directly activates: IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]
directly activates: (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate [NT5C2]
directly activates: Catalysis2640
directly activates: Catalysis2642
directly activates: Catalysis2656
directly activates: Control456
directly activates: Control457
directly activates: Control458
directly activates: Control459
directly activates: Control460
label: FAICAR => IMP + H2O

IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003938
BFO_0000050: Purine ribonucleoside monophosphate biosynthesis
directly activates: XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate
directly activates: Catalysis2641
label: inosine 5'-monophosphate (IMP) + NAD+ + H2O => xanthosine 5'-monophosphate (XMP) + NADH + H+

XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: GMPS
type: Restriction
  on property: enabled by
  some values from: GMPS
type: GO_0003921
BFO_0000050: Purine ribonucleoside monophosphate biosynthesis
directly activates: BiochemicalReaction296
directly activates: (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate [NT5C2]
directly activates: BiochemicalReaction5519
directly activates: Catalysis111
directly activates: Catalysis2656
directly activates: Catalysis2705
directly activates: Control14
label: xanthosine 5'-monophosphate (XMP) + L-glutamine + ATP + H2O => guanosine 5'-monophosphate (GMP) + L-glutamate + adenosine 5'-monophosphate (AMP) + pyrophosphate

IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004019
BFO_0000050: Purine ribonucleoside monophosphate biosynthesis
directly activates: Adenylosuccinate => AMP + Fumarate
directly activates: Catalysis2643
label: inosine 5'-monophosphate + L-aspartate + GTP => adenylosuccinate + guanosine 5'-diphosphate + orthophosphate

Adenylosuccinate => AMP + Fumarate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004018
BFO_0000050: Purine ribonucleoside monophosphate biosynthesis
directly activates: AMP + H2O => IMP + NH3 [AMPD]
directly activates: BiochemicalReaction5513
directly activates: Catalysis2648
directly activates: Catalysis2699
label: adenylosuccinate => adenosine 5'-monophosphate + fumarate

(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH3 [ADA]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: ADA
type: Restriction
  on property: enabled by
  some values from: ADA
type: GO_0004000
BFO_0000050: Purine salvage
directly activates: (deoxy)inosine + orthophosphate <=> hypoxanthine + (deoxy)ribose 1-phosphate [NP]
directly activates: Catalysis2661

(2'-deoxy)adenosine + ATP => (d)AMP + ADP [ADK]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004001
BFO_0000050: Purine salvage
directly activates: BiochemicalReaction5513
directly activates: Catalysis2699

deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP [DCK]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0019206
BFO_0000050: Purine salvage

dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP [DGUOK]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0019206
BFO_0000050: Purine salvage
directly activates: BiochemicalReaction5519
directly activates: Catalysis2705

AMP + H2O => IMP + NH3 [AMPD]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003876
BFO_0000050: Purine salvage
directly activates: (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate [NT5C2]
directly activates: Catalysis2656

Deamination of N6-methyl-AMP to form IMP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004000
BFO_0000050: Purine salvage
label: N6-methyl-AMP + H2O => IMP + methylamine

guanine + (deoxy)ribose 1-phosphate <=> (deoxy)guanosine + orthophosphate [NP]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004731
BFO_0000050: Purine salvage

hypoxanthine + (deoxy)ribose 1-phosphate <=> (deoxy)inosine + orthophosphate [NP]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004731
BFO_0000050: Purine salvage

Adenine + PRPP => AMP + PPi
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003999
BFO_0000050: Purine salvage
directly activates: BiochemicalReaction296
directly activates: AMP + H2O => IMP + NH3 [AMPD]
directly activates: Catalysis111
directly activates: Catalysis2648
directly activates: Control14

guanine or hypoxanthine + PRPP => GMP or IMP + PPi [HPRT1]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004422
BFO_0000050: Purine salvage
directly activates: BiochemicalReaction296
directly activates: GMP + NADPH + H+ => IMP + NADP+ + NH4+ [GMPR,GMPR2]
directly activates: (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate [NT5C2]
directly activates: Catalysis111
directly activates: Catalysis2654
directly activates: Catalysis2656
directly activates: Control14

GMP + NADPH + H+ => IMP + NADP+ + NH4+ [GMPR,GMPR2]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003920
BFO_0000050: Purine salvage

AMP, dAMP, GMP, or IMP + H2O => adenosine, deoxyadenosine, guanosine, or inosine + orthophosphate [NT5E]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0008253
BFO_0000050: Purine catabolism

(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate [NT5C2]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008253
BFO_0000050: Purine catabolism
directly activates: (deoxy)guanosine + orthophosphate <=> guanine + (deoxy)ribose 1-phosphate [NP]
directly activates: Catalysis2660

AMP + H2O => adenosine + orthophosphate [NT5C1B]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: AIRP
type: Restriction
  on property: enabled by
  some values from: AIRP
type: GO_0008253
BFO_0000050: Purine catabolism

(2'-deoxy)purine nucleoside 5'-monophosphate + H2O => (2'-deoxy)purine nucleoside + orthophosphate [NT5C1A]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008253
BFO_0000050: Purine catabolism
label: (d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate [NT5C1A]

(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate [NT5C]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008253
BFO_0000050: Purine catabolism

(deoxy)guanosine + orthophosphate <=> guanine + (deoxy)ribose 1-phosphate [NP]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004731
BFO_0000050: Purine catabolism
directly activates: Guanine + H2O => Xanthine + NH3
directly activates: Catalysis2662

(deoxy)inosine + orthophosphate <=> hypoxanthine + (deoxy)ribose 1-phosphate [NP]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004731
BFO_0000050: Purine catabolism
directly activates: Hypoxanthine + H2O + O2 => Xanthine + H2O2
directly activates: Catalysis2663

Guanine + H2O => Xanthine + NH3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008892
BFO_0000050: Purine catabolism
directly activates: Xanthine + H2O + O2 => Urate + H2O2
directly activates: Catalysis2664

Hypoxanthine + H2O + O2 => Xanthine + H2O2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004855
BFO_0000050: Purine catabolism
directly activates: Xanthine + H2O + O2 => Urate + H2O2
directly activates: 2 H2O2 => O2 + 2 H2O
directly activates: Catalysis2664
directly activates: Catalysis2666

Xanthine + H2O + O2 => Urate + H2O2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004855
BFO_0000050: Purine catabolism
directly activates: 2 H2O2 => O2 + 2 H2O
directly activates: Catalysis2666

2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004602
BFO_0000050: Purine catabolism

2 H2O2 => O2 + 2 H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0004096
BFO_0000050: Purine catabolism

Purine metabolism
type: GO_0008150

Purine ribonucleoside monophosphate biosynthesis
type: GO_0008150
BFO_0000050: Purine metabolism

Purine salvage
type: GO_0008150
BFO_0000050: Purine metabolism

Purine catabolism
type: GO_0008150
BFO_0000050: Purine metabolism